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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC CDK2 203
TK ABL1 261
Other AURKA 133
Other AURKB 77
Other AURKC 43
TK BMX 422
CMGC CDC2 4
CMGC CDK4 6
CMGC CDK6 13
CMGC CLK2 163
CMGC CLK4 159
Other EIF2AK2 267
TK FER 563
TK FGFR2 481
TK JAK2 849
TK JAK3 822
TK LCK 245
TKL LIMK1 339
TK MET 1078
TK NTRK3 538
STE PAK7 449
TK PTK6 191
AGC ROCK2 92
TK SRC 270
TK TNK2 150
Other TTK 525
TK YES1 277
----FQKVEKIGEGTYGVVYKARNK-------L-TGE-VVALKKIRLD--T-ETE---GV--PSTAIR-EISLLKEL--N-----HPN----IVKLLDVIH--T-----------------------------ENKLYLVFEFLHQ-DLKKFMDA-SALT-----------------GI--PLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAI-------------------KLADFGLARAF----GVPVRTY--------------TH---EVVTLWYRAPEILL----------GCKYYSTAVDIWSLGCIFAEMVT-RR-AL---------------FPGD-SEIDQLFRI-FRTLGTPDEVVWPGVTSMPDYKPSFPKWAR---------------QDFSKVVPPLDEDGRSLLSQMLHYDPNK--RISAKAALAHPFF---
----ITMKHKLGGGQYGEVYEGVWK-------K-YSL-TVAVKTLK-E--D-TM----EV--EEFL-K-EAAVMKEI--K-----HPN----LVQLLGVCT--R-----------------------------EPPFYIITEFMTYGNLLDYLR----EC--------------NRQEV--NAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLV-------------------KVADFGLSRLM----T--GDTY--------------TAHAGAKFPIKWTAPESLA-----------YNKFSIKSDVWAFGVLLWEIATYGM-SP---------------YPGI-DLSQVYELL-EKDYRMERPEGCP-------------------------------------------EKVYELMRACWQWNPSD--RPSFAEIHQA--F---
----FEIGRPLGKGKFGNVYLAREK-------Q-SKF-ILALKVLFKA--QLEKA---GV--EHQLRR-EVEIQSHL--R-----HPN----ILRLYGYFH--D-----------------------------ATRVYLILEYAPLGTVYRELQ---KLS-----------------KF--DEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGEL-------------------KIADFGWSV------HAPSSRR--------------TT---LCGTLDYLPPEMIE-----------GRMHDEKVDLWSLGVLCYEFLV-GK-PP---------------FEAN----TYQETY-KRISRVEFTFPDFVT-----------------------------------------EGARDLISRLLKHNPSQ--RPMLREVLEHPWI---
----FEIGRPLGKGKFGNVYLAREK-------K-SHF-IVALKVLFKS--Q-IEK---EG--VEHQLRREIEIQAHL--H-----HPN----ILRLYNYFY--D-----------------------------RRRIYLILEYAPRGELYKELQ---KSC-----------------TF--DEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLGLKGEL-------------------KIADFGWSV------HAPSLRR--------------KT---MCGTLDYLPPEMIE-----------GRMHNEKVDLWCIGVLCYELLV-GN-PP---------------FESA----SHNETY-RRIVKVDLKFPASVP-----------------------------------------MGAQDLISKLLRHNPSE--RLPLAQVSAHPWV---
----FEIGRPLGKGKFGNVYLARLK-------E-SHF-IVALKVLFKS--Q-IEK---EG--LEHQLRREIEIQAHL--Q-----HPN----ILRLYNYFH--D-----------------------------ARRVYLILEYAPRGELYKELQ---KSE-----------------KL--DEQRTATIIEELADALTYCHDKKVIHRDIKPENLLLGFRGEV-------------------KIADFGWSV------HTPSLRR--------------KT---MCGTLDYLPPEMIE-----------GRTYDEKVDLWCIGVLCYELLV-GY-PP---------------FESA----SHSETY-RRILKVDVRFPLSMP-----------------------------------------LGARDLISRLLRYQPLE--RLPLAQILKHPWV---
----ITLLKELGSGQFGVVQLGKWK---------GQY-DVAVKMIK-E--G-SM----SE--DEFF-Q-EAQTMMKL--S-----HPK----LVKFYGVCS--K-----------------------------EYPIYIVTEYISNGCLLNYLR----SH---------------GKGL--EPSQLLEMCYDVCEGMAFLESHQFIHRDLAARNCLVDRDLCV-------------------KVSDFGMTRYV----L--DDQY--------------VSSVGTKFPVKWSAPEVFH-----------YFKYSSKSDVWAFGILMWEVFSLGK-QP---------------YDLY-DNSQVVLKV-SQGHRLYRPHLAS-------------------------------------------DTIYQIMYSCWHELPEK--RPTFQQLLSS--I---
