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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK BLK 203
TK ABL1 261
TK ALK 1116
CMGC CDC2 4
TK CSK 195
TK EGFR 712
TK EPHB4 615
TK FGFR1 478
TK FGFR2 481
TK IGF1R 999
TK INSR 1023
TK JAK2 849
TK KDR 834
TK LCK 245
TK PTK2 422
TK RET 724
AGC RPS6KA1 62
TK SRC 270
TK TEK 824
TK YES1 277
TK ZAP70 338
---L-RLVRKLGSGQFGEV---WMGYYK--------NNMKVAIKTLK-EGTM-SP--EAFL-GEANVMKAL-QHERLVRLYAVVT---KEPIYIVTEYMARGCLLDFLK----TD----------------------------------------------------------------EGSRLSLPRLIDMSAQIAEGMAYIERMNSIHRDLRAANILVSE---ALCCKIADFGLARII-------DSEYTAQEGAKFPIKWTAPEAIH-FGVFTIKADVWSFGVLLMEVVTYGRVP---------------YPGM-SNPEVIRNLERGYRMPRPDTCP----------------------------PELYRGVIAECWRSRPEERPT-----FEFLQSV--L--
----ITMKHKLGGGQYGEV---YEGVWK-------KYSLTVAVKTLK-EDTM-EV--EEFL-KEAAVMKEI-KHPNLVQLLGVCT--REPPFYIITEFMTYGNLLDYLR----EC----------------------------------------------------------------NRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGE---NHLVKVADFGLSRLM----T--GDTYTAHAGAKFPIKWTAPESLA-YNKFSIKSDVWAFGVLLWEIATYGMSP---------------YPGI-DLSQVYELLEKDYRMERPEGCP----------------------------EKVYE-LMRACWQWNPSDRPS-----FAEIHQA--F--
---I-TLIRGLGHGAFGEV---YEGQVSG--MPNDPSPLQVAVKTLP-EVCS-EQDELDFL-MEALIISKF-NHQNIVRCIGVSL--QSLPRFILLELMAGGDLKSFLR----ETRP-----------------------------------------------------------RPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDI---YR--ASYYRKGGCAMLPVKWMPPEAFM-EGIFTSKTDTWSFGVLLWEIFSLGYMP---------------YPSK-SNQEVLEFVTSGGRMDPPKNCP----------------------------GPVYR-IMTQCWQHQPEDRPN-----FAIILER--I--
----YTKIEKIGEGTYGVV---YKGRHK-------TTGQVVAMKKIRLESEEEGV--PSTAIREISLLKEL-RHPNIVSLQDVLM--QDSRLYLIFEFLSM-DLKKYLDSIPPGQ-------------------------------------------------------------------YMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDD---KGTIKLADFGLARAF----GIPIRVYTH---EVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELAT-KKPL---------------FHGD-SEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLD-LLSKMLIYDPAKRIS-----GKMALNHPYF--
----LKLLQTIGKGEFGDV---MLGDYR---------GNKVAVKCIK-NDAT-AQ---AFL-AEASVMTQL-RHSNLVQLLGVIV-EEKGGLYIVTEYMAKGSLVDYLR----SR----------------------------------------------------------------GRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSE---DNVAKVSDFGLTKEA----------SSTQDTGKLPVKWTAPEALR-EKKFSTKSDVWSFGILLWEIYSFGRVP---------------YPRI-PLKDVVPRVEKGYKMDAPDGCP----------------------------PAVYE-VMKNCWHLDAAMRPS-----FLQLREQL----
---F-KKIKVLGSGAFGTV---YKGLWIP---EGEKVKIPVAIKELR-EATS-PKANKEIL-DEAYVMASV-DNPHVCRLLGICL---TSTVQLITQLMPFGCLLDYVR----EH-----------------------------------------------------------------KDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKT---PQHVKITDFGLAKLL---GA--EEKEYHAEGGKVPIKWMALESIL-HRIYTHQSDVWSYGVTVWELMTFGSKP---------------YDGI-PASEISSILEKGERLPQPPICT----------------------------IDVYM-IMVKCWMIDADSRPK-----FRELI----IEF
