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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CAMK CHEK1 203
CAMK CHEK2 220
TK JAK1 875
AGC PRKACA 44
AGC ROCK2 92
TK SRC 270
-W-DLVQTLGEGAYGEVQLAVNR----VTEEAVAVKIVDMKRAVDCP--ENI-KK------EICINKMLNHENVVKFYGHRR-EGNI--QYLFLEYCSGGELFDRIEPDI---GMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDNL---KISDFGLATVFR--YNNRERLLNK---MCGTLPYVAPELLK---RREFHAEPVDVWSCGIVLTAMLA-GELP--------------WDQP--SDSCQEYSDWKEKKTYLNPWKKI--DSAPLALLHKILVENPSA--RIT-----IPDIKKDRW-Y
YI--MSKTLGSGACGEVKLAFER----KTCKKVAIKIISKRKFAIGS--AREADPALNVETEIEILKKLNHPCIIKIKNFF--DAED--YYIVLELMEGGELFDKVVGNK---RLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKI-----LGETSLMRT---LCGTPTYLAPEVLVS-VGTAGYNRAVDCWSLGVILFICLS-GYPP--------------FSEH--RTQVSLKDQITSGKYNFIPEVWAEVSEKALDLVKKLLVVDPKA--RFT-----TEEALRHPWL-
-L-KRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLK-PESG-GNHIADLK-K------EIEILRNLYHENIVKYKGICTED-GGNGIKLIMEFLPSGSLKEYLP-KN-KNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQV---KIGDFGLTKAI-ET-D--KEYYTVKDDRDSPVFWYAPECLM----QSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCP------DEVYQLMRKCWEFQPSN--RTS-----FQNLIE---GF
-F-ERIKTLGTGSFGRVMLVKHK----ETGNHYAMKILDKQKVVKLK--QIEHTL-----NEKRILQAVNFPFLVKLEFSFK-DNSN--LYMVMEYVPGGEMFSHLRRIG---RFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYI---QVTDFGFAK-------RVKGRTWT---LCGTPEYLAPEIIL----SKGYNKAVDWWALGVLIYEMAA-GYPP--------------FFAD---QPIQIYEKIVSGKVRFPSHFS----SDLKDLLRNLLQVDLTK--RFGNLKNGVNDIKNHKWF-
--YDVVKVIGRGAFGEVQLVRHK----ASQKVYAMKLLSKFEMIKRS--DSAFFW-----EERDIMAFANSPWVVQLFYAFQ-DDRY--LYMVMEYMPGGDLVNLMS-NY---DVPEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGHL---KLADFGTCMKM---DETGMVHCDT---AVGTPDYISPEVLKSQGGDGFYGRECDWWSVGVFLYEMLV-GDTP--------------FYAD---SLVGTYSKIMDHKNSLCFPEDAEISKHAKNLICAFLTDREVRLGRNG-----VEEIRQHPFF-
-L-RLEVKLGQGCFGEVWMGTWN-----GTTRVAIKTLK-PGTM-SP--EAFL-Q------EAQVMKKLRHEKLVQLYAVVS--EEP--IYIVTEYMSKGSLLDFLK-GETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVC---KVADFGLARLI----E--DNEYTARQGAKFPIKWTAPEAAL----YGRFTIKSDVWSFGILLTELTTKGRVP--------------YPGMVNREVLDQVERGYRMPCPPECP------ESLHDLMCQCWRKEPEE--RPT-----FEYLQAF--L-
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