----YTKIEKIGEGTYGVVYKGRHK-------T-TGQ-VVAMKKIRLE--S-EEE---GV--PSTAIR-EISLLKEL--R-----HPN----IVSLQDVLM--Q-----------------------------DSRLYLIFEFLSM-DLKKYLDSIPPGQ-----------------YM--DSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTI-------------------KLADFGLARAF----GIPIRVY--------------TH---EVVTLWYRSPEVLL----------GSARYSTPVDIWSIGTIFAELAT-KK-PL---------------FHGD-SEIDQLFRI-FRALGTPNNEVWPEVESLQDYKNTFPKWKP---------------GSLASHVKNLDENGLDLLSKMLIYDPAK--RISGKMALNHPYF---
---Y-EPVAEIGVGAYGTVYKARDP-------H-SGH-FVALKSVRVP--N-GGGGGGGL--PISTVR-EVALLRRL--EA--FEHPN----VVRLMDVCA--TSR------------------------TDREIKVTLVFEHVDQ-DLRTYLDK-APPP-----------------GL--PAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTV-------------------KLADFGLARI-----YSYQMAL--------------TP---VVVTLWYRAPEVLL-----------QSTYATPVDMWSVGCIFAEMFR-RK-PL---------------FCGN-SEADQLGKI-FDLIGLPPEDDWPRDVSLPRGAFPPRGPR-----------------PVQSVVPEMEESGAQLLLEMLTFNPHK--RISAFRALQHSYL---
----YECVAEIGEGAYGKVFKARDL-------K-NGGRFVALKRVRVQ--T-GEE---GM--PLSTIR-EVAVLRHL--ET--FEHPN----VVRLFDVCT--VSR------------------------TDRETKLTLVFEHVDQ-DLTTYLDK-VPEP-----------------GV--PTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQI-------------------KLADFGLARI-----YSFQMAL--------------TS---VVVTLWYRAPEVLL-----------QSSYATPVDLWSVGCIFAEMFR-RK-PL---------------FRGS-SDVDQLGKI-LDVIGLPGEEDWPRDVALPRQAFHSKSAQ-----------------PIEKFVTDIDELGKDLLLKCLTFNPAK--RISAYSALSHPYF---
----YEIVSTLGEGTFGRVVQCVDH-------R-RGGARVALKIIKNV--E-KYK---EA--AR---L-EINVLEKI--NEKDPDNKN---LCVQMFDWFD--Y-----------------------------HGHMCISFELLGL-STFDFLK---DNN-----------------YLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSAT-------FDHEHH--------------ST---IVSTRHYRAPEVIL-----------ELGWSQPCDVWSIGCIIFEYYV-GF-TL---------------FQTH-DNREHLAMM-ERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAK--RLTLGEALQHPFF---
----YEIVDTLGEGAFGKVVECIDH-------GMDGM-HVAVKIVKNV--G-RYR---EA--ARS----EIQVLEHL--NS---TDPNSVFRCVQMLEWFD--H-----------------------------HGHVCIVFELLGL-STYDFIK---ENS-----------------FLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSA-------TYDDEHH--------------ST---LVSTRHYRAPEVIL-----------ALGWSQPCDVWSIGCILIEYYL-GF-TV---------------FQTH-DSKEHLAMM-ERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQ--RITLDEALQHPFF---
---F-KEIELIGSGGFGQVFKAKHR-------I-DGK-TYVIKRVKYN--N-EKA---ER---------EVKALAKL--D-----HVN----IVHYNGCWD--GFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEK-RRGE-----------------KL--DKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQV-------------------KIGDFGLVTS-----LKNDGKR--------------TR---SKGTLRYMSPEQIS-----------SQDYGKEVDLYALGLILAELLH-VCDTA---------------FET--------SKF-FTDLRDGIISDIFDK------------------------------------------KEKTLLQKLLSKKPED--RPNTSEILR----TLT
--VI--LGELLGKGNFGEVYKGTLK---------DKT-SVAVKTCK-E--D-LP----QELKIKFL-Q-EAKILKQY--D-----HPN----IVKLIGVCT--Q-----------------------------RQPVYIIMELVSGGDFLTFLR----RK---------------KDEL--KLKQLVKFSLDAAAGMLYLESKNCIHRDLAARNCLVGENNVL-------------------KISDFGMSRQE----D--GGVY--------------SSSGLKQIPIKWTAPEALN-----------YGRYSSESDVWSFGILLWETFSLGV-CP---------------YPGM-TNQQAREQV-ERGYRMSAPQHCP-------------------------------------------EDISKIMMKCWDYKPEN--RPKFSELQKEL-----
