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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC DYRK2 203
Other AURKA 133
Other AURKB 77
Other AURKC 43
CAMK BRSK1 50
CAMK BRSK2 19
CMGC CDC2 4
CMGC CDK2 4
CMGC CDK3 4
CMGC CDK5 4
CMGC CDK6 13
CMGC GSK3A 119
CMGC GSK3B 56
CAMK NUAK1 55
AGC PDPK1 82
-YEVLKVIGKGSFGQVVKAYDHKVHQ-HVALKMVRNEK-RFHRQAA-E----EIRILEHLRKQDKDNTMNVIHMLENFTF-----RNHIC--MTFELLSM---NLYELIKK--NKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLK-QQGRSGIKVIDFGSSC-----YEHQRVYTYIQSRFYRAPEVIL-GARYGMPIDMWSLGCILAELLT-GYPLLPGEDEGDQLACMIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWL-----------
-FEIGRPLGKGKFGNVYLAREKQSKF-ILALKVLFKAQLEKAGVEH-QLRR-EVEIQSHLR------HPNILRLYGYFHD-----ATRVY--LILEYAPLG--TVYRELQ----KLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLG-SAGEL--KIADFGWSV----HAPSSRRTTLCGTLDYLPPEMIE-GRMHDEKVDLWSLGVLCYEFLV-GKPPFEAN---TYQETYKRISRVEFTFPDFVT--------------------------------------------------------EGARDLISRLLKHNPSQRPMLREVLEHPWI-----------
-FEIGRPLGKGKFGNVYLAREKKSHF-IVALKVLFKSQ-IEKEGVE-HQLRREIEIQAHLH------HPNILRLYNYFYD-----RRRIY--LILEYAPRG--ELYKELQ----KSCTFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLG-LKGEL--KIADFGWSV----HAPSLRRKTMCGTLDYLPPEMIE-GRMHNEKVDLWCIGVLCYELLV-GNPPFESA---SHNETYRRIVKVDLKFPASVP--------------------------------------------------------MGAQDLISKLLRHNPSERLPLAQVSAHPWV-----------
-FEIGRPLGKGKFGNVYLARLKESHF-IVALKVLFKSQ-IEKEGLE-HQLRREIEIQAHLQ------HPNILRLYNYFHD-----ARRVY--LILEYAPRG--ELYKELQ----KSEKLDEQRTATIIEELADALTYCHDKKVIHRDIKPENLLLG-FRGEV--KIADFGWSV----HTPSLRRKTMCGTLDYLPPEMIE-GRTYDEKVDLWCIGVLCYELLV-GYPPFESA---SHSETYRRILKVDVRFPLSMP--------------------------------------------------------LGARDLISRLLRYQPLERLPLAQILKHPWV-----------
-YRLEKTLGKGQTGLVKLGVHCITGQ-KVAIKIVNREK-LSESVLM-KVER-EIAILKLIE------HPHVLKLHDVYEN-----KKYLY--LVLEHVSGG--ELFDYLV----KKGRLTPKEARKFFRQIVSALDFCHSYSICHRDLKPENLLLD-EKNNI--RIADFGMASL---QVGDSLLETSCGSPHYACPEVIKGEKYDGRRADMWSCGVILFALLV-GALPFDDD---NLRQLLEKVKRGVFHMPHFIP--------------------------------------------------------PDCQSLLRGMIEVEPEKRLSLEQIQKHPW-Y----------
-YRLEKTLGKGQTGLVKLGVHCVTCQ-KVAIKIVNREK-LSESVLM-KVER-EIAILKLIE------HPHVLKLHDVYEN-----KKYLY--LVLEHVSGG--ELFDYLV----KKGRLTPKEARKFFRQIISALDFCHSHSICHRDLKPENLLLD-EKNNI--RIADFGMASL---QVGDSLLETSCGSPHYACPEVIRGEKYDGRKADVWSCGVILFALLV-GALPFDDD---NLRQLLEKVKRGVFHMPHFIP--------------------------------------------------------PDCQSLLRGMIEVDAARRLTLEHIQKHIW-Y----------
-YTKIEKIGEGTYGVVYKGRHKTTGQ-VVAMKKIRLES-EEEGVPS-TAIR-EISLLKELR------HPNIVSLQDVLMQ-----DSRLY--LIFEFLSM---DLKKYLDS-IPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLID-DKGTI--KLADFGLARAF--GIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELAT-KKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKP------------------------------GSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF-----------
-FQKVEKIGEGTYGVVYKARNKLTGE-VVALKKIRLDT-ETEGVPS-TAIR-EISLLKELN------HPNIVKLLDVIHT-----ENKLY--LVFEFLHQ---DLKKFMDA--SALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLIN-TEGAI--KLADFGLARAF--GVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR------------------------------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF-----------
-FQKVEKIGEGTYGVVYKAKNRETGQ-LVALKKIRLDL-EMEGVPS-TAIR-EISLLKELK------HPNIVRLLDVVHN-----ERKLY--LVFEFLSQ---DLKKYMDS--TPGSELPLHLIKSYLFQLLQGVSFCHSHRVIHRDLKPQNLLIN-ELGAI--KLADFGLARAF--GVPLRTYTHEVVTLWYRAPEILLGSKFYTTAVDIWSIGCIFAEMVT-RKALFPGDSEIDQLFRIFRMLGTPSEDTWPGVTQLPDYKGSFPKWTR------------------------------KGLEEIVPNLEPEGRDLLMQLLQYDPSQRITAKTALAHPYF-----------
-YEKLEKIGEGTYGTVFKAKNRETHE-IVALKRVRLDD-DDEGVPS-SALR-EICLLKELK------HKNIVRLHDVLHS-----DKKLT--LVFEFCDQ---DLKKYFD---SCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLIN-RNGEL--KLADFGLARAF--GIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPAT------------------------------TSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYF-----------
-YECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQT-GEEGMPL-STIR-EVAVLRHLET---FEHPNVVRLFDVCTVSRTDRETKLT--LVFEHVDQ---DLTTYLDK--VPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVT-SSGQI--KLADFGLARI---YSFQMALTSVVVTLWYRAPEVLL-QSSYATPVDLWSVGCