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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CAMK CHEK1 203
AGC AKT1 150
CAMK CHEK2 220
AGC PDPK1 82
TK SRC 270
-WDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPEN-I-KK------EICINKMLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDI---GMPEPDAQRFFHQLMAGVVYLHG-IGITHRDIKPENLLLDERDNL---KISDFGLATVFRYNNRERLLNK---MCGTLPYVAPELLK--RREFHAEPVDVWSCGIVLTAMLA-GELPWDQP--SDSCQEYSDWKEKKTYLNPWKKI--DSAPLALLHKILVENPSARIT-----IPDIKKDRW-Y----------
-FEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEV-AHTL-----TENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRER---VFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHI---KITDFGLCKEG--IKDGATMKT---FCGTPEYLAPEVLE---DNDYGRAVDWWGLGVVMYEMMC-GRLPFYNQ---DHEKLFELILMEEIRFPRTLG----PEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFF-----------
YI-MSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAR-EADPALNVETEIEILKKLNHPCIIKIKNFF-DAEDYYIVLELMEGGELFDKVVGNK---RLKEATCKLYFYQMLLAVQYLHE-NGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKI---LGETSLMRT---LCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLS-GYPPFSEH--RTQVSLKDQITSGKYNFIPEVWAEVSEKALDLVKKLLVVDPKARFT-----TEEALRHPWL-----------
-FKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTR------ERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIG---SFDETCTRFYTAEIVSALEYLHG-KGIIHRDLKPENILLNEDMHI---QITDFGTAKVLSPESKQARANS---FVGTAQYVSPELLT---EKSACKSSDLWALGCIIYQLVA-GLPPFRAG---NEYLIFQKIIKLEYDFPEKFF----PKARDLVEKLLVLDATKRLG-----CEEM------EGYGPLKAHPF
-LRLEVKLGQGCFGEVWMGTWN-GTTRVAIKTLK-PGTM-SPEA-FL-Q------EAQVMKKLRHEKLVQLYAVVS-EEPIYIVTEYMSKGSLLDFLK-GETGKYLRLPQLVDMAAQIASGMAYVER-MNYVHRDLRAANILVGENLVC---KVADFGLARLI--E--DNEYTARQGAKFPIKWTAPEAAL---YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECP------ESLHDLMCQCWRKEPEERPT-----FEYLQAF--L-----------
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