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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
AGC CDC42BPA 203
Other AURKA 133
TKL BRAF 456
CMGC CDC2 4
CMGC CDK2 4
CMGC CDK5 4
CMGC CDK9 2.7.11.23
CAMK CHEK1 9
Other CHUK 15
CMGC CSNK2A1 39
CMGC CSNK2A2 40
CAMK DAPK1 13
CAMK DAPK2 23
CAMK DAPK3 13
TK JAK1 875
TKL LIMK2 331
CMGC MAPK1 13
STE YSK4 1162
--FEILKVIGRGAFGEVAVVKLK----NADKVFAM-KILNKW-E-MLKRA--ETACFR---EERDVLVNG-DNKWITTLHYAFQ-D--------DNN--LYLVMDYYVGGDLLTLLS--KFED--RLPEDMARFYLAEMVIAIDSVHQLHYVHRDIKPDNILMD-MNGHI----RLADFGSCLKL----------------MEDGTVQS---------SV---AVGTPDYISPEILQAMEDGKGR---YGPECDWWSLGVCMYEMLY-GETP--------------FY-AE-----------SLV---ETYGKIMN----HKERFQFPAQVTDVS------------------------------ENAKDLIRRLICSREHR-LGQNGIEDFKKHPFF---------
--FEIGRPLGKGKFGNVYLAREK----QSKFILAL-KVLFKA-QLEKAGV--EHQLRR----EVEIQSHL-RHPNILRLYGYFH-D--------ATR--VYLILEYAPLGTVYRELQ---KLS--KFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLG-SAGEL----KIADFGWSV-------------------HAPSSRR---------TT---LCGTLDYLPPEMIE-----GRM---HDEKVDLWSLGVLCYEFLV-GKPP--------------FE-AN--------------TYQETYKRISR----VEFTFPDFVT-----------------------------------EGARDLISRLLKHNPSQRPM---LREVLEHPWI---------
--ITVGQRIGSGSFGTVYKGKWH-------GDVAV-KMLN-VTA-PT-PQQLQAFK-N----EVGVLRKT-RHVNILLFMGYST----------KPQ--LAIVTQWCEGSSLYHHLH----IIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLH-EDLTV----KIGDFGLATVK-------------S---R--WSGS---------HQFEQLSGSILWMAPEVIR-----MQDKNPYSFQSDVYAFGIVLYELMT-GQLP--------------YS-NI-N---------NRDQIIFMVGRGYLSPDLSKVRSNCP-------------------------------------KAMKRLMAECLKKKRDERPL---FPQILA---SI--------
--YTKIEKIGEGTYGVVYKGRHK----TTGQVVAM-KKIRLE-S-EEEGV--PSTAIR----EISLLKEL-RHPNIVSLQDVLM-Q--------DSR--LYLIFEFLSM-DLKKYLDSIPPGQ--YMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLID-DKGTI----KLADFGLARAF-----------------GIPIRVY---------TH---EVVTLWYRSPEVLL----GSAR---YSTPVDIWSIGTIFAELAT-KKPL--------------FH-GD-----------SEIDQLFRIFRALG----TPNNEVWPEV-ESLQDYKNTFPKWKP--------GSLASHVKNLDENGLDLLSKMLIYDPAKRIS---GKMALNHPYF---------
--FQKVEKIGEGTYGVVYKARNK----LTGEVVAL-KKIRLD-T-ETEGV--PSTAIR----EISLLKEL-NHPNIVKLLDVIH-T--------ENK--LYLVFEFLHQ-DLKKFMDA-SALT--GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLIN-TEGAI----KLADFGLARAF-----------------GVPVRTY---------TH---EVVTLWYRAPEILL----GCKY---YSTAVDIWSLGCIFAEMVT-RRAL--------------FP-GD-----------SEIDQLFRIFRTLG----TPDEVVWPGV-TSMPDYKPSFPKWAR--------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS---AKAALAHPFF---------
--YEKLEKIGEGTYGTVFKAKNR----ETHEIVAL-KRVRLD-D-DDEGV--PSSALR----EICLLKEL-KHKNIVRLHDVLH-S--------DKK--LTLVFEFCDQ-DLKKYFD--SCNG--DLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLIN-RNGEL----KLADFGLARAF-----------------GIPVRCY---------SA---EVVTLWYRPPDVLF----GAKL---YSTSIDMWSAGCIFAELANAGRPL--------------FP-GN-----------DVDDQLKRIFRLLG----TPTEEQWPSM-TKLPDYKPYPMYPAT--------TSLVNVVPKLNATGRDLLQNLLKCNPVQRIS---AEEALQHPYF---------
--YEKLAKIGQGTFGEVFKARHR----KTGQKVAL-KKVLME-N-EKEGF--PITALR----EIKILQLL-KHENVVNLIEICR-TKASPYNRCKGS--IYLVFDFCEH-DLAGLLS--NVLV--KFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLIT-RDGVL----KLADFGLARAFSL-------------AKNSQPNRY---------TN---RVVTLWYRPPELLL----GERD---YGPPIDLWGAGCIMAEMWT-RSPI--------------MQ-GN-----------TEQHQLALISQLCG----SITPEVWPNV-DNYELYEKLELVKGQK-----RKVKDRLKAYVRDPYALDLIDKLLVLDPAQRID---SDDALNHDFF---------
-W-DLVQTLGEGAYGEVQLAVNR----VTEEAVAV-KIVDMK-R-AVDCP--ENI-KK----EICINKML-NHENVVKFYGHRR-E--------GNI--QYLFLEYCSGGELFDRIE---PDI--GMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLD-ERDNL----KISDFGLATVFR---------------YNNRERLL---------NK---MCGTLPYVAPELLK----RREF---HAEPVDVWSCGIVLTAMLA-GELP--------------WD-QP-------------SDSCQEYSDWKE----KKTYLNPWKK-I--D------------------------------SAPLALLHKILVENPSARIT---IPDIKKDRW-Y--------
-W-EMRERLGTGGFGNVCLYQHR----ELDLKIAI-KSCRLE-L-STKNR--ER-WCH----EIQIMKKL-NHANVVKACDVPE-ELN---ILIHDV--PLLAMEYCSGGDLRKLLNKPENCC--GLKESQILSLLSDIGSGIRYLHENKIIHRDLKPENIVLQ-DVGGKI-IHKIIDLGYAKD------------------VDQGSLC---------TS---FVGTLQYLAPELFE-----NKP---YTATVDYWSFGTMVFECIA-GYRP--------------FL-HHLQPFTWHEKIKKKDPKCIFACEEMS----GEVRFSSHLP-QPNSLCS------------------------LVVEPMENWLQLMLNWDPQQRG--------------GPVDLTLKQ
--YQLVRKLGRGKYSEVFEAINI----TNNEKVVV-KILKPV-K-KKKIK--R---------EIKILENLRGGPNIITLADIVK-DP------VSRT--PALVFEHVNNTDFKQLY------Q--TLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKL----RLIDWGLAEF------------------YHPGQEY---------NV---RVASRYFKGPELLV----DYQM---YDYSLDMWSLGCMLASMIF-RKEP--------------FFHGH-----------DNYDQLVRIAKVLG----TEDLYDYIDK-YNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLT---AREAMEHPYF---------
--YQLVRKLGRGKYSEVFEAINI----TNNERVVV-KILKPV-K-KKKIK--R---------EVKILENLRGGTNIIKLIDTVK-DP------VSKT--PALVFEYINNTDFKQLY------Q--ILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKL----RLIDWGLAEF------------------YHPAQEY---------NV---RVASRYFKGPELLV----DYQM---YDYSLDMWSLGCMLASMIF-RREP--------------FFHGQ-----------DNYDQLVRIAKVLG----TEELYGYLKK-YHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLT---AKEAMEHPYF---------
--YDTGEELGSGQFAVVKKCREK----STGLQYAA-KFIKKR-R-TKSSR--RGVSREDIEREVSILKEI-QHPNVITLHEVYE-N--------KTD--VILILELVAGGELFDFLA---EKE--SLTEEEATEFLKQILNGVYYLHSLQIAHFDLKPENIMLL-DRNVPKPRIKIIDFGLAHK------------------IDFGNEF---------KN---IFGTPEFVAPEIVN-----YEP---LGLEADMWSIGVITYILLS-GASP--------------FL-GD--------------TKQETLANVSA----VNYEFEDEYF-SNTS------------------------------ALAKDFIRRLLVKDPKKRMT---IQDSLQHPWI---------
--YDIGEELGSGQFAIVKKCREK----STGLEYAA-KFIKKR-Q-SRASR--RGVSREEIEREVSILRQV-LHHNVITLHDVYE-N--------RTD--VVLILELVSGGELFDFLA---QKE--SLSEEEATSFIKQILDGVNYLHTKKIAHFDLKPENIMLL-DKNIPIPHIKLIDFGLAHE------------------IEDGVEF---------KN---IFGTPEFVAPEIVN-----YEP---LGLEADMWSIGVITYILLS-GASP--------------FL-GD--------------TKQETLANITA----VSYDFDEEFF-SQTS------------------------------ELAKDFIRKLLVKETRKRLT---IQEALRHPWI---------
--YEMGEELGSGQFAIVRKCRQK----GTGKEYAA-KFIKKR-R-LSSSR--RGVSREEIEREVNILREI-RHPNIITLHDIFE-N--------KTD--VVLILELVSGGELFDFLA---EKE--SLTEDEATQFLKQILDGVHYLHSKRIAHFDLKPENIMLL-DKNVPNPRIKLIDFGIAHK------------------IEAGNEF---------KN---IFGTPEFVAPEIVN-----YEP---LGLEADMWSIGVITYILLS-GASP--------------FL-GE--------------TKQETLTNISA----VNYDFDEEYF-SNTS------------------------------ELAKDFIRRLLVKDPKRRMT---IAQSLEHSWI---------
-L-KRIRDLGEGHFGKVELCRYDPEGDNTGEQVAV-KSLK-P-E-SG-GNHIADLK-K----EIEILRNL-YHENIVKYKGICTED---------GGNGIKLIMEFLPSGSLKEYLP----KNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVE-SEHQV----KIGDFGLTKAI------------ET---D--KEYY---------TVKDDRDSPVFWYAPECLM-----QSK---FYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHG-QM-----------TVTRLVNTLKEGKR----LPCPPNCP-------------------------------------DEVYQLMRKCWEFQPSNRTS---FQNLIE---GF--------
LI--HGEVLGKGFFGQAIKVTHK-----ATGKVMVMKEL--I-R-CD-EETQKTFL-T----EVKVMRSL-DHPNVLKFIGVLY-K--------DKK--LNLLTEYIEGGTLKDFLR----SM-DPFPWQQKVRFAKGIASGMAYLHSMCIIHRDLNSHNCLIK-LDKTV----VVADFGLSRLIVEERKRAPMEKATT---------KKRTLRKNDRKKRYTVVGNPYWMAPEMLN-----GKS---YDETVDIFSFGIVLCEIIGQVYAD--------------PD-CL-P---------RTLDFGLNVKLFWE----KFVPTDCP-------------------------------------PAFFPLAAICCRLEPESRPA---FSKLED---SF--------
--YTNLSYIGEGAYGMVCSAYDN----VNKVRVAI-KKISPF-E-HQTYC--QRT-LR----EIKILLRF-RHENIIGINDIIR-APT---IEQMKD--VYIVQDLMET-DLYKLLK----TQ--HLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLN-TTCDL----KICDFGLARVAD--------------PDHDHTGFL---------TE---YVATRWYRAPEIML----NSKG---YTKSIDIWSVGCILAEMLS-NRPI--------------FP-GK-----------HYLDQLNHILGILG----SPSQEDLNCI-INLKARNYLLSLPHKN------KVPWNRLFPNADSKALDLLDKMLTFNPHKRIE---VEQALAHPYL---------
--WTKGEILGKGAYGTVYCGLTS----QGQ-LIAV-KQVALD-T-SNKLA--AEKEYRKLQEEVDLLKAL-KHVNIVAYLGTCL-Q--------ENT--VSIFMEFVPGGSISSIIN---RFG--PLPEMVFCKYTKQILQGVAYLHENCVVHRDIKGNNVMLM-PTGII----KLIDFGCARRLAWA-----------GLNGTHSDML---------KS---MHGTPYWMAPEVIN-----ESG---YGRKSDIWSIGCTVFEMAT-GKPP--------------LA-SM-------------DRMAAMFYIGAH----RGLMPPLPDH-FS--------------------------------ENAADFVRMCLTRDQHERPS---ALQLLKHSFL---------
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