|
|
Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC CDK2 203
Other AURKA 133
Other AURKB 77
Other AURKC 43
CMGC CDC2 4
CMGC CDK4 6
CMGC CDK9 2.7.11.23
TK LCK 245
AGC RPS6KB1 91
TK SRC 270
-FQKVEKIGEGTYGVVYKARN---KLTGEVVALKKIRLDT-ETE---GVPSTAIR--EISLLKELN---HPNIVKLLDVIHT--------ENKLYLVFEFLHQ-DLKKFMDA-SALT---GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAF----GVPVRTYTH---EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR---QDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS-----AKAALAHPFF
-FEIGRPLGKGKFGNVYLARE---KQSKFILALKVLFKAQLEKA---GVEHQLRR--EVEIQSHLR---HPNILRLYGYFHD--------ATRVYLILEYAPLGTVYRELQ---KLS---KFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSV------HAPSSRRTT---LCGTLDYLPPEMIE-GRMHDEKVDLWSLGVLCYEFLV-GKPPFEAN---TYQETYKRISRVEFTFPDFVT-----------------------------EGARDLISRLLKHNPSQRPM-----LREVLEHPWI
-FEIGRPLGKGKFGNVYLARE---KKSHFIVALKVLFKSQ-IEK---EGVEHQLR-REIEIQAHLH---HPNILRLYNYFYD--------RRRIYLILEYAPRGELYKELQ---KSC---TFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSV------HAPSLRRKT---MCGTLDYLPPEMIE-GRMHNEKVDLWCIGVLCYELLV-GNPPFESA---SHNETYRRIVKVDLKFPASVP-----------------------------MGAQDLISKLLRHNPSERLP-----LAQVSAHPWV
-FEIGRPLGKGKFGNVYLARL---KESHFIVALKVLFKSQ-IEK---EGLEHQLR-REIEIQAHLQ---HPNILRLYNYFHD--------ARRVYLILEYAPRGELYKELQ---KSE---KLDEQRTATIIEELADALTYCHDKKVIHRDIKPENLLLGFRGEVKIADFGWSV------HTPSLRRKT---MCGTLDYLPPEMIE-GRTYDEKVDLWCIGVLCYELLV-GYPPFESA---SHSETYRRILKVDVRFPLSMP-----------------------------LGARDLISRLLRYQPLERLP-----LAQILKHPWV
-YTKIEKIGEGTYGVVYKGRH---KTTGQVVAMKKIRLES-EEE---GVPSTAIR--EISLLKELR---HPNIVSLQDVLMQ--------DSRLYLIFEFLSM-DLKKYLDSIPPGQ---YMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAF----GIPIRVYTH---EVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELAT-KKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKP---GSLASHVKNLDENGLDLLSKMLIYDPAKRIS-----GKMALNHPYF
Y-EPVAEIGVGAYGTVYKARD---PHSGHFVALKSVRVPN-GGGGGGGLPISTVR--EVALLRRLEAFEHPNVVRLMDVCATSR---TDREIKVTLVFEHVDQ-DLRTYLDK-APPP---GLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARI-----YSYQMALTP---VVVTLWYRAPEVLL-QSTYATPVDMWSVGCIFAEMFR-RKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPR-----PVQSVVPEMEESGAQLLLEMLTFNPHKRIS-----AFRALQHSYL
-YEKLAKIGQGTFGEVFKARH---RKTGQKVALKKVLMEN-EKE---GFPITALR--EIKILQLLK---HENVVNLIEICRTKASPYNRCKGSIYLVFDFCEH-DLAGLLS--NVLV---KFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTN---RVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWT-RSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRID-----SDDALNHDFF
-LKLVERLGAGQFGEVWMGYY---N-GHTKVAVKSLK-QG-SM----SPDAFL-A--EANLMKQLQ---HQRLVRLYAVVT---------QEPIYIITEYMENGSLVDFLK----TPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLI----E--DNEYTAREGAKFPIKWTAPEAIN-YGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCP-------------------------------EELYQLMRLCWKERPEDRPT-----FDYLRSV--L
-FELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAM-IVR---NAKDTAHTKAERNILEEVK---HPFIVDLIYAFQT--------GGKLYLILEYLSGGELFMQLE---REG---IFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKES----IHDGTVTHT---FCGTIEYMAPEILM-RSGHNRAVDWWSLGALMYDMLT-GAPPFTGE---NRKKTIDKILKCKLNLPPYLT-----------------------------QEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFF
L-RLEVKLGQGCFGEVWMGTW---N-GTTRVAIKTLK-PG-TM----SPEAFL-Q--EAQVMKKLR---HEKLVQLYAVVS---------EEPIYIVTEYMSKGSLLDFLK----GETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLI----E--DNEYTARQGAKFPIKWTAPEAAL-YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECP-------------------------------ESLHDLMCQCWRKEPEERPT-----FEYLQAF--L
|