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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC CDK2 203
TK ABL1 261
Other AURKC 43
TK AXL 527
TK BLK 241
CMGC CDK4 6
CMGC CDK7 2.7.11.23
CAMK CHEK2 220
CAMK DAPK3 13
CAMK DCLK3 356
TK DDR1 572
TK DDR2 563
TK EPHA1 624
TK EPHB1 619
TK FGFR2 481
TK FGFR3 472
TK FGFR4 467
TK FGR 263
TK FYN 271
Other GAK 40
CMGC GSK3B 56
TK HCK 241
CMGC HIPK4 -1
TKL IRAK4 186
TK LCK 245
STE MAP2K1 68
STE MAP2K5 166
CMGC MAPK10 64
CMGC MAPK4 20
CMGC MAPK6 20
CMGC MAPK9 26
TK MET 1078
CMGC NLK 126
CAMK PHKG1 20
CAMK PHKG2 24
CAMK PIM3 40
AGC PRKCQ 380
CAMK PRKD1 583
TK PTK6 191
AGC ROCK2 92
Other SBK1 53
STE SLK 34
TK SRC 270
TK SRMS 230
CAMK STK17A 61
CAMK STK17B 33
Other STK35 202
Other STK36 4
TKL TNNI3K 463
TK YES1 277
---FQKVEKIGEGTYGVVYKARNK----------------LTGEVVALKKIRLD--TETE---GV--P-STAIR-------EISLLKEL--N-----HPNIVKLLDVIH-T-------------------------------------ENK------LY--LVFEFLHQ---DLKKFMDA--SALT--------------------GI---PLPLIKSYLFQLLQGLAFCHS--H--RVLHRDLKPQNLLIN--TEGAI----KLADFGLARAF--------------------GVPVRTY--TH---EVVTLWYRAPEILL-----GCKY-YSTAVDIWSLGCIFAEMVT-RR-ALFPGDSEIDQ-LFRI----FR----TLG---TPDEVVWPGVTSMPDYKPSFPKWAR-------------------------------------------------QDFSKVVPPLDEDGRS-LLSQMLHYDPNK--RISAK-AALAHPFF-----
---ITMKHKLGGGQYGEVYEGVWK----------------KYSLTVAVKTLK-E--DTM----EV--E-EFL-K-------EAAVMKEI--K-----HPNLVQLLGVCT-R-------------------------------------EPP------FY--IITEFMTYG--NLLDYLR-----EC-----------------NRQEV---NAVVLLYMATQISSAMEYLEK--K--NFIHRDLAARNCLVG--ENHLV----KVADFGLSRLM--------------------T--GDTY--TAHAGAKFPIKWTAPESLA------YNK-FSIKSDVWAFGVLLWEIATYGM-SPYPGIDLSQV-YELL----EK----DYR---MERPEGCP-----------------------------------------------------------------------------EKVYE-LMRACWQWNPSD--RPSFA-EIHQA--F-----
---FEIGRPLGKGKFGNVYLARLK----------------ESHFIVALKVLFKS--QIEK---EG--L-EHQLR------REIEIQAHL--Q-----HPNILRLYNYFH-D-------------------------------------ARR------VY--LILEYAPRG--ELYKELQ----KSE--------------------KL---DEQRTATIIEELADALTYCHD--K--KVIHRDIKPENLLLG--FRGEV----KIADFGWSV----------------------HTPSLRR--KT---MCGTLDYLPPEMIE------GRT-YDEKVDLWCIGVLCYELLV-GY-PPFESA---SH-SETY----RR----ILK---VDVRFPLSMP---------------------------------------------------------------------------LGARD-LISRLLRYQPLE--RLPLA-QILKHPWV-----
--V-ALGKTLGEGEFGAVMEGQLN--------------QDDSILKVAVKTMK-I-AICT----RSELE-DFL-S-------EAVCMKEF--D-----HPNVMRLIGVCF-Q-------------------------------------GSERESFPAPV--VILPFMKHG--DLHSFLL-----YSRL-------------GDQPVYL---PTQMLVKFMADIASGMEYLST--K--RFIHRDLAARNCMLN--ENMSV----CVADFGLSKKI----------Y---------N--GDYY--RQGRIAKMPVKWIAIESLA------DRV-YTSKSDVWSFGVTMWEIATRGQ-TPYPGVENSEI-YDYL----RQ----GNR---LKQPADCL-----------------------------------------------------------------------------DGLYA-LMSRCWELNPQD--RPSFT-ELREDL-------
--L-RLVRKLGSGQFGEVWMGYYK-----------------NNMKVAIKTLK-E--GTM----SP--E-AFL-G-------EANVMKAL--Q-----HERLVRLYAVVT---------------------------------------KEP------IY--IVTEYMARG--CLLDFLK-----TD-----------------EGSRL---SLPRLIDMSAQIAEGMAYIER--M--NSIHRDLRAANILVS--EALCC----KIADFGLARII-----------------------DSEY--TAQEGAKFPIKWTAPEAIH------FGV-FTIKADVWSFGVLLMEVVTYGR-VPYPGMSNPEV-IRNL----ER----GYR---MPRPDTCP-----------------------------------------------------------------------------PELYRGVIAECWRSRPEE--RPTFE-FLQSV--L-----
