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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
Other AURKB 203
TK ALK 1116
Other AURKA 133
CMGC CDC2 4
CMGC CDK2 4
CMGC CDK5 4
TK EGFR 712
TK JAK2 849
TK JAK3 822
TK LCK 245
CAMK NUAK1 55
-FEIGRPLGKGKFGNVYLAREK-----KSHFIVALKVLFKSQ-IEKEG--VEHQLRREIEIQAHLHHPNILRLYNYFY--DRRRIYLILEYAPRGELYKELQ---KSC--------TFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLGL---KGELKIADFGWSV----HAPSLRRKT---MCGTLDYLPPEMIE-GRMHNEKVDLWCIGVLCYELLV-GNPP---------------FESA----SHNETYRRIVKVDLKFPASVP--------------------------MGAQDLISKLLRHNPSERLPLAQVSAHPWV--
I-TLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLP-EV-CS-EQDELDFL-M-EALIISKFNHQNIVRCIGVSL--QSLPRFILLELMAGGDLKSFLR----ETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDI-YR--ASYYRKGGCAMLPVKWMPPEAFM-EGIFTSKTDTWSFGVLLWEIFSLGYMP---------------YPSK-SNQEVLEFVTSGGRMDPPKNCP----------------------------GPVYRIMTQCWQHQPEDRPNFAIILER--I--
-FEIGRPLGKGKFGNVYLAREK-----QSKFILALKVLFKAQLEKAGV--EHQLRR-EVEIQSHLRHPNILRLYGYFH--DATRVYLILEYAPLGTVYRELQ---KLS--------KFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGS---AGELKIADFGWSV----HAPSSRRTT---LCGTLDYLPPEMIE-GRMHDEKVDLWSLGVLCYEFLV-GKPP---------------FEAN----TYQETYKRISRVEFTFPDFVT--------------------------EGARDLISRLLKHNPSQRPMLREVLEHPWI--
-YTKIEKIGEGTYGVVYKGRHK-----TTGQVVAMKKIRLES-EEEGV--PSTAIR-EISLLKELRHPNIVSLQDVLM--QDSRLYLIFEFLSM-DLKKYLDSIPPGQ--------YMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDD---KGTIKLADFGLARAF--GIPIRVYTH---EVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELAT-KKPL---------------FHGD-SEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF--
-FQKVEKIGEGTYGVVYKARNK-----LTGEVVALKKIRLDT-ETEGV--PSTAIR-EISLLKELNHPNIVKLLDVIH--TENKLYLVFEFLHQ-DLKKFMDA-SALT--------GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINT---EGAIKLADFGLARAF--GVPVRTYTH---EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRAL---------------FPGD-SEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF--
-YEKLEKIGEGTYGTVFKAKNR-----ETHEIVALKRVRLDD-DDEGV--PSSALR-EICLLKELKHKNIVRLHDVLH--SDKKLTLVFEFCDQ-DLKKYFD--SCNG--------DLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINR---NGELKLADFGLARAF--GIPVRCYSA---EVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPL---------------FPGN-DVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYF--
F-KKIKVLGSGAFGTVYKGLWIP-EGEKVKIPVAIKELR-EA-TS-PKANKEIL-D-EAYVMASVDNPHVCRLLGICL---TSTVQLITQLMPFGCLLDYVR----EH------KDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKT---PQHVKITDFGLAKLL-GA--EEKEYHAEGGKVPIKWMALESIL-HRIYTHQSDVWSYGVTVWELMTFGSKP---------------YDGI-PASEISSILEKGERLPQPPICT----------------------------IDVYMIMVKCWMIDADSRPKFRELI----IEF
-LKFLQQLGKGNFGSVEMCRYDP-LQDNTGEVVAVKKLQ-HS-TE--EHLRDFE-R-EIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQ----KH------KERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVEN---ENRVKIGDFGLTKVLPQD--KEYYKVKEPGESPIFWYAPESLT-ESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQM-IVFHLIELLKNNGRLPRPDGCP----------------------------DEIYMIMTECWNNNVNQRPSFRDLA----LRV
L-KYISQLGKGNFGSVELCRYDP-LGDNTGALVAVKQLQ-HS-GP-DQ-QRDFQ-R-EIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQ----RH------RARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVES---EAHVKIADFGLAKLLPLD--KDYYVVREPGQSPIFWYAPESLS-DNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAE--FLRMMGCERDVPALCRLLELLEEGQRLPAPPACP----------------------------AEVHELMKLCWAPSPQDRPSFSALGP---QL-
-LKLVERLGAGQFGEVWMGYYN------GHTKVAVKSLK-QG-SM-SP--DAFL-A-EANLMKQLQHQRLVRLYAVVT---QEPIYIITEYMENGSLVDFLK----TP-----SGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSD---TLSCKIADFGLARLI--E--DNEYTAREGAKFPIKWTAPEAIN-YGTFTIKSDVWSFGILLTEIVTHGRIP---------------YPGM-TNPEVIQNLERGYRMVRPDNCP----------------------------EELYQLMRLCWKERPEDRPTFDYLRSV--L--
-YELQETLGKGTYGKVKRATER-----FSGRVVAIKSIRKDK-IKDEQ--DMVHIRREIEIMSSLNHPHIISIYEVFE--NKDKIVIIMEYASKGELYDYIS---ERR--------RLSERETRHFFRQIVSAVHYCHKNGVVHRDLKLENILLDD---NCNIKIADFGLSNL---YQKDKFLQT---FCGSPLYASPEIVNGRPYRGPEVDSWALGVLLYTLVY-GTMP---------------FDGF----DHKNLIRQISSGEYREPTQP---------------------------SDARGLIRWMLMVNPDRRATIEDIANHWW-V-
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