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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC CDC2L6 203
Other AURKA 133
Other AURKB 77
CMGC CDK2 4
CMGC CDK8 2.7.11.23
CAMK CHEK1 9
CMGC GSK3B 56
TK JAK2 849
TK JAK3 822
STE MAP2K1 68
CMGC MAPK1 13
CMGC MAPK10 64
CMGC MAPK14 24
CAMK MAPKAPK2 64
CAMK MARK2 53
Other PLK1 53
Other PLK2 82
Other PLK3 62
EGC-----KVGRGTYGHVYKARRK----DGKDEKEYALKQIEGTG-ISMSA--C----R-EIALLREL-KHPNVIALQKVFL--SH----SDRKVW--LLFDYAEH---DLWHIIKFHR--ASKANKK--PMQLPRSMVKSLLYQILDGIHYLHA-NWVLHRDLKPANILVMGEGPERGRV---KIADMGFARLFN--SPLKPLADLDP---VVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLT-SEPI---------------FHCRQEDIKTSNPFHHDQLDRIFSVMGFPADKDWEDIRKMPEYPTLQKDFRRTTYA------NSSLIKYMEKHKVKPDSKVFLLLQKLLTMDPTKRITSEQALQDPYF--
---FEIGRPLGKGKFGNVYLAREK----QSKF--ILALKVLFKAQLEKAGV--EHQLRR-EVEIQSHL-RHPNILRLYGYFH--D------ATRVY--LILEYAPLG--TVYRELQ---------KLS--KF--DEQRTATYITELANALSYCHS-KRVIHRDIKPENLLLG----SAGEL---KIADFGWSV-------HAPSSRRTT---LCGTLDYLPPEMIE-GRMHDEKVDLWSLGVLCYEFLV-GKPP---------------FEAN------------TYQETYKRISRVEFTFPDFVT-----------------------------------------EGARDLISRLLKHNPSQRPMLREVLEHPWI--
---FEIGRPLGKGKFGNVYLAREK----KSHF--IVALKVLFKSQ-IEKEG--VEHQLRREIEIQAHL-HHPNILRLYNYFY--D------RRRIY--LILEYAPRG--ELYKELQ---------KSC--TF--DEQRTATIMEELADALMYCHG-KKVIHRDIKPENLLLG----LKGEL---KIADFGWSV-------HAPSLRRKT---MCGTLDYLPPEMIE-GRMHNEKVDLWCIGVLCYELLV-GNPP---------------FESA------------SHNETYRRIVKVDLKFPASVP-----------------------------------------MGAQDLISKLLRHNPSERLPLAQVSAHPWV--
---FQKVEKIGEGTYGVVYKARNK----LTGE--VVALKKIRLDT-ETEGV--PSTAIR-EISLLKEL-NHPNIVKLLDVIH--T------ENKLY--LVFEFLHQ---DLKKFMDA-------SALT--GI--PLPLIKSYLFQLLQGLAFCHS-HRVLHRDLKPQNLLIN----TEGAI---KLADFGLARAF-----GVPVRTYTH---EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRAL---------------FPGD---------SEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR---------------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF--
EGC-----KVGRGTYGHVYKAKRK----DGKDDKDYALKQIEGTG-ISMSA--C----R-EIALLREL-KHPNVISLQKVFL--SH----ADRKVW--LLFDYAEH---DLWHIIKFHRASKANKKPV--QL--PRGMVKSLLYQILDGIHYLHA-NWVLHRDLKPANILVMGEGPERGRV---KIADMGFARLFN--SPLKPLADLDP---VVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLT-SEPI---------------FHCRQEDIKTSNPYHHDQLDRIFNVMGFPADKDWEDIKKMPEHSTLMKDFRRNTYT------NCSLIKYMEKHKVKPDSKAFHLLQKLLTMDPIKRITSEQAMQDPYF--
