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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC DYRK1A 203
CMGC CDC2 4
CMGC CDK2 4
CMGC GSK3B 56
CMGC MAPK14 24
YEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQI---EVRLLELMNKHDTEMKYYIVHLKRHFMF------RNHLC--LVFEMLSY---NLYDLLR-----NTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQ---LGQRIYQYIQSRFYRSPEVLL-GMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFF
YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKEL-RHPN-----IVSLQDVLMQ------DSRLY--LIFEFLSM---DLKKYLDS-IPPGQYM---DSSLVKSYLYQILQGIVFCHS--RRVLHRDLKPQNLLID--DKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKP-----------------------------------GSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF
FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKEL-NHPN-----IVKLLDVIHT------ENKLY--LVFEFLHQ---DLKKFMDA--SALTGI---PLPLIKSYLFQLLQGLAFCHS--HRVLHRDLKPQNLLIN--TEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR-----------------------------------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF
YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNR------ELQIMRKL-DHCN-----IVRLRYFFYSSG--EKKDEVYLNLVLDYVPETVYRVA---RHYSRAKQTL---PVIYVKLYMYQLFRSLAYIHS--FGICHRDIKPQNLLLD-PDTAVLKLCDFGSAKQ-LVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH-----------------------------------PWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFF
YQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHM-KHEN-----VIGLLDVFTPARSLEEFNDVY--LVTHLMGA---DLNNIVK-----CQKL---TDDHVQFLIYQILRGLKYIHS--ADIIHRDLKPSNLAVN--EDCELKILDFGLAR---HTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMP---------------------------------KMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYF
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