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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC CDKL2 203
CAMK CAMK1G 23
CAMK CAMK2B 14
Other CAMKK1 128
Other CAMKK2 165
CMGC CDC2 4
CMGC CDK2 4
CMGC CDK6 13
CAMK CHEK1 9
CAMK CHEK2 220
CMGC CLK3 156
CMGC CSNK2A1 39
CAMK DAPK1 13
CAMK DAPK2 23
CAMK DAPK3 13
CMGC DYRK1A 150
CMGC DYRK1B 111
CMGC DYRK2 222
CMGC HIPK1 190
CMGC HIPK2 199
CMGC HIPK3 197
CMGC HIPK4 -1
CMGC ICK 4
TKL IRAK4 186
CMGC MAK 4
CMGC MAPK8 26
CAMK MAPKAPK2 64
CAMK MAPKAPK5 22
TK MATK 235
AGC PDPK1 82
CAMK PHKG1 20
CAMK PHKG2 24
CAMK PRKD1 583
CAMK PRKD2 551
CAMK PRKD3 576
AGC RPS6KA4 33
AGC RPS6KA5 49
AGC RPS6KB1 91
Other SBK1 53
TK SRC 270
CAMK STK17A 61
CAMK STK17B 33
STE STK24 24
CAMK STK33 116
Other STK35 202
Other TBK1 9
Other TLK2 440
Other TTK 525
Other ULK3 14
TK YES1 277
---YENLGLVGEGSYGMVMKCRN---K-DTGR-IVAIKKFLESDDDKMVK-K-IAMR-------------------------EIKLLKQL--R------HEN-----LVNLLEVCKK-------------------------------------KKRWYLVFEFVDHTILDDLEL---FPN---GL---DYQVVQKYLFQIINGIGFCHS--H--NIIHRDIKPENIL--VS---QSGVV--------------------KLCDFGFARTL-----------------AAPGEVYTD---YVATRWYRAPELLV-----------------GDVK--YGKAVDVWAIGCLVTEMFM-GEPLFP-GD----SDIDQ-LYHIMMCLGNLIPRHQELFNKNPVFAGVRLPEIKE-----------------------------------------------REPLERRYPKLSEVVIDLAKKCLHIDPDKRPF-----CAELLHHDFF------------------------------------------------------
-FI--FMEVLGSGAFSEVFLVKQ---R-LTGK-LFALKCIKKSPAFRDSS-L-E--N-------------------------EIAVLKKI--K------HEN-----IVTLEDIYES-------------------------------------TTHYYLVMQLVSGGELFDRIL---ERG---VY---TEKDASLVIQQVLSAVKYLHE--N--GIVHRDLKPENLL--YLTPEENSKI--------------------MITDFGLSK-------------------MEQNGIMST---ACGTPGYVAPEVLA------------------QKP--YSKAVDCWSIGVITYILLC-GYPPFY-EE-------TE-SKLFEKIKEGYYEFESPFWDDIS-----------------------------------------------------------------------ESAKDFICHLLEKDPNERYT-----CEKALSHPWI------------------------------------------------------
---YQLYEDIGKGAFSVVRRCVK---L-CTGH-EYAAKIINTKKLSARDH-Q-KLER-------------------------EARICRLL--K------HSN-----IVRLHDSISE-------------------------------------EGFHYLVFDLVTGGELFEDIV---ARE---YY---SEADASHCIQQILEAVLHCHQ--M--GVVHRDLKPENLL--LA---SKCKGA-----------------AVKLADFGLAIEV-----------------QGDQQAWFG---FAGTPGYLSPEVLR------------------KEA--YGKPVDIWACGVILYILLV-GYPPFW-DE-------DQ-HKLYQQIKAGAYDFPSPEWDTVT-----------------------------------------------------------------------PEAKNLINQMLTINPAKRIT-----AHEALKHPWV------------------------------------------------------
---YKLQSEIGKGAYGVVRLAYN---E-SEDR-HYAMKVLSKKKLLKQYG-F-PR-RPPPRGSQAAQGGPAKQLLPLERVYQEIAILKKL--D------HVN-----VVKLIEVLDDP-----------------------------------AEDNLYLVFDLLRKGPVMEVPC----DK---PF---SEEQARLYLRDVILGLEYLHC--Q--KIVHRDIKPSNLL--LG---DDGHV--------------------KIADFGVSNQF-----------------EGNDAQLSS---TAGTPAFMAPEAISD---------------SGQSF--SGKALDVWATGVTLYCFVY-GKCPFI-DD-------FI-LALHRKIKNEPVVFPEEPEIS-------------------------------------------------------------------------EELKDLILKMLDKNPETRIG-----VPDIKLHPWV------------------------------------------------------
---YTLKDEIGKGSYGVVKLAYN---E-NDNT-YYAMKVLSKKKLIRQAG-F-PR-RPPPRGTRPAPGGCIQPRGPIEQVYQEIAILKKL--D------HPN-----VVKLVEVLDDP-----------------------------------NEDHLYMVFELVNQGPVMEVPT----LK---PL---SEDQARFYFQDLIKGIEYLHY--Q--KIIHRDIKPSNLL--VG---EDGHI--------------------KIADFGVSNEF-----------------KGSDALLSN---TVGTPAFMAPESLS-----------------ETRKIFSGKALDVWAMGVTLYCFVF-GQCPFM-DE-------RI-MCLHSKIKSQALEFPDQPDIA-------------------------------------------------------------------------EDLKDLITRMLDKNPESRIV-----VPEIKLHPWV------------------------------------------------------
---YTKIEKIGEGTYGVVYKGRH---K-TTGQ-VVAMKKIRLESEEEGVP-S-TAIR-------------------------EISLLKEL--R------HPN-----IVSLQDVLMQ-------------------------------------DSRLYLIFEFLSM-DLKKYLDSIPPGQ---YM---DSSLVKSYLYQILQGIVFCHS--R--RVLHRDLKPQNLL--ID---DKGTI--------------------KLADFGLARAF-----------------GIPIRVYTH---EVVTLWYRSPEVLL-----------------GSAR--YSTPVDIWSIGTIFAELAT-KKPLFH-GD----SEIDQ-LFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKP-------------------------------------------------GSLASHVKNLDENGLDLLSKMLIYDPAKRIS-----GKMALNHPYF------------------------------------------------------
---FQKVEKIGEGTYGVVYKARN---K-LTGE-VVALKKIRLDTETEGVP-S-TAIR-------------------------EISLLKEL--N------HPN-----IVKLLDVIHT-------------------------------------ENKLYLVFEFLHQ-DLKKFMDA-SALT---GI---PLPLIKSYLFQLLQGLAFCHS--H--RVLHRDLKPQNLL--IN---TEGAI--------------------KLADFGLARAF-----------------GVPVRTYTH---EVVTLWYRAPEILL-----------------GCKY--YSTAVDIWSLGCIFAEMVT-RRALFP-GD----SEIDQ-LFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR-------------------------------------------------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS-----AKAALAHPFF------------------------------------------------------
---YECVAEIGEGAYGKVFKARD---L-KNGGRFVALKRVRVQTGEEGMP-L-STIR-------------------------EVAVLRHL--ET---FEHPN-----VVRLFDVCTVSR--------------------------------TDRETKLTLVFEHVDQ-DLTTYLDK-VPEP---GV---PTETIKDMMFQLLRGLDFLHS--H--RVVHRDLKPQNIL--VT---SSGQI--------------------KLADFGLARI------------------YSFQMALTS---VVVTLWYRAPEVLL------------------QSS--YATPVDLWSVGCIFAEMFR-RKPLFR-GS----SDVDQ-LGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQ---------------------------------------------------PIEKFVTDIDELGKDLLLKCLTFNPAKRIS-----AYSALSHPYF------------------------------------------------------
--W-DLVQTLGEGAYGEVQLAVN---R-VTEE-AVAVKIVDMKRAVDCPE-N-I-KK-------------------------EICINKML--N------HEN-----VVKFYGHRRE-------------------------------------GNIQYLFLEYCSGGELFDRIE---PDI---GM---PEPDAQRFFHQLMAGVVYLHG--I--GITHRDIKPENLL--LD---ERDNL--------------------KISDFGLATVFR---------------YNNRERLLNK---MCGTLPYVAPELLK-----------------RREF--HAEPVDVWSCGIVLTAMLA-GELPWD-QP------SDS-CQEYSDWKEKKTYLNPWKKI--D-----------------------------------------------------------------------SAPLALLHKILVENPSARIT-----IPDIKKDRW-Y-----------------------------------------------------
-YI--MSKTLGSGACGEVKLAFE---R-KTCK-KVAIKIISKRKFAIGSA-R-EADPALN-------------------VETEIEILKKL--N------HPC-----IIKIKNFF-D-------------------------------------AEDYYIVLELMEGGELFDKVV---GNK---RL---KEATCKLYFYQMLLAVQYLHE--N--GIIHRDLKPENVL--LS---SQEEDC-----------------LIKITDFGHSKI------------------LGETSLMRT---LCGTPTYLAPEVLVS---------------VGTAG--YNRAVDCWSLGVILFICLS-GYPPFS-EH------RTQ-VSLKDQITSGKYNFIPEVWAEVS-----------------------------------------------------------------------EKALDLVKKLLVVDPKARFT-----TEEALRHPWL------------------------------------------------------
---YEIVGNLGEGTFGKVVECLD---H-ARGKSQVALKIIRNVGKYREAA-R----L-------------------------EINVLKKI--KE---KDKENK--FLCVLMSDWFNF-------------------------------------HGHMCIAFELLGK-NTFEFLK----EN---NFQPYPLPHVRHMAYQLCHALRFLHE--N--QLTHTDLKPENIL--FV---NSE-FETLYNEHKSCEEKSVKNTSIRVADFGSAT--------------------FDHEHHTT---IVATRHYRPPEVIL------------------ELG--WAQPCDVWSIGCILFEYYR-GFTLFQ-TH----ENREH-LVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRY----------------------------------VKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRIT-----LAEALLHPFF------------------------------------------------------