--W-DLVQTLGEGAYGEVQLAVNR----VTEE--AVAVKIVDMKR-AVDCP--ENI-KK-EICINKML-NHENVVKFYGHRR--E------GNIQY--LFLEYCSGG--ELFDRIE---------PDI--GM--PEPDAQRFFHQLMAGVVYLHG-IGITHRDIKPENLLLD----ERDNL---KISDFGLATVFR---YNNRERLLNK---MCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLA-GELP---------------WDQP-----------SDSCQEYSDWKEKKTYLNPWKKI--D-------------------------------------SAPLALLHKILVENPSARITIPDIKKDRW-Y-
---YTDTKVIGNGSFGVVYQAKLC----DSGE--LVAIKKVLQDK-RFKNR---------ELQIMRKL-DHCNIVRLRYFFY--SSG--EKKDEVYLNLVLDYVPETVYRVA---RHY-----SRAKQ--TL--PVIYVKLYMYQLFRSLAYIHS-FGICHRDIKPQNLLLD---PDTAVL---KLCDFGSAKQ------LVRGEPNVS---YICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLL-GQPI---------------FPGD---------SGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH---------------PWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFF--
---LKFLQQLGKGNFGSVEMCRYDPLQDNTGE--VVAVKKLQ-HS-TE--EHLRDFE-R-EIEILKSL-QHDNIVKYKGVCYSAG------RRNLK--LIMEYLPYG--SLRDYLQ----------KHKERI--DHIKLLQYTSQICKGMEYLGT-KRYIHRDLATRNILVE----NENRV---KIGDFGLTKVL-PQ--D--KEYYKVKEPGESPIFWYAPESLT-ESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQM---------IVFHLIELLKNNGRLPRPDGCP-------------------------------------------DEIYMIMTECWNNNVNQRPSFRDLA----LRV
--L-KYISQLGKGNFGSVELCRYDPLGDNTGA--LVAVKQLQ-HS-GP-DQ-QRDFQ-R-EIQILKAL-HSDFIVKYRGVSYGPG------RQSLR--LVMEYLPSG--CLRDFLQ----------RHRARL--DASRLLLYSSQICKGMEYLGS-RRCVHRDLAARNILVE----SEAHV---KIADFGLAKLL-PL--D--KDYYVVREPGQSPIFWYAPESLS-DNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAE--FLRMMGCERDV-P-------ALCRLLELLEEGQRLPAPPACP-------------------------------------------AEVHELMKLCWAPSPQDRPSFSALGP---QL-
---FEKISELGAGNGGVVFKVSHK----PSGL---VMARKLIHLE-IKPAI--RNQIIR-ELQVLHEC-NSPYIVGFYGAFY--S------DGEIS--ICMEHMDGG--SLDQVLK---------KAG--RI--PEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVN----SRGEI---KLCDFGVSG-------QLIDSMANS---FVGTRSYMSPERLQ-GTHYSVQSDIWSMGLSLVEMAV-GRYP---------------IPPP---------DAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFI--
---YTNLSYIGEGAYGMVCSAYDN----VNKV--RVAIKKISPFE-HQTYC--QRT-LR-EIKILLRF-RHENIIGINDIIR--APT-IEQMKDVY--IVQDLMET---DLYKLLK----------TQ--HL--SNDHICYFLYQILRGLKYIHS-ANVLHRDLKPSNLLLN----TTCDL---KICDFGLARVAD--PDHDHTGFLTE---YVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS-NRPI---------------FPGK---------HYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKN-------------KVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYL--
---YQNLKPIGSGAQGIVCAAYDA----VLDR--NVAIKKLSRPF-QNQTH--AKRAYR-ELVLMKCV-NHKNIISLLNVFT--PQKTLEEFQDVY--LVMELMDA---NLCQVIQ-----------M--EL--DHERMSYLLYQMLCGIKHLHS-AGIIHRDLKPSNIVVK----SDCTL---KILDFGLART------AGTSFMMTP---YVVTRYYRAPEVIL-GMGYKENVDIWSVGCIMGEMVR-HKIL---------------FPGR---------DYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPK--LFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYI--
