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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CAMK CHEK2 203
Other AURKA 133
CMGC CDK2 4
CMGC CSNK2A1 39
CAMK DAPK1 13
AGC GRK6 186
CMGC MAPK12 27
CAMK MAPKAPK2 64
Other NEK2 8
STE OXSR1 17
AGC PDPK1 82
CAMK PIM1 38
Other PLK1 53
AGC PRKCI 245
CAMK STK11 49
-YI--MSKTLGSGACGEVKLAFERKTCKKVAIKIISKRK-FAIGSAR-EADPALNVETEIEILKKL-NHPC--IIKIKNFF-D------AEDYYIVLELMEGG--ELFDKVV--------GNKRLKEATCKLYFYQMLLAVQYLHEN-----GIIHRDLKPENVLLS-SQEEDC-LIKITDFGHSKI------LGETSLMRTLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFS-EH--------RTQVSLKDQITSGKYNFIPEVWAEVS------------------------------EKALDLVKKLLVVDPKARFT------TEEALRHPWL-----------
---FEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEH-QLRR------EVEIQSHL-RHPN--ILRLYGYFHD------ATRVYLILEYAPLG--TVYRELQ--------KLSKFDEQRTATYITELANALSYCHSK-----RVIHRDIKPENLLLG-SAGEL----KIADFGWSV-------HAPSSRRTTLCGTLDYLPPEMIE---GRMHDEKVDLWSLGVLCYEFLVGKPPFE-AN---------TYQETYKRISRVEFTFPDFVT----------------------------------EGARDLISRLLKHNPSQRPM------LREVLEHPWI-----------
---FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDT-ETEGVPS-TAIR------EISLLKEL-NHPN--IVKLLDVIHT------ENKLYLVFEFLHQ---DLKKFMDA------SALTGIPLPLIKSYLFQLLQGLAFCHSH-----RVLHRDLKPQNLLIN-TEGAI----KLADFGLARAF-----GVPVRTYTHEVVTLWYRAPEILL--GCKYYSTAVDIWSLGCIFAEMVTRRALFP-GD------SEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR--------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS------AKAALAHPFF-----------
---YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVK-KKKIKR------------EIKILENLRGGPN--IITLADIVKDP----VSRTPALVFEHVNNT--DFKQLY-----------QTLTDYDIRFYMYEILKALDYCHSM-----GIMHRDVKPHNVMIDHEHRKL----RLIDWGLAEF------YHPGQEYNVRVASRYFKGPELLV--DYQMYDYSLDMWSLGCMLASMIFRKEPFFHGH------DNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLT------AREAMEHPYF-----------
---YDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRR-TKSSRRG-VSREDI--EREVSILKEI-QHPN--VITLHEVYEN------KTDVILILELVAGG--ELFDFLA--------EKESLTEEEATEFLKQILNGVYYLHSL-----QIAHFDLKPENIMLL-DRNVPKPRIKIIDFGLAHK------IDFGNEFKNIFGTPEFVAPEIVN---YEPLGLEADMWSIGVITYILLSGASPFL-GD---------TKQETLANVSAVNYEFEDEYFSNTS------------------------------ALAKDFIRRLLVKDPKKRMT------IQDSLQHPWI-----------
--F-RQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKR-IKKRKGE-AMAL-----NEKQILEKV-NSRF--VVSLAYAYET------KDALCLVLTLMNGG--DLKFHIYH------MGQAGFPEARAVFYAAEICCGLEDLHRE-----RIVYRDLKPENILLD-DHGHI----RISDLGLAVH------VPEGQTIKGRVGTVGYMAPEVVK---NERYTFSPDWWALGCLLYEMIAGQSPFQ-QR------KKKIKREEVERLVK-EVPEEYSER--FS------------------------------PQARSLCSQLLCKDPAERLGCR-GGSAREVKEHPLF-----------
---YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPF-QSELFAK-RAYR------ELRLLKHM-RHEN--VIGLLDVFTPDETLDDFTDFYLVMPFMGT---DLGKLMK---------HEKLGEDRIQFLVYQMLKGLRYIHAA-----GIIHRDLKPGNLAVN-EDCEL----KILDFGLAR--------QADSEMTGYVVTRWYRAPEVIL--NWMRYTQTVDIWSVGCIMAEMITGKTLFK-GS------DHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELE------KKDFASILTNASPLAVNLLEKMLVLDAEQRVT------AGEALAHPYF-----------
