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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
Other AURKB 203
Other AURKA 133
TK IGF1R 999
TK JAK2 849
FEIGRPLGKGKFGNVYLAREK-----KSHFIVALKVLFKSQ-IEKEG--VEHQLRREIEIQAHLHHPNILRLYNYFY--DRRRIYLILEYAPRGELYKELQKSC-----------TFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSV----HAPSLRRKT---MCGTLDYLPPEMIEGRMHNEKVDLWCIGVLCYELLV-GNPP---------------FESA---SHNETYRRIVKVDLKFPASVPMGAQDLISKLLRHNPSERLPLAQVSAHPWV--
FEIGRPLGKGKFGNVYLAREK-----QSKFILALKVLFKAQLEKAGV--EHQLRR-EVEIQSHLRHPNILRLYGYFH--DATRVYLILEYAPLGTVYRELQKLS-----------KFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSV----HAPSSRRTT---LCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLV-GKPP---------------FEAN---TYQETYKRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLREVLEHPWI--
ITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVN-EA-AS-MRERIEFL-N-EASVMKEFNCHHVVRLLGVVS--QGQPTLVIMELMTRGDLKSYLR-SLRPEMENNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDI-YE--TDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQP---------------YQGLSNEQVLRFVMEGGLLDKPDNCP--DMLFELMRMCWQYNPKMRPSFLEIISS--I--
LKFLQQLGKGNFGSVEMCRYDP-LQDNTGEVVAVKKLQ-HS-TE--EHLRDFE-R-EIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQ-KH---------KERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQD--KEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCP--DEIYMIMTECWNNNVNQRPSFRDLA----LRV
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