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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC CDK2 203
Other AURKA 133
Other AURKB 77
Other AURKC 43
CMGC CDC2 4
CMGC CDK4 6
CMGC CDK9 2.7.11.23
CMGC GSK3B 56
TK LCK 245
CMGC MAPK14 24
Other PLK1 53
AGC RPS6KB1 91
TK SRC 270
TK ZAP70 338
----FQKVEKIGEGTYGVVYKARN---K--LTGEVVALKKIRLDT-ETE---GV--PSTAIR--EISLLKELN---HPNIVKLLDVIHT--------ENKLY--LVFEFLHQ---DLKKFMDA--SALT---GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLIN-TEGAIKLADFGLARAF------GVPVRTYTH---EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR---QDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS-----AKAALAHPFF
----FEIGRPLGKGKFGNVYLARE---K--QSKFILALKVLFKAQLEKA---GV--EHQLRR--EVEIQSHLR---HPNILRLYGYFHD--------ATRVY--LILEYAPLG--TVYRELQ----KLS---KFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLG-SAGELKIADFGWSV--------HAPSSRRTT---LCGTLDYLPPEMIE-GRMHDEKVDLWSLGVLCYEFLV-GKPPFEAN---TYQETYKRISRVEFTFPDFVT-----------------------------EGARDLISRLLKHNPSQRPM-----LREVLEHPWI
----FEIGRPLGKGKFGNVYLARE---K--KSHFIVALKVLFKSQ-IEK---EG--VEHQLR-REIEIQAHLH---HPNILRLYNYFYD--------RRRIY--LILEYAPRG--ELYKELQ----KSC---TFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLG-LKGELKIADFGWSV--------HAPSLRRKT---MCGTLDYLPPEMIE-GRMHNEKVDLWCIGVLCYELLV-GNPPFESA---SHNETYRRIVKVDLKFPASVP-----------------------------MGAQDLISKLLRHNPSERLP-----LAQVSAHPWV
----FEIGRPLGKGKFGNVYLARL---K--ESHFIVALKVLFKSQ-IEK---EG--LEHQLR-REIEIQAHLQ---HPNILRLYNYFHD--------ARRVY--LILEYAPRG--ELYKELQ----KSE---KLDEQRTATIIEELADALTYCHDKKVIHRDIKPENLLLG-FRGEVKIADFGWSV--------HTPSLRRKT---MCGTLDYLPPEMIE-GRTYDEKVDLWCIGVLCYELLV-GYPPFESA---SHSETYRRILKVDVRFPLSMP-----------------------------LGARDLISRLLRYQPLERLP-----LAQILKHPWV
----YTKIEKIGEGTYGVVYKGRH---K--TTGQVVAMKKIRLES-EEE---GV--PSTAIR--EISLLKELR---HPNIVSLQDVLMQ--------DSRLY--LIFEFLSM---DLKKYLDS-IPPGQ---YMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLID-DKGTIKLADFGLARAF------GIPIRVYTH---EVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELAT-KKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKP---GSLASHVKNLDENGLDLLSKMLIYDPAKRIS-----GKMALNHPYF
---Y-EPVAEIGVGAYGTVYKARD---P--HSGHFVALKSVRVPN-GGGGGGGL--PISTVR--EVALLRRLEAFEHPNVVRLMDVCATSR---TDREIKVT--LVFEHVDQ---DLRTYLDK--APPP---GLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVT-SGGTVKLADFGLARI-------YSYQMALTP---VVVTLWYRAPEVLL-QSTYATPVDMWSVGCIFAEMFR-RKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPR-----PVQSVVPEMEESGAQLLLEMLTFNPHKRIS-----AFRALQHSYL
----YEKLAKIGQGTFGEVFKARH---R--KTGQKVALKKVLMEN-EKE---GF--PITALR--EIKILQLLK---HENVVNLIEICRTKASPYNRCKGSIY--LVFDFCEH---DLAGLLS---NVLV---KFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLIT-RDGVLKLADFGLARAFSL--AKNSQPNRYTN---RVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWT-RSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRID-----SDDALNHDFF
----YTDTKVIGNGSFGVVYQAKL---C--DSGELVAIKKVLQDK-RFK---NR----------ELQIMRKLD---HCNIVRLRYFFYSSG----EKKDEVYLNLVLDYVPETVYRVA---RHYSRAKQ---TLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQ-------LVRGEPNVS---YICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLL-GQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH---PWTKVFRPRTPPEAIALCSRLLEYTPTARLT-----PLEACAHSFF
----LKLVERLGAGQFGEVWMGYY---N---GHTKVAVKSLK-QG-SM----SP--DAFL-A--EANLMKQLQ---HQRLVRLYAVVT---------QEPIY--IITEYMENG--SLVDFLK-----TPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVS-DTLSCKIADFGLARLI------E--DNEYTAREGAKFPIKWTAPEAIN-YGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCP-------------------------------EELYQLMRLCWKERPEDRPT-----FDYLRSV--L
----YQNLSPVGSGAYGSVCAAFD---T--KTGLRVAVKKLSRPF-QSI---IH--AKRTYR--ELRLLKHMK---HENVIGLLDVFTPARS--LEEFNDVY--LVTHLMGA---DLNNIVK-----CQ---KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVN-EDCELKILDFGLAR---------HTDDEMTG---YVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMP-KMNFANVFIGANPLAVDLLEKMLVLDSDKRIT-----AAQALAHAYF
--YV--RGRFLGKGGFAKCFEISD---A--DTKEVFAGKIVPKSL-LLK---PH--QREKMS-MEISIHRSLA---HQHVVGFHGFFED--------NDFVF--VVLELCRRR--SLLELHK----RRK---ALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLN-EDLEVKIGDFGLATKV------EYDGERKKT---LCGTPNYIAPEVLS-KKGHSFEVDVWSIGCIMYTLLV-GKPPFETS---CLKETYLRIKKNEYSIPKHIN-----------------------------PVAASLIQKMLQTDPTARPT-----INELLNDEFF
----FELLRVLGKGGYGKVFQVRKVTGA--NTGKIFAMKVLKKAM-IVR---NA--KDTAHTKAERNILEEVK---HPFIVDLIYAFQT--------GGKLY--LILEYLSGG--ELFMQLE----REG---IFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLN-HQGHVKLTDFGLCKES------IHDGTVTHT---FCGTIEYMAPEILM-RSGHNRAVDWWSLGALMYDMLT-GAPPFTGE---NRKKTIDKILKCKLNLPPYLT-----------------------------QEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFF
---L-RLEVKLGQGCFGEVWMGTW---N---GTTRVAIKTLK-PG-TM----SP--EAFL-Q--EAQVMKKLR---HEKLVQLYAVVS---------EEPIY--IVTEYMSKG--SLLDFLK-----GETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVG-ENLVCKVADFGLARLI------E--DNEYTARQGAKFPIKWTAPEAAL-YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECP-------------------------------ESLHDLMCQCWRKEPEERPT-----FEYLQAF--L
LIAD----IELGCGNFGSVRQGVY---RMRKKQIDVAIKVLK-QG-TE----KADTEEMM-R--EAQIMHQLD---NPYIVRLIGVCQ---------AEALM--LVMEMAGGG--PLHKFLV-----GK-REEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLV-NRHYAKISDFGLSKAL--GA--D--DSYYTARSAGKWPLKWYAPECIN-FRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECP-------------------------------PELYALMSDCWIYKWEDRPD-----FLTVEQR--M
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