---V-KIEEVIGAGEFGEV---CRGRLK----APGKKESCVAIKTLK-GGYT-ERQRREFL-SEASIMGQF-EHPNIIRLEGVVT--NSMPVMILTEFMENGALDSFLR----LN-----------------------------------------------------------------DGQFTVIQLVGMLRGIASGMRYLAEMSYVHRDLAARNILVNS---NLVCKVSDFGLSRFLEENSS--DPTYTSSLGGKIPIRWTAPEAIA-FRKFTSASDAWSYGIVMWEVMSFGERP---------------YWDM-SNQDVINAIEQDYRLPPPPDCP----------------------------TSLHQ-LMLDCWQKDRNARPR-----FPQVVSAL----
---L-VLGKPLGEGCFGQV---VLAEAIGLDKDKPNRVTKVAVKMLK-SDAT-EKDLSDLI-SEMEMMKMIGKHKNIINLLGACT--QDGPLYVIVEYASKGNLREYLQ----ARRPPGLEY--------------------------------------------------CYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTE---DNVMKIADFGLARDI---HH--IDYYKKTTNGRLPVKWMAPEALF-DRIYTHQSDVWSFGVLLWEIFTLGGSP---------------YPGV-PVEELFKLLKEGHRMDKPSNCT----------------------------NELYM-MMRDCWHAVPSQRPT-----FKQLVEDL----
----LTLGKPLGEGCFGQV---VMAEAVGIDKDKPKEAVTVAVKMLK-DDAT-EKDLSDLV-SEMEMMKMIGKHKNIINLLGACT--QDGPLYVIVEYASKGNLREYLR----ARRPPGMEY--------------------------------------------------SYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTE---NNVMKIADFGLARDI---NN--IDYYKKTTNGRLPVKWMAPEALF-DRVYTHQSDVWSFGVLMWEIFTLGGSP---------------YPGI-PVEELFKLLKEGHRMDKPANCT----------------------------NELYM-MMRDCWHAVPSQRPT-----FKQLVEDL----
----ITMSRELGQGSFGMV---YEGVAKG--VVKDEPETRVAIKTVN-EAAS-MRERIEFL-NEASVMKEF-NCHHVVRLLGVVS--QGQPTLVIMELMTRGDLKSYLR----SLRPEM--------------------------------------------------------ENNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAE---DFTVKIGDFGMTRDI---YE--TDYYRKGGKGLLPVRWMSPESLK-DGVFTTYSDVWSFGVVLWEIATLAEQP---------------YQGL-SNEQVLRFVMEGGLLDKPDNCP----------------------------DMLFE-LMRMCWQYNPKMRPS-----FLEIISS--I--
----ITLLRELGQGSFGMV---YEGNARD--IIKGEAETRVAVKTVN-ESAS-LRERIEFL-NEASVMKGF-TCHHVVRLLGVVS--KGQPTLVVMELMAHGDLKSYLR----SLRPEA--------------------------------------------------------ENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAH---DFTVKIGDFGMTRDI---YE--TDYYRKGGKGLLPVRWMAPESLK-DGVFTTSSDMWSFGVVLWEITSLAEQP---------------YQGL-SNEQVLKFVMDGGYLDQPDNCP----------------------------ERVTD-LMRMCWQFNPKMRPT-----FLEIVNLL----
----LKFLQQLGKGNFGSV---EMCRYDP---LQDNTGEVVAVKKLQ-HSTE--EHLRDFE-REIEILKSL-QHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQ----KH-----------------------------------------------------------------KERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVEN---ENRVKIGDFGLTKVL--PQD--KEYYKVKEPGESPIFWYAPESLT-ESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQM-IVFHLIELLKNNGRLPRPDGCP----------------------------DEIYM-IMTECWNNNVNQRPS-----FRDLA----LRV
----LKLGKPLGRGAFGQV---IEADAFG--IDKTATCRTVAVKMLK-EGAT-HSEHRALM-SELKILIHIGHHLNVVNLLGACT-KPGGPLMVIVEFCKFGNLSTYLR----SKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSE---KNVVKICDFGLARDI---YK--DPDYVRKGDARLPLKWMAPETIF-DRVYTIQSDVWSFGVLLWEIFSLGASP---------------YPGVKIDEEFCRRLKEGTRMRAPDYTT----------------------------PEMYQ-TMLDCWHGEPSQRPT-----FSELVEHL----
----LKLVERLGAGQFGEV---WMGYYN--------GHTKVAVKSLK-QGSM-SP--DAFL-AEANLMKQL-QHQRLVRLYAVVT---QEPIYIITEYMENGSLVDFLK----TP----------------------------------------------------------------SGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSD---TLSCKIADFGLARLI----E--DNEYTAREGAKFPIKWTAPEAIN-YGTFTIKSDVWSFGILLTEIVTHGRIP---------------YPGM-TNPEVIQNLERGYRMVRPDNCP----------------------------EELYQ-LMRLCWKERPEDRPT-----FDYLRSV--L--
