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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK DDR1 203
AGC AKT1 150
Other AURKA 133
Other AURKB 77
CMGC CDC2 4
CMGC CDC2L6 20
CMGC CDK2 4
CMGC CDK4 6
CMGC CDK8 2.7.11.23
Other CHUK 15
CMGC CLK4 159
CMGC DYRK1A 150
CMGC GSK3B 56
TK JAK2 849
TK JAK3 822
TK LCK 245
CMGC MAPK10 64
CMGC MAPK14 24
Other PLK1 53
TK PTK2 422
TK PTK6 191
AGC ROCK2 92
TK SRC 270
---LRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKG-HPL--LVAVKILR-PD-AT----KNARNDFL-K-EVKIMSRL-K---DPN-----IIRLLGVCV--Q------DDPLC--MITDYMENG--DLNQFLS----------AHQLEDKAAEGAPGDGQAAQGPTI---SYPMLLHVAAQIASGMRYLAT--LNFVHRDLATRNCLVG----ENFTI-------------------KIADFGMSRNL--Y--A--GDYYRVQGRAVLPIRWMAWECIL----MGKFTTASDVWAFGVTLWEVLMLCRAQP---------------FGQL-----------TDEQVIENAGEFFRDQGRQVYLSRPPACP---------------------------------------------------------------QGLYELMLRCWSRESEQ--RPP-----FSQLHRFL-----------
--F-EYLKLLGKGTFGKVILVKEK----------------A-TGR--YYAMKILKKEV-IVA---KD--EVAHTLTENRVLQNS-R---HPF-----LTALKYSFQ--T------HDRLC--FVMEYANGG--ELFFHLS---------RER--------------------VF---SEDRARFYGAEIVSALDYLHS-EKNVVYRDLKLENLMLD----KDGHI-------------------KITDFGLCKEG-----IKDGATMKT---FCGTPEYLAPEVLE----DNDYGRAVDWWGLGVVMYEMMC-GR-LP---------------FYNQ--------------DHEKLF----ELILM---EEIRFPRTLG-------------------------------------------------------------PEAKSLLSGLLKKDPKQ--RLGGGSEDAKEIMQHRFF---------
---FEIGRPLGKGKFGNVYLAREK----------------Q-SKF--ILALKVLFKAQLEKA---GV--EHQLRR-EVEIQSHL-R---HPN-----ILRLYGYFH--D------ATRVY--LILEYAPLG--TVYRELQ---------KLS--------------------KF---DEQRTATYITELANALSYCHS--KRVIHRDIKPENLLLG----SAGEL-------------------KIADFGWSV-------HAPSSRRTT---LCGTLDYLPPEMIE----GRMHDEKVDLWSLGVLCYEFLV-GK-PP---------------FEAN--------------TYQETY----KRISR---VEFTFPDFVT-------------------------------------------------------------EGARDLISRLLKHNPSQ--RPM-----LREVLEHPWI---------
---FEIGRPLGKGKFGNVYLAREK----------------K-SHF--IVALKVLFKSQ-IEK---EG--VEHQLRREIEIQAHL-H---HPN-----ILRLYNYFY--D------RRRIY--LILEYAPRG--ELYKELQ---------KSC--------------------TF---DEQRTATIMEELADALMYCHG--KKVIHRDIKPENLLLG----LKGEL-------------------KIADFGWSV-------HAPSLRRKT---MCGTLDYLPPEMIE----GRMHNEKVDLWCIGVLCYELLV-GN-PP---------------FESA--------------SHNETY----RRIVK---VDLKFPASVP-------------------------------------------------------------MGAQDLISKLLRHNPSE--RLP-----LAQVSAHPWV---------
---YTKIEKIGEGTYGVVYKGRHK----------------T-TGQ--VVAMKKIRLES-EEE---GV--PSTAIR-EISLLKEL-R---HPN-----IVSLQDVLM--Q------DSRLY--LIFEFLSM---DLKKYLDS------IPPGQ--------------------YM---DSSLVKSYLYQILQGIVFCHS--RRVLHRDLKPQNLLID----DKGTI-------------------KLADFGLARAF-----GIPIRVYTH---EVVTLWYRSPEVLL---GSARYSTPVDIWSIGTIFAELAT-KK-PL---------------FHGD-----------SEIDQLFRI----FRALG---TPNNEVWPEVESLQDYKNTFPKWKP-----------------------------------GSLASHVKNLDENGLDLLSKMLIYDPAK--RIS-----GKMALNHPYF---------