--Y-EPVAEIGVGAYGTVYKARDP----------------HSGHFVALKSVRVP--NGGGGGGGL--P-ISTVR-------EVALLRRL--EA--FEHPNVVRLMDVCA-TSR--------------------------------TDREIK------VT--LVFEHVDQ---DLRTYLDK--APPP--------------------GL---PAETIKDLMRQFLRGLDFLHA--N--CIVHRDLKPENILVT--SGGTV----KLADFGLARI---------------------YSYQMAL--TP---VVVTLWYRAPEVLL------QST-YATPVDMWSVGCIFAEMFR-RK-PLFCGNSEADQ-LGKI----FD----LIG---LPPEDDWPRDVSLPRGAFPPRGPR---------------------------------------------------PVQSVVPEMEESGAQ-LLLEMLTFNPHK--RISAF-RALQHSYL-----
---YEKLDFLGEGQFATVYKARDK----------------NTNQIVAIKKIKLG--HRSE---AK--D-GINRTA----LREIKLLQEL--S-----HPNIIGLLDAFG-H-------------------------------------KSN------IS--LVFDFMET---DLEVIIK---DNSL--------------------VL---TPSHIKAYMLMTLQGLEYLHQ--H--WILHRDLKPNNLLLD--ENGVL----KLADFGLAKSF--------------------GSPNRAY--TH---QVVTRWYRAPELLF-----GARM-YGVGVDMWAVGCILAELLL-RV-PFLPGDSDLDQ-LTRI----FE----TLG---TPTEEQWPDMCSLPDYVTFKSFPG--------------------------------------------------IPLHHIFSAAGDDLLD-LIQGLFLFNPCA--RITAT-QALKMKYF-----
-YI--MSKTLGSGACGEVKLAFER----------------KTCKKVAIKIISKR--KFAI---GS--A-READPALN-VETEIEILKKL--N-----HPCIIKIKNFF--D-------------------------------------AED------YY--IVLELMEGG--ELFDKVV----GNK--------------------RL---KEATCKLYFYQMLLAVQYLHE--N--GIIHRDLKPENVLLS--SQEEDC-LIKITDFGHSKI---------------------LGETSLM--RT---LCGTPTYLAPEVLVS---VGTAG-YNRAVDCWSLGVILFICLS-GY-PPFSEH--RTQ-VSLK----DQ----ITS---GKYNFIPEVWAEVS-----------------------------------------------------------------------EKALD-LVKKLLVVDPKA--RFTTE-EALRHPWL-----
---YEMGEELGSGQFAIVRKCRQK----------------GTGKEYAAKFIKKR--RLSS---SR--R-GVSREEI---EREVNILREI--R-----HPNIITLHDIFE-N-------------------------------------KTD------VV--LILELVSGG--ELFDFLA----EKE--------------------SL---TEDEATQFLKQILDGVHYLHS--K--RIAHFDLKPENIMLL--DKNVPNPRIKLIDFGIAHK---------------------IEAGNEF--KN---IFGTPEFVAPEIVN------YEP-LGLEADMWSIGVITYILLS-GA-SPFLGE---TK-QETL----TN----ISA---VNYDFDEEYFSNTS-----------------------------------------------------------------------ELAKD-FIRRLLVKDPKR--RMTIA-QSLEHSWI-----
---YETGRVIGDGNFAVVKECRHR----------------ETRQAYAMKIIDKS--RLKG---KE--D-MV-DS-------EILIIQSL--S-----HPNIVKLHEVYE-T-------------------------------------DME------IY--LILEYVQGG--DLFDAII----ESV--------------------KF---PEPDAALMIMDLCKALVHMHD--K--SIVHRDLKPENLLVQ--RNEDKSTTLKLADFGLAK-----------------------HVVRPI--FT---VCGTPTYVAPEILS------EKG-YGLEVDMWAAGVILYILLC-GF-PPFRSP-ERDQ-DELF----NI----IQL---GHFEFLPPYWDNIS-----------------------------------------------------------------------DAAKD-LVSRLLVVDPKK--RYTAH-QVLQHPWI-----
---LRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILR-P--DAT----KNARN-DFL-K-------EVKIMSRL--K-----DPNIIRLLGVCV-Q-------------------------------------DDP------LC--MITDYMENG--DLNQFLS-----AHQLEDKAAEGAPGDGQAAQGPTI---SYPMLLHVAAQIASGMRYLAT--L--NFVHRDLATRNCLVG--ENFTI----KIADFGMSRNL----------Y---------A--GDYY--RVQGRAVLPIRWMAWECIL------MGK-FTTASDVWAFGVTLWEVLMLCRAQPFGQLTDEQV-IENAGEFFRD----QGRQVYLSRPPACP-----------------------------------------------------------------------------QGLYE-LMLRCWSRESEQ--RPPFS-QLHRFL-------
---LTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLR-A--DAN----KNARN-DFL-K-------EIKIMSRL--K-----DPNIIHLLAVCI-T-------------------------------------DDP------LC--MITEYMENG--DLNQFLS-----RHEPPN---------SSSSDVRTV---SYTNLKFMATQIASGMKYLSS--L--NFVHRDLATRNCLVG--KNYTI----KIADFGMSRNL----------Y---------S--GDYY--RIQGRAVLPIRWMSWESIL------LGK-FTTASDVWAFGVTLWETFTFCQEQPYSQLSDEQV-IENT----GEFFRDQGRQTYLPQPAICP-----------------------------------------------------------------------------DSVYK-LMLSCWRRDTKN--RPSFQ-EIHL---LL----
-LM--VDTVIGEGEFGEVYRGTLR-------------LPSQDCKTVAIKTLK-D--TSP----GGQWW-NFL-R-------EATIMGQF--S-----HPHILHLEGVVT-K-------------------------------------RKP------IM--IITEFMENG--ALDAFLR-----ER------------------EDQL---VPGQLVAMLQGIASGMNYLSN--H--NYVHRDLAARNILVN--QNLCC----KVSDFGLTRLL----------D---------D--FDGT--YETQGGKIPIRWTAPEAIA------HRI-FTTASDVWSFGIVMWEVLSFGD-KPYGEMSNQEV-MKSI----ED----GYR---LPPPVDCP-----------------------------------------------------------------------------APLYE-LMKNCWAYDRAR--RPHFQ-KLQAHL-------
--V-KIEEVIGAGEFGEVYKGRLK-------------LPGKREIYVAIKTLK-A--GYS----EKQRR-DFL-S-------EASIMGQF--D-----HPNIIRLEGVVT-K-------------------------------------SRP------VM--IITEFMENG--ALDSFLR-----QN------------------DGQF---TVIQLVGMLRGIAAGMKYLAE--M--NYVHRDLAARNILVN--SNLVC----KVSDFGLSRYLQ-------DDT---------S--DPTY--TSSLGGKIPVRWTAPEAIA------YRK-FTSASDVWSYGIVMWEVMSFGE-RPYWDMSNQDV-INAI----EQ----DYR---LPPPMDCP-----------------------------------------------------------------------------AALHQ-LMLDCWQKDRNS--RPRFA-EIVNTL-------
---LTLGKPLGEGCFGQVVMAEAVGI---------DKDKPKEAVTVAVKMLK-D--DAT----EKDLS-DLV-S-------EMEMMKMIG-K-----HKNIINLLGACT-Q-------------------------------------DGP------LY--VIVEYASKG--NLREYLR-----ARRPPGMEY---SYDINRVPEEQM---TFKDLVSCTYQLARGMEYLAS--Q--KCIHRDLAARNVLVT--ENNVM----KIADFGLARDI----------N---------N--IDYY--KKTTNGRLPVKWMAPEALF------DRV-YTHQSDVWSFGVLMWEIFTLGG-SPYPGIPVEEL-FKLL----KE----GHR---MDKPANCT-----------------------------------------------------------------------------NELYM-MMRDCWHAVPSQ--RPTFK-QLVEDL-------
---LTLGKPLGEGCFGQVVMAEAIGI---------DKDRAAKPVTVAVKMLK-D--DAT----DKDLS-DLV-S-------EMEMMKMIG-K-----HKNIINLLGACT-Q-------------------------------------GGP------LY--VLVEYAAKG--NLREFLR-----ARRPPGLDY---SFDTCKPPEEQL---TFKDLVSCAYQVARGMEYLAS--Q--KCIHRDLAARNVLVT--EDNVM----KIADFGLARDV----------H---------N--LDYY--KKTTNGRLPVKWMAPEALF------DRV-YTHQSDVWSFGVLLWEIFTLGG-SPYPGIPVEEL-FKLL----KE----GHR---MDKPANCT-----------------------------------------------------------------------------HDLYM-IMRECWHAAPSQ--RPTFK-QLVEDL-------
--L-VLGKPLGEGCFGQVVRAEAFGM---------DPARPDQASTVAVKMLK-D--NAS----DKDLA-DLV-S-------EMEVMKLIG-R-----HKNIINLLGVCT-Q-------------------------------------EGP------LY--VIVECAAKG--NLREFLR-----ARRPPGPDL---SPDGPRSSEGPL---SFPVLVSCAYQVARGMQYLES--R--KCIHRDLAARNVLVT--EDNVM----KIADFGLARGV----------H---------H--IDYY--KKTSNGRLPVKWMAPEALF------DRV-YTHQSDVWSFGILLWEIFTLGG-SPYPGIPVEEL-FSLL----RE----GHR---MDRPPHCP-----------------------------------------------------------------------------PELYG-LMRECWHAAPSQ--RPTFK-QLVEAL-------
---ITLERRLGTGCFGDVWLGTWN-----------------GSTKVAVKTLK-P--GTM----SP--K-AFL-E-------EAQVMKLL--R-----HDKLVQLYAVVS---------------------------------------EEP------IY--IVTEFMCHG--SLLDFLK-----NP-----------------EGQDL---RLPQLVDMAAQVAEGMAYMER--M--NYIHRDLRAANILVG--ERLAC----KIADFGLARLI--------------------K--DDEY--NPCQGSKFPIKWTAPEAAL------FGR-FTIKSDVWSFGILLTELITKGR-IPYPGMNKREV-LEQV----EQ----GYH---MPCPPGCP-----------------------------------------------------------------------------ASLYE-AMEQTWRLDPEE--RPTFE-YLQSFL-------
