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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC CDK2 203
TK ABL1 261
TK ABL2 288
AGC AKT1 150
Other AURKA 133
Other AURKB 77
TK BMX 422
CMGC CDC2 4
CMGC CDK4 6
CAMK CHEK1 9
CAMK CHEK2 220
Other CHUK 15
CMGC CLK3 156
CMGC CLK4 159
CMGC CSNK2A1 39
CMGC CSNK2A2 40
CAMK DAPK1 13
Other EIF2AK2 267
TK FER 563
TK FGFR1 478
TK FYN 271
CMGC GSK3A 119
CMGC GSK3B 56
TK ITK 363
TK JAK2 849
TK JAK3 822
TK LCK 245
TKL MAP3K11 117
TKL MAP3K9 144
CMGC MAPK10 64
CMGC MAPK14 24
TK NTRK2 538
TK NTRK3 538
CAMK NUAK1 55
AGC PDPK1 82
CAMK PIM1 38
Other PLK1 53
AGC PRKCD 349
AGC PRKCQ 380
AGC ROCK1 76
AGC ROCK2 92
STE SLK 34
TK SRC 270
CAMK STK33 116
TK TNK2 150
TK YES1 277
--FQKVEKIGEGTYGVVYKARNK-------L-TGE-VVALKKIRLD--T-ETE---GV-----PS-TAIR------EISLLKEL--N---HPN----IVKLLDVIH--T-----------------------------ENKLY--LVFEFLHQ---DLKKFMDA--SALT-----------------GI---PLPLIKSYLFQLLQGLAFCHS-H---R---VLHRDLKPQNLLIN-T--------EGAI--------------------KLADFGLARAF----GVPVRTY--------------TH---EVVTLWYRAPEILL----GCKYYSTAVDIWSLGCIFAEMVT-RR-AL---------------FP-GD-----------SEIDQLFRI-FRTLGTPDEVVWPGVTSMPDYKPSFPKWAR---------------QDFSKVVPPLDEDGRSLLSQMLHYDPNK--RIS-----AK-AALAHPFF-----------
--ITMKHKLGGGQYGEVYEGVWK-------K-YSL-TVAVKTLK-E--D-TM----EV-----EE-FL-K------EAAVMKEI--K---HPN----LVQLLGVCT--R-----------------------------EPPFY--IITEFMTYG--NLLDYLR-----EC--------------NRQEV---NAVVLLYMATQISSAMEYLEK-K---N---FIHRDLAARNCLVG-E--------NHLV--------------------KVADFGLSRLM----T--GDTY--------------TAHAGAKFPIKWTAPESLA-----YNKFSIKSDVWAFGVLLWEIATYGM-SP---------------YP-GI-----------DLSQVYELL-EKDYRMERPEGCP-------------------------------------------EKVYELMRACWQWNPSD--RPS-----FA-EIHQA--F-----------
--ITMKHKLGGGQYGEVYVGVWK-------K-YSL-TVAVKTLK-E--D-TM----EV-----EE-FL-K------EAAVMKEI--K---HPN----LVQLLGVCT--L-----------------------------EPPFY--IVTEYMPYG--NLLDYLR-----EC--------------NREEV---TAVVLLYMATQISSAMEYLEK-K---N---FIHRDLAARNCLVG-E--------NHVV--------------------KVADFGLSRLM----T--GDTY--------------TAHAGAKFPIKWTAPESLA-----YNTFSIKSDVWAFGVLLWEIATYGM-SP---------------YP-GI-----------DLSQVYDLL-EKGYRMEQPEGCP-------------------------------------------PKVYELMRACWKWSPAD--RPS-----FA-ETHQA--F-----------
-F-EYLKLLGKGTFGKVILVKEK-------A-TGR-YYAMKILKKE--V-IVA---KD-----EV-AHTL-----TENRVLQNS--R---HPF----LTALKYSFQ--T-----------------------------HDRLC--FVMEYANGG--ELFFHLS----RER-----------------VF---SEDRARFYGAEIVSALDYLHSEK---N---VVYRDLKLENLMLD-K--------DGHI--------------------KITDFGLCKEG----IKDGATM--------------KT---FCGTPEYLAPEVLE-----DNDYGRAVDWWGLGVVMYEMMC-GR-LP---------------FY-NQ--------------DHEKLF-ELILMEEIRFPRTLG-----------------------------------------PEAKSLLSGLLKKDPKQ--RLGGGSEDAK-EIMQHRFF-----------
--FEIGRPLGKGKFGNVYLAREK-------Q-SKF-ILALKVLFKA--QLEKA---GV-----EH-QLRR------EVEIQSHL--R---HPN----ILRLYGYFH--D-----------------------------ATRVY--LILEYAPLG--TVYRELQ----KLS-----------------KF---DEQRTATYITELANALSYCHS-K---R---VIHRDIKPENLLLG-S--------AGEL--------------------KIADFGWSV------HAPSSRR--------------TT---LCGTLDYLPPEMIE-----GRMHDEKVDLWSLGVLCYEFLV-GK-PP---------------FE-AN--------------TYQETY-KRISRVEFTFPDFVT-----------------------------------------EGARDLISRLLKHNPSQ--RPM-----LR-EVLEHPWI-----------