---YQLVRKLGRGKYSEVFEAIN---I-TNNE-KVVVKILKPVKKKKIKR--------------------------------EIKILENL-RG------GPN-----IITLADIVKDP-----------------------------------VSRTPALVFEHVNNTDFKQLY------Q---TL---TDYDIRFYMYEILKALDYCHS--M--GIMHRDVKPHNVM--ID--HEHRKL--------------------RLIDWGLAEF------------------YHPGQEYNV---RVASRYFKGPELLV-----------------DYQM--YDYSLDMWSLGCMLASMIF-RKEPFFHGH----DNYDQ-LVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRK-----------------------------------------RWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLT-----AREAMEHPYF------------------------------------------------------
---YDTGEELGSGQFAVVKKCRE---K-STGL-QYAAKFIKKRRTKSSRR-G-VSREDI---------------------EREVSILKEI--Q------HPN-----VITLHEVYEN-------------------------------------KTDVILILELVAGGELFDFLA---EKE---SL---TEEEATEFLKQILNGVYYLHS--L--QIAHFDLKPENIM--LL---DRNVPKP----------------RIKIIDFGLAHK------------------IDFGNEFKN---IFGTPEFVAPEIVN------------------YEP--LGLEADMWSIGVITYILLS-GASPFL-GD-------TK-QETLANVSAVNYEFEDEYFSNTS-----------------------------------------------------------------------ALAKDFIRRLLVKDPKKRMT-----IQDSLQHPWI------------------------------------------------------
---YDIGEELGSGQFAIVKKCRE---K-STGL-EYAAKFIKKRQSRASRR-G-VSREEI---------------------EREVSILRQV--L------HHN-----VITLHDVYEN-------------------------------------RTDVVLILELVSGGELFDFLA---QKE---SL---SEEEATSFIKQILDGVNYLHT--K--KIAHFDLKPENIM--LL---DKNIPIP----------------HIKLIDFGLAHE------------------IEDGVEFKN---IFGTPEFVAPEIVN------------------YEP--LGLEADMWSIGVITYILLS-GASPFL-GD-------TK-QETLANITAVSYDFDEEFFSQTS-----------------------------------------------------------------------ELAKDFIRKLLVKETRKRLT-----IQEALRHPWI------------------------------------------------------
---YEMGEELGSGQFAIVRKCRQ---K-GTGK-EYAAKFIKKRRLSSSRR-G-VSREEI---------------------EREVNILREI--R------HPN-----IITLHDIFEN-------------------------------------KTDVVLILELVSGGELFDFLA---EKE---SL---TEDEATQFLKQILDGVHYLHS--K--RIAHFDLKPENIM--LL---DKNVPNP----------------RIKLIDFGIAHK------------------IEAGNEFKN---IFGTPEFVAPEIVN------------------YEP--LGLEADMWSIGVITYILLS-GASPFL-GE-------TK-QETLTNISAVNYDFDEEYFSNTS-----------------------------------------------------------------------ELAKDFIRRLLVKDPKRRMT-----IAQSLEHSWI------------------------------------------------------
---YEIDSLIGKGSFGQVVKAYD---R-VEQE-WVAIKIIKNKKAFLNQA-Q-I----------------------------EVRLLELM-NK------HDTEMKYYIVHLKRHFMF-------------------------------------RNHLCLVFEMLSY-NLYDLLR----NT---NFRGVSLNLTRKFAQQMCTALLFLATPEL--SIIHCDLKPENIL--LCN-PKRSAI--------------------KIVDFGSSCQ--------------------LGQRIYQ---YIQSRFYRSPEVLL------------------GMP--YDLAIDMWSLGCILVEMHT-GEPLFS-GA----NEVDQ-MNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGT--------------RKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQ-----PYYALQHSFF------------------------------------------------------
---YEIDSLIGKGSFGQVVKAYD---H-QTQE-LVAIKIIKNKKAFLNQA-Q-I----------------------------ELRLLELM-NQ------HDTEMKYYIVHLKRHFMF-------------------------------------RNHLCLVFELLSY-NLYDLLR----NT---HFRGVSLNLTRKLAQQLCTALLFLATPEL--SIIHCDLKPENIL--LCN-PKRSAI--------------------KIVDFGSSCQ--------------------LGQRIYQ---YIQSRFYRSPEVLL------------------GTP--YDLAIDMWSLGCILVEMHT-GEPLFS-GS----NEVDQ-MNRIVEVLGIPPAAMLDQAPKARKYFERLPGGGWTLRRTKELRKDYQGPGT--------------RRLQEVLGVQTGGPGGRRAGEPGHSPADYLRFQDLVLRMLEYEPAARIS-----PLGALQHGFF------------------------------------------------------
---YEVLKVIGKGSFGQVVKAYD---H-KVHQ-HVALKMVRNEKRFHRQA-A-E----------------------------EIRILEHL--RKQDKDNTMN-----VIHMLENFTF-------------------------------------RNHICMTFELLSM-NLYELIKK-NKFQ---GF---SLPLVRKFAHSILQCLDALHK--N--RIIHCDLKPENIL--LK---QQGRSG------------------IKVIDFGSSC--------------------YEHQRVYT---YIQSRFYRAPEVIL------------------GAR--YGMPIDMWSLGCILAELLT-GYPLLP-GE----DEGDQ-LACMIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNG-------------------GRSRRGKLRGPPESREWGNALKGCDDPLFLDFLKQCLEWDPAVRMT-----PGQALRHPWL------------------------------------------------------