---LQLIKRLGNGQFGEVWMGTWN-----------------GNTKVAIKTLK-P--GTM----SP--E-SFL-E-------EAQIMKKL--K-----HDKLVQLYAVVS---------------------------------------EEP------IY--IVTEYMNKG--SLLDFLK-----DG-----------------EGRAL---KLPNLVDMAAQVAAGMAYIER--M--NYIHRDLRSANILVG--NGLIC----KIADFGLARLI--------------------E--DNEY--TARQGAKFPIKWTAPEAAL------YGR-FTIKSDVWSFGILLTELVTKGR-VPYPGMNNREV-LEQV----ER----GYR---MPCPQDCP-----------------------------------------------------------------------------ISLHE-LMIHCWKKDPEE--RPTFE-YLQSFL-------
-LR--VRRVLAEGGFAFVYEAQDV----------------GSGREYALKRLLSN--EEEK---NR--A-I--IQ-------EVCFMKKL-SG-----HPNIVQFCSAAS-IGKEE-----------------------------SDTGQAE------FL--LLTELCKG---QLVEFLKK-MESRG--------------------PL---SCDTVLKIFYQTCRAVQHMHR--QKPPIIHRDLKVENLLLS--NQGTI----KLCDFGSATTISHYPDY--------SWSAQRRALVEEE--IT---RNTTPMYRTPEIIDL---YSNFP-IGEKQDIWALGCILYLLCF-RQ-HPFEDG---AK-LRIV----NG----KYS----IPPHDTQY----------------------------------------------------------------------------TVFHS-LIRAMLQVNPEE--RLSIA-EVVHQ---L----
---YTDTKVIGNGSFGVVYQAKLC----------------DSGELVAIKKVLQD--KRFK---NR----------------ELQIMRKL--D-----HCNIVRLRYFFY-SSG---------------------------------EKKDE------VYLNLVLDYVPETVYRVA---RHYSRAKQ--------------------TL---PVIYVKLYMYQLFRSLAYIHS--F--GICHRDIKPQNLLLD-PDTAVL----KLCDFGSAKQ---------------------LVRGEPN--VS---YICSRYYRAPELIF-----GATD-YTSSIDVWSAGCVLAELLL-GQ-PIFPGDSGVDQ-LVEI----IK----VLG---TPTREQIREMNPNYTEFKFPQIKAH-------------------------------------------------PWTKVFRPRTPPEAIA-LCSRLLEYTPTA--RLTPL-EACAHSFF-----
---LKLEKKLGAGQFGEVWMATYN-----------------KHTKVAVKTMK-P--GSM----SV--E-AFL-A-------EANVMKTL--Q-----HDKLVKLHAVVT---------------------------------------KEP------IY--IITEFMAKG--SLLDFLK-----SD-----------------EGSKQ---PLPKLIDFSAQIAEGMAFIEQ--R--NYIHRDLRAANILVS--ASLVC----KIADFGLARVI--------------------E--DNEY--TAREGAKFPIKWTAPEAIN------FGS-FTIKSDVWSFGILLMEIVTYGR-IPYPGMSNPEV-IRAL----ER----GYR---MPRPENCP-----------------------------------------------------------------------------EELYN-IMMRCWKNRPEE--RPTFE-YIQSV--L-----
---YDIIEVLGKGTFGEVAKGWRR----------------STGEMVAIKILKND--AYRN---RI--I-KN----------ELKLLHCM--RGLDPEEAHVIRFLEFFH-D-------------------------------------ALK------FY--LVFELLEQ---NLFEFQK-----EN--------------------NFAPLPARHIRTVTLQVLTALARLKE--L--AIIHADLKPENIMLV--DQTRCPFRVKVIDFGSASIF--------------------SEVRYVK--EP---YIQSRFYRAPEILL------GLP-FCEKVDVWSLGCVMAELHL-GW-PLYPGNNEYDQ-VRYI----CE----TQG---LPKPHLLHAACKAHHFFKRNPHPDAANPWQLKSSADYLAETKVRPLERRKYMLKSLDQIETVNGGSVASRLTFPDREALAEHADLKSMVE-LIKRMLTWESHE--RISPS-AALRHPFV-----
VGG----NKMGEGGFGVVYKGYVN----------------NTT--VAVKKLAAM--VDIT---TE--ELKQQFD------QEIKVMAKC--Q-----HENLVELLGFSS-D-------------------------------------GDD------LC--LVYVYMPNG--SLLDRLSC-LDGTP--------------------PL---SWHMRCKIAQGAANGINFLHE--N--HHIHRDIKSANILLD--EAFTA----KISDFGLARASE------------------KFAQTVMT--SR---IVGTTAYMAPEALR-------GE-ITPKSDIYSFGVVLLEIIT-GL-PAVDEHREPQL-LLDI----KE----EIE---DEEKTIEDYIDKKMNDAD---------------------------------------------------------------STSVEAMYS-VASQCLHEKKNK--RPDIK-KVQQ----LLQ--