KVT---SQVLGLGINGKVLQIFNKRTQEKFALKMLQDCP-KAR--------R------EVELHWRASQCPH--IVRIVDVYENLY--AGRKCLLIVMECLDGG--ELFSRIQD------RGDQAFTEREASEIMKSIGEAIQYLHSI-----NIAHRDVKPENLLYT-SKRPNA-ILKLTDFGFAKE------TTSHNSLTTPCYTPYYVAPEVLG---PEKYDKSCDMWSLGVIMYILLCGYPPFY-SN-----HGLAISPGMKTRIRMGQYEFPNPEWSEVS------------------------------EEVKMLIRNLLKTEPTQRMT------ITEFMNHPWI-----------
---YEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGS-MTEAEKQ-MLVS------EVNLLREL-KHPN--IVRYYDRIIDR----TNTTLYIVMEYCEGG--DLASVITKG----TKERQYLDEEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLD-GKQNV----KLGDFGLARIL-----NHDTSFAKTFVGTPYYMSPEQMN---RMSYNEKSDIWSLGCLLYELCALMPPFT-AF---------SQKELAGKIREGKFRRIPYRY---S------------------------------DELNEIITRMLNLKDYHRPS------VEEILENPL-I----------
---YELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEK-CQTSMDE--LLK------EIQAMSQC-HHPN--IVSYYTSFVV------KDELWLVMKLLSGG--SVLDIIKHIVAKGEHKSGVLDESTIATILREVLEGLEYLHKN-----GQIHRDVKAGNILLG-EDGSV----QIADFGVSAFLATGGDITRNKVRKTFVGTPCWMAPEVME--QVRGYDFKADIWSFGITAIELATGAAPYH-KY------PPMKVLMLTLQNDPPSLETGVQDKE--MLK-------------------------KYGKSFRKMISLCLQKDPEKRPT------AAELLRHKFF-----------
--F-KFGKILGEGSFSTVVLARELATSREYAIKILEKRH-IIKENKVPYVTR------ERDVMSRL-DHPF--FVKLYFTFQD------DEKLYFGLSYAKNG--ELLKYIR--------KIGSFDETCTRFYTAEIVSALEYLHGK-----GIIHRDLKPENILLN-EDMHI----QITDFGTAKVLS---PESKQARANSFVGTAQYVSPELLT---EKSACKSSDLWALGCIIYQLVAGLPPFR-AG---------NEYLIFQKIIKLEYDFPEKFF----------------------------------PKARDLVEKLLVLDATKRLG------CEEM------EGYGPLKAHPF
---YQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDR-ISDWGEL-PNGTRV--PMEVVLLKKV-SSGFSGVIRLLDWFER------PDSFVLILERPEPV-QDLFDFIT--------ERGALQEELARSFFWQVLEAVRHCHNC-----GVLHRDIKDENILIDLNRGEL----KLIDFGSGA-------LLKDTVYTDFDGTRVYSPPEWIR--YHRYHGRSAAVWSLGILLYDMVCGDIPFE-HD---------------EEIIRGQVFFRQRVS----------------------------------SECQHLIRWCLALRPSDRPT------FEEIQNHPWM-----------
-YV--RGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSL-LLKPHQR-EKMS-----MEISIHRSL-AHQH--VVGFHGFFED------NDFVFVVLELCRRR--SLLELHK--------RRKALTEPEARYYLRQIVLGCQYLHRN-----RVIHRDLKLGNLFLN-EDLEV----KIGDFGLATKV-----EYDGERKKTLCGTPNYIAPEVLS---KKGHSFEVDVWSIGCIMYTLLVGKPPFE-TS---------CLKETYLRIKKNEYSIPKHIN----------------------------------PVAASLIQKMLQTDPTARPT------INELLNDEFF-----------
--F-DLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKEL-VNDDEDI-DWVQ-----TEKHVFEQASNHPF--LVGLHSCFQT------ESRLFFVIEYVNGG--DLMFHMQ--------RQRKLPEEHARFYSAEISLALNYLHER-----GIIYRDLKLDNVLLD-SEGHI----KLTDYGMCKEG-----LRPGDTTSTFCGTPNYIAPEILR---GEDYGFSVDWWALGVLMFEMMAGRSPFD-IVGSSDNPDQNTEDYLFQVILEKQIRIPRSLS----------------------------------VKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPF-F----------
YLM---GDLLGEGSYGKVKEVLDSETLCRRAVKILKKKK-LRRIPNG-EANVK----KEIQLLRRL-RHKN--VIQLVDVLYNE----EKQKMYMVMEYCVCGMQEMLDSVP---------EKRFPVCQAHGYFCQLIDGLEYLHSQ-----GIVHKDIKPGNLLLT-TGGTL----KISDLGVAEALH---PFAADDTCRTSQGSPAFQPPEIAN-GLDTFSGFKVDIWSAGVTLYNITTGLYPFE-GD---------NIYKLFENIGKGSYAIPGDCG----------------------------------PPLSDLLKGMLEYEPAKRFS------IRQIRQHSWF-----------
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