---YQNLSPVGSGAYGSVCAAFDT----KTGL--RVAVKKLSRPF-QSIIH--AKRTYR-ELRLLKHM-KHENVIGLLDVFT--PARSLEEFNDVY--LVTHLMGA---DLNNIVK----------CQ--KL--TDDHVQFLIYQILRGLKYIHS-ADIIHRDLKPSNLAVN----EDCEL---KILDFGLAR--------HTDDEMTG---YVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTL---------------FPGT---------DHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMP-------------KMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYF--
KVT---SQVLGLGINGKVLQIFNK----RTQE--KFALKMLQDCP-KAR---------R-EVELHWRASQCPHIVRIVDVYE--NLY--AGRKCLL--IVMECLDGG--ELFSRIQD-------RGDQ--AF--TEREASEIMKSIGEAIQYLHS-INIAHRDVKPENLLYT----SKRPNAILKLTDFGFAKE------TTSHNSLTT---PCYTPYYVAPEVLG-PEKYDKSCDMWSLGVIMYILLC-GYPP---------------FYSN--------HGLAISPGMKTRIRMGQYEFPNPEWSEVS-------------------------------------EEVKMLIRNLLKTEPTQRMTITEFMNHPWI--
---YRLLKTIGKGNFAKVKLARHI----LTGK--EVAVKIIDKTQ-LNSSS--LQKLFR-EVRIMKVL-NHPNIVKLFEVIE--T------EKTLY--LVMEYASGG--EVFDYLV---------AHG--RM--KEKEARAKFRQIVSAVQYCHQ-KFIVHRDLKAENLLLD----ADMNI---KIADFGFSNE------FTFGNKLDT---FCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVS-GSLP---------------FDGQ------------NLKELRERVLRGKYRIPFYMS-----------------------------------------TDCENLLKKFLILNPSKRGTLEQIMKDRWM--
-YV--RGRFLGKGGFAKCFEISDA----DTKE--VFAGKIVPKSL-LLKPH--QREKMSMEISIHRSL-AHQHVVGFHGFFE--D------NDFVF--VVLELCRRR--SLLELHK---------RRK--AL--TEPEARYYLRQIVLGCQYLHR-NRVIHRDLKLGNLFLN----EDLEV---KIGDFGLATKV-----EYDGERKKT---LCGTPNYIAPEVLS-KKGHSFEVDVWSIGCIMYTLLV-GKPP---------------FETS------------CLKETYLRIKKNEYSIPKHIN-----------------------------------------PVAASLIQKMLQTDPTARPTINELLNDEFF--
--Y-CRGKVLGKGGFAKCYEMTDL----TNNK--VYAAKIIPHSR-VAKPH--QREKIDKEIELHRIL-HHKHVVQFYHYFE--D------KENIY--ILLEYCSRR--SMAHILK---------ARK--VL--TEPEVRYYLRQIVSGLKYLHE-QEILHRDLKLGNFFIN----EAMEL---KVGDFGLAARL-----EPLEHRRRT---ICGTPNYLSPEVLN-KQGHGCESDIWALGCVMYTMLL-GRPP---------------FETT------------NLKETYRCIREARYTMPSSLL-----------------------------------------APAKHLIASMLSKNPEDRPSLDDIIRHDFF--
-YL--KGRLLGKGGFARCYEATDT----ETGS--AYAVKVIPQSR-VAKPH--QREKILNEIELHRDL-QHRHIVRFSHHFE--D------ADNIY--IFLELCSRK--SLAHIWK---------ARH--TL--LEPEVRYYLRQILSGLKYLHQ-RGILHRDLKLGNFFIT----ENMEL---KVGDFGLAARL-----EPPEQRKKT---ICGTPNYVAPEVLL-RQGHGPEADVWSLGCVMYTLLC-GSPP---------------FETA------------DLKETYRCIKQVHYTLPASLS-----------------------------------------LPARQLLAAILRASPRDRPSIDQILRHDFF--
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