---LKLVERLGAGQFGEVWMGYYN-----------------GHTKVAVKSLK-Q--GSM----SP--D-AFL-A-------EANLMKQL--Q-----HQRLVRLYAVVT---------------------------------------QEP------IY--IITEYMENG--SLVDFLK-----TP-----------------SGIKL---TINKLLDMAAQIAEGMAFIEE--R--NYIHRDLRAANILVS--DTLSC----KIADFGLARLI--------------------E--DNEY--TAREGAKFPIKWTAPEAIN------YGT-FTIKSDVWSFGILLTEIVTHGR-IPYPGMTNPEV-IQNL----ER----GYR---MVRPDNCP-----------------------------------------------------------------------------EELYQ-LMRLCWKERPED--RPTFD-YLRSV--L-----
---FEKISELGAGNGGVVFKVSHK----------------PSGL-VMARKLIHL--EIKP---AI--R-NQIIR-------ELQVLHEC--N-----SPYIVGFYGAFY-S-------------------------------------DGE------IS--ICMEHMDGG--SLDQVLK----KAG--------------------RI---PEQILGKVSIAVIKGLTYLRE-KH--KIMHRDVKPSNILVN--SRGEI----KLCDFGVSG----------------------QLIDSMA--NS---FVGTRSYMSPERLQ------GTH-YSVQSDIWSMGLSLVEMAV-GR-YPIPPPDAKEL-ELMF----GC----QVE---GDAAETPPRPRTPGRPLSSYGMDSRPPMAIFE----------------------------------LLDYIVNEPPPKLPSGVFSLEFQD-FVNKCLIKNPAE--RADLK-QLMVHAFI-----
IRY---RDTLGHGNGGTVYKAYHV----------------PSGKILAVKVILLD--ITLE---LQ--K-QI-MS-------ELEILYKC--D-----SSYIIGFYGAFF-V-------------------------------------ENR------IS--ICTEFMDGG--SLD--------VYR--------------------KM---PEHVLGRIAVAVVKGLTYLWS--L--KILHRDVKPSNMLVN--TRGQV----KLCDFGVST----------------------QLVNSIA--KT---YVGTNAYMAPERIS------GEQ-YGIHSDVWSLGISFMELAL-GR-FPYPQIQKNQG-SLMP----LQ----LLQ---CIVDEDSPVLPVGEF---------------------------------------------------------------------SEPFVH-FITQCMRKQPKE--RPAPE-ELMGHPFI-----
---YQNLKPIGSGAQGIVCAAYDA----------------VLDRNVAIKKLSRP--FQNQ---TH--A-KRAYR-------ELVLMKCV--N-----HKNIISLLNVFT-PQKT-------------------------------LEEFQD------VY--LVMELMDA---NLCQVIQ------M--------------------EL---DHERMSYLLYQMLCGIKHLHS--A--GIIHRDLKPSNIVVK--SDCTL----KILDFGLART---------------------AGTSFMM--TP---YVVTRYYRAPEVIL------GMG-YKENVDIWSVGCIMGEMVR-HK-ILFPGRDYIDQ-WNKV----IE----QLG---TPCPEFMKKLQPTVRNYVENRPKYAGLTFPK------------------------------------LFPDSLFPADSEHNKLKASQARD-LLSKMLVIDPAK--RISVD-DALQHPYI-----
FVD---FQPLGFGVNGLVLSAVDS----------------RACRKVAVKKIALS--DARS---MK--H---ALR-------EIKIIRRL--D-----HDNIVKVYEVLG-PKGTDL--------------------------QGELFKFSV------AY--IVQEYMET---DLARLLE-----QG--------------------TL---AEEHAKLFMYQLLRGLKYIHS--A--NVLHRDLKPANIFIS-TEDLVL----KIGDFGLARIVD-----------------QHYSHKGYL--SE---GLVTKWYRSPRLLL-----SPNN-YTKAIDMWAAGCILAEMLT-GR-MLFAGAHELEQ-MQLI----LE----TIP---VIREEDKDELLRVMPSFVSSTWEVK-------------------------------------------------RPLRKLLPEVNSEAID-FLEKILTFNPMD--RLTAE-MGLQHPYM-----
-YM--DLKPLGCGGNGLVFSAVDN----------------DCDKRVAIKKIVLT--DPQS---VK--H---ALR-------EIKIIRRL--D-----HDNIVKVFEILG-PSGSQLTD-----------------------DVGSLTELNS------VY--IVQEYMET---DLANVLE-----QG--------------------PL---LEEHARLFMYQLLRGLKYIHS--A--NVLHRDLKPANLFIN-TEDLVL----KIGDFGLARIMD-----------------PHYSHKGHL--SE---GLVTKWYRSPRLLL-----SPNN-YTKAIDMWAAGCIFAEMLT-GK-TLFAGAHELEQ-MQLI----LE----SIP---VVHEEDRQELLSVIPVYIRNDMTEP------------------------------------------------HKPLTQLLPGISREALD-FLEQILTFSPMD--RLTAE-EALSHPYM-----
---YQQLKPIGSGAQGIVCAAFDT----------------VLGINVAVKKLSRP--FQNQ---TH--A-KRAYR-------ELVLLKCV--N-----HKNIISLLNVFT-PQKT-------------------------------LEEFQD------VY--LVMELMDA---NLCQVIH------M--------------------EL---DHERMSYLLYQMLCGIKHLHS--A--GIIHRDLKPSNIVVK--SDCTL----KILDFGLART---------------------ACTNFMM--TP---YVVTRYYRAPEVIL------GMG-YKENVDIWSVGCIMGELVK-GC-VIFQGTDHIDQ-WNKV----IE----QLG---TPSAEFMKKLQPTVRNYVENRPKYPGIKFEE------------------------------------LFPDWIFPSESERDKIKTSQARD-LLSKMLVIDPDK--RISVD-EALRHPYI-----
