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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TKL BRAF 203
CAMK CHEK1 9
TK KDR 834
AGC PRKCA 339
AGC PRKCD 349
TKL RAF1 349
--ITVGQRIGSGSFGTVYKGKWH--------GDVAVKMLN-VTAPT-PQQLQAFK-N-EVGVLRKT--RHVNILLFMGYST--KPQLAIVTQWCEGSSLYHHLH-II-----------------------------------------------------------------ETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVK-S-R--WSGSHQFEQLSGSILWMAPEVIR-MQDKNPYSFQSDVYAFGIVLYELMT-GQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCP----KAMKRLMAECLKKKRDERPL-FPQILA---SI-------------
-W-DLVQTLGEGAYGEVQLAVNR-----VTEEAVAVKIVDMK-RAVDCP--ENI-KK-EICINKML--NHENVVKFYGHRR-EGNIQYLFLEYCSGGELFDRIEPDI-------------------------------------------------------------------GMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDNLKISDFGLATVFR-YNNRERLLNK---MCGTLPYVAPELLKRREF---HAEPVDVWSCGIVLTAMLA-GELPWDQP---SDSCQEYSDWKE----KKTYLNPWKKIDSAPLALLHKILVENPSARIT-IPDIKKDRW-Y-------------
--LKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLK-E-GAT-HSEHRALM-S-ELKILIHIG-HHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLR-SKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDI-Y-K--DPDYVRKGDARLPLKWMAPETIF-DRV---YTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTR----MRAPDYTT----PEMYQTMLDCWHGEPSQRPT-FSELVEHL----------------
-F-NFLMVLGKGSFGKVMLADRK-----GTEELYAIKILKKD-VVIQDD--DVECTMVEKRVLALL-DKPPFLTQLHSCFQ-TVDRLYFVMEYVNGGDLMYHIQQVG-------------------------------------------------------------------KFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEH---MMDGVTTRT---FCGTPDYIAPEIIA-YQP---YGKSVDWWAYGVLLYEMLA-GQPPFDGE----DEDELFQSIME----HNVSYPKSLS--KEAVSVCKGLMTKHPAKRLG-C---------GPEGERDVREHAFF
FI--FHKVLGKGSFGKVLLGELK-----GRGEYFAIKALKKD-VVLIDD--DVECTMVEKRVLTLA-AENPFLTHLICTFQ-TKDHLFFVMEFLNGGDLMYHIQDKG-------------------------------------------------------------------RFELYRATFYAAEIMCGLQFLHSKGIIYRDLKLDNVLLDRDGHIKIADFGMCKEN---IFGESRAST---FCGTPDYIAPEILQ-GLK---YTFSVDWWSFGVLLYEMLI-GQSPFHGD----DEDELFESIRV----DTPHYPRWIT--KESKDILEKLFEREPTKRLGVTGNIKIHPFF--------------
VM--LSTRIGSGSFGTVYKGKWH--------GDVAVKILK-VVDPT-PEQFQAFR-N-EVAVLRKT--RHVNILLFMGYMT--KDNLAIVTQWCEGSSLYKHLH-VQ-----------------------------------------------------------------ETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVK-S-R--WSGSQQVEQPTGSVLWMAPEVIR-MQDNNPFSFQSDVYSYGIVLYELMT-GELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCP----KAMKRLVADCVKKVKEERPL-FPQILSS--I--------------
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