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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
Other AURKB 203
TK ABL1 261
TK EGFR 712
AGC PDPK1 82
TK RET 724
-FEIGRPLGKGKFGNVYLAREK-----KSHFIVALKVLFKSQIEKEG--VE-HQLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSC-------------------------TFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSV-----HAPSLRRKT---MCGTLDYLPPEMIEGRMHNEKVDLWCIGVLCYELLV-GNPPFESA---SHNETYRRIVKVDLKFPASVPMGAQDLISKLLRHNPSERLPLAQVSAHPWV-----------
-ITMKHKLGGGQYGEVYEGVWK-----KYSLTVAVKTLK-EDTM-EV--EE-FL-K-EAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLR-EC----------------------NRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLM---T--GDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCP--EKVYELMRACWQWNPSDRPSFAEIHQA--F-----------
F-KKIKVLGSGAFGTVYKGLWIP-EGEKVKIPVAIKELR-EATS-PKANKE-IL-D-EAYVMASVDNPHVCRLLGICL-TSTVQLITQLMPFGCLLDYVR-EH-----------------------KDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLL-G-A--EEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICT--IDVYMIMVKCWMIDADSRPKFRELI----IEF---------
F-KFGKILGEGSFSTVVLAREL-----ATSREYAIKILEKRHIIKEN--KVPYVTR-ERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIG-------------------------SFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLS-PESKQARANS---FVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVA-GLPPFRAG---NEYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGCEEM------EGYGPLKAHPF
L-VLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLK-ENAS-PSELRD-LL-S-EFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLR-ESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDV-Y-E--EDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCS--EEMYRLMLQCWKQEPDKRPVFADISKDL-------------
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