---YEVLEFLGRGTFGQVAKCWK---R-STKE-IVAIKILKNHPSYARQG-Q-I----------------------------EVSILSRL--S------SENADEYNFVRSYECFQH-------------------------------------KNHTCLVFEMLEQ-NLYDFLKQ-NKFS---PL---PLKYIRPILQQVATALMKLKS--L--GLIHADLKPENIM--LV---DPVRQPY----------------RVKVIDFGSAS-------------------HVSKAVCST---YLQSRYYRAPEIIL------------------GLP--FCEAIDMWSLGCVIAELFL-GWPLYP-GA----SEYDQ-IRYISQTQGLPAEYLLSAGTKTTRFFNRDPNLGYPLWRLKTPEEHELETGIKSKE------ARKYIFNCLDDMAQVNMSTDLEGTDMLAEKADRREYIDLLKKMLTIDADKRIT-----PLKTLNHQFV------------------------------------------------------
---YEVLEFLGRGTFGQVVKCWK---R-GTNE-IVAIKILKNHPSYARQG-Q-I----------------------------EVSILARL--STE-SADDYN-----FVRAYECFQH-------------------------------------KNHTCLVFEMLEQ-NLYDFLKQ-NKFS---PL---PLKYIRPVLQQVATALMKLKS--L--GLIHADLKPENIM--LV---DPSRQPY----------------RVKVIDFGSAS-------------------HVSKAVCST---YLQSRYYRAPEIIL------------------GLP--FCEAIDMWSLGCVIAELFL-GWPLYP-GA----SEYDQ-IRYISQTQGLPAEYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEAETGIKSKE------ARKYIFNCLDDMAQVNMTTDLEGSDMLVEKADRREFIDLLKKMLTIDADKRIT-----PIETLNHPFV------------------------------------------------------
---YEVLDFLGRGTFGQVVKCWK---R-GTNE-IVAIKILKNHPSYARQG-Q-I----------------------------EVSILARL--S------TENADEYNFVRAYECFQH-------------------------------------RNHTCLVFEMLEQ-NLYDFLKQ-NKFS---PL---PLKVIRPILQQVATALKKLKS--L--GLIHADLKPENIM--LV---DPVRQPY----------------RVKVIDFGSAS-------------------HVSKTVCST---YLQSRYYRAPEIIL------------------GLP--FCEAIDMWSLGCVIAELFL-GWPLYP-GA----LEYDQ-IRYISQTQGLPGEQLLNVGTKSTRFFCKETDMSHSGWRLKTLEEHEAETGMKSKE------ARKYIFNSLDDVAHVNTVMDLEGSDLLAEKADRREFVSLLKKMLLIDADLRIT-----PAETLNHPFV------------------------------------------------------
---YDIIEVLGKGTFGEVAKGWR---R-STGE-MVAIKILKNDAYRNRII-K-N----------------------------ELKLLHCM--RGL-DPEEAH-----VIRFLEFFHD-------------------------------------ALKFYLVFELLEQ-NLFEFQK----EN---NFAPLPARHIRTVTLQVLTALARLKE--L--AIIHADLKPENIM--LV---DQTRCPF----------------RVKVIDFGSASIF-----------------SEVRYVKEP---YIQSRFYRAPEILL------------------GLP--FCEKVDVWSLGCVMAELHL-GWPLYP-GN----NEYDQ-VRYICETQGLPKPHLLHAACKAHHFFKRNPHPDAANPWQLKSSADYLAETKVRPLERRKYMLKSLDQIETVNGGSVASRLTFPDREALAEHADLKSMVELIKRMLTWESHERIS-----PSAALRHPFV------------------------------------------------------
---YTTIRQLGDGTYGSVLLGRS---I-ESGE-LIAIKKMKRKFYSWEEC---MNLR-------------------------EVKSLKKL--N------HAN-----VVKLKEVIRE-------------------------------------NDHLYFIFEYMKE-NLYQLIK--ERNK---LF---PESAIRNIMYQILQGLAFIHK--H--GFFHRDLKPENLL--CM---GPELV--------------------KIADFGLARE------------------IRSKPPYTD---YVSTRWYRAPEVLL-----------------RSTN--YSSPIDVWAVGCIMAEVYT-LRPLFP-GA----SEIDT-IFKICQVLGTPKKTDWPEGYQLSSAMNFRWPQCV------------------------------------------------PNNLKTLIPNASSEAVQLLRDMLQWDPKKRPT-----ASQALRYPYF------------------------------------------------------
VGG----NKMGEGGFGVVYKGYV---N-NTT---VAVKKLAAMVDITTEELK-QQFD------------------------QEIKVMAKC--Q------HEN-----LVELLGFSSD-------------------------------------GDDLCLVYVYMPNGSLLDRLSCLDGTP---PL---SWHMRCKIAQGAANGINFLHE--N--HHIHRDIKSANIL--LD---EAFTA--------------------KISDFGLARASE---------------KFAQTVMTSR---IVGTTAYMAPEALR-------------------GE--ITPKSDIYSFGVVLLEIIT-GLPAVD-EH----REPQL-LLDIKEEIEDEEKTIEDYIDKKMNDAD---------------------------------------------------------------STSVEAMYSVASQCLHEKKNKRPD-----IKKVQQ----LLQ---------------------------------------------------
