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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC CDK2 203
TK ABL1 261
Other AURKA 133
CMGC CDC2 4
CMGC CDK4 6
CMGC CSNK2A1 39
TK FGFR2 481
TK MET 1078
TK PTK2 422
TK SRC 270
-FQKVEKIGEGTYGVVYKARNK-------LTGEVVALKKIRLDT-ETE---GV--PSTAIREISLLKEL--N---HPNIVKLLDVIH-T-----ENKLYLVFEFLHQ-DLKKFMDA-SALT-----------------GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLIN-TEGAIKLADFGLARAF-GVPVRTY--TH---EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFP-GDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR--------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF
-ITMKHKLGGGQYGEVYEGVWK-------KYSLTVAVKTLK-ED-TM----EV--EEFL-KEAAVMKEI--K---HPNLVQLLGVCT-R-----EPPFYIITEFMTYGNLLDYLR----EC--------------NRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVG-ENHLVKVADFGLSRLM-T--GDTY--TAHAGAKFPIKWTAPESLA-YNKFSIKSDVWAFGVLLWEIATYGMSPYP-GIDLSQVYELLEKDYRMERPEGCP------------------------------------EKVYELMRACWQWNPSDRPSFAEIHQA--F
-FEIGRPLGKGKFGNVYLAREK-------QSKFILALKVLFKAQLEKA---GV--EHQLRREVEIQSHL--R---HPNILRLYGYFH-D-----ATRVYLILEYAPLGTVYRELQ---KLS-----------------KFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLG-SAGELKIADFGWSV---HAPSSRR--TT---LCGTLDYLPPEMIE-GRMHDEKVDLWSLGVLCYEFLV-GKPPFE-AN---TYQETYKRISRVEFTFPDFVT----------------------------------EGARDLISRLLKHNPSQRPMLREVLEHPWI
-YTKIEKIGEGTYGVVYKGRHK-------TTGQVVAMKKIRLES-EEE---GV--PSTAIREISLLKEL--R---HPNIVSLQDVLM-Q-----DSRLYLIFEFLSM-DLKKYLDSIPPGQ-----------------YMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLID-DKGTIKLADFGLARAF-GIPIRVY--TH---EVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELAT-KKPLFH-GDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKP--------GSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF
Y-EPVAEIGVGAYGTVYKARDP-------HSGHFVALKSVRVPN-GGGGGGGL--PISTVREVALLRRL--EAFEHPNVVRLMDVCA-TSRTDREIKVTLVFEHVDQ-DLRTYLDK-APPP-----------------GLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVT-SGGTVKLADFGLARI--YSYQMAL--TP---VVVTLWYRAPEVLL-QSTYATPVDMWSVGCIFAEMFR-RKPLFC-GNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPR----------PVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYL
-YQLVRKLGRGKYSEVFEAINI-------TNNEKVVVKILKPVK-KKK---IK--R-----EIKILENL-RG---GPNIITLADIVK-DP---VSRTPALVFEHVNNTDFKQLY------Q-----------------TLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEF--YHPGQEY--NV---RVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIF-RKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF
-LTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLK-DD-AT----EKDLSDLV-SEMEMMKMIG-K---HKNIINLLGACT-Q-----DGPLYVIVEYASKGNLREYLR----ARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVT-ENNVMKIADFGLARDINN--IDYY--KKTTNGRLPVKWMAPEALF-DRVYTHQSDVWSFGVLMWEIFTLGGSPYP-GIPVEELFKLLKEGHRMDKPANCT------------------------------------NELYMMMRDCWHAVPSQRPTFKQLVEDL--
-VHFNEVIGRGHFGCVYHGTLL----DNDGKKIHCAVKSLN-RI-TD----IGEVSQFL-TEGIIMKDF--S---HPNVLSLLGICLRS-----EGSPLVVLPYMKHGDLRNFIR----NE---------------THNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLD-EKFTVKVADFGLARDMYD--KEYYSVHNKTGAKLPVKWMALESLQ-TQKFTTKSDVWSFGVLLWELMTRGAPPYP-DVNTFDITVYLLQGRRLLQPEYCP------------------------------------DPLYEVMLKCWHPKAEMRPSFSELVSR--I
-IELGRCIGEGQFGDVHQGIYM----SPENPALAVAIKTCK-NC-TS----DSVREKFL-QEALTMRQF--D---HPHIVKLIGVIT-------ENPVWIIMELCTLGELRSFLQ----VR---------------KYSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVS-SNDCVKLGDFGLSRYM-E--DSTY--YKASKGKLPIKWMAPESIN-FRRFTSASDVWMFGVCMWEILMHGVKPFQ-GVKNNDVIGRIENGERLPMPPNCP------------------------------------PTLYSLMTKCWAYDPSRRPRFTELKAQL--
L-RLEVKLGQGCFGEVWMGTWN--------GTTRVAIKTLK-PG-TM----SP--EAFL-QEAQVMKKL--R---HEKLVQLYAVVS-------EEPIYIVTEYMSKGSLLDFLK----GE--------------TGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVG-ENLVCKVADFGLARLI-E--DNEY--TARQGAKFPIKWTAPEAAL-YGRFTIKSDVWSFGILLTELTTKGRVPYP-GMVNREVLDQVERGYRMPCPPECP------------------------------------ESLHDLMCQCWRKEPEERPTFEYLQAF--L
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