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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
Other AURKB 203
Other AURKA 133
CAMK PIM1 38
CAMK PIM2 132
CAMK PIM3 40
FEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQ-IEKEGVEHQLR---REIEIQAHLH----HPN--ILRLYNYFYDRRRIYLILEY-APRG-ELYKELQKSCTFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLG-LKGELKIADFGWSVHAPSLRRKTMCGTLDYLPPEMIE-GRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGAQDLISKLLRHNPSERLPLAQVSAHPWV
FEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRR----EVEIQSHLR----HPN--ILRLYGYFHDATRVYLILEY-APLG-TVYRELQKLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLG-SAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIE-GRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLREVLEHPWI
YQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDR-ISDWGELPNGTRVPMEVVLLKKVS----SGFSGVIRLLDWFERPDSFVLILER-PEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHD------EEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWM
YRLGPLLGKGGFGTVFAGHRLTDRLQVAIKVIPRNR-VLGWSPLSDSVTCPLEVALLWKVGAGGGHPG--VIRLLDWFETQEGFMLVLERPLPAQ-DLFDYITEKGPLGEGPSRCFFGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFGSGALLHDEPYTDFDGTRVYSPPEWISRHQYHALPATVWSLGILLYDMVCGDIPFERD------QEILEAELHFPAHVSPDCCALIRRCLAPKPSSRPSLEEILLDPWM
YQVGAVLGSGGFGTVYAGSRIADGLPVAVKHVVKER-VTEWGSLGGATV-PLEVVLLRKVGAAGGARG--VIRLLDWFERPDGFLLVLER-PEPAQDLFDFITERGALDEPLARRFFAQVLAAVRHCHSCGVVHRDIKDENLLVDLRSGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSATVWSLGVLLYDMVCGDIPFEQD------EEILRGRLLFRRRVSPECQQLIRWCLSLRPSERPSLDQIAAHPWM
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