---VHFNEVIGRGHFGCVYHGTLL-------------DNDGKKIHCAVKSLN-R--ITD----IGEVS-QFL-T-------EGIIMKDF--S-----HPNVLSLLGICLRS-------------------------------------EGS------PL--VVLPYMKHG--DLRNFIR-----NE------------------THNP---TVKDLIGFGLQVAKGMKYLAS--K--KFVHRDLAARNCMLD--EKFTV----KVADFGLARDM----------Y---------D--KEYYSVHNKTGAKLPVKWMALESLQ------TQK-FTTKSDVWSFGVLLWELMTRGA-PPYPDVNTFDI-TVYL----LQ----GRR---LLQPEYCP-----------------------------------------------------------------------------DPLYE-VMLKCWHPKAEM--RPSFS-ELVSR--I-----
IEP---DRPIGYGAFGVVWSVTDP----------------RDGKRVALKKMPNV--FQNL---VS--C-KRVFR-------ELKMLCFF--K-----HDNVLSALDILQ-PPH--------------------------------IDYFEE------IY--VVTELMQS---DLHKIIV----SPQ--------------------PL---SSDHVKVFLYQILRGLKYLHS--A--GILHRDIKPGNLLVN--SNCVL----KICDFGLARVE-------------------ELDESRHM--TQ---EVVTQYYRAPEILM-----GSRH-YSNAIDIWSVGCIFAELLG-RR-ILFQAQSPIQQ-LDLI----TD----LLG---TPSLEAMRTACEGAKAHILRGPHKQP----------------------------------------------SLPVLYTLSSQATHEAVH-LLCRMLVFDPSK--RISAK-DALAHPYL-----
---YEPKEILGRGVSSVVRRCIHK----------------PTSQEYAVKVIDVT--GGGS---FS--P-EEVRELREATLKEVDILRKV-SG-----HPNIIQLKDTYE-T-------------------------------------NTF------FF--LVFDLMKRG--ELFDYLT----EKV--------------------TL---SEKETRKIMRALLEVICTLHK--L--NIVHRDLKPENILLD--DNMNI----KLTDFGFSCQ---------------------LEPGERL--RE---VCGTPSYLAPEIIECSMNEDHPG-YGKEVDMWSTGVIMYTLLA-GS-PPFWHR---KQ-MLML----RM----IMS---GNYQFGSPEWDDYS-----------------------------------------------------------------------DTVKD-LVSRFLVVQPQN--RYTAE-EALAHPFF-----
YDP---KDVIGRGVSSVVRRCVHR----------------ATGHEFAVKIMEVT--AERL---SP--E-QLEEVREA-TRRETHILRQV-AG-----HPHIITLIDSYE-S-------------------------------------SSF------MF--LVFDLMRKG--ELFDYLT----EKV--------------------AL---SEKETRSIMRSLLEAVSFLHA--N--NIVHRDLKPENILLD--DNMQI----RLSDFGFSCH---------------------LEPGEKL--RE---LCGTPGYLAPEILKCSMDETHPG-YGKEVDLWACGVILFTLLA-GS-PPFWHR---RQ-ILML----RM----IME---GQYQFSSPEWDDRS-----------------------------------------------------------------------STVKD-LISRLLQVDPEA--RLTAE-QALQHPFF-----
---YQVGAVLGSGGFGTVYAGSRI----------------ADGLPVAVKHVVKE--RVTE---WG--S-LGGATV----PLEVVLLRKV--GAA-GGARGVIRLLDWFE-R-------------------------------------PDG------FL--LVLERPEPA-QDLFDFIT----ERG--------------------AL---DEPLARRFFAQVLAAVRHCHS--C--GVVHRDIKDENLLVD-LRSGEL----KLIDFGSGA----------------------LLKDTVY--TD---FDGTRVYSPPEWIR-----YHRY-HGRSATVWSLGVLLYDMVC-GD-IPFEQD--------------EE----ILR---GRLLFRRRVS---------------------------------------------------------------------------PECQQ-LIRWCLSLRPSE--RPSLD-QIAAHPWM-----
-FI--LHKMLGKGSFGKVFLAEFK----------------KTNQFFAIKALKKD--VVLM---DD--D-VECTM------VEKRVLSLA-WE-----HPFLTHMFCTFQ-T-------------------------------------KEN------LF--FVMEYLNGG--DLMYHIQ----SCH--------------------KF---DLSRATFYAAEIILGLQFLHS--K--GIVYRDLKLDNILLD--KDGHI----KIADFGMCKEN--------------------MLGDAKT--NT---FCGTPDYIAPEILL------GQK-YNHSVDWWSFGVLLYEMLI-GQ-SPFHGQ---DE-EELF----HS----IRM---DNPFYPRWLE---------------------------------------------------------------------------KEAKD-LLVKLFVREPEK--RLGVRGDIRQHPLF-----
