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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
Other AURKB 203
TK ABL1 261
Other AURKA 133
TK LCK 245
CMGC MAPK9 26
AGC PRKCQ 380
TKL RAF1 349
TK TEK 824
--FEIGRPLGKGKFGNVYLAREK--KSHFIVALKVLFKS-Q-IEKEG--VEHQLRREIEIQAHL--HHPNILRLYNYFYD------RRRIYLILEYAPRGELYKELQKSC-----------------TFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSV---HAPSLRRKT---MCGTLDYLPPEMIEGRM---HNEKVDLWCIGVLCYELLV-GNPPFESA----SHNETYRRIVK----VDLKFPASVP---------------------------------------MGAQDLISKLLRHNPSERLPLA-QVSAHPWV-
--ITMKHKLGGGQYGEVYEGVWK--KYSLTVAVKTLK-E-D-TM-EV--EEFL-K-EAAVMKEI--KHPNLVQLLGVCTR------EPPFYIITEFMTYGNLLDYLR-EC--------------NRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLM-T--GDTYTAHAGAKFPIKWTAPESLAYNK---FSIKSDVWAFGVLLWEIATYGMSPYPGI-DLSQVYELLEKDYR----MERPEGCP-----------------------------------------EKVYELMRACWQWNPSDRPSFA-EIHQA--F-
--FEIGRPLGKGKFGNVYLAREK--QSKFILALKVLFKA-QLEKAGV--EHQLRR-EVEIQSHL--RHPNILRLYGYFHD------ATRVYLILEYAPLGTVYRELQKLS-----------------KFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSV---HAPSSRRTT---LCGTLDYLPPEMIEGRM---HDEKVDLWSLGVLCYEFLV-GKPPFEAN----TYQETYKRISR----VEFTFPDFVT---------------------------------------EGARDLISRLLKHNPSQRPMLR-EVLEHPWI-
--LKLVERLGAGQFGEVWMGYYN---GHTKVAVKSLK-Q-G-SM-SP--DAFL-A-EANLMKQL--QHQRLVRLYAVVT-------QEPIYIITEYMENGSLVDFLK-TP--------------SGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLI-E--DNEYTAREGAKFPIKWTAPEAINYGT---FTIKSDVWSFGILLTEIVTHGRIPYPGM-TNPEVIQNLERGYR----MVRPDNCP-----------------------------------------EELYQLMRLCWKERPEDRPTFD-YLRSV--L-
--YQQLKPIGSGAQGIVCAAFDT--VLGINVAVKKLSRP-F-QNQTH--AKRAYR-ELVLLKCV--NHKNIISLLNVFTPQKTLEEFQDVYLVMELMDA-NLCQVIH--M-----------------ELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLART--ACTNFMMTP---YVVTRYYRAPEVILGMG---YKENVDIWSVGCIMGELVK-GCVIFQGT-DHIDQWNKVIEQLG----TPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRISVD-EALRHPYI-
FI--LHKMLGKGSFGKVFLAEFK--KTNQFFAIKALKKD-V-VLMDD--DVECTMVEKRVLSLA-WEHPFLTHMFCTFQT------KENLFFVMEYLNGGDLMYHIQSCH-----------------KFDLSRATFYAAEIILGLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKEN-MLGDAKTNT---FCGTPDYIAPEILLGQK---YNHSVDWWSFGVLLYEMLI-GQSPFHGQ----DEEELFHSIRM----DNPFYPRWLE---------------------------------------KEAKDLLVKLFVREPEKRLGVRGDIRQHPLF-
VM--LSTRIGSGSFGTVYKGKWH-----GDVAVKILK-VVD-PT-PEQFQAFR-N-EVAVLRKT--RHVNILLFMGYMT-------KDNLAIVTQWCEGSSLYKHLH-VQ---------------ETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSR--WSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMT-GELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCP-----------------------------------------KAMKRLVADCVKKVKEERPLFP-QILSS--I-
--IKFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMK-E-Y-AS-KDDHRDFA-G-ELEVLCKLG-HHPNIINLLGACEH------RGYLYLAIEYAPHGNLLDFLR-KSRVLETDPAFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQ-----EVYVKKTMGRLPVRWMAIESLNYSV---YTTNSDVWSYGVLLWEIVSLGGTPYCGM-TCAELYEKLPQGYR----LEKPLNCD-----------------------------------------DEVYDLMRQCWREKPYERPSFA-QILV---SL
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