---YTTMRQLGDGTYGSVLMGKS---N-ESGE-LVAIKRMKRKFYSWDEC-M--NLR-------------------------EVKSLKKL--N------HAN-----VIKLKEVIRE-------------------------------------NDHLYFIFEYMKE-NLYQLMK--DRNK---LF---PESVIRNIMYQILQGLAFIHK--H--GFFHRDMKPENLL--CM---GPELV--------------------KIADFGLARE------------------LRSQPPYTD---YVSTRWYRAPEVLL-----------------RSSV--YSSPIDVWAVGSIMAELYM-LRPLFP-GT----SEVDE-IFKICQVLGTPKKSDWPEGYQLASSMNFRFPQCV------------------------------------------------PINLKTLIPNASNEAIQLMTEMLNWDPKKRPT-----ASQALKHPYF------------------------------------------------------
---YQNLKPIGSGAQGIVCAAYD---A-ILER-NVAIKKLSRPFQNQTHA-K-RAYR-------------------------ELVLMKCV--N------HKN-----IIGLLNVFTPQKS-------------------------------LEEFQDVYIVMELMDA-NLCQVIQ-----M---EL---DHERMSYLLYQMLCGIKHLHS--A--GIIHRDLKPSNIV--VK---SDCTL--------------------KILDFGLART------------------AGTSFMMTP---YVVTRYYRAPEVIL------------------GMG--YKENVDLWSVGCIMGEMVC-HKILFP-GR----DYIDQ-WNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEK------------------------------------LFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRIS-----VDEALQHPYI------------------------------------------------------
KVT---SQVLGLGINGKVLQIFN---K-RTQE-KFALKMLQDCPKAR---------R-------------------------EVELHWRA-SQ------CPH-----IVRIVDVYENLY---------------------------------AGRKCLLIVMECLDGGELFSRIQD-RGDQ---AF---TEREASEIMKSIGEAIQYLHS--I--NIAHRDVKPENLL--YT---SKRPNA-----------------ILKLTDFGFAKE------------------TTSHNSLTT---PCYTPYYVAPEVLG------------------PEK--YDKSCDMWSLGVIMYILLC-GYPPFY-SN---HGLAIS-PGMKTRIRMGQYEFPNPEWSEVS-----------------------------------------------------------------------EEVKMLIRNLLKTEPTQRMT-----ITEFMNHPWI------------------------------------------------------
INW---TQKLGAGISGPVRVCVK---K-STQE-RFALKILLDRPKAR---------N-------------------------EVRLHMMC-AT------HPN-----IVQIIEVFANSVQFP---------------------------HESSPRARLLIVMEMMEGGELFHRIS---QHR---HF---TEKQASQVTKQIALALRHCHL--L--NIAHRDLKPENLL--FK---DNS-LDA----------------PVKLCDFGFAK--------------------IDQGDLMT---PQFTPYYVAPQVLEAQRRHQKEKSGIIPTSPTPYT--YNKSCDLWSLGVIIYVMLC-GYPPFY-SKH--HSRTIP-KDMRRKIMTGSFEFPEEEWSQIS-----------------------------------------------------------------------EMAKDVVRKLLKVKPEERLT-----IEGVLDHPWL------------------------------------------------------
---LTLGAQIGEGEFGAVLQGEY---L---GQ-KVAVKNIK-CDVT-AQ--A-FL-D-------------------------ETAVMTKM--Q------HEN-----LVRLLGVIL--------------------------------------HQGLYIVMEHVSKGNLVNFLR----TRGRALV---NTAQLLQFSLHVAEGMEYLES--K--KLVHRDLAARNIL--VS---EDLVA--------------------KVSDFGLAKAE-----------------------RKGLDSSRLPVKWTAPEALK------------------HGK--FTSKSDVWSFGVLLWEVFSYGRAPYP-KM----SLKEV-SEAVEKGYRMEPPEGCP-----------------------------------------------------------------------------GPVHVLMSSCWEAEPARRPP-----FRKLAEKL--------------------------------------------------------
--F-KFGKILGEGSFSTVVLARE---L-ATSR-EYAIKILEKRHIIKENK-VPYVTR-------------------------ERDVMSRL--D------HPF-----FVKLYFTFQD-------------------------------------DEKLYFGLSYAKNGELLKYIR---KIG---SF---DETCTRFYTAEIVSALEYLHG--K--GIIHRDLKPENIL--LN---EDMHI--------------------QITDFGTAKVLS---------------PESKQARANS---FVGTAQYVSPELLT------------------EKS--ACKSSDLWALGCIIYQLVA-GLPPFR-AG-------NE-YLIFQKIIKLEYDFPEKFF---------------------------------------------------------------------------PKARDLVEKLLVLDATKRLG-----CEEM------EGYGPLKAHPF-------------------------------------------
---YEPKEILGRGVSSVVRRCIH---K-PTSQ-EYAVKVIDVTGGGSFSP-E-EVRELRE------------------ATLKEVDILRKV-SG------HPN-----IIQLKDTYET-------------------------------------NTFFFLVFDLMKRGELFDYLT---EKV---TL---SEKETRKIMRALLEVICTLHK--L--NIVHRDLKPENIL--LD---DNMNI--------------------KLTDFGFSCQ------------------LEPGERLRE---VCGTPSYLAPEIIECS------------MNEDHPG--YGKEVDMWSTGVIMYTLLA-GSPPFW-HR-------KQ-MLMLRMIMSGNYQFGSPEWDDYS-----------------------------------------------------------------------DTVKDLVSRFLVVQPQNRYT-----AEEALAHPFF------------------------------------------------------