--FEIGRPLGKGKFGNVYLAREK-------K-SHF-IVALKVLFKS--Q-IEK---EG-----VE-HQLR-----REIEIQAHL--H---HPN----ILRLYNYFY--D-----------------------------RRRIY--LILEYAPRG--ELYKELQ----KSC-----------------TF---DEQRTATIMEELADALMYCHG-K---K---VIHRDIKPENLLLG-L--------KGEL--------------------KIADFGWSV------HAPSLRR--------------KT---MCGTLDYLPPEMIE-----GRMHNEKVDLWCIGVLCYELLV-GN-PP---------------FE-SA--------------SHNETY-RRIVKVDLKFPASVP-----------------------------------------MGAQDLISKLLRHNPSE--RLP-----LA-QVSAHPWV-----------
--ITLLKELGSGQFGVVQLGKWK---------GQY-DVAVKMIK-E--G-SM----SE-----DE-FF-Q------EAQTMMKL--S---HPK----LVKFYGVCS--K-----------------------------EYPIY--IVTEYISNG--CLLNYLR-----SH---------------GKGL---EPSQLLEMCYDVCEGMAFLES-H---Q---FIHRDLAARNCLVD-R--------DLCV--------------------KVSDFGMTRYV----L--DDQY--------------VSSVGTKFPVKWSAPEVFH-----YFKYSSKSDVWAFGILMWEVFSLGK-QP---------------YD-LY-----------DNSQVVLKV-SQGHRLYRPHLAS-------------------------------------------DTIYQIMYSCWHELPEK--RPT-----FQ-QLLSS--I-----------
--YTKIEKIGEGTYGVVYKGRHK-------T-TGQ-VVAMKKIRLE--S-EEE---GV-----PS-TAIR------EISLLKEL--R---HPN----IVSLQDVLM--Q-----------------------------DSRLY--LIFEFLSM---DLKKYLDS-IPPGQ-----------------YM---DSSLVKSYLYQILQGIVFCHS-R---R---VLHRDLKPQNLLID-D--------KGTI--------------------KLADFGLARAF----GIPIRVY--------------TH---EVVTLWYRSPEVLL----GSARYSTPVDIWSIGTIFAELAT-KK-PL---------------FH-GD-----------SEIDQLFRI-FRALGTPNNEVWPEVESLQDYKNTFPKWKP---------------GSLASHVKNLDENGLDLLSKMLIYDPAK--RIS-----GK-MALNHPYF-----------
-Y-EPVAEIGVGAYGTVYKARDP-------H-SGH-FVALKSVRVP--N-GGGGGGGL-----PI-STVR------EVALLRRL--EAFEHPN----VVRLMDVCA--TSR------------------------TDREIKVT--LVFEHVDQ---DLRTYLDK--APPP-----------------GL---PAETIKDLMRQFLRGLDFLHA-N---C---IVHRDLKPENILVT-S--------GGTV--------------------KLADFGLARI-----YSYQMAL--------------TP---VVVTLWYRAPEVLL-----QSTYATPVDMWSVGCIFAEMFR-RK-PL---------------FC-GN-----------SEADQLGKI-FDLIGLPPEDDWPRDVSLPRGAFPPRGPR-----------------PVQSVVPEMEESGAQLLLEMLTFNPHK--RIS-----AF-RALQHSYL-----------
-W-DLVQTLGEGAYGEVQLAVNR-------V-TEE-AVAVKIVDMK--R-AVD---CP-----EN-I-KK------EICINKML--N---HEN----VVKFYGHRR--E-----------------------------GNIQY--LFLEYCSGG--ELFDRIE----PDI-----------------GM---PEPDAQRFFHQLMAGVVYLHG-I---G---ITHRDIKPENLLLD-E--------RDNL--------------------KISDFGLATVFR--YNNRERLL--------------NK---MCGTLPYVAPELLK----RREFHAEPVDVWSCGIVLTAMLA-GE-LP---------------WD-QP-------------SDSCQEY-SDWKEKKTYLNPWKKI--D-------------------------------------SAPLALLHKILVENPSA--RIT-----IP-DIKKDRW-Y----------
YI--MSKTLGSGACGEVKLAFER-------K-TCK-KVAIKIISKR--K-FAI---GS-----AR-EADPALNVETEIEILKKL--N---HPC----IIKIKNFF---D-----------------------------AEDYY--IVLELMEGG--ELFDKVV----GNK-----------------RL---KEATCKLYFYQMLLAVQYLHE-N---G---IIHRDLKPENVLLS-S--------QEEDC-----------------LIKITDFGHSKI-----LGETSLM--------------RT---LCGTPTYLAPEVLVS--VGTAGYNRAVDCWSLGVILFICLS-GY-PP---------------FS-EH-------------RTQVSLK-DQITSGKYNFIPEVWAEVS-------------------------------------EKALDLVKKLLVVDPKA--RFT-----TE-EALRHPWL-----------