----LTLGKPLGEGCFGQVVMAEAVGIDKDKPK-EAV-TVAVKMLK-D--D-AT----EKDLSDLV-S-EMEMMKMIG-K-----HKN----IINLLGACT--Q-----------------------------DGPLYVIVEYASKGNLREYLR----ARRPPGMEYSYDINRVPEEQM--TFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVM-------------------KIADFGLARDI--N-N--IDYY--------------KKTTNGRLPVKWMAPEALF-----------DRVYTHQSDVWSFGVLMWEIFTLGG-SP---------------YPGI-PVEELFKLL-KEGHRMDKPANCT-------------------------------------------NELYMMMRDCWHAVPSQ--RPTFKQLVEDL-----
----LKFLQQLGKGNFGSVEMCRYDP---LQDN-TGE-VVAVKKLQ-H--S-TE-----EHLRDFE-R-EIEILKSL--Q-----HDN----IVKYKGVCYSAG-----------------------------RRNLKLIMEYLPYGSLRDYLQ----KH---------------KERI--DHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRV-------------------KIGDFGLTKVL-PQ-D--KEYY--------------KVKEPGESPIFWYAPESLT-----------ESKFSVASDVWSFGVVLYELFTYIE-KSKSPPAEFMRMIGNDKQGQM-IVFHLIELL-KNNGRLPRPDGCP-------------------------------------------DEIYMIMTECWNNNVNQ--RPSFRDLA----LRV-
---L-KYISQLGKGNFGSVELCRYDP---LGDN-TGA-LVAVKQLQ-H--S-GP----DQ-QRDFQ-R-EIQILKAL--H-----SDF----IVKYRGVSYGPG-----------------------------RQSLRLVMEYLPSGCLRDFLQ----RH---------------RARL--DASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHV-------------------KIADFGLAKLL-PL-D--KDYY--------------VVREPGQSPIFWYAPESLS-----------DNIFSRQSDVWSFGVVLYELFTYCD-KSCSPSAE--FLRMMGCERDVPALCRLLELL-EEGQRLPAPPACP-------------------------------------------AEVHELMKLCWAPSPQD--RPSFSALGP---QL--
----LKLVERLGAGQFGEVWMGYYN---------GHT-KVAVKSLK-Q--G-SM----SP--DAFL-A-EANLMKQL--Q-----HQR----LVRLYAVVT--------------------------------QEPIYIITEYMENGSLVDFLK----TP--------------SGIKL--TINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSC-------------------KIADFGLARLI----E--DNEY--------------TAREGAKFPIKWTAPEAIN-----------YGTFTIKSDVWSFGILLTEIVTHGR-IP---------------YPGM-TNPEVIQNL-ERGYRMVRPDNCP-------------------------------------------EELYQLMRLCWKERPED--RPTFDYLRSV--L---
--LI--HGEVLGKGCFGQAIKVTHR-------E-TGE-VMVMKELI----R-FD----EETQRTFL-K-EVKVMRCL--E-----HPN----VLKFIGVLY--K-----------------------------DKRLNFITEYIKGGTLRGIIK----SM---------------DSQY--PWSQRVSFAKDIASGMAYLHSMNIIHRDLNSHNCLVRENKNV-------------------VVADFGLARLM--V-D--EKTQPEGLRS--LKKPDRKKRYTVVGNPYWMAPEMIN-----------GRSYDEKVDVFSFGIVLCEIIGRVN-AD---------------PDYLPRTMDFGLNV-RGFLDRYCPPNCP-------------------------------------------PSFFPITVRCCDLDPEK--RPSFVKLEH---WL--
----VHFNEVIGRGHFGCVYHGTLL----DNDG-KKI-HCAVKSLN-R--I-TD----IGEVSQFL-T-EGIIMKDF--S-----HPN----VLSLLGICL-RS-----------------------------EGSPLVVLPYMKHGDLRNFIR----NE---------------THNP--TVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTV-------------------KVADFGLARDM--Y-D--KEYYS------------VHNKTGAKLPVKWMALESLQ-----------TQKFTTKSDVWSFGVLLWELMTRGA-PP---------------YPDV-NTFDITVYL-LQGRRLLQPEYCP-------------------------------------------DPLYEVMLKCWHPKAEM--RPSFSELVSR--I---
---I-VLKRELGEGAFGKVFLAECYN--LSPTK-DKM-LVAVKALK-D--P-TL----AA-RKDFQ-R-EAELLTNL--Q-----HEH----IVKFYGVCG--D-----------------------------GDPLIMVFEYMKHGDLNKFLR----AHGPDAMILVDGQPRQAKGEL--GLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLV-------------------KIGDFGMSRDV--Y-S--TDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIM-----------YRKFTTESDVWSFGVILWEIFTYGK-QP---------------WFQL-SNTEVIECI-TQGRVLERPRVCP-------------------------------------------KEVYDVMLGCWQREPQQ--RLNIKEIYKIL-----
