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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CAMK CHEK1 203
Other AURKA 133
Other CHUK 15
CMGC MAPK14 24
Other PLK1 53
Other PLK2 82
-W-DLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKR-AVDCPENI-KK-EICINKMLNHENVVKFYGHRRE------GNIQYLFLEYCSGGELFDRIE---PDIGMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDNL---KISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAGELPWDQP-------------SDSCQEYSDWKEKKTYLNPWKKI--D------------------------SAPLALLHKILVENPSARITIPDIKKDRW-Y--------
--FEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRR-EVEIQSHLRHPNILRLYGYFHD------ATRVYLILEYAPLGTVYRELQ---KLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGEL---KIADFGWSV----HAPSSRRTTLCGTLDYLPPEMIE-GRMHDEKVDLWSLGVLCYEFLVGKPPFEAN--------------TYQETYKRISRVEFTFPDFVT----------------------------EGARDLISRLLKHNPSQRPMLREVLEHPWI---------
-W-EMRERLGTGGFGNVCLYQHRELDLKIAIKSCRLEL-STKNRER-WCH-EIQIMKKLNHANVVKACDVPEELN-ILIHDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQILSLLSDIGSGIRYLHENKIIHRDLKPENIVLQDVGGKIIHKIIDLGYAKD---VDQGSLCTSFVGTLQYLAPELFE-NKPYTATVDYWSFGTMVFECIAGYRPFLHHLQPFTWHEKIKKKDPKCIFACEEMSGEVRFSSHLPQPNSLCS------------------LVVEPMENWLQLMLNWDPQQRG-----------GPVDLTLKQ
--YQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPF-QSIIHAKRTYR-ELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGA-DLNNIVK----CQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCEL---KILDFGLAR-----HTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGT-----------DHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYF---------
YV--RGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSL-LLKPHQREKMSMEISIHRSLAHQHVVGFHGFFED------NDFVFVVLELCRRRSLLELHK---RRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEV---KIGDFGLATKV--EYDGERKKTLCGTPNYIAPEVLS-KKGHSFEVDVWSIGCIMYTLLVGKPPFETS--------------CLKETYLRIKKNEYSIPKHIN----------------------------PVAASLIQKMLQTDPTARPTINELLNDEFF---------
-Y-CRGKVLGKGGFAKCYEMTDLTNNKVYAAKIIPHSR-VAKPHQREKIDKEIELHRILHHKHVVQFYHYFED------KENIYILLEYCSRRSMAHILK---ARKVLTEPEVRYYLRQIVSGLKYLHEQEILHRDLKLGNFFINEAMEL---KVGDFGLAARL--EPLEHRRRTICGTPNYLSPEVLN-KQGHGCESDIWALGCVMYTMLLGRPPFETT--------------NLKETYRCIREARYTMPSSLL----------------------------APAKHLIASMLSKNPEDRPSLDDIIRHDFF---------
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