YDP---KDVIGRGVSSVVRRCVH---R-ATGH-EFAVKIMEVTAERLSPE-Q-LEEVREA-------------------TRRETHILRQV-AG------HPH-----IITLIDSYES-------------------------------------SSFMFLVFDLMRKGELFDYLT---EKV---AL---SEKETRSIMRSLLEAVSFLHA--N--NIVHRDLKPENIL--LD---DNMQI--------------------RLSDFGFSCH------------------LEPGEKLRE---LCGTPGYLAPEILKCS------------MDETHPG--YGKEVDLWACGVILFTLLA-GSPPFW-HR-------RQ-ILMLRMIMEGQYQFSSPEWDDRS-----------------------------------------------------------------------STVKDLISRLLQVDPEARLT-----AEQALQHPFF------------------------------------------------------
-PD----EVLGSGQFGIVYGGKH---R-KTGR-DVAIKIIDKLRFPTKQE-S-QLRN-------------------------EVAILQNL--H------HPG-----VVNLECMFET-------------------------------------PERVFVVMEKLHGDMLEMILS--SEKG---RL---PEHITKFLITQILVALRHLHF--K--NIVHCDLKPENVL--LA---SADPFP-----------------QVKLCDFGFARI------------------IGEKSFRRS---VVGTPAYLAPEVLR------------------NKG--YNRSLDMWSVGVIIYVSLS-GTFPFN-ED----------EDIHDQIQNAAFMYPPNPWKEIS-----------------------------------------------------------------------HEAIDLINNLLQVKMRKRYS-----VDKTLSHPWL------------------------------------------------------
-PD----EVLGSGQFGVVYGGKH---R-KTGR-DVAVKVIDKLRFPTKQE-S-QLRN-------------------------EVAILQSL--R------HPG-----IVNLECMFET-------------------------------------PEKVFVVMEKLHGDMLEMILS--SEKG---RL---PERLTKFLITQILVALRHLHF--K--NIVHCDLKPENVL--LA---SADPFP-----------------QVKLCDFGFARI------------------IGEKSFRRS---VVGTPAYLAPEVLL------------------NQG--YNRSLDMWSVGVIMYVSLS-GTFPFN-ED----------EDINDQIQNAAFMYPASPWSHIS-----------------------------------------------------------------------AGAIDLINNLLQVKMRKRYS-----VDKSLSHPWL------------------------------------------------------
FAD----EVLGSGQFGIVYGGKH---R-KTGR-DVAIKVIDKMRFPTKQE-S-QLRN-------------------------EVAILQNL--H------HPG-----IVNLECMFET-------------------------------------PERVFVVMEKLHGDMLEMILS--SEKS---RL---PERITKFMVTQILVALRNLHF--K--NIVHCDLKPENVL--LA---SAEPFP-----------------QVKLCDFGFARI------------------IGEKSFRRS---VVGTPAYLAPEVLR------------------SKG--YNRSLDMWSVGVIIYVSLS-GTFPFN-ED----------EDINDQIQNAAFMYPPNPWREIS-----------------------------------------------------------------------GEAIDLINNLLQVKMRKRYS-----VDKSLSHPWL------------------------------------------------------
REP-----ALGQGSFSVCRRCRQ---R-QSGQ-EFAVKILSRRLEANTQR--------------------------------EVAALRLC-QS------HPN-----VVNLHEVHHD-------------------------------------QLHTYLVLELLRGGELLEHIR---KKR---HF---SESEASQILRSLVSAVSFMHE-EA--GVVHRDLKPENIL--YA---DDT-PGA----------------PVKIIDFGFARLR----------------PQSPGVPMQT---PCFTLQYAAPELLA------------------QQG--YDESCDLWSLGVILYMMLS-GQVPFQ-GASGQGGQSQA-AEIMCKIREGRFSLDGEAWQGVS-----------------------------------------------------------------------EEAKELVRGLLTVDPAKRLK-----LEGLRGSSW-L-----------------------------------------------------
---FELLKVLGTGAYGKVFLVRKISGH-DTGK-LYAMKVLKKATIVQKAK-T-TEHTR-----------------------TERQVLEHI-RQ------SPF-----LVTLHYAFQT-------------------------------------ETKLHLILDYINGGELFTHLS---QRE---RF---TEHEVQIYVGEIVLALEHLHK--L--GIIYRDIKLENIL--LD---SNGHV--------------------VLTDFGLSKEF----------------VADETERAYS---FCGTIEYMAPDIVR----------------GGDSG--HDKAVDWWSLGVLMYELLT-GASPFT-VD---GEKNSQ-AEISRRILKSEPPYPQEMS---------------------------------------------------------------------------ALAKDLIQRLLMKDPKKRLGCGPRDADEIKEHLFF------------------------------------------------------
