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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC CDK2 203
Other AURKA 133
Other AURKB 77
CMGC CDC2 4
CMGC CDK4 6
CMGC CDK9 2.7.11.23
Other PLK1 53
AGC ROCK1 76
TK SRC 270
TK ZAP70 338
----FQKVEKIGEGTYGVVYKARNK--LTGEVVALKKIRLDT-ETE---GV--PSTAIR-EISLLKELN---HPNIVKLLDVIHT--------ENKLYLVFEFLHQ-DLKKFMDA-SALT---GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAF------GVPVRTYTH---EVVTLWYRAPEILL---GCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR---QDFSKVVPPLDEDGRSLLSQMLHYDPNK--RISAKAALAHPFF
----FEIGRPLGKGKFGNVYLAREK--QSKFILALKVLFKAQLEKA---GV--EHQLRR-EVEIQSHLR---HPNILRLYGYFHD--------ATRVYLILEYAPLGTVYRELQ---KLS---KFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSV--------HAPSSRRTT---LCGTLDYLPPEMIE----GRMHDEKVDLWSLGVLCYEFLV-GKPPFEAN---TYQETYKRISRVEFTFPDFVT-----------------------------EGARDLISRLLKHNPSQ--RPMLREVLEHPWI
----FEIGRPLGKGKFGNVYLAREK--KSHFIVALKVLFKSQ-IEK---EG--VEHQLRREIEIQAHLH---HPNILRLYNYFYD--------RRRIYLILEYAPRGELYKELQ---KSC---TFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSV--------HAPSLRRKT---MCGTLDYLPPEMIE----GRMHNEKVDLWCIGVLCYELLV-GNPPFESA---SHNETYRRIVKVDLKFPASVP-----------------------------MGAQDLISKLLRHNPSE--RLPLAQVSAHPWV
----YTKIEKIGEGTYGVVYKGRHK--TTGQVVAMKKIRLES-EEE---GV--PSTAIR-EISLLKELR---HPNIVSLQDVLMQ--------DSRLYLIFEFLSM-DLKKYLDSIPPGQ---YMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAF------GIPIRVYTH---EVVTLWYRSPEVLL---GSARYSTPVDIWSIGTIFAELAT-KKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKP---GSLASHVKNLDENGLDLLSKMLIYDPAK--RISGKMALNHPYF
---Y-EPVAEIGVGAYGTVYKARDP--HSGHFVALKSVRVPN-GGGGGGGL--PISTVR-EVALLRRLEAFEHPNVVRLMDVCATSR---TDREIKVTLVFEHVDQ-DLRTYLDK-APPP---GLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARI-------YSYQMALTP---VVVTLWYRAPEVLL----QSTYATPVDMWSVGCIFAEMFR-RKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPR-----PVQSVVPEMEESGAQLLLEMLTFNPHK--RISAFRALQHSYL
----YEKLAKIGQGTFGEVFKARHR--KTGQKVALKKVLMEN-EKE---GF--PITALR-EIKILQLLK---HENVVNLIEICRTKASPYNRCKGSIYLVFDFCEH-DLAGLLS--NVLV---KFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSL--AKNSQPNRYTN---RVVTLWYRPPELLL---GERDYGPPIDLWGAGCIMAEMWT-RSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQ--RIDSDDALNHDFF
--YV--RGRFLGKGGFAKCFEISDA--DTKEVFAGKIVPKSL-LLK---PH--QREKMSMEISIHRSLA---HQHVVGFHGFFED--------NDFVFVVLELCRRRSLLELHK---RRK---ALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKV------EYDGERKKT---LCGTPNYIAPEVLS----KKGHSFEVDVWSIGCIMYTLLV-GKPPFETS---CLKETYLRIKKNEYSIPKHIN-----------------------------PVAASLIQKMLQTDPTA--RPTINELLNDEFF
----YEVVKVIGRGAFGEVQLVRHK--STRKVYAMKLLSKFE-MIK---RS--DSAFFWEERDIMAFAN---SPWVVQLFYAFQD--------DRYLYMVMEYMPGGDLVNLMS----NY---DVPEKWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKM-----NKEGMVRCDT---AVGTPDYISPEVLKSQGGDGYYGRECDWWSVGVFLYEMLV-GDTPFYAD---SLVGTYSKIMNHKNSLTFPDDNDIS-------------------------KEAKNLICAFLTDREVRLGRNGVEEIKRHLFF
---L-RLEVKLGQGCFGEVWMGTWN---GTTRVAIKTLK-PG-TM----SP--EAFL-Q-EAQVMKKLR---HEKLVQLYAVVS---------EEPIYIVTEYMSKGSLLDFLK----GETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLI------E--DNEYTARQGAKFPIKWTAPEAAL----YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECP-------------------------------ESLHDLMCQCWRKEPEE--RPTFEYLQAF--L
LIAD----IELGCGNFGSVRQGVYRMRKKQIDVAIKVLK-QG-TE----KADTEEMM-R-EAQIMHQLD---NPYIVRLIGVCQ---------AEALMLVMEMAGGGPLHKFLV----GK-REEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKAL--GA--D--DSYYTARSAGKWPLKWYAPECIN----FRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECP-------------------------------PELYALMSDCWIYKWED--RPDFLTVEQR--M
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