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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC CDC2L6 203
CMGC CDC2 4
CMGC CDK2 4
CMGC CDK4 6
CMGC CDK8 2.7.11.23
Other CHUK 15
TK DDR1 572
CMGC GSK3B 56
TK JAK2 849
TK JAK3 822
TK LCK 245
CMGC MAPK14 24
TK PTK6 191
EGC-----KVGRGTYGHVYKARRK----------------DGKDEKEYALKQIEGTGISM---SA--C----REIALLRELK---HPNVIALQKVFL--SH----SDRKVW--LLFDYAEH---DLWHIIKFHR--ASKANKK--------------------PMQLPRSMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRV---KIADMGFARLFN--SPLKPLADLDP---VVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLT-SE-PI---------------FHCRQEDI--KTSNPFHHDQLDRI----FSVMG---FPADKDWEDIRKMPEYPTLQKDFRRTTYANSSLIKYMEKHKVKPDSKVFLLLQKLLTMDPTKRITSEQALQDPYF---------
---YTKIEKIGEGTYGVVYKGRHK----------------TTGQ--VVAMKKIRLESEEE---GV--PSTAIREISLLKELR---HPNIVSLQDVLM--Q------DSRLY--LIFEFLSM---DLKKYLDS------IPPGQ--------------------YM--DSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLID----DKGTI---KLADFGLARAF-----GIPIRVYTH---EVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELAT-KK-PL---------------FHGD-----------SEIDQLFRI----FRALG---TPNNEVWPEVESLQDYKNTFPKWKP---------GSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF---------
---FQKVEKIGEGTYGVVYKARNK----------------LTGE--VVALKKIRLDTETE---GV--PSTAIREISLLKELN---HPNIVKLLDVIH--T------ENKLY--LVFEFLHQ---DLKKFMDA-------SALT--------------------GI--PLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLIN----TEGAI---KLADFGLARAF-----GVPVRTYTH---EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RR-AL---------------FPGD-----------SEIDQLFRI----FRTLG---TPDEVVWPGVTSMPDYKPSFPKWAR---------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF---------
--Y-EPVAEIGVGAYGTVYKARDP----------------HSGH--FVALKSVRVPNGGGGGGGL--PISTVREVALLRRLEAFEHPNVVRLMDVCA--TSR-TDREIKVT--LVFEHVDQ---DLRTYLDK-------APPP--------------------GL--PAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVT----SGGTV---KLADFGLARI------YSYQMALTP---VVVTLWYRAPEVLL-QSTYATPVDMWSVGCIFAEMFR-RK-PL---------------FCGN-----------SEADQLGKI----FDLIG---LPPEDDWPRDVSLPRGAFPPRGPR-----------PVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYL---------
EGC-----KVGRGTYGHVYKAKRK----------------DGKDDKDYALKQIEGTGISM---SA--C----REIALLRELK---HPNVISLQKVFL--SH----ADRKVW--LLFDYAEH---DLWHIIKFHRASKANKKPV--------------------QL--PRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRV---KIADMGFARLFN--SPLKPLADLDP---VVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLT-SE-PI---------------FHCRQEDI--KTSNPYHHDQLDRI----FNVMG---FPADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYMEKHKVKPDSKAFHLLQKLLTMDPIKRITSEQAMQDPYF---------
--W-EMRERLGTGGFGNVCLYQHR----------------ELDL--KIAIKSCRLELSTK---NR--ER-WCHEIQIMKKLN---HANVVKACDVPE--ELN-ILIHDVPL--LAMEYCSGG--DLRKLLNK------PENCC--------------------GL--KESQILSLLSDIGSGIRYLHENKIIHRDLKPENIVLQ----DVGGKIIHKIIDLGYAKD------VDQGSLCTS---FVGTLQYLAPELFE-NKPYTATVDYWSFGTMVFECIA-GY-RP---------------FLHHLQPFTWHEKIKKKDPKCIFA----CEEMS---GEVRFSSHLPQPNSLCS-------------------------LVVEPMENWLQLMLNWDPQQRG-----------GPVDLTLKQ
---LRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPL--LVAVKILR-PDAT----KNARNDFL-KEVKIMSRLK---DPNIIRLLGVCV--Q------DDPLC--MITDYMENG--DLNQFLS----------AHQLEDKAAEGAPGDGQAAQGPTI--SYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVG----ENFTI---KIADFGMSRNL--Y--A--GDYYRVQGRAVLPIRWMAWECIL-MGKFTTASDVWAFGVTLWEVLMLCRAQP---------------FGQL-----------TDEQVIENAGEFFRDQGRQVYLSRPPACP-------------------------------------QGLYELMLRCWSRESEQRPPFSQLHRFL-----------
---YTDTKVIGNGSFGVVYQAKLC----------------DSGE--LVAIKKVLQDKRFK---NR--------ELQIMRKLD---HCNIVRLRYFFY--SSG--EKKDEVYLNLVLDYVPETVYRVA---RHY-----SRAKQ--------------------TL--PVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLD---PDTAVL---KLCDFGSAKQ------LVRGEPNVS---YICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLL-GQ-PI---------------FPGD-----------SGVDQLVEI----IKVLG---TPTREQIREMNPNYTEFKFPQIKAH---------PWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFF---------
---LKFLQQLGKGNFGSVEMCRYDP------------LQDNTGE--VVAVKKLQ-HSTE-----EHLRDFE-REIEILKSLQ---HDNIVKYKGVCYSAG------RRNLK--LIMEYLPYG--SLRDYLQ----------KH------------------KERI--DHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVE----NENRV---KIGDFGLTKVL-PQ--D--KEYYKVKEPGESPIFWYAPESLT-ESKFSVASDVWSFGVVLYELFTYIE-KSKSPPAEFMRMIGNDKQGQM-----------IVFHLIELL----KNNGR---LPRPDGCP-------------------------------------DEIYMIMTECWNNNVNQRPSFRDLA----LRV-------
--L-KYISQLGKGNFGSVELCRYDP------------LGDNTGA--LVAVKQLQ-HSGP----DQ-QRDFQ-REIQILKALH---SDFIVKYRGVSYGPG------RQSLR--LVMEYLPSG--CLRDFLQ----------RH------------------RARL--DASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVE----SEAHV---KIADFGLAKLL-PL--D--KDYYVVREPGQSPIFWYAPESLS-DNIFSRQSDVWSFGVVLYELFTYCD-KSCSPSAE--FLRMMGCERDV-P---------ALCRLLELL----EEGQR---LPAPPACP-------------------------------------AEVHELMKLCWAPSPQDRPSFSALGP---QL--------
---LKLVERLGAGQFGEVWMGYYN-----------------GHT--KVAVKSLK-QGSM----SP--DAFL-AEANLMKQLQ---HQRLVRLYAVVT---------QEPIY--IITEYMENG--SLVDFLK----------TP-----------------SGIKL--TINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVS----DTLSC---KIADFGLARLI-----E--DNEYTAREGAKFPIKWTAPEAIN-YGTFTIKSDVWSFGILLTEIVTHGR-IP---------------YPGM-----------TNPEVIQNL----ERGYR---MVRPDNCP-------------------------------------EELYQLMRLCWKERPEDRPTFDYLRSV--L---------
---YQNLSPVGSGAYGSVCAAFDT----------------KTGL--RVAVKKLSRPFQSI---IH--AKRTYRELRLLKHMK---HENVIGLLDVFT--PARSLEEFNDVY--LVTHLMGA---DLNNIVK----------CQ--------------------KL--TDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVN----EDCEL---KILDFGLAR--------HTDDEMTG---YVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GR-TL---------------FPGT-----------DHIDQLKLI----LRLVG---TPGAELLKKISSESARNYIQSLTQMP-------KMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYF---------
--F-TLCRKLGSGYFGEVFEGLWK-----------------DRV--QVAIKVIS-RDNL----LH-QQMLQ-SEIQAMKKLR---HKHILALYAVVS--V------GDPVY--IITELMAKG--SLLELLR----------DS-----------------DEKVL--PVSELLDIAWQVAEGMCYLESQNYIHRDLAARNILVG----ENTLC---KVGDFGLARLI--------KEDVYLSHDHNIPYKWTAPEALS-RGHYSTKSDVWSFGILLHEMFSRGQ-VP---------------YPGM-----------SNHEAFLRV----DAGYR---MPCPLECP-------------------------------------PSVHKLMLTCWCRDPEQRPCFKALRERL-----------
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