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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CAMK CHEK1 203
CMGC CDC2 4
CMGC CDK2 4
CMGC CDK5 4
CAMK CHEK2 220
CMGC CSNK2A1 39
CMGC GSK3B 56
STE MAP3K5 677
CMGC MAPK1 13
CAMK MAPKAPK2 64
AGC PDPK1 82
AGC PRKACA 44
AGC PRKCA 339
AGC PRKCB 342
--W-DLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPEN-I-KK------EICINKML-NHENVVKFYGHRRE-----GNIQY--LFLEYCSGG--ELFDRIE----PDIGM--PEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLD-ERDNL---KISDFGLATVFR-YNNRERLLNKMCGTLPYVAPELLK--RREFHAEPVDVWSCGIVLTAMLA-GELPWD-QP---SDSCQEYSDWKEKKTYLNPWKKI--D------------------------------SAPLALLHKILVENPSARIT-----IPDIKKDRW-Y-------------
---YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPS-TAIR------EISLLKEL-RHPNIVSLQDVLMQ-----DSRLY--LIFEFLSM---DLKKYLDS-IPPGQYM--DSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLID-DKGTI---KLADFGLARAF---GIPIRVYTHEVVTLWYRSPEVLL--GSARYSTPVDIWSIGTIFAELAT-KKPLFH-GD-SEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKP--------GSLASHVKNLDENGLDLLSKMLIYDPAKRIS-----GKMALNHPYF--------------
---FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPS-TAIR------EISLLKEL-NHPNIVKLLDVIHT-----ENKLY--LVFEFLHQ---DLKKFMDA--SALTGI--PLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLIN-TEGAI---KLADFGLARAF---GVPVRTYTHEVVTLWYRAPEILL--GCKYYSTAVDIWSLGCIFAEMVT-RRALFP-GD-SEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR--------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS-----AKAALAHPFF--------------
---YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPS-SALR------EICLLKEL-KHKNIVRLHDVLHS-----DKKLT--LVFEFCDQ---DLKKYFD---SCNGDL--DPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLIN-RNGEL---KLADFGLARAF---GIPVRCYSAEVVTLWYRPPDVLF--GAKLYSTSIDMWSAGCIFAELANAGRPLFP-GN-DVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPAT--------TSLVNVVPKLNATGRDLLQNLLKCNPVQRIS-----AEEALQHPYF--------------
-YI--MSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAR-EADPALNVETEIEILKKL-NHPCIIKIKNFF-D-----AEDYY--IVLELMEGG--ELFDKVV----GNKRL--KEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLS-SQEEDCLIKITDFGHSKI----LGETSLMRTLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLS-GYPPFS-EH---RTQVSLKDQITSGKYNFIPEVWAEVS------------------------------EKALDLVKKLLVVDPKARFT-----TEEALRHPWL--------------
---YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKR------------EIKILENLRGGPNIITLADIVKDP---VSRTPA--LVFEHVNNT--DFKQLY-------QTL--TDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKL---RLIDWGLAEF----YHPGQEYNVRVASRYFKGPELLV--DYQMYDYSLDMWSLGCMLASMIF-RKEPFFHGH-DNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLT-----AREAMEHPYF--------------
---YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNR-------------ELQIMRKL-DHCNIVRLRYFFYSSG-EKKDEVYLNLVLDYVPETVYRVA---RHYSRAKQTL--PVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVL---KLCDFGSAKQ----LVRGEPNVSYICSRYYRAPELIF--GATDYTSSIDVWSAGCVLAELLL-GQPIFP-GD-SGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH--------PWTKVFRPRTPPEAIALCSRLLEYTPTARLT-----PLEACAHSFF--------------
DRV-----VLGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQPL-H--E------EIALHKHL-KHKNIVQYLGSFSE-----NGFIK--IFMEQVPGG--SLSALLR---SKWGPLKDNEQTIGFYTKQILEGLKYLHDNQIVHRDIKGDNVLINTYSGVL---KISDFGTSKRL---AGINPCTETFTGTLQYMAPEIID-KGPRGYGKAADIWSLGCTIIEMAT-GKPPFY-EL---GEPQAAMFKVGMFKVHPEIPESMS--------------------------------AEAKAFILKCFEPDPDKRAC-----ANDLLVDEF-L-------------
---YTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQR-T-LR------EIKILLRF-RHENIIGINDIIRAPTIEQMKDVY--IVQDLMET---DLYKLLK-----TQHL--SNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLN-TTCDL---KICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIML--NSKGYTKSIDIWSVGCILAEMLS-NRPIFP-GK-HYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKN------KVPWNRLFPNADSKALDLLDKMLTFNPHKRIE-----VEQALAHPYL--------------
KVT---SQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKAR--------R------EVELHWRASQCPHIVRIVDVYENLY-AGRKCLL--IVMECLDGG--ELFSRIQD--RGDQAF--TEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYT-SKRPNAILKLTDFGFAKE----TTSHNSLTTPCYTPYYVAPEVLG---PEKYDKSCDMWSLGVIMYILLC-GYPPFY-SNHGLAISPGMKTRIRMGQYEFPNPEWSEVS------------------------------EEVKMLIRNLLKTEPTQRMT-----ITEFMNHPWI--------------
--F-KFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTR------ERDVMSRL-DHPFFVKLYFTFQD-----DEKLY--FGLSYAKNG--ELLKYIR----KIGSF--DETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLN-EDMHI---QITDFGTAKVLS-PESKQARANSFVGTAQYVSPELLT---EKSACKSSDLWALGCIIYQLVA-GLPPFR-AG----NEYLIFQKIIKLEYDFPEKFF----------------------------------PKARDLVEKLLVLDATKRLG-----CEEM------EGYGPLKAHPF---
--F-ERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQI-EHTL-----NEKRILQAV-NFPFLVKLEFSFKD-----NSNLY--MVMEYVPGG--EMFSHLR----RIGRF--SEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLID-QQGYI---QVTDFGFAK------RVKGRTWTLCGTPEYLAPEIIL---SKGYNKAVDWWALGVLIYEMAA-GYPPFF-AD----QPIQIYEKIVSGKVRFPSHFS----------------------------------SDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWF--------------
--F-NFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDV-ECTM-----VEKRVLALLDKPPFLTQLHSCFQT-----VDRLY--FVMEYVNGG--DLMYHIQ----QVGKF--KEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLD-SEGHI---KIADFGMCKEH---MMDGVTTRTFCGTPDYIAPEIIA---YQPYGKSVDWWAYGVLLYEMLA-GQPPFD-GE----DEDELFQSIMEHNVSYPKSLS----------------------------------KEAVSVCKGLMTKHPAKRLG-----C---------GPEGERDVREHAFF
--F-NFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDV-ECTM-----VEKRVLALPGKPPFLTQLHSCFQT-----MDRLY--FVMEYVNGG--DLMYHIQ----QVGRF--KEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLD-SEGHI---KIADFGMCKEN---IWDGVTTKTFCGTPDYIAPEIIA---YQPYGKSVDWWAFGVLLYEMLA-GQAPFE-GE----DEDELFQSIMEHNVAYPKSMS----------------------------------KEAVAICKGLMTKHPGKRLG-----C---------GPEGERDIKEHAFF
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