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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
Other AURKB 203
Other AURKA 133
CMGC CDK2 4
TK JAK2 849
AGC PDPK1 82
-FEIGRPLGKGKFGNVYLAREK----KSHFIVALKVLFKSQ-IEKEG--VE-HQLRREIEIQAHLHHPNILRLYNYFY--DRRRIYLILEYAPRGELYKELQ--KSC--TFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSV------HAPSLRRKT---MCGTLDYLPPEMIE-GRMHNEKVDLWCIGVLCYELLV-GNPP---------------FESA---SHNETYRRIVKVDLKFPASVP--------------------------MGAQDLISKLLRHNPSERLPLAQVSAHPWV-----------
-FEIGRPLGKGKFGNVYLAREK----QSKFILALKVLFKAQLEKAGV--EH-QLRR-EVEIQSHLRHPNILRLYGYFH--DATRVYLILEYAPLGTVYRELQ--KLS--KFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSV------HAPSSRRTT---LCGTLDYLPPEMIE-GRMHDEKVDLWSLGVLCYEFLV-GKPP---------------FEAN---TYQETYKRISRVEFTFPDFVT--------------------------EGARDLISRLLKHNPSQRPMLREVLEHPWI-----------
-FQKVEKIGEGTYGVVYKARNK----LTGEVVALKKIRLDT-ETEGV--PS-TAIR-EISLLKELNHPNIVKLLDVIH--TENKLYLVFEFLHQ-DLKKFMDASALT--GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAF----GVPVRTYTH---EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRAL---------------FPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF-----------
-LKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQ-HS-TE--EHLRD-FE-R-EIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQ---KHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVL-PQ-D--KEYYKVKEPGESPIFWYAPESLT-ESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCP----------------------------DEIYMIMTECWNNNVNQRPSFRDLA----LRV---------
F-KFGKILGEGSFSTVVLAREL----ATSREYAIKILEKRH-IIKEN--KVPYVTR-ERDVMSRLDHPFFVKLYFTFQ--DDEKLYFGLSYAKNGELLKYIR--KIG--SFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLS--PESKQARANS---FVGTAQYVSPELLT-EKSACKSSDLWALGCIIYQLVA-GLPP---------------FRAG---NEYLIFQKIIKLEYDFPEKFF--------------------------PKARDLVEKLLVLDATKRLGCEEM------EGYGPLKAHPF
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