EGC-----KVGRGTYGHVYKARRK----------------D-GKDEKEYALKQIEGTG-ISM---SA--C----R-EIALLREL-K---HPN-----VIALQKVFL--SH----SDRKVW--LLFDYAEH---DLWHIIKFHR--ASKANKK--------------------PMQ-LPRSMVKSLLYQILDGIHYLHA--NWVLHRDLKPANILVMGEGPERGRV-------------------KIADMGFARLFN--SPLKPLADLDP---VVVTFWYRAPELLL---GARHYTKAIDIWAIGCIFAELLT-SE-PI---------------FHCRQEDI--KTSNPFHHDQLDRI----FSVMG---FPADKDWEDIRKMPEYPTLQKDFRRTTYA--------------------------NSSLIKYMEKHKVKPDSKVFLLLQKLLTMDPTK--RIT-----SEQALQDPYF---------
---FQKVEKIGEGTYGVVYKARNK----------------L-TGE--VVALKKIRLDT-ETE---GV--PSTAIR-EISLLKEL-N---HPN-----IVKLLDVIH--T------ENKLY--LVFEFLHQ---DLKKFMDA-------SALT--------------------GI---PLPLIKSYLFQLLQGLAFCHS--HRVLHRDLKPQNLLIN----TEGAI-------------------KLADFGLARAF-----GVPVRTYTH---EVVTLWYRAPEILL---GCKYYSTAVDIWSLGCIFAEMVT-RR-AL---------------FPGD-----------SEIDQLFRI----FRTLG---TPDEVVWPGVTSMPDYKPSFPKWAR-----------------------------------QDFSKVVPPLDEDGRSLLSQMLHYDPNK--RIS-----AKAALAHPFF---------
--Y-EPVAEIGVGAYGTVYKARDP----------------H-SGH--FVALKSVRVPN-GGGGGGGL--PISTVR-EVALLRRL-EAFEHPN-----VVRLMDVCA--TSR-TDREIKVT--LVFEHVDQ---DLRTYLDK-------APPP--------------------GL---PAETIKDLMRQFLRGLDFLHA--NCIVHRDLKPENILVT----SGGTV-------------------KLADFGLARI------YSYQMALTP---VVVTLWYRAPEVLL----QSTYATPVDMWSVGCIFAEMFR-RK-PL---------------FCGN-----------SEADQLGKI----FDLIG---LPPEDDWPRDVSLPRGAFPPRGPR-------------------------------------PVQSVVPEMEESGAQLLLEMLTFNPHK--RIS-----AFRALQHSYL---------
EGC-----KVGRGTYGHVYKAKRK----------------D-GKDDKDYALKQIEGTG-ISM---SA--C----R-EIALLREL-K---HPN-----VISLQKVFL--SH----ADRKVW--LLFDYAEH---DLWHIIKFHRASKANKKPV--------------------QL---PRGMVKSLLYQILDGIHYLHA--NWVLHRDLKPANILVMGEGPERGRV-------------------KIADMGFARLFN--SPLKPLADLDP---VVVTFWYRAPELLL---GARHYTKAIDIWAIGCIFAELLT-SE-PI---------------FHCRQEDI--KTSNPYHHDQLDRI----FNVMG---FPADKDWEDIKKMPEHSTLMKDFRRNTYT--------------------------NCSLIKYMEKHKVKPDSKAFHLLQKLLTMDPIK--RIT-----SEQAMQDPYF---------
--W-EMRERLGTGGFGNVCLYQHR----------------E-LDL--KIAIKSCRLEL-STK---NR--ER-WCH-EIQIMKKL-N---HAN-----VVKACDVPE--ELN-ILIHDVPL--LAMEYCSGG--DLRKLLNK------PENCC--------------------GL---KESQILSLLSDIGSGIRYLHE--NKIIHRDLKPENIVLQ----DVGGKI----------------IHKIIDLGYAKD------VDQGSLCTS---FVGTLQYLAPELFE----NKPYTATVDYWSFGTMVFECIA-GY-RP---------------FLHHLQPFTWHEKIKKKDPKCIFA----CEEMS---GEVRFSSHLPQPNSLCS---------------------------------------------------LVVEPMENWLQLMLNWDPQQ--RG----------------GPVDLTLKQ
---YEIVDTLGEGAFGKVVECIDH----------------GMDGM--HVAVKIVKNVG-RYR---EA--ARS----EIQVLEHL-NS-TDPNSV-FRCVQMLEWFD--H------HGHVC--IVFELLGL---STYDFIK---------ENS--------------------FLP-FQIDHIRQMAYQICQSINFLHH--NKLTHTDLKPENILFV----KSDYVVKYNSKMKRDERTLKNTDIKVVDFGSA--------TYDDEHHST---LVSTRHYRAPEVIL----ALGWSQPCDVWSIGCILIEYYL-GF-TV---------------FQTH-----------DSKEHLAMM----ERILG---PIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRY--------------------VRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQ--RIT-----LDEALQHPFF---------