ANFI-----KIGEGSTGIVCIATEK-------H-TGK-QVAVKKMDLR--K-QQR---RE--L--LFN-EVVIMRDY--H-----HDN----VVDMYSSYL--V-----------------------------GDELWVVMEFLEGGALTDIVT----HT-----------------RM--NEEQIATVCLSVLRALSYLHNQGVIHRDIKSDSILLTSDGRI-------------------KLSDFGFCAQV----SKEVPKR--------------KS---LVGTPYWMAPEVIS-----------RLPYGTEVDIWSLGIMVIEMID-GE-PP---------------YFNE-PPLQAMRRI-RDSLPPRVKDLHK----VS-------------------------------------SVLRGFLDLMLVREPSQ--RATAQELLGHPFL---
---F-TLCRKLGSGYFGEVFEGLWK---------DRV-QVAIKVIS-R--D-NL----LH-QQMLQ-S-EIQAMKKL--R-----HKH----ILALYAVVS--V-----------------------------GDPVYIITELMAKGSLLELLR----DS--------------DEKVL--PVSELLDIAWQVAEGMCYLESQNYIHRDLAARNILVGENTLC-------------------KVGDFGLARLI-------KEDV--------------YLSHDHNIPYKWTAPEALS-----------RGHYSTKSDVWSFGILLHEMFSRGQ-VP---------------YPGM-SNHEAFLRV-DAGYRMPCPLECP-------------------------------------------PSVHKLMLTCWCRDPEQ--RPCFKALRERL-----
----YDVVKVIGRGAFGEVQLVRHK-------A-SQK-VYAMKLLSKF--E-MIK---RS--DSAFFWEERDIMAFA--N-----SPW----VVQLFYAFQ--D-----------------------------DRYLYMVMEYMPGGDLVNLMS----NY-----------------DV--PEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGHL-------------------KLADFGTCMKM---DETGMVHC--------------DT---AVGTPDYISPEVLKS-------QGGDGFYGRECDWWSVGVFLYEMLV-GD-TP---------------FYAD----SLVGTY-SKIMDHKNSLCFPEDAEIS-------------------------------------KHAKNLICAFLTDREVRLGRNGVEEIRQHPFF---
---L-RLEVKLGQGCFGEVWMGTWN---------GTT-RVAIKTLK-P--G-TM----SP--EAFL-Q-EAQVMKKL--R-----HEK----LVQLYAVVS--------------------------------EEPIYIVTEYMSKGSLLDFLK----GE--------------TGKYL--RLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVC-------------------KVADFGLARLI----E--DNEY--------------TARQGAKFPIKWTAPEAAL-----------YGRFTIKSDVWSFGILLTELTTKGR-VP---------------YPGM-VNREVLDQV-ERGYRMPCPPECP-------------------------------------------ESLHDLMCQCWRKEPEE--RPTFEYLQAF--L---
---L-RLLEKLGDGSFGVVRRGEWD----APSG-KTV-SVAVKCLK-PDVL-SQ----PEAMDDFI-R-EVNAMHSL--D-----HRN----LIRLYGVVL--------------------------------TPPMKMVTELAPLGSLLDRLR----KH---------------QGHF--LLGTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLATRDLV-------------------KIGDFGLMRAL-PQ-N--DDHY--------------VMQEHRKVPFAWCAPESLK-----------TRTFSHASDTWMFGVTLWEMFTYGQ-EP---------------WIGL-NGSQILHKIDKEGERLPRPEDCP-------------------------------------------QDIYNVMVQCWAHKPED--RPTFVALRDF--L---
----YSILKQIGSGGSSKVFQVLNE-------K-KQ--IYAIKYVNLE--E-ADN---QT--LDSYRN-EIAYLNKL-QQ----HSDK----IIRLYDYEI--T-----------------------------DQYIYMVMECGNI-DLNSWLK---KKK-----------------SI--DPWERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLIV-DGML-------------------KLIDFGIANQMQ--PDTTSVVK--------------DS---QVGTVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTY-GK-TP---------------FQQI---INQISKL-HAIIDPNHEIEFPDIPE---------------------------------------KDLQDVLKCCLKRDPKQ--RISIPELLAHPYV---
---L-RLEVKLGQGCFGEVWMGTWN---------GTT-KVAIKTLK-P--G-TM----MP--EAFL-Q-EAQIMKKL--R-----HDK----LVPLYAVVS--------------------------------EEPIYIVTEFMSKGSLLDFLK----EG--------------DGKYL--KLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLVC-------------------KIADFGLARLI----E--DNEY--------------TARQGAKFPIKWTAPEAAL-----------YGRFTIKSDVWSFGILQTELVTKGR-VP---------------YPGM-VNREVLEQV-ERGYRMPCPQGCP-------------------------------------------ESLHELMNLCWKKDPDE--RPTFEYIQSFL-----
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