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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TKL BRAF 203
TK ALK 1116
TK EGFR 712
TK KDR 834
TK RET 724
-ITVGQRIGSGSFGTVYKGKWH--------GDVAVKMLNVTAPTPQQLQAFKNEVGVLRKT-RHVNILLFMGYST--KPQLAIVTQWCEGSSLYHHLHII-----------------------------------------------------------------ETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHE---DLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMT-GQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILA--SI-
I-TLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPE-VCSEQDELDFLMEALIISKF-NHQNIVRCIGVSL-QSLPRFILLELMAGGDLKSFLRETRP-----------------------------------------------------------RPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGI---FTSKTDTWSFGVLLWEIFSLGYMPYPSK-SNQEVLEFVTSGGR----MDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILER-I--
F-KKIKVLGSGAFGTVYKGLWIP-EGEKVKIPVAIKELRE-ATSPKANKEILDEAYVMASV-DNPHVCRLLGICL--TSTVQLITQLMPFGCLLDYVREH-----------------------------------------------------------------KDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKT---PQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRI---YTHQSDVWSYGVTVWELMTFGSKPYDGI-PASEISSILEKGER----LPQPPICTIDVYMIMVKCWMIDADSRPKFRELI---IEF
-LKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKE-GATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSE---KNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRV---YTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTR----MRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHL---
L-VLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKE-NASPSELRDLLSEFNVLKQV-NHPHVIKLYGACS-QDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSG------------------------------------------GSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAE---GRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHI---YTTQSDVWSFGVLLWEIVTLGGNPYPGI-PPERLFNLLKTGHR----MERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDL---
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