---YEIDSLIGKGSFGQVVKAYDR----------------V-EQE--WVAIKIIKNKK-AFL---NQ--AQI----EVRLLELMNK---HDTEMKYYIVHLKRHFM--F------RNHLC--LVFEMLSY---NLYDLLR----------NT--------------------NFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCN--PKRSAI-------------------KIVDFGSSCQ--------LGQRIYQ---YIQSRFYRSPEVLL----GMPYDLAIDMWSLGCILVEMHT-GE-PL---------------FSGA-----------NEVDQMNKI----VEVLG---IPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKT--RIQ-----PYYALQHSFF---------
---YTDTKVIGNGSFGVVYQAKLC----------------D-SGE--LVAIKKVLQDK-RFK---NR---------ELQIMRKL-D---HCN-----IVRLRYFFY--SSG--EKKDEVYLNLVLDYVPETVYRVA---RHY-----SRAKQ--------------------TL---PVIYVKLYMYQLFRSLAYIHS--FGICHRDIKPQNLLLD---PDTAVL-------------------KLCDFGSAKQ------LVRGEPNVS---YICSRYYRAPELIF---GATDYTSSIDVWSAGCVLAELLL-GQ-PI---------------FPGD-----------SGVDQLVEI----IKVLG---TPTREQIREMNPNYTEFKFPQIKAH-----------------------------------PWTKVFRPRTPPEAIALCSRLLEYTPTA--RLT-----PLEACAHSFF---------
---LKFLQQLGKGNFGSVEMCRYDP------------LQDN-TGE--VVAVKKLQ-HS-TE-----EHLRDFE-R-EIEILKSL-Q---HDN-----IVKYKGVCYSAG------RRNLK--LIMEYLPYG--SLRDYLQ----------KH------------------KERI---DHIKLLQYTSQICKGMEYLGT--KRYIHRDLATRNILVE----NENRV-------------------KIGDFGLTKVL-PQ--D--KEYYKVKEPGESPIFWYAPESLT----ESKFSVASDVWSFGVVLYELFTYIE-KSKSPPAEFMRMIGNDKQGQM-----------IVFHLIELL----KNNGR---LPRPDGCP---------------------------------------------------------------DEIYMIMTECWNNNVNQ--RPS-----FRDLA----LRV-------
--L-KYISQLGKGNFGSVELCRYDP------------LGDN-TGA--LVAVKQLQ-HS-GP----DQ-QRDFQ-R-EIQILKAL-H---SDF-----IVKYRGVSYGPG------RQSLR--LVMEYLPSG--CLRDFLQ----------RH------------------RARL---DASRLLLYSSQICKGMEYLGS--RRCVHRDLAARNILVE----SEAHV-------------------KIADFGLAKLL-PL--D--KDYYVVREPGQSPIFWYAPESLS----DNIFSRQSDVWSFGVVLYELFTYCD-KSCSPSAE--FLRMMGCERDV-P---------ALCRLLELL----EEGQR---LPAPPACP---------------------------------------------------------------AEVHELMKLCWAPSPQD--RPS-----FSALGP---QL--------
---LKLVERLGAGQFGEVWMGYYN------------------GHT--KVAVKSLK-QG-SM----SP--DAFL-A-EANLMKQL-Q---HQR-----LVRLYAVVT---------QEPIY--IITEYMENG--SLVDFLK----------TP-----------------SGIKL---TINKLLDMAAQIAEGMAFIEE--RNYIHRDLRAANILVS----DTLSC-------------------KIADFGLARLI-----E--DNEYTAREGAKFPIKWTAPEAIN----YGTFTIKSDVWSFGILLTEIVTHGR-IP---------------YPGM-----------TNPEVIQNL----ERGYR---MVRPDNCP---------------------------------------------------------------EELYQLMRLCWKERPED--RPT-----FDYLRSV--L---------
---YQNLKPIGSGAQGIVCAAYDA----------------V-LDR--NVAIKKLSRPF-QNQ---TH--AKRAYR-ELVLMKCV-N---HKN-----IISLLNVFT--PQKTLEEFQDVY--LVMELMDA---NLCQVIQ-----------M--------------------EL---DHERMSYLLYQMLCGIKHLHS--AGIIHRDLKPSNIVVK----SDCTL-------------------KILDFGLART------AGTSFMMTP---YVVTRYYRAPEVIL----GMGYKENVDIWSVGCIMGEMVR-HK-IL---------------FPGR-----------DYIDQWNKV----IEQLG---TPCPEFMKKLQPTVRNYVENRPKYAGLTFPK----------------------LFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAK--RIS-----VDDALQHPYI---------
---YQNLSPVGSGAYGSVCAAFDT----------------K-TGL--RVAVKKLSRPF-QSI---IH--AKRTYR-ELRLLKHM-K---HEN-----VIGLLDVFT--PARSLEEFNDVY--LVTHLMGA---DLNNIVK----------CQ--------------------KL---TDDHVQFLIYQILRGLKYIHS--ADIIHRDLKPSNLAVN----EDCEL-------------------KILDFGLAR--------HTDDEMTG---YVATRWYRAPEIML---NWMHYNQTVDIWSVGCIMAELLT-GR-TL---------------FPGT-----------DHIDQLKLI----LRLVG---TPGAELLKKISSESARNYIQSLTQMP---------------------------------KMNFANVFIGANPLAVDLLEKMLVLDSDK--RIT-----AAQALAHAYF---------
-YV--RGRFLGKGGFAKCFEISDA----------------D-TKE--VFAGKIVPKSL-LLK---PH--QREKMSMEISIHRSL-A---HQH-----VVGFHGFFE--D------NDFVF--VVLELCRRR--SLLELHK---------RRK--------------------AL---TEPEARYYLRQIVLGCQYLHR--NRVIHRDLKLGNLFLN----EDLEV-------------------KIGDFGLATKV-----EYDGERKKT---LCGTPNYIAPEVLS----KKGHSFEVDVWSIGCIMYTLLV-GK-PP---------------FETS--------------CLKETY----LRIKK---NEYSIPKHIN-------------------------------------------------------------PVAASLIQKMLQTDPTA--RPT-----INELLNDEFF---------
---IELGRCIGEGQFGDVHQGIYM-------------SPEN-PAL--AVAIKTCK-NC-TS----DSVREKFL-Q-EALTMRQF-D---HPH-----IVKLIGVIT---------ENPVW--IIMELCTLG--ELRSFLQ----------VR------------------KYSL---DLASLILYAYQLSTALAYLES--KRFVHRDIAARNVLVS----SNDCV-------------------KLGDFGLSRYM-----E--DSTYYKASKGKLPIKWMAPESIN----FRRFTSASDVWMFGVCMWEILMHGV-KP---------------FQGV-----------KNNDVIGRI----ENGER---LPMPPNCP---------------------------------------------------------------PTLYSLMTKCWAYDPSR--RPR-----FTELKAQL-----------
--F-TLCRKLGSGYFGEVFEGLWK------------------DRV--QVAIKVIS-RD-NL----LH-QQMLQ-S-EIQAMKKL-R---HKH-----ILALYAVVS--V------GDPVY--IITELMAKG--SLLELLR----------DS-----------------DEKVL---PVSELLDIAWQVAEGMCYLES--QNYIHRDLAARNILVG----ENTLC-------------------KVGDFGLARLI--------KEDVYLSHDHNIPYKWTAPEALS----RGHYSTKSDVWSFGILLHEMFSRGQ-VP---------------YPGM-----------SNHEAFLRV----DAGYR---MPCPLECP---------------------------------------------------------------PSVHKLMLTCWCRDPEQ--RPC-----FKALRERL-----------
---YDVVKVIGRGAFGEVQLVRHK----------------A-SQK--VYAMKLLSKFE-MIK---RS--DSAFFWEERDIMAFA-N---SPW-----VVQLFYAFQ--D------DRYLY--MVMEYMPGG--DLVNLMS----------NY--------------------DV---PEKWAKFYTAEVVLALDAIHS--MGLIHRDVKPDNMLLD----KHGHL-------------------KLADFGTCMKM----DETGMVHCDT---AVGTPDYISPEVLKSQGGDGFYGRECDWWSVGVFLYEMLV-GD-TP---------------FYAD--------------SLVGTY----SKIMD---HKNSLCFPEDAEIS---------------------------------------------------------KHAKNLICAFLTDREVRLGRNG-----VEEIRQHPFF---------
--L-RLEVKLGQGCFGEVWMGTWN------------------GTT--RVAIKTLK-PG-TM----SP--EAFL-Q-EAQVMKKL-R---HEK-----LVQLYAVVS---------EEPIY--IVTEYMSKG--SLLDFLK----------GE-----------------TGKYL---RLPQLVDMAAQIASGMAYVER--MNYVHRDLRAANILVG----ENLVC-------------------KVADFGLARLI-----E--DNEYTARQGAKFPIKWTAPEAAL----YGRFTIKSDVWSFGILLTELTTKGR-VP---------------YPGM-----------VNREVLDQV----ERGYR---MPCPPECP---------------------------------------------------------------ESLHDLMCQCWRKEPEE--RPT-----FEYLQAF--L---------
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