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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC CDK2 203
Other AURKA 133
Other AURKB 77
Other AURKC 43
CMGC CDC2 4
CMGC CDK4 6
CMGC CDK7 2.7.11.23
CMGC CDK9 2.7.11.23
CMGC GSK3B 56
TK LCK 245
CMGC MAPK14 24
Other PLK1 53
TK SRC 270
TK ZAP70 338
----FQKVEKIGEGTYGVVYKARNK--LTGEVVALKKIRLDT-ETE---GV--PSTAIR---EISLLKELN---HPNIVKLLDVIHT--------ENKLY--LVFEFLHQ---DLKKFMDA--SALT---GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLIN-TEGAIKLADFGLARAF------GVPVRTYTH---EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR---QDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF
----FEIGRPLGKGKFGNVYLAREK--QSKFILALKVLFKAQLEKA---GV--EHQLRR---EVEIQSHLR---HPNILRLYGYFHD--------ATRVY--LILEYAPLG--TVYRELQ----KLS---KFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLG-SAGELKIADFGWSV--------HAPSSRRTT---LCGTLDYLPPEMIE-GRMHDEKVDLWSLGVLCYEFLV-GKPPFEAN---TYQETYKRISRVEFTFPDFVT-----------------------------EGARDLISRLLKHNPSQRPMLREVLEHPWI
----FEIGRPLGKGKFGNVYLAREK--KSHFIVALKVLFKSQ-IEK---EG--VEHQLR--REIEIQAHLH---HPNILRLYNYFYD--------RRRIY--LILEYAPRG--ELYKELQ----KSC---TFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLG-LKGELKIADFGWSV--------HAPSLRRKT---MCGTLDYLPPEMIE-GRMHNEKVDLWCIGVLCYELLV-GNPPFESA---SHNETYRRIVKVDLKFPASVP-----------------------------MGAQDLISKLLRHNPSERLPLAQVSAHPWV
----FEIGRPLGKGKFGNVYLARLK--ESHFIVALKVLFKSQ-IEK---EG--LEHQLR--REIEIQAHLQ---HPNILRLYNYFHD--------ARRVY--LILEYAPRG--ELYKELQ----KSE---KLDEQRTATIIEELADALTYCHDKKVIHRDIKPENLLLG-FRGEVKIADFGWSV--------HTPSLRRKT---MCGTLDYLPPEMIE-GRTYDEKVDLWCIGVLCYELLV-GYPPFESA---SHSETYRRILKVDVRFPLSMP-----------------------------LGARDLISRLLRYQPLERLPLAQILKHPWV
----YTKIEKIGEGTYGVVYKGRHK--TTGQVVAMKKIRLES-EEE---GV--PSTAIR---EISLLKELR---HPNIVSLQDVLMQ--------DSRLY--LIFEFLSM---DLKKYLDS-IPPGQ---YMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLID-DKGTIKLADFGLARAF------GIPIRVYTH---EVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELAT-KKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKP---GSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF
---Y-EPVAEIGVGAYGTVYKARDP--HSGHFVALKSVRVPN-GGGGGGGL--PISTVR---EVALLRRLEAFEHPNVVRLMDVCATSR---TDREIKVT--LVFEHVDQ---DLRTYLDK--APPP---GLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVT-SGGTVKLADFGLARI-------YSYQMALTP---VVVTLWYRAPEVLL-QSTYATPVDMWSVGCIFAEMFR-RKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPR-----PVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYL
----YEKLDFLGEGQFATVYKARDK--NTNQIVAIKKIKLGH-RSE---AK--DGINRTALREIKLLQELS---HPNIIGLLDAFGH--------KSNIS--LVFDFMET---DLEVIIK---DNSL---VLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLD-ENGVLKLADFGLAKSF------GSPNRAYTH---QVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLL-RVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPG----IPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYF
----YEKLAKIGQGTFGEVFKARHR--KTGQKVALKKVLMEN-EKE---GF--PITALR---EIKILQLLK---HENVVNLIEICRTKASPYNRCKGSIY--LVFDFCEH---DLAGLLS---NVLV---KFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLIT-RDGVLKLADFGLARAFSL--AKNSQPNRYTN---RVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWT-RSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFF
----YTDTKVIGNGSFGVVYQAKLC--DSGELVAIKKVLQDK-RFK---NR-----------ELQIMRKLD---HCNIVRLRYFFYSSG----EKKDEVYLNLVLDYVPETVYRVA---RHYSRAKQ---TLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQ-------LVRGEPNVS---YICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLL-GQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH---PWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFF
----LKLVERLGAGQFGEVWMGYYN---GHTKVAVKSLK-QG-SM----SP--DAFL-A---EANLMKQLQ---HQRLVRLYAVVT---------QEPIY--IITEYMENG--SLVDFLK-----TPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVS-DTLSCKIADFGLARLI------E--DNEYTAREGAKFPIKWTAPEAIN-YGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCP-------------------------------EELYQLMRLCWKERPEDRPTFDYLRSV--L
----YQNLSPVGSGAYGSVCAAFDT--KTGLRVAVKKLSRPF-QSI---IH--AKRTYR---ELRLLKHMK---HENVIGLLDVFTPARS--LEEFNDVY--LVTHLMGA---DLNNIVK-----CQ---KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVN-EDCELKILDFGLAR---------HTDDEMTG---YVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMP-KMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYF
--YV--RGRFLGKGGFAKCFEISDA--DTKEVFAGKIVPKSL-LLK---PH--QREKMS--MEISIHRSLA---HQHVVGFHGFFED--------NDFVF--VVLELCRRR--SLLELHK----RRK---ALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLN-EDLEVKIGDFGLATKV------EYDGERKKT---LCGTPNYIAPEVLS-KKGHSFEVDVWSIGCIMYTLLV-GKPPFETS---CLKETYLRIKKNEYSIPKHIN-----------------------------PVAASLIQKMLQTDPTARPTINELLNDEFF
---L-RLEVKLGQGCFGEVWMGTWN---GTTRVAIKTLK-PG-TM----SP--EAFL-Q---EAQVMKKLR---HEKLVQLYAVVS---------EEPIY--IVTEYMSKG--SLLDFLK-----GETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVG-ENLVCKVADFGLARLI------E--DNEYTARQGAKFPIKWTAPEAAL-YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECP-------------------------------ESLHDLMCQCWRKEPEERPTFEYLQAF--L
LIAD----IELGCGNFGSVRQGVYRMRKKQIDVAIKVLK-QG-TE----KADTEEMM-R---EAQIMHQLD---NPYIVRLIGVCQ---------AEALM--LVMEMAGGG--PLHKFLV-----GK-REEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLV-NRHYAKISDFGLSKAL--GA--D--DSYYTARSAGKWPLKWYAPECIN-FRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECP-------------------------------PELYALMSDCWIYKWEDRPDFLTVEQR--M
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