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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TKL BRAF 203
Other AURKA 133
Other AURKB 77
TK JAK2 849
TK JAK3 822
TK KDR 834
TKL TGFBR1 205
--ITVGQRIGSGSFGTVYKGKWH--------GDVAVKMLN-VTA-PT-PQQLQAFK-N-EVGVLRKT-RHVNILLFMGYST-------KPQLAIVTQWCEGSSLYHHLH-II-----------------------------------------------------------------ETKFEMIKLIDIARQTAQGMDYLHAK--------SIIHRDLKSNNIFLHEDLTVKIGDFGLATVK---S--R--WSGSHQFEQLSGSILWMAPEVIR------MQDKNPYSFQSDVYAFGIVLYELMT-GQ----------LP---------------YSNI-N---NRDQIIFMVGRGYLSPDLSKVRSNCP------KAMKRLMAECLKKKRDERPLFPQILA---SI-
--FEIGRPLGKGKFGNVYLAREK-----QSKFILALKVLFKA-QLEKAGV--EHQLRR-EVEIQSHL-RHPNILRLYGYFH--D----ATRVYLILEYAPLGTVYRELQKLS-------------------------------------------------------------------KFDEQRTATYITELANALSYCHSK--------RVIHRDIKPENLLLGSAGELKIADFGWSV--------HAPSSRRTT---LCGTLDYLPPEMIE------GRM---HDEKVDLWSLGVLCYEFLV-GK----------PP---------------FEAN--------TYQETYKRISR----VEFTFPDFVT----EGARDLISRLLKHNPSQRPMLREVLEHPWI--
--FEIGRPLGKGKFGNVYLAREK-----KSHFIVALKVLFKS-Q-IEKEG--VEHQLRREIEIQAHL-HHPNILRLYNYFY--D----RRRIYLILEYAPRGELYKELQKSC-------------------------------------------------------------------TFDEQRTATIMEELADALMYCHGK--------KVIHRDIKPENLLLGLKGELKIADFGWSV--------HAPSLRRKT---MCGTLDYLPPEMIE------GRM---HNEKVDLWCIGVLCYELLV-GN----------PP---------------FESA--------SHNETYRRIVK----VDLKFPASVP----MGAQDLISKLLRHNPSERLPLAQVSAHPWV--
--LKFLQQLGKGNFGSVEMCRYDP-LQDNTGEVVAVKKLQ-H-S-TE--EHLRDFE-R-EIEILKSL-QHDNIVKYKGVCYSAG----RRNLKLIMEYLPYGSLRDYLQ-KH-----------------------------------------------------------------KERIDHIKLLQYTSQICKGMEYLGTK--------RYIHRDLATRNILVENENRVKIGDFGLTKVL--PQ--D--KEYYKVKEPGESPIFWYAPESLT------ESK---FSVASDVWSFGVVLYELFTYIE----------KSKSPPAEFMRMIGNDKQGQM-----IVFHLIELLKNNGR----LPRPDGCP------DEIYMIMTECWNNNVNQRPSFRDLA----LRV
-L-KYISQLGKGNFGSVELCRYDP-LGDNTGALVAVKQLQ-H-S-GP-DQ-QRDFQ-R-EIQILKAL-HSDFIVKYRGVSYGPG----RQSLRLVMEYLPSGCLRDFLQ-RH-----------------------------------------------------------------RARLDASRLLLYSSQICKGMEYLGSR--------RCVHRDLAARNILVESEAHVKIADFGLAKLL--PL--D--KDYYVVREPGQSPIFWYAPESLS------DNI---FSRQSDVWSFGVVLYELFTYCD----------KSCSPSAE--FLRMMGCERDV-P---ALCRLLELLEEGQR----LPAPPACP------AEVHELMKLCWAPSPQDRPSFSALGP---QL-
--LKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLK-E-G-AT-HSEHRALM-S-ELKILIHIGHHLNVVNLLGACT-KP----GGPLMVIVEFCKFGNLSTYLR-SKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASR--------KCIHRDLAARNILLSEKNVVKICDFGLARDI---Y--K--DPDYVRKGDARLPLKWMAPETIF------DRV---YTIQSDVWSFGVLLWEIFSLGA----------SP---------------YPGV-K---IDEEFCRRLKEGTR----MRAPDYTT------PEMYQTMLDCWHGEPSQRPTFSELVEHL----
IV--LQESIGKGRFGEVWRGKWR-----GEE--VAVKIFSSR-E-ERSWF--REA----EIYQTVML-RHENILGFIAADN--KDNGTWTQLWLVSDYHEHGSLFDYLN-RY-------------------------------------------------------------------TVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDS--ATDTIDIAPNH---RVGTKRYMAPEVLDDSINMKHFE---SFKRADIYAMGLVFWEIAR-RCSIGGIHEDYQLP---------------YYDLVPSDPSVEEMRKVVCEQKL----RPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKK----TL
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