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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC CDK9 203
Other AURKA 133
CAMK CASK 12
CMGC CDK2 4
CAMK CHEK2 220
CMGC CSNK2A1 39
CAMK DAPK1 13
Other EIF2AK2 267
CMGC GSK3B 56
TKL IRAK4 186
STE MAP2K1 68
CMGC MAPK10 64
CMGC MAPK12 27
Other NEK2 8
AGC RPS6KA1 62
TK SRC 270
STE STK24 24
---YEKLAKIGQGTFGEV---FKARHRKTGQKVALKKVLMEN-EKEGFP-ITALR------EIKILQLL-KHENVVNLIEICRTKASP---------------------YNRCKGSIY--LVFDFCEH---DLA-GLLS---NVLV---KFTLSEIKRVMQMLLNGLYYIHR-N-----KILHRDMKAANVLIT-RDGVL----KLADFGLARAFSLAKNSQPNRYTN---RVVTLWYRPPELLL--GERDYGPPIDLWGAGCIMAEMWT-RS-PIMQ-GNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQK------------RKVKDRLKAYVRDPYALDLIDKLLVLDPAQRID-----SDDALNHDFF---
---FEIGRPLGKGKFGNV---YLAREKQSKFILALKVLFKAQLEKAGVE-HQLRR------EVEIQSHL-RHPNILRLYGYFHD-----------------------------ATRVY--LILEYAPLG--TVY-RELQ----KLS---KFDEQRTATYITELANALSYCHS-K-----RVIHRDIKPENLLLG-SAGEL----KIADFGWSV------HAPSSRRTT---LCGTLDYLPPEMIE---GRMHDEKVDLWSLGVLCYEFLV-GK-PPFE-AN---TYQETYKRISRVEFTFPDFVT-----------------------------------------EGARDLISRLLKHNPSQRPM-----LREVLEHPWI---
---YELCEVIGKGPFSVV---RRCINRETGQQFAVKIVDVAK-FTSSPG-LSTEDL---KREASICHML-KHPHIVELLETYSS-----------------------------DGMLY--MVFEFMDGA--DLCFEIVKR-ADAGF---VYSEAVASHYMRQILEALRYCHD-N-----NIIHRDVKPHCVLLA-SKENSA-PVKLGGFGVAIQL----GESGLVAGG---RVGTPHFMAPEVVK---REPYGKPVDVWGCGVILFILLS-GC-LPFY-GT----KERLFEGIIKGKYKMNPRQWSHIS-------------------------------------ESAKDLVRRMLMLDPAERIT-----VYEALNHPWL---
---FQKVEKIGEGTYGVV---YKARNKLTGEVVALKKIRLDT-ETEGVP-STAIR------EISLLKEL-NHPNIVKLLDVIHT-----------------------------ENKLY--LVFEFLHQ---DLK-KFMDA--SALT---GIPLPLIKSYLFQLLQGLAFCHS-H-----RVLHRDLKPQNLLIN-TEGAI----KLADFGLARAF----GVPVRTYTH---EVVTLWYRAPEILL--GCKYYSTAVDIWSLGCIFAEMVT-RR-ALFP-GDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR---------------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS-----AKAALAHPFF---
-YI--MSKTLGSGACGEV---KLAFERKTCKKVAIKIISKRK-FAIGSA-READPALNVETEIEILKKL-NHPCIIKIKNFF-D-----------------------------AEDYY--IVLELMEGG--ELF-DKVV----GNK---RLKEATCKLYFYQMLLAVQYLHE-N-----GIIHRDLKPENVLLS-SQEEDC-LIKITDFGHSKI-----LGETSLMRT---LCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLS-GY-PPFS-EH--RTQVSLKDQITSGKYNFIPEVWAEVS-------------------------------------EKALDLVKKLLVVDPKARFT-----TEEALRHPWL---
