|
|
Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CAMK DAPK3 203
CMGC CDC2 4
CMGC CDK2 4
CMGC CDK5 4
CAMK PIM1 38
CAMK PIM2 132
YEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREEIEREVNILREIR----HPN--IITLHDIFENKTDVVLILEL-VSGG-ELFDFLA---EKESLTEDEATQFLKQILDGVHYLHSKRIAHFDLKPENIMLL-DKNVPNPRIKLIDFGIAHK-IEAGNEFKNIFGTPEFVAPEIVN-YEPLGLEADMWSIGVITYILLS-GASPFLGE---TKQETLTNISAVNYDFDEEYFSNTS----------------------ELAKDFIRRLLVKDPKRRMTIAQSLEHSWI
YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIR----EISLLKELR----HPN--IVSLQDVLMQDSRLYLIFEF-LSM--DLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLID-DKGTI----KLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELAT-KKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF
FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIR----EISLLKELN----HPN--IVKLLDVIHTENKLYLVFEF-LHQ--DLKKFMDA-SALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLIN-TEGAI----KLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF
YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALR----EICLLKELK----HKN--IVRLHDVLHSDKKLTLVFEF-CDQ--DLKKYFD--SCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLIN-RNGEL----KLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYF
YQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVS----SGFSGVIRLLDWFERPDSFVLILER-PEPVQDLFDFIT---ERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGEL----KLIDFGSGA--LLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVC-GDIPFEHD---------EEIIRGQVFFRQRVS--------------------------SECQHLIRWCLALRPSDRPTFEEIQNHPWM
YRLGPLLGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPLEVALLWKVGAGGGHPG--VIRLLDWFETQEGFMLVLERPLPAQ-DLFDYIT---EKGPLGEGPSRCFFGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCA----KLIDFGSGA--LLHDEPYTDFDGTRVYSPPEWISRHQYHALPATVWSLGILLYDMVC-GDIPFERD---------QEILEAELHFPAHVS--------------------------PDCCALIRRCLAPKPSSRPSLEEILLDPWM
|