-PD----EVLGSGQFGIVYGGKHR----------------KTGRDVAIKIIDKL--RFPT---KQ--E-SQLRN-------EVAILQNL--H-----HPGVVNLECMFE-T-------------------------------------PER------VF--VVMEKLHGD--MLEMILS---SEKG--------------------RL---PEHITKFLITQILVALRHLHF--K--NIVHCDLKPENVLLA--SADPFP-QVKLCDFGFARI---------------------IGEKSFR--RS---VVGTPAYLAPEVLR------NKG-YNRSLDMWSVGVIIYVSLS-GT-FPFNED------EDIH----DQ----IQN---AAFMYPPNPWKEIS-----------------------------------------------------------------------HEAID-LINNLLQVKMRK--RYSVD-KTLSHPWL-----
--F-TLCRKLGSGYFGEVFEGLWK-----------------DRVQVAIKVIS-R--DNL----LH-QQ-MLQ-S-------EIQAMKKL--R-----HKHILALYAVVS-V-------------------------------------GDP------VY--IITELMAKG--SLLELLR-----DS-----------------DEKVL---PVSELLDIAWQVAEGMCYLES--Q--NYIHRDLAARNILVG--ENTLC----KVGDFGLARLI-----------------------KEDV--YLSHDHNIPYKWTAPEALS------RGH-YSTKSDVWSFGILLHEMFSRGQ-VPYPGMSNHEA-FLRV----DA----GYR---MPCPLECP-----------------------------------------------------------------------------PSVHK-LMLTCWCRDPEQ--RPCFK-ALRERL-------
---YDVVKVIGRGAFGEVQLVRHK----------------ASQKVYAMKLLSKF--EMIK---RS--D-SAFFW------EERDIMAFA--N-----SPWVVQLFYAFQ-D-------------------------------------DRY------LY--MVMEYMPGG--DLVNLMS-----NY--------------------DV---PEKWAKFYTAEVVLALDAIHS--M--GLIHRDVKPDNMLLD--KHGHL----KLADFGTCMKM-------------------DETGMVHC--DT---AVGTPDYISPEVLKS--QGGDGF-YGRECDWWSVGVFLYEMLV-GD-TPFYAD---SL-VGTY----SK----IMD---HKNSLCFPEDAEIS-----------------------------------------------------------------------KHAKN-LICAFLTDREVRLGRNGVE-EIRQHPFF-----
---YELVRELGKGTYGKVDLVVYK----------------GTGTKMALKFVNKS--KTKL---KN--F----LR-------EVSITNSL-SS-----SPFIIKVFDVVF-E------------------------------------TEDC------YV--FAQEYAPAG--DLFDIIP----PQV--------------------GL---PEDTVKRCVQQLGLALDFMHG--R--QLVHRDIKPENVLLFDRECRRV----KLADFGMTR-----------------------RVGCRV--KR---VSGTIPYTAPEVCQAG-RADGLA-VDTGVDVWAFGVLIFCVLT-GN-FPWEAASGADAFFEEF----VR----WQR---GRLPGLPSQWRRFT-----------------------------------------------------------------------EPALR-MFQRLLALEPER--RGPAK-EVF-----RFLKH
---WEIIGELGDGAFGKVYKAQNK----------------ETSVLAAAKVIDTK--SEEE---LE--D-YM--V-------EIDILASC--D-----HPNIVKLLDAFY-Y-------------------------------------ENN------LW--ILIEFCAGG--AVDAVML---ELER--------------------PL---TESQIQVVCKQTLDALNYLHD--N--KIIHRDLKAGNILFT--LDGDI----KLADFGVSAKN--------------------TRTIQRR--DS---FIGTPYWMAPEVVMCE-TSKDRP-YDYKADVWSLGITLIEMAE-IE-PPHHELNPMRV-LLKI----AK----SEP---PTLAQPSRWS---------------------------------------------------------------------------SNFKD-FLKKCLEKNVDA--RWTTS-QLLQHPFV-----
--L-RLEVKLGQGCFGEVWMGTWN-----------------GTTRVAIKTLK-P--GTM----SP--E-AFL-Q-------EAQVMKKL--R-----HEKLVQLYAVVS---------------------------------------EEP------IY--IVTEYMSKG--SLLDFLK-----GE-----------------TGKYL---RLPQLVDMAAQIASGMAYVER--M--NYVHRDLRAANILVG--ENLVC----KVADFGLARLI--------------------E--DNEY--TARQGAKFPIKWTAPEAAL------YGR-FTIKSDVWSFGILLTELTTKGR-VPYPGMVNREV-LDQV----ER----GYR---MPCPPECP-----------------------------------------------------------------------------ESLHD-LMCQCWRKEPEE--RPTFE-YLQAF--L-----
-FA--LGRKLGEGYFGEVWEGLWL-----------------GSLPVAIKVIK-S--ANM----K--LT-DLA-K-------EIQTLKGL--R-----HERLIRLHAVCS-G-------------------------------------GEP------VY--IVTELMRKG--NLQAFLG-----TP-----------------EGRAL---RLPPLLGFACQVAEGMSYLEE--Q--RVVHRDLAARNVLVD--DGLAC----KVADFGLARLL--------------------K--DDIY--SPSSSSKIPVKWTAPEAAN------YRV-FSQKSDVWSFGVLLHEVFTYGQ-CPYEGMTNHET-LQQI----MR----GYR---LPRPAACP-----------------------------------------------------------------------------AEVYV-LMLECWRSSPEE--RPSFA-TLREKL-------