---FELLRVLGKGGYGKVFQVRKVTGA-NTGK-IFAMKVLKKAMIVRNAK-D-TAHTK-----------------------AERNILEEV--K------HPF-----IVDLIYAFQT-------------------------------------GGKLYLILEYLSGGELFMQLE---REG---IF---MEDTACFYLAEISMALGHLHQ--K--GIIYRDLKPENIM--LN---HQGHV--------------------KLTDFGLCKES-----------------IHDGTVTHT---FCGTIEYMAPEILM------------------RSG--HNRAVDWWSLGALMYDMLT-GAPPFT-GE-------NR-KKTIDKILKCKLNLPPYLT---------------------------------------------------------------------------QEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFF------------------------------------------------------
---YELVRELGKGTYGKVDLVVY---K-GTGT-KMALKFVNKSKTKLKNF-----LR-------------------------EVSITNSL-SS------SPF-----IIKVFDVVFE------------------------------------TEDCYVFAQEYAPAGDLFDIIP---PQV---GL---PEDTVKRCVQQLGLALDFMHG--R--QLVHRDIKPENVL--LFD-RECRRV--------------------KLADFGMTR--------------------RVGCRVKR---VSGTIPYTAPEVCQAG-------------RADGLA--VDTGVDVWAFGVLIFCVLT-GNFPWE-AA----SGADAFFEEFVRWQRGRLPGLPSQWRRFT-----------------------------------------------------------------------EPALRMFQRLLALEPERRGP-----AKEVF-----RFLKH-------------------------------------------------
--L-RLEVKLGQGCFGEVWMGTW---N--GTT-RVAIKTLK-PGTM-SPE-A-FL-Q-------------------------EAQVMKKL--R------HEK-----LVQLYAVVS--------------------------------------EEPIYIVTEYMSKGSLLDFLK----GETGKYL---RLPQLVDMAAQIASGMAYVER--M--NYVHRDLRAANIL--VG---ENLVC--------------------KVADFGLARLI-----------------E--DNEYTARQGAKFPIKWTAPEAAL------------------YGR--FTIKSDVWSFGILLTELTTKGRVPYP-GM----VNREV-LDQVERGYRMPCPPECP-----------------------------------------------------------------------------ESLHDLMCQCWRKEPEERPT-----FEYLQAF--L------------------------------------------------------
LCP---GRELGRGKFAVVRKCIK---K-DSGK-EFAAKFMRKRRKGQDCR-M-EIIH-------------------------EIAVLELA-QD------NPW-----VINLHEVYET-------------------------------------ASEMILVLEYAAGGEIFDQCVA-DREE---AF---KEKDVQRLMRQILEGVHFLHT--R--DVVHLDLKPQNIL--LT---SESPLG-----------------DIKIVDFGLSRI------------------LKNSEELRE---IMGTPEYVAPEILS------------------YDP--ISMATDMWSIGVLTYVMLT-GISPFL-GN-------DK-QETFLNISQMNLSYSEEEFDVLS-----------------------------------------------------------------------ESAVDFIRTLLVKKPEDRAT-----AEECLKHPWL------------------------------------------------------
ILT---SKELGRGKFAVVRQCIS---K-STGQ-EYAAKFLKKRRRGQDCR-A-EILH-------------------------EIAVLELA-KS------CPR-----VINLHEVYEN-------------------------------------TSEIILILEYAAGGEIFSLCLP-ELAE---MV---SENDVIRLIKQILEGVYYLHQ--N--NIVHLDLKPQNIL--LS---SIYPLG-----------------DIKIVDFGMSRK------------------IGHACELRE---IMGTPEYLAPEILN------------------YDP--ITTATDMWNIGIIAYMLLT-HTSPFV-GE-------DN-QETYLNISQVNVDYSEETFSSVS-----------------------------------------------------------------------QLATDFIQSLLVKNPEKRPT-----AEICLSHSWL------------------------------------------------------
---FTKLEKIGKGSFGEVFKGID---N-RTQK-VVAIKIIDLEEAEDEIE-D-IQ-Q-------------------------EITVLSQC--D------SPY-----VTKYYGSYLK-------------------------------------DTKLWIIMEYLGGGSALDLLE----PG---PL---DETQIATILREILKGLDYLHS--E--KKIHRDIKAANVL--LS---EHGEV--------------------KLADFGVAGQL-----------------TDTQIKRNT---FVGTPFWMAPEVIK------------------QSA--YDSKADIWSLGITAIELAR-GEPPHS-EL----HPMKV-LFLIPKNNPPTLEGNYS-----------------------------------------------------------------------------KPLKEFVEACLNKEPSFRPT-----AKELLKHKFI------------------------------------------------------
---YTFGRILGKGSFGIVIEATD---K-ETET-KWAIKKVNKEKAGSSAV-K-LLER-------------------------EVNILKSV--K------HEH-----IIHLEQVFET-------------------------------------PKKMYLVMELCEDGELKEILD---RKG---HF---SENETRWIIQSLASAIAYLHN--N--DIVHRDLKLENIM--VK---SSLIDDNNE-----------INLNIKVTDFGLAVKK----------------QSRSEAMLQA---TCGTPIYMAPEVIS------------------AHD--YSQQCDIWSIGVVMYMLLR-GEPPFL-AS-------SE-EKLFELIRKGELHFENAVWNSIS-----------------------------------------------------------------------DCAKSVLKQLMKVDPAHRIT-----AKELLDNQWL------------------------------------------------------