----IELGRCIGEGQFGDV---HQGIYM----SPENPALAVAIKTCK-NCTS-DSVREKFL-QEALTMRQF-DHPHIVKLIGVIT---ENPVWIIMELCTLGELRSFLQ----VR-----------------------------------------------------------------KYSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSS---NDCVKLGDFGLSRYM----E--DSTYYKASKGKLPIKWMAPESIN-FRRFTSASDVWMFGVCMWEILMHGVKP---------------FQGV-KNNDVIGRIENGERLPMPPNCP----------------------------PTLYS-LMTKCWAYDPSRRPR-----FTELKAQL----
---L-VLGKTLGEGEFGKV---VKATAFH--LKGRAGYTTVAVKMLK-ENAS-PSELRDLL-SEFNVLKQV-NHPHVIKLYGACS--QDGPLLLIVEYAKYGSLRGFLR----ESRKVGPGYLGSG------------------------------------------GSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAE---GRKMKISDFGLSRDV---YE--EDSYVKRSQGRIPVKWMAIESLF-DHIYTTQSDVWSFGVLLWEIVTLGGNP---------------YPGI-PPERLFNLLKTGHRMERPDNCS----------------------------EEMYR-LMLQCWKQEPDKRPV-----FADISKDL----
----FELLKVLGQGSFGKVFLVRKVTRP-------DSGHLYAMKVLKKATLKVRD--RVRTKMERDILADV-NHPFVVKLHYAFQ--TEGKLYLILDFLRGGDLFTRLS---KEV-------------------------------------------------------------------MFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDE---EGHIKLTDFGLSKEA----IDHEKKAYS---FCGTVEYMAPEVVN-RQGHSHSADWWSYGVLMFEMLT-GSLP---------------FQGK----DRKETMTLILKAKLGMPQFLS--------------------------TEAQS-LLRALFKRNPANRLGSGPDGAEEIKRHV--FY
---L-RLEVKLGQGCFGEV---WMGTWN--------GTTRVAIKTLK-PGTM-SP--EAFL-QEAQVMKKL-RHEKLVQLYAVVS---EEPIYIVTEYMSKGSLLDFLK----GE----------------------------------------------------------------TGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGE---NLVCKVADFGLARLI----E--DNEYTARQGAKFPIKWTAPEAAL-YGRFTIKSDVWSFGILLTELTTKGRVP---------------YPGM-VNREVLDQVERGYRMPCPPECP----------------------------ESLHD-LMCQCWRKEPEERPT-----FEYLQAF--L--
----IKFQDVIGEGNFGQV---LKARIK-----KDGLRMDAAIKRMK-EYAS-KDDHRDFA-GELEVLCKLGHHPNIINLLGACE--HRGYLYLAIEYAPHGNLLDFLR----KSRVLETDP--------------------------------------------------AFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGE---NYVAKIADFGLSRGQ--------EVYVKKTMGRLPVRWMAIESLN-YSVYTTNSDVWSYGVLLWEIVSLGGTP---------------YCGM-TCAELYEKLPQGYRLEKPLNCD----------------------------DEVYD-LMRQCWREKPYERPS-----FAQILV---SL-
---L-RLEVKLGQGCFGEV---WMGTWN--------GTTKVAIKTLK-PGTM-MP--EAFL-QEAQIMKKL-RHDKLVPLYAVVS---EEPIYIVTEFMSKGSLLDFLK----EG----------------------------------------------------------------DGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGE---NLVCKIADFGLARLI----E--DNEYTARQGAKFPIKWTAPEAAL-YGRFTIKSDVWSFGILQTELVTKGRVP---------------YPGM-VNREVLEQVERGYRMPCPQGCP----------------------------ESLHE-LMNLCWKKDPDERPT-----FEYIQSFL----
LIAD----IELGCGNFGSV---RQGVYR-----MRKKQIDVAIKVLK-QGTE-KADTEEMM-REAQIMHQL-DNPYIVRLIGVCQ---AEALMLVMEMAGGGPLHKFLV----GK-----------------------------------------------------------------REEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVN---RHYAKISDFGLSKAL--GAD--DSYYTARSAGKWPLKWYAPECIN-FRKFSSRSDVWSYGVTMWEALSYGQKP---------------YKKM-KGPEVMAFIEQGKRMECPPECP----------------------------PELYA-LMSDCWIYKWEDRPD-----FLTVEQR--M--
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