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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK BLK 203
TK ABL1 261
TK ABL2 288
TK FGR 263
TK FYN 271
TK HCK 241
TK LCK 245
TK LYN 247
CMGC MAPK11 24
CMGC MAPK14 24
TK SRC 270
TK YES1 277
--L-RLVRKLGSGQFGEVWMGYYK-NNMKVAIKTLK-EGTM-SPEAFL-GEANVMKALQHERLVRLYAVVT-------KEPIYIVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQIAEGMAYIERMNSIHRDLRAANILVSEALCCKIADFGLARII---DSEYTAQEGAKFPIKWTAPEAIH-FGVFTIKADVWSFGVLLMEVVTYGRVPYPGMSNPEVIRNLERGYRMPRPDTCP------------------------------PELYRGVIAECWRSRPEERPTFEFLQSV--L
---ITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLK-EDTM-EVEEFL-KEAAVMKEIKHPNLVQLLGVCTR------EPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMT--GDTYTAHAGAKFPIKWTAPESLA-YNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCP------------------------------EKVYE-LMRACWQWNPSDRPSFAEIHQA--F
---ITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLK-EDTM-EVEEFL-KEAAVMKEIKHPNLVQLLGVCTL------EPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMT--GDTYTAHAGAKFPIKWTAPESLA-YNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCP------------------------------PKVYE-LMRACWKWSPADRPSFAETHQA--F
---ITLERRLGTGCFGDVWLGTWN-GSTKVAVKTLK-PGTM-SPKAFL-EEAQVMKLLRHDKLVQLYAVVS-------EEPIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEGMAYMERMNYIHRDLRAANILVGERLACKIADFGLARLIK--DDEYNPCQGSKFPIKWTAPEAAL-FGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCPPGCP------------------------------ASLYE-AMEQTWRLDPEERPTFEYLQSFL--
---LQLIKRLGNGQFGEVWMGTWN-GNTKVAIKTLK-PGTM-SPESFL-EEAQIMKKLKHDKLVQLYAVVS-------EEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIE--DNEYTARQGAKFPIKWTAPEAAL-YGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCP------------------------------ISLHE-LMIHCWKKDPEERPTFEYLQSFL--
---LKLEKKLGAGQFGEVWMATYN-KHTKVAVKTMK-PGSM-SVEAFL-AEANVMKTLQHDKLVKLHAVVT-------KEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIE--DNEYTAREGAKFPIKWTAPEAIN-FGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCP------------------------------EELYN-IMMRCWKNRPEERPTFEYIQSV--L
---LKLVERLGAGQFGEVWMGYYN-GHTKVAVKSLK-QGSM-SPDAFL-AEANLMKQLQHQRLVRLYAVVT-------QEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIE--DNEYTAREGAKFPIKWTAPEAIN-YGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCP------------------------------EELYQ-LMRLCWKERPEDRPTFDYLRSV--L
---IKLVKRLGAGQFGEVWMGYYN-NSTKVAVKTLK-PGTM-SVQAFL-EEANLMKTLQHDKLVRLYAVVTR------EEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIE--DNEYTAREGAKFPIKWTAPEAIN-FGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCP------------------------------DELYD-IMKMCWKEKAEERPTFDYLQSV--L
LQG---LRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGA-DLNNIVKCQ---ALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLAR---QADEEMTG---YVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQ-GKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAID-LLGRMLVLDSDQRVSAAEALAHAYF
---YQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGA-DLNNIVKCQ---KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR---HTDDEMTG---YVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVD-LLEKMLVLDSDKRITAAQALAHAYF
--L-RLEVKLGQGCFGEVWMGTWN-GTTRVAIKTLK-PGTM-SPEAFL-QEAQVMKKLRHEKLVQLYAVVS-------EEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIE--DNEYTARQGAKFPIKWTAPEAAL-YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECP------------------------------ESLHD-LMCQCWRKEPEERPTFEYLQAF--L
--L-RLEVKLGQGCFGEVWMGTWN-GTTKVAIKTLK-PGTM-MPEAFL-QEAQIMKKLRHDKLVPLYAVVS-------EEPIYIVTEFMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLVCKIADFGLARLIE--DNEYTARQGAKFPIKWTAPEAAL-YGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCP------------------------------ESLHE-LMNLCWKKDPDERPTFEYIQSFL--
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