---YSLLAEIGRGSYGVVYEAVA---G-RSGA-RVAVKKIRCDAPENVEL----ALA-------------------------EFWALTSLKRR------HQN-----VVQFEECVLQRNGLAQRMSHGNKSSQLYLRLVETSLKGERILGYAEEPCYLWFVMEFCEGGDLNQYVL----SR---RP---DPATNKSFMLQLTSAIAFLHK--N--HIVHRDLKPDNIL--IT---ERSGTP-----------------ILKVADFGLSKVCAGLAPRGKEGNQDNKNVNVNKYWLSS---ACGSDFYMAPEVWE-------------------GH--YTAKADIFALGIIIWAMIE-RITFID-SE----TKKEL-LGTYIKQGTEIVPVGEALLENPKMELHIPQ---------------------------------------------------------KRRTSMSEGIKQLLKDMLAANPQDRPD-----AFEL------ETRM--------------------------------------------------
WLL---SDILGQGATANVFRGRH---K-KTGD-LFAIKVFNNISFLRPVD-V-Q-MR-------------------------EFEVLKKL--N------HKN-----IVKLFAIEEET-----------------------------------TTRHKVLIMEFCPCGSLYTVLEEPSNAY---GL---PESEFLIVLRDVVGGMNHLRE--N--GIVHRDIKPGNIMRVIG---EDGQSV------------------YKLTDFGAARE------------------LEDDEQFVS---LYGTEEYLHPDMYERAV----------LRKDHQKK--YGATVDLWSIGVTFYHAAT-GSLPFR-PF---EGPRRN-KEVMYKIITGKPSGAISGVQKAENGPIDWSGDM--------------------------------------------------PVSCSLSRGLQV----------------------------------LLTPVLANILEADQEKCWGFDQFFAETSDILHRMVIHVFSLQQMTAHKIYIHSY
-YL--LLHLLGRGGFSEVYKAFD---L-TEQR-YVAVKIHQLNKNWRDEK-K-ENYHKH--------------------ACREYRIHKEL--D------HPR-----IVKLYDYFSL------------------------------------DTDSFCTVLEYCEGNDLDFYLK---QHK---LM---SEKEARSIIMQIVNALKYLNE--IKPPIIHYDLKPGNIL--LV---NGTACG-----------------EIKITDFGLSKIMDDD----------SYNSVDGMELTSQ---GAGTYWYLPPECFVV--------------GKEPPK--ISNKVDVWSVGVIFYQCLY-GRKPFG-HN-----QSQQ-DILQENTILKATEVQFPPKPVVT-----------------------------------------------------------------------PEAKAFIRRCLAYRKEDRID-----VQQLACDPYL------------------------------------------------------
---YSILKQIGSGGSSKVFQVLN---E-KKQ--IYAIKYVNLEEADNQTL-D-SYRN-------------------------EIAYLNKL-QQ-----HSDK-----IIRLYDYEIT-------------------------------------DQYIYMVMECGNI-DLNSWLK---KKK---SI---DPWERKSYWKNMLEAVHTIHQ--H--GIVHSDLKPANFL--IV----DGML--------------------KLIDFGIANQMQ---------------PDTTSVVKDS---QVGTVNYMPPEAIKDMSSS-------RENGKSKSK--ISPKSDVWSLGCILYYMTY-GKTPFQ-QI------INQ-ISKLHAIIDPNHEIEFPDIPE-------------------------------------------------------------------------KDLQDVLKCCLKRDPKQRIS-----IPELLAHPYV------------------------------------------------------
-FI--LTERLGSGTYATVYKAYA---KKDTRE-VVAIKCVAKKSLNKASV-E-NLLT-------------------------EIEILKGI--R------HPH-----IVQLKDFQWD-------------------------------------SDNIYLIMEFCAGGDLSRFIH---TRR---IL---PEKVARVFMQQLASALQFLHE--R--NISHLDLKPQNIL--LSS-LEKPHL--------------------KLADFGFAQH------------------MSPWDEKHV---LRGSPLYMAPEMVC------------------QRQ--YDARVDLWSMGVILYEALF-GQPPFA-SR----SFSEL-EEKIRSNRVIELPLRPLLS---------------------------------------------------------------------------RDCRDLLQRLLERDPSRRIS-----FQDFFAHPWV------------------------------------------------------
--L-RLEVKLGQGCFGEVWMGTW---N--GTT-KVAIKTLK-PGTM-MPE-A-FL-Q-------------------------EAQIMKKL--R------HDK-----LVPLYAVVS--------------------------------------EEPIYIVTEFMSKGSLLDFLK----EGDGKYL---KLPQLVDMAAQIADGMAYIER--M--NYIHRDLRAANIL--VG---ENLVC--------------------KIADFGLARLI-----------------E--DNEYTARQGAKFPIKWTAPEAAL------------------YGR--FTIKSDVWSFGILQTELVTKGRVPYP-GM----VNREV-LEQVERGYRMPCPQGCP-----------------------------------------------------------------------------ESLHELMNLCWKKDPDERPT-----FEYIQSFL--------------------------------------------------------
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