---YQLVRKLGRGKYSEV---FEAINITNNEKVVVKILKPVK-KKKIKR------------EIKILENLRGGPNIITLADIVKDP---------------------------VSRTPA--LVFEHVNNT--DFK-QLY-------Q---TLTDYDIRFYMYEILKALDYCHS-M-----GIMHRDVKPHNVMIDHEHRKL----RLIDWGLAEF-----YHPGQEYNV---RVASRYFKGPELLV--DYQMYDYSLDMWSLGCMLASMIF-RK-EPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRK-------RWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLT-----AREAMEHPYF---
---YDTGEELGSGQFAVV---KKCREKSTGLQYAAKFIKKRR-TKSSRR-GVSREDI--EREVSILKEI-QHPNVITLHEVYEN-----------------------------KTDVI--LILELVAGG--ELF-DFLA----EKE---SLTEEEATEFLKQILNGVYYLHS-L-----QIAHFDLKPENIMLL-DRNVPKPRIKIIDFGLAHK-----IDFGNEFKN---IFGTPEFVAPEIVN---YEPLGLEADMWSIGVITYILLS-GA-SPFL-GD---TKQETLANVSAVNYEFEDEYFSNTS-------------------------------------ALAKDFIRRLLVKDPKKRMT-----IQDSLQHPWI---
--F-KEIELIGSGGFGQV---FKAKHRIDGKTYVIKRVKYNN-EKAER-------------EVKALAKL-DHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLF--IQMEFCDKG--TLE-QWIEK--RRGE---KLDKVLALELFEQITKGVDYIHS-K-----KLIHRDLKPSNIFLV-DTKQV----KIGDFGLVTS-----LKNDGKRTR---SKGTLRYMSPEQIS---SQDYGKEVDLYALGLILAELLH-VCDTAFE-T-------SKFFTDLRDGIISDIFDK------------------------------------------KEKTLLQKLLSKKPEDRPN-----TSEILR----TLT
---YTDTKVIGNGSFGVV---YQAKLCDSGELVAIKKVLQDK-RFKNR-------------ELQIMRKL-DHCNIVRLRYFFYSSG-------------------------EKKDEVYLNLVLDYVPETVYRVA----RHYSRAKQ---TLPVIYVKLYMYQLFRSLAYIHS-F-----GICHRDIKPQNLLLDPDTAVL----KLCDFGSAKQ-----LVRGEPNVS---YICSRYYRAPELIF--GATDYTSSIDVWSAGCVLAELLL-GQ-PIFP-GDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH---------------PWTKVFRPRTPPEAIALCSRLLEYTPTARLT-----PLEACAHSFF---
VGG----NKMGEGGFGVV---YKGYVNNTT--VAVKKLAAMV-DITTEELKQQFD-----QEIKVMAKC-QHENLVELLGFSSD-----------------------------GDDLC--LVYVYMPNG--SLL-DRLSC-LDGTP---PLSWHMRCKIAQGAANGINFLHE-N-----HHIHRDIKSANILLD-EAFTA----KISDFGLARASE--KFAQTVMTSR---IVGTTAYMAPEALR----GEITPKSDIYSFGVVLLEIIT-GL-PAVD-EHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDAD-----------------------------STSVEAMYSVASQCLHEKKNKRPD-----IKKVQQ----LLQ
---FEKISELGAGNGGVV---FKVSHKPSGL-VMARKLIHLE-IKPAIR-NQIIR------ELQVLHEC-NSPYIVGFYGAFYS-----------------------------DGEIS--ICMEHMDGG--SLD-QVLK----KAG---RIPEQILGKVSIAVIKGLTYLREKH-----KIMHRDVKPSNILVN-SRGEI----KLCDFGVSG------QLIDSMANS---FVGTRSYMSPERLQ---GTHYSVQSDIWSMGLSLVEMAV-GR-YPIP-PPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERAD-----LKQLMVHAFI---
