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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CAMK CHEK1 203
CMGC CDC2 4
CMGC CDK2 4
CAMK CHEK2 220
TK NTRK1 510
CAMK NUAK1 55
CAMK PRKD1 583
CAMK PRKD2 551
CAMK PRKD3 576
CAMK STK11 49
CAMK TSSK1B 12
----W-DLVQTLGEGAYGEVQLAVNR-----VTEEAVAVKIVDMKRAVDCP-ENI-KK------EICINKMLNHENVVKFYGHRRE--GNIQYLFLEYCSGG--ELFDRIE---PDI----------------GMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDNL---KISDFGLATVFR---YNNRERLLNK---MCGTLPYVAPELLK--RREFHAEPVDVWSCGIVLTAMLA-GELPWDQP--SDSCQEYSDWKEKKTYLNPWKKI--D----------------------SAPLALLHKILVENPSARITIPDIKKDRW-Y
-----YTKIEKIGEGTYGVVYKGRHK-----TTGQVVAMKKIRLESEEEGV-PSTAIR------EISLLKELRHPNIVSLQDVLMQ--DSRLYLIFEFLSM---DLKKYLDSIPPGQ----------------YMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTI---KLADFGLARAF-----GIPIRVYTH---EVVTLWYRSPEVLL--GSARYSTPVDIWSIGTIFAELAT-KKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF-
-----FQKVEKIGEGTYGVVYKARNK-----LTGEVVALKKIRLDTETEGV-PSTAIR------EISLLKELNHPNIVKLLDVIHT--ENKLYLVFEFLHQ---DLKKFMDA-SALT----------------GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAI---KLADFGLARAF-----GVPVRTYTH---EVVTLWYRAPEILL--GCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF-
---YI--MSKTLGSGACGEVKLAFER-----KTCKKVAIKIISKRKFAIGS-AREADPALNVETEIEILKKLNHPCIIKIKNFF-D--AEDYYIVLELMEGG--ELFDKVV---GNK----------------RLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKI------LGETSLMRT---LCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLS-GYPPFSEH--RTQVSLKDQITSGKYNFIPEVWAEVS----------------------EKALDLVKKLLVVDPKARFTTEEALRHPWL-
---IV--LKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALK-EASE-SARQDFQ-R------EAELLTMLQHQHIVRFFGVCTE--GRPLLMVFEYMRHG--DLNRFLR----SHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVV---KIGDFGMSRDI--Y--S--TDYYRVGGRTMLPIRWMPPESIL---YRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACP----------------------------PEVYAIMRGCWQREPQQRHSIKDVHARL---
-----YELQETLGKGTYGKVKRATER-----FSGRVVAIKSIRKDKIKDEQ-DMVHIR-----REIEIMSSLNHPHIISIYEVFEN--KDKIVIIMEYASKG--ELYDYIS---ERR----------------RLSERETRHFFRQIVSAVHYCHKNGVVHRDLKLENILLDDNCNI---KIADFGLSNL------YQKDKFLQT---FCGSPLYASPEIVN--GRPYRGPEVDSWALGVLLYTLVY-GTMPFDGF---DHKNLIRQISSGEYREPTQP---------------------------SDARGLIRWMLMVNPDRRATIEDIANHWW-V
---PD----EVLGSGQFGIVYGGKHR-----KTGRDVAIKIIDKLRFPTKQ-ESQLRN------EVAILQNLHHPGVVNLECMFET--PERVFVVMEKLHGD--MLEMILS--SEKG----------------RLPEHITKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFGFARI------IGEKSFRRS---VVGTPAYLAPEVLR---NKGYNRSLDMWSVGVIIYVSLS-GTFPFNED-----EDIHDQIQNAAFMYPPNPWKEIS----------------------HEAIDLINNLLQVKMRKRYSVDKTLSHPWL-
---PD----EVLGSGQFGVVYGGKHR-----KTGRDVAVKVIDKLRFPTKQ-ESQLRN------EVAILQSLRHPGIVNLECMFET--PEKVFVVMEKLHGD--MLEMILS--SEKG----------------RLPERLTKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFGFARI------IGEKSFRRS---VVGTPAYLAPEVLL---NQGYNRSLDMWSVGVIMYVSLS-GTFPFNED-----EDINDQIQNAAFMYPASPWSHIS----------------------AGAIDLINNLLQVKMRKRYSVDKSLSHPWL-
--FAD----EVLGSGQFGIVYGGKHR-----KTGRDVAIKVIDKMRFPTKQ-ESQLRN------EVAILQNLHHPGIVNLECMFET--PERVFVVMEKLHGD--MLEMILS--SEKS----------------RLPERITKFMVTQILVALRNLHFKNIVHCDLKPENVLLASAEPFPQVKLCDFGFARI------IGEKSFRRS---VVGTPAYLAPEVLR---SKGYNRSLDMWSVGVIIYVSLS-GTFPFNED-----EDINDQIQNAAFMYPPNPWREIS----------------------GEAIDLINNLLQVKMRKRYSVDKSLSHPWL-
--YLM---GDLLGEGSYGKVKEVLDS-----ETLCRRAVKILKKKKLRRIP-NGEANVK----KEIQLLRRLRHKNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDSVP----EK----------------RFPVCQAHGYFCQLIDGLEYLHSQGIVHKDIKPGNLLLTTGGTL---KISDLGVAEALH---PFAADDTCRT---SQGSPAFQPPEIAN-GLDTFSGFKVDIWSAGVTLYNITT-GLYPFEGD---NIYKLFENIGKGSYAIPGDCG--------------------------PPLSDLLKGMLEYEPAKRFSIRQIRQHSWF-
YLLGI-----NLGEGSYAKVKSAYSE-----RLKFNVAIKIIDRKKAPADF-LEKFLP-----REIEILAMLNHCSIIKTYEIFET-SHGKVYIVMELAVQG--DLLELIK---TRG----------------ALHEDEARKKFHQLSLAIKYCHDLDVVHRDLKCDNLLLDKDFNI---KLSDFSFSKRCLR-DDSGRMALSKT---FCGSPAYAAPEVLQ--GIPYQPKVYDIWSLGVILYIMVC-GSMPYDDS---NIKKMLRIQKEHRVNFPRSKHLT------------------------GECKDLIYHMLQPDVNRRLHIDEILSHCWM-
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