-W-EMRERLGTGGFGNVCLYQHR-------E-LDL-KIAIKSCRLE--L-STK---NR-----ER--WCH------EIQIMKKL--N---HAN----VVKACDVPE--ELN------------------------ILIHDVPL--LAMEYCSGG--DLRKLLNK-PENCC-----------------GL---KESQILSLLSDIGSGIRYLHE-N---K---IIHRDLKPENIVLQ-D--------VGGKI-----------------IHKIIDLGYAKD-----VDQGSLC--------------TS---FVGTLQYLAPELFE-----NKPYTATVDYWSFGTMVFECIA-GY-RP---------------FL-HHLQPFTWHEKIKKKDPKCIFA-CEEMSGEVRFSSHLPQPNSLCS-------------------------------LVVEPMENWLQLMLNWDPQQ--RG-----------------GPVDLTLKQ--
--YEIVGNLGEGTFGKVVECLDH-------A-RGKSQVALKIIRNV--G-KYR---EA-----AR----L------EINVLKKI--KEKDKENK-FLCVLMSDWFN--F-----------------------------HGHMC--IAFELLGK---NTFEFLK-----EN-----------------NFQPYPLPHVRHMAYQLCHALRFLHE-N---Q---LTHTDLKPENILFV-N--------SE-FETLYNEHKSCEEKSVKNTSIRVADFGSAT-------FDHEHH--------------TT---IVATRHYRPPEVIL-----ELGWAQPCDVWSIGCILFEYYR-GF-TL---------------FQ-TH-----------ENREHLVMM-EKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQ--RIT-----LA-EALLHPFF-----------
--YEIVDTLGEGAFGKVVECIDH-------GMDGM-HVAVKIVKNV--G-RYR---EA-----AR-S---------EIQVLEHL--NS-TDPNSVFRCVQMLEWFD--H-----------------------------HGHVC--IVFELLGL---STYDFIK----ENS-----------------FLP-FQIDHIRQMAYQICQSINFLHH-N---K---LTHTDLKPENILFV-K--------SDYVVKYNSKMKR-DERTLKNTDIKVVDFGSA-------TYDDEHH--------------ST---LVSTRHYRAPEVIL-----ALGWSQPCDVWSIGCILIEYYL-GF-TV---------------FQ-TH-----------DSKEHLAMM-ERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQ--RIT-----LD-EALQHPFF-----------
--YQLVRKLGRGKYSEVFEAINI-------T-NNE-KVVVKILKPV--K-KKK---IK-----R------------EIKILENL-RG---GPN----IITLADIVK--DP---------------------------VSRTPA--LVFEHVNNT--DFKQLY-------Q-----------------TL---TDYDIRFYMYEILKALDYCHS-M---G---IMHRDVKPHNVMIDHE--------HRKL--------------------RLIDWGLAEF-----YHPGQEY--------------NV---RVASRYFKGPELLV----DYQMYDYSLDMWSLGCMLASMIF-RK-EP---------------FFHGH-----------DNYDQLVRI-AKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRK-------RWERFVHSENQHLVSPEALDFLDKLLRYDHQS--RLT-----AR-EAMEHPYF-----------
--YQLVRKLGRGKYSEVFEAINI-------T-NNE-RVVVKILKPV--K-KKK---IK-----R------------EVKILENL-RG---GTN----IIKLIDTVK--DP---------------------------VSKTPA--LVFEYINNT--DFKQLY-------Q-----------------IL---TDFDIRFYMYELLKALDYCHS-K---G---IMHRDVKPHNVMIDHQ--------QKKL--------------------RLIDWGLAEF-----YHPAQEY--------------NV---RVASRYFKGPELLV----DYQMYDYSLDMWSLGCMLASMIF-RR-EP---------------FFHGQ-----------DNYDQLVRI-AKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRK-------RWENFIHSENRHLVSPEALDLLDKLLRYDHQQ--RLT-----AK-EAMEHPYF-----------
--YDTGEELGSGQFAVVKKCREK-------S-TGL-QYAAKFIKKR--R-TKS---SR-----RG-VSREDI--EREVSILKEI--Q---HPN----VITLHEVYE--N-----------------------------KTDVI--LILELVAGG--ELFDFLA----EKE-----------------SL---TEEEATEFLKQILNGVYYLHS-L---Q---IAHFDLKPENIMLL-D--------RNVPKP----------------RIKIIDFGLAHK-----IDFGNEF--------------KN---IFGTPEFVAPEIVN-----YEPLGLEADMWSIGVITYILLS-GA-SP---------------FL-GD--------------TKQETL-ANVSAVNYEFEDEYFSNTS-------------------------------------ALAKDFIRRLLVKDPKK--RMT-----IQ-DSLQHPWI-----------
-F-KEIELIGSGGFGQVFKAKHR-------I-DGK-TYVIKRVKYN--N-EKA---ER------------------EVKALAKL--D---HVN----IVHYNGCWD--GFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLF--IQMEFCDKG--TLEQWIEK--RRGE-----------------KL---DKVLALELFEQITKGVDYIHS-K---K---LIHRDLKPSNIFLV-D--------TKQV--------------------KIGDFGLVTS-----LKNDGKR--------------TR---SKGTLRYMSPEQIS-----SQDYGKEVDLYALGLILAELLH-VCDTA---------------FE-T------------------SKF-FTDLRDGIISDIFDK------------------------------------------KEKTLLQKLLSKKPED--RPN-----TS-EILR----TLT--------
VI--LGELLGKGNFGEVYKGTLK---------DKT-SVAVKTCK-E--D-LP----QEL---KIK-FL-Q------EAKILKQY--D---HPN----IVKLIGVCT--Q-----------------------------RQPVY--IIMELVSGG--DFLTFLR-----RK---------------KDEL---KLKQLVKFSLDAAAGMLYLES-K---N---CIHRDLAARNCLVG-E--------NNVL--------------------KISDFGMSRQE----D--GGVY--------------SSSGLKQIPIKWTAPEALN-----YGRYSSESDVWSFGILLWETFSLGV-CP---------------YP-GM-----------TNQQAREQV-ERGYRMSAPQHCP-------------------------------------------EDISKIMMKCWDYKPEN--RPK-----FS-ELQKEL-------------
-L-VLGKPLGEGCFGQVVLAEAIGLDKDKPN-RVT-KVAVKMLK-S--D-AT----EKD---LSD-LI-S------EMEMMKMIG-K---HKN----IINLLGACT--Q-----------------------------DGPLY--VIVEYASKG--NLREYLQ-----ARRPPGLEYCYNPSHNPEEQL---SSKDLVSCAYQVARGMEYLAS-K---K---CIHRDLAARNVLVT-E--------DNVM--------------------KIADFGLARDI--H-H--IDYY--------------KKTTNGRLPVKWMAPEALF-----DRIYTHQSDVWSFGVLLWEIFTLGG-SP---------------YP-GV-----------PVEELFKLL-KEGHRMDKPSNCT-------------------------------------------NELYMMMRDCWHAVPSQ--RPT-----FK-QLVEDL-------------
--LQLIKRLGNGQFGEVWMGTWN---------GNT-KVAIKTLK-P--G-TM----SP-----ES-FL-E------EAQIMKKL--K---HDK----LVQLYAVVS--------------------------------EEPIY--IVTEYMNKG--SLLDFLK-----DG--------------EGRAL---KLPNLVDMAAQVAAGMAYIER-M---N---YIHRDLRSANILVG-N--------GLIC--------------------KIADFGLARLI----E--DNEY--------------TARQGAKFPIKWTAPEAAL-----YGRFTIKSDVWSFGILLTELVTKGR-VP---------------YP-GM-----------NNREVLEQV-ERGYRMPCPQDCP-------------------------------------------ISLHELMIHCWKKDPEE--RPT-----FE-YLQSFL-------------
--YTDIKVIGNGSFGVVYQARLA-------E-TRE-LVAIKKVLQD--K-RFK---NR------------------ELQIMRKL--D---HCN----IVRLRYFFY--SSG-------------------------EKKDELYLNLVLEYVPETVYRVARHFT---KAKL-----------------TI---PILYVKVYMYQLFRSLAYIHS-Q---G---VCHRDIKPQNLLVDPD--------TAVL--------------------KLCDFGSAKQ-----LVRGEPN--------------VS---YICSRYYRAPELIF----GATDYTSSIDVWSAGCVLAELLL-GQ-PI---------------FP-GD-----------SGVDQLVEI-IKVLGTPTREQIREMNPNYTEFKFPQIKAH---------------PWTKVFKSRTPPEAIALCSSLLEYTPSS--RLS-----PL-EACAHSFF-----------
--YTDTKVIGNGSFGVVYQAKLC-------D-SGE-LVAIKKVLQD--K-RFK---NR------------------ELQIMRKL--D---HCN----IVRLRYFFY--SSG-------------------------EKKDEVYLNLVLDYVPETVYRVA---RHYSRAKQ-----------------TL---PVIYVKLYMYQLFRSLAYIHS-F---G---ICHRDIKPQNLLLDPD--------TAVL--------------------KLCDFGSAKQ-----LVRGEPN--------------VS---YICSRYYRAPELIF----GATDYTSSIDVWSAGCVLAELLL-GQ-PI---------------FP-GD-----------SGVDQLVEI-IKVLGTPTREQIREMNPNYTEFKFPQIKAH---------------PWTKVFRPRTPPEAIALCSRLLEYTPTA--RLT-----PL-EACAHSFF-----------
--LTFVQEIGSGQFGLVHLGYWL---------NKD-KVAIKTIR-E--G-AM----SE-----ED-FI-E------EAEVMMKL--S---HPK----LVQLYGVCL--E-----------------------------QAPIC--LVFEFMEHG--CLSDYLR-----TQ---------------RGLF---AAETLLGMCLDVCEGMAYLEE-A---C---VIHRDLAARNCLVG-E--------NQVI--------------------KVSDFGMTRFV----L--DDQY--------------TSSTGTKFPVKWASPEVFS-----FSRYSSKSDVWSFGVLMWEVFSEGK-IP---------------YE-NR-----------SNSEVVEDI-STGFRLYKPRLAS-------------------------------------------THVYQIMNHCWKERPED--RPA-----FS-RLLRQL-------------
--LKFLQQLGKGNFGSVEMCRYDP---LQDN-TGE-VVAVKKLQ-H--S-TE-----EH---LRD-FE-R------EIEILKSL--Q---HDN----IVKYKGVCYSAG-----------------------------RRNLK--LIMEYLPYG--SLRDYLQ-----KH---------------KERI---DHIKLLQYTSQICKGMEYLGT-K---R---YIHRDLATRNILVE-N--------ENRV--------------------KIGDFGLTKVL-PQ-D--KEYY--------------KVKEPGESPIFWYAPESLT-----ESKFSVASDVWSFGVVLYELFTYIE-KSKSPPAEFMRMIGNDKQG-QM-----------IVFHLIELL-KNNGRLPRPDGCP-------------------------------------------DEIYMIMTECWNNNVNQ--RPS-----FR-DLA----LRV---------
-L-KYISQLGKGNFGSVELCRYDP---LGDN-TGA-LVAVKQLQ-H--S-GP----DQ----QRD-FQ-R------EIQILKAL--H---SDF----IVKYRGVSYGPG-----------------------------RQSLR--LVMEYLPSG--CLRDFLQ-----RH---------------RARL---DASRLLLYSSQICKGMEYLGS-R---R---CVHRDLAARNILVE-S--------EAHV--------------------KIADFGLAKLL-PL-D--KDYY--------------VVREPGQSPIFWYAPESLS-----DNIFSRQSDVWSFGVVLYELFTYCD-KSCSPSAE--FLRMMGCER-DV-P---------ALCRLLELL-EEGQRLPAPPACP-------------------------------------------AEVHELMKLCWAPSPQD--RPS-----FS-ALGP---QL----------
--LKLVERLGAGQFGEVWMGYYN---------GHT-KVAVKSLK-Q--G-SM----SP-----DA-FL-A------EANLMKQL--Q---HQR----LVRLYAVVT--------------------------------QEPIY--IITEYMENG--SLVDFLK-----TP--------------SGIKL---TINKLLDMAAQIAEGMAFIEE-R---N---YIHRDLRAANILVS-D--------TLSC--------------------KIADFGLARLI----E--DNEY--------------TAREGAKFPIKWTAPEAIN-----YGTFTIKSDVWSFGILLTEIVTHGR-IP---------------YP-GM-----------TNPEVIQNL-ERGYRMVRPDNCP-------------------------------------------EELYQLMRLCWKERPED--RPT-----FD-YLRSV--L-----------
--LRLEEVIGIGGFGKVYRGSWR----------GE-LVAVKAAR-Q--D-PD----EDISVTAES-VR-Q------EARLFAML--A---HPN----IIALKAVCL--E-----------------------------EPNLC--LVMEYAAGG--PLSRALA-----GR-----------------RV---PPHVLVNWAVQIARGMHYLHC-E---ALVPVIHRDLKSNNILLL-QPIESDDMEHKTL--------------------KITDFGLAREW---------HK--------------TTQMSAAGTYAWMAPEVIK-----ASTFSKGSDVWSFGVLLWELLT-GE-VP---------------YR-GI-----------DCLAVAYGVAVNKLTLPIPSTCP-------------------------------------------EPFAQLMADCWAQDPHR--RPD-----FA-SILQQL-------------
-L-TLEEIIGIGGFGKVYRAFWI-------G-DE---VAVKAARHDP-D-EDI---SQ-----TI-ENVR-----QEAKLFAML--K---HPN----IIALRGVCL--K-----------------------------EPNLC--LVMEFARGG--PLNRVLS-----GK-----------------RI---PPDILVNWAVQIARGMNYLHD-EAIVP---IIHRDLKSSNILIL-Q--------KVENGDLS------------NKILKITDFGLAR------EWHRTTK--------------MS---AAGTYAWMAPEVIR-----ASMFSKGSDVWSYGVLLWELLT-GE-VP---------------FR-GI--------------DGLAVA-YGVAMNKLALPIPSTCP---------------------------------------EPFAKLMEDCWNPDPHS--RPS-----FT-NILDQ---LT---------
--YQNLKPIGSGAQGIVCAAYDA-------V-LDR-NVAIKKLSRP--F-QNQ---TH-----AK-RAYR------ELVLMKCV--N---HKN----IISLLNVFT--PQKT-----------------------LEEFQDVY--LVMELMDA---NLCQVIQ------M-----------------EL---DHERMSYLLYQMLCGIKHLHS-A---G---IIHRDLKPSNIVVK-S--------DCTL--------------------KILDFGLART-----AGTSFMM--------------TP---YVVTRYYRAPEVIL-----GMGYKENVDIWSVGCIMGEMVR-HK-IL---------------FP-GR-----------DYIDQWNKV-IEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPK--LFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAK--RIS-----VD-DALQHPYI-----------
--YQNLSPVGSGAYGSVCAAFDT-------K-TGL-RVAVKKLSRP--F-QSI---IH-----AK-RTYR------ELRLLKHM--K---HEN----VIGLLDVFT--PARS-----------------------LEEFNDVY--LVTHLMGA---DLNNIVK-----CQ-----------------KL---TDDHVQFLIYQILRGLKYIHS-A---D---IIHRDLKPSNLAVN-E--------DCEL--------------------KILDFGLAR-------HTDDEM--------------TG---YVATRWYRAPEIML----NWMHYNQTVDIWSVGCIMAELLT-GR-TL---------------FP-GT-----------DHIDQLKLI-LRLVGTPGAELLKKISSESARNYIQSLTQMP-------------KMNFANVFIGANPLAVDLLEKMLVLDSDK--RIT-----AA-QALAHAYF-----------
-I-VLKRELGEGAFGKVFLAECYN--LCPEQ-DKI-LVAVKTLK-D--A-SD----NA----RKD-FH-R------EAELLTNL--Q---HEH----IVKFYGVCV--E-----------------------------GDPLI--MVFEYMKHG--DLNKFLR-----AHGPDAV---LMAEGNPPTEL---TQSQMLHIAQQIAAGMVYLAS-Q---H---FVHRDLATRNCLVG-E--------NLLV--------------------KIGDFGMSRDV--Y-S--TDYY--------------RVGGHTMLPIRWMPPESIM-----YRKFTTESDVWSLGVVLWEIFTYGK-QP---------------WY-QL-----------SNNEVIECI-TQGRVLQRPRTCP-------------------------------------------QEVYELMLGCWQREPHM--RKN-----IK-GIHTL--L-----------
-I-VLKRELGEGAFGKVFLAECYN--LSPTK-DKM-LVAVKALK-D--P-TL----AA----RKD-FQ-R------EAELLTNL--Q---HEH----IVKFYGVCG--D-----------------------------GDPLI--MVFEYMKHG--DLNKFLR-----AHGPDAMILVDGQPRQAKGEL---GLSQMLHIASQIASGMVYLAS-Q---H---FVHRDLATRNCLVG-A--------NLLV--------------------KIGDFGMSRDV--Y-S--TDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIM-----YRKFTTESDVWSFGVILWEIFTYGK-QP---------------WF-QL-----------SNTEVIECI-TQGRVLERPRVCP-------------------------------------------KEVYDVMLGCWQREPQQ--RLN-----IK-EIYKIL-------------
--YELQETLGKGTYGKVKRATER-------F-SGR-VVAIKSIRKD--K-IKD---EQ-----DM-VHIR-----REIEIMSSL--N---HPH----IISIYEVFE--N-----------------------------KDKIV--IIMEYASKG--ELYDYIS----ERR-----------------RL---SERETRHFFRQIVSAVHYCHK-N---G---VVHRDLKLENILLD-D--------NCNI--------------------KIADFGLSNL-----YQKDKFL--------------QT---FCGSPLYASPEIVN----GRPYRGPEVDSWALGVLLYTLVY-GT-MP---------------FD-GF--------------DHKNLI-RQISSGEYREPTQP------------------------------------------SDARGLIRWMLMVNPDR--RAT-----IE-DIANHWW-V----------
-F-KFGKILGEGSFSTVVLAREL-------A-TSR-EYAIKILEKR--H-IIK---EN-----KVPYVTR------ERDVMSRL--D---HPF----FVKLYFTFQ--D-----------------------------DEKLY--FGLSYAKNG--ELLKYIR----KIG-----------------SF---DETCTRFYTAEIVSALEYLHG-K---G---IIHRDLKPENILLN-E--------DMHI--------------------QITDFGTAKVLS--PESKQARA--------------NS---FVGTAQYVSPELLT-----EKSACKSSDLWALGCIIYQLVA-GL-PP---------------FR-AG--------------NEYLIF-QKIIKLEYDFPEKFF-----------------------------------------PKARDLVEKLLVLDATK--RLG-----CE-EM------EGYGPLKAHPF
--YQVGPLLGSGGFGSVYSGIRV-------S-DNL-PVAIKHVEKD--R-ISD---WG-----EL-PNGTRV--PMEVVLLKKV--S---SGFS--GVIRLLDWFE--R-----------------------------PDSFV--LILERPEPV-QDLFDFIT----ERG-----------------AL---QEELARSFFWQVLEAVRHCHN-C---G---VLHRDIKDENILIDLN--------RGEL--------------------KLIDFGSGA------LLKDTVY--------------TD---FDGTRVYSPPEWIR----YHRYHGRSAAVWSLGILLYDMVC-GD-IP---------------FE-HD---------------------EEIIRGQVFFRQRVS-----------------------------------------SECQHLIRWCLALRPSD--RPT-----FE-EIQNHPWM-----------
YV--RGRFLGKGGFAKCFEISDA-------D-TKE-VFAGKIVPKS--L-LLK---PH-----QR-EKMS-----MEISIHRSL--A---HQH----VVGFHGFFE--D-----------------------------NDFVF--VVLELCRRR--SLLELHK----RRK-----------------AL---TEPEARYYLRQIVLGCQYLHR-N---R---VIHRDLKLGNLFLN-E--------DLEV--------------------KIGDFGLATKV----EYDGERK--------------KT---LCGTPNYIAPEVLS-----KKGHSFEVDVWSIGCIMYTLLV-GK-PP---------------FE-TS--------------CLKETY-LRIKKNEYSIPKHIN-----------------------------------------PVAASLIQKMLQTDPTA--RPT-----IN-ELLNDEFF-----------
FI--FHKVLGKGSFGKVLLGELK-------G-RGE-YFAIKALKKD--V-VLI---DD-----DV-ECTM-----VEKRVLTLA-AE---NPF----LTHLICTFQ--T-----------------------------KDHLF--FVMEFLNGG--DLMYHIQ----DKG-----------------RF---ELYRATFYAAEIMCGLQFLHS-K---G---IIYRDLKLDNVLLD-R--------DGHI--------------------KIADFGMCKEN----IFGESRA--------------ST---FCGTPDYIAPEILQ-----GLKYTFSVDWWSFGVLLYEMLI-GQ-SP---------------FH-GD--------------DEDELF-ESIRVDTPHYPRWIT-----------------------------------------KESKDILEKLFEREPTK--RLG----VTG-NIKIHPFF-----------
FI--LHKMLGKGSFGKVFLAEFK-------K-TNQ-FFAIKALKKD--V-VLM---DD-----DV-ECTM-----VEKRVLSLA-WE---HPF----LTHMFCTFQ--T-----------------------------KENLF--FVMEYLNGG--DLMYHIQ----SCH-----------------KF---DLSRATFYAAEIILGLQFLHS-K---G---IVYRDLKLDNILLD-K--------DGHI--------------------KIADFGMCKEN----MLGDAKT--------------NT---FCGTPDYIAPEILL-----GQKYNHSVDWWSFGVLLYEMLI-GQ-SP---------------FH-GQ--------------DEEELF-HSIRMDNPFYPRWLE-----------------------------------------KEAKDLLVKLFVREPEK--RLG-----VRGDIRQHPLF-----------
--YEVVKVIGRGAFGEVQLVRHK-------S-TRK-VYAMKLLSKF--E-MIK---RS-----DS-AFFW-----EERDIMAFA--N---SPW----VVQLFYAFQ--D-----------------------------DRYLY--MVMEYMPGG--DLVNLMS-----NY-----------------DV---PEKWARFYTAEVVLALDAIHS-M---G---FIHRDVKPDNMLLD-K--------SGHL--------------------KLADFGTCMKM---NKEGMVRC--------------DT---AVGTPDYISPEVLKS-QGGDGYYGRECDWWSVGVFLYEMLV-GD-TP---------------FY-AD--------------SLVGTY-SKIMNHKNSLTFPDDNDIS-------------------------------------KEAKNLICAFLTDREVRLGRNG-----VE-EIKRHLFF-----------
--YDVVKVIGRGAFGEVQLVRHK-------A-SQK-VYAMKLLSKF--E-MIK---RS-----DS-AFFW-----EERDIMAFA--N---SPW----VVQLFYAFQ--D-----------------------------DRYLY--MVMEYMPGG--DLVNLMS-----NY-----------------DV---PEKWAKFYTAEVVLALDAIHS-M---G---LIHRDVKPDNMLLD-K--------HGHL--------------------KLADFGTCMKM---DETGMVHC--------------DT---AVGTPDYISPEVLKS-QGGDGFYGRECDWWSVGVFLYEMLV-GD-TP---------------FY-AD--------------SLVGTY-SKIMDHKNSLCFPEDAEIS-------------------------------------KHAKNLICAFLTDREVRLGRNG-----VE-EIRQHPFF-----------
--WEIIGELGDGAFGKVYKAQNK-------E-TSV-LAAAKVIDTK--S-EEE---LE-----DY-M--V------EIDILASC--D---HPN----IVKLLDAFY--Y-----------------------------ENNLW--ILIEFCAGG--AVDAVML---ELER-----------------PL---TESQIQVVCKQTLDALNYLHD-N---K---IIHRDLKAGNILFT-L--------DGDI--------------------KLADFGVSAKN----TRTIQRR--------------DS---FIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIEMAE-IE-PP---------------HH-EL-----------NPMRVLLKI-AKSEPPTLAQPSRWS-----------------------------------------SNFKDFLKKCLEKNVDA--RWT-----TS-QLLQHPFV-----------
-L-RLEVKLGQGCFGEVWMGTWN---------GTT-RVAIKTLK-P--G-TM----SP-----EA-FL-Q------EAQVMKKL--R---HEK----LVQLYAVVS--------------------------------EEPIY--IVTEYMSKG--SLLDFLK-----GE--------------TGKYL---RLPQLVDMAAQIASGMAYVER-M---N---YVHRDLRAANILVG-E--------NLVC--------------------KVADFGLARLI----E--DNEY--------------TARQGAKFPIKWTAPEAAL-----YGRFTIKSDVWSFGILLTELTTKGR-VP---------------YP-GM-----------VNREVLDQV-ERGYRMPCPPECP-------------------------------------------ESLHDLMCQCWRKEPEE--RPT-----FE-YLQAF--L-----------
--YTFGRILGKGSFGIVIEATDK-------E-TET-KWAIKKVNKE--K-AGS---SA-----VK-LLER------EVNILKSV--K---HEH----IIHLEQVFE--T-----------------------------PKKMY--LVMELCEDG--ELKEILD----RKG-----------------HF---SENETRWIIQSLASAIAYLHN-N---D---IVHRDLKLENIMVK-S--------SLIDDNNE-----------INLNIKVTDFGLAVKK---QSRSEAML--------------QA---TCGTPIYMAPEVIS-----AHDYSQQCDIWSIGVVMYMLLR-GE-PP---------------FL-AS--------------SEEKLF-ELIRKGELHFENAVWNSIS-------------------------------------DCAKSVLKQLMKVDPAH--RIT-----AK-ELLDNQWL-----------
-L-RLLEKLGDGSFGVVRRGEWD----APSG-KTV-SVAVKCLK-PDVL-SQ----PEA---MDD-FI-R------EVNAMHSL--D---HRN----LIRLYGVVL--------------------------------TPPMK--MVTELAPLG--SLLDRLR-----KH---------------QGHF---LLGTLSRYAVQVAEGMGYLES-K---R---FIHRDLAARNLLLA-T--------RDLV--------------------KIGDFGLMRAL-PQ-N--DDHY--------------VMQEHRKVPFAWCAPESLK-----TRTFSHASDTWMFGVTLWEMFTYGQ-EP---------------WI-GL-----------NGSQILHKIDKEGERLPRPEDCP-------------------------------------------QDIYNVMVQCWAHKPED--RPT-----FV-ALRDF--L-----------
-L-RLEVKLGQGCFGEVWMGTWN---------GTT-KVAIKTLK-P--G-TM----MP-----EA-FL-Q------EAQIMKKL--R---HDK----LVPLYAVVS--------------------------------EEPIY--IVTEFMSKG--SLLDFLK-----EG--------------DGKYL---KLPQLVDMAAQIADGMAYIER-M---N---YIHRDLRAANILVG-E--------NLVC--------------------KIADFGLARLI----E--DNEY--------------TARQGAKFPIKWTAPEAAL-----YGRFTIKSDVWSFGILQTELVTKGR-VP---------------YP-GM-----------VNREVLEQV-ERGYRMPCPQGCP-------------------------------------------ESLHELMNLCWKKDPDE--RPT-----FE-YIQSFL-------------
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