---YQNLKPIGSGAQGIV---CAAYDAVLDRNVAIKKLSRPF-QNQTHA-KRAYR------ELVLMKCV-NHKNIISLLNVFTPQKT-----------------------LEEFQDVY--LVMELMDA---NLC-QVIQ------M---ELDHERMSYLLYQMLCGIKHLHS-A-----GIIHRDLKPSNIVVK-SDCTL----KILDFGLART-----AGTSFMMTP---YVVTRYYRAPEVIL---GMGYKENVDIWSVGCIMGEMVR-HK-ILFP-GRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPK--LFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRIS-----VDDALQHPYI---
---YRDLQPVGSGAYGAV---CSAVDGRTGAKVAIKKLYRPF-QSELFA-KRAYR------ELRLLKHM-RHENVIGLLDVFTPDET-----------------------LDDFTDFY--LVMPFMGT---DLG-KLMK-----HE---KLGEDRIQFLVYQMLKGLRYIHA-A-----GIIHRDLKPGNLAVN-EDCEL----KILDFGLAR-------QADSEMTG---YVVTRWYRAPEVIL--NWMRYTQTVDIWSVGCIMAEMIT-GK-TLFK-GSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELE-------------KKDFASILTNASPLAVNLLEKMLVLDAEQRVT-----AGEALAHPYF---
---YEVLYTIGTGSYGRC---QKIRRKSDGKILVWKELDYGS-MTEAEK-QMLVS------EVNLLREL-KHPNIVRYYDRIIDR---------------------------TNTTLY--IVMEYCEGG--DLA-SVITKGTKERQ---YLDEEFVLRVMTQLTLALKECHR-RSDGGHTVLHRDLKPANVFLD-GKQNV----KLGDFGLARIL----NHDTSFAKT---FVGTPYYMSPEQMN---RMSYNEKSDIWSLGCLLYELCA-LM-PPFT-AF---SQKELAGKIREGKFRRIPYRY---S-------------------------------------DELNEIITRMLNLKDYHRPS-----VEEILENPL-I--
---FELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKAT-LKVRDR-VRTKM------ERDILADV-NHPFVVKLHYAFQT-----------------------------EGKLY--LILDFLRGG--DLF-TRLS----KEV---MFTEEDVKFYLAELALGLDHLHS-L-----GIIYRDLKPENILLD-EEGHI----KLTDFGLSKEA----IDHEKKAYS---FCGTVEYMAPEVVN---RQGHSHSADWWSYGVLMFEMLT-GS-LPFQ-GK---DRKETMTLILKAKLGMPQFLS-----------------------------------------TEAQSLLRALFKRNPANRLGSGPDGAEEIKRHV--FY-
--L-RLEVKLGQGCFGEV---WMGTWN-GTTRVAIKTLK-PG-TM-SPE-AFL-Q------EAQVMKKL-RHEKLVQLYAVVS------------------------------EEPIY--IVTEYMSKG--SLL-DFLK-----GETGKYLRLPQLVDMAAQIASGMAYVER-M-----NYVHRDLRAANILVG-ENLVC----KVADFGLARLI----E--DNEYTARQGAKFPIKWTAPEAAL---YGRFTIKSDVWSFGILLTELTTKGR-VPYP-GMVNREVLDQVERGYRMPCPPECP-------------------------------------------ESLHDLMCQCWRKEPEERPT-----FEYLQAF--L---
---FTKLEKIGKGSFGEV---FKGIDNRTQKVVAIKIIDLEE-AEDEIE-DIQ-Q------EITVLSQC-DSPYVTKYYGSYLK-----------------------------DTKLW--IIMEYLGGG--SAL-DLLE-----PG---PLDETQIATILREILKGLDYLHS-E-----KKIHRDIKAANVLLS-EHGEV----KLADFGVAGQL----TDTQIKRNT---FVGTPFWMAPEVIK---QSAYDSKADIWSLGITAIELAR-GE-PPHS-ELHPMKVLFLIPKNNPPTLEGNYS-------------------------------------------KPLKEFVEACLNKEPSFRPT-----AKELLKHKFI---
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