LCP---GRELGRGKFAVVRKCIKK----------------DSGKEFAAKFMRKR--RKGQ---DC--R-MEIIH-------EIAVLELA-QD-----NPWVINLHEVYE-T-------------------------------------ASE------MI--LVLEYAAGG--EIFDQCVA--DREE--------------------AF---KEKDVQRLMRQILEGVHFLHT--R--DVVHLDLKPQNILLT--SESPLG-DIKIVDFGLSRI---------------------LKNSEEL--RE---IMGTPEYVAPEILS------YDP-ISMATDMWSIGVLTYVMLT-GI-SPFLGN---DK-QETF----LN----ISQ---MNLSYSEEEFDVLS-----------------------------------------------------------------------ESAVD-FIRTLLVKKPED--RATAE-ECLKHPWL-----
ILT---SKELGRGKFAVVRQCISK----------------STGQEYAAKFLKKR--RRGQ---DC--R-AEILH-------EIAVLELA-KS-----CPRVINLHEVYE-N-------------------------------------TSE------II--LILEYAAGG--EIFSLCLP--ELAE--------------------MV---SENDVIRLIKQILEGVYYLHQ--N--NIVHLDLKPQNILLS--SIYPLG-DIKIVDFGMSRK---------------------IGHACEL--RE---IMGTPEYLAPEILN------YDP-ITTATDMWNIGIIAYMLLT-HT-SPFVGE---DN-QETY----LN----ISQ---VNVDYSEETFSSVS-----------------------------------------------------------------------QLATD-FIQSLLVKNPEK--RPTAE-ICLSHSWL-----
---YSLLAEIGRGSYGVVYEAVAG----------------RSGARVAVKKIRCD--APEN---VE--L---ALA-------EFWALTSLKRR-----HQNVVQFEECVL-QRNGLAQRMSHGNKSSQLYLRLVETSLKGERILGYAEEPCY------LW--FVMEFCEGG--DLNQYVL-----SR--------------------RP---DPATNKSFMLQLTSAIAFLHK--N--HIVHRDLKPDNILIT--ERSGTP-ILKVADFGLSKVCAGLAPRGK---EGNQDNKNVNVNKYWL--SS---ACGSDFYMAPEVWE-------GH-YTAKADIFALGIIIWAMIE-RI-TFIDSETKKEL-LGTY----IK----QGT---EIVPVGEALLENPKMELHIPQ---------------------------------------------------------KRRTSMSEGIKQ-LLKDMLAANPQD--RPDAF-EL------ETRM-
---YHVLEMIGEGSFGRVYKGRRK----------------YSAQVVALKFIPKL--GRSE---KE--L-RNLQR-------EIEIMRGL--R-----HPNIVHMLDSFE-T-------------------------------------DKE------VV--VVTDYAEG---ELFQILE----DDG--------------------KL---PEDQVQAIAAQLVSALYYLHS--H--RILHRDMKPQNILLA--KGGGI----KLCDFGFARAM--------------------STNTMVL--TS---IKGTPLYMSPELVE------ERP-YDHTADLWSVGCILYELAV-GT-PPFYAT---SI-FQLV----SL----ILK---DPVRWPSTIS---------------------------------------------------------------------------PCFKN-FLQGLLTKDPRQ--RLSWP-DLLYHPFI-----
---IEFHEIIGSGSFGKVYKGRCR------------------NKIVAIKRYR-ANTYCS----KSDVD-MFC-R-------EVSILCQL--N-----HPCVIQFVGACLND-------------------------------------PSQ------FA--IVTQYISGG--SLFSLLH-----EQ------------------KRIL---DLQSKLIIAVDVAKGMEYLHNLTQ--PIIHRDLNSHNILLY--EDGHA----VVADFGESRFL----------Q---------S--LD-E--DNMTKQPGNLRWMAPEVFT------QCTRYTIKADVFSYALCLWEILT-GE-IPFAHLKPAAA-AADM---AYH----HIR---PPIGYSIP-----------------------------------------------------------------------------KPISS-LLIRGWNACPEG--RPEFS-EVVMKL-------
--L-RLEVKLGQGCFGEVWMGTWN-----------------GTTKVAIKTLK-P--GTM----MP--E-AFL-Q-------EAQIMKKL--R-----HDKLVPLYAVVS---------------------------------------EEP------IY--IVTEFMSKG--SLLDFLK-----EG-----------------DGKYL---KLPQLVDMAAQIADGMAYIER--M--NYIHRDLRAANILVG--ENLVC----KIADFGLARLI--------------------E--DNEY--TARQGAKFPIKWTAPEAAL------YGR-FTIKSDVWSFGILQTELVTKGR-VPYPGMVNREV-LEQV----ER----GYR---MPCPQGCP-----------------------------------------------------------------------------ESLHE-LMNLCWKKDPDE--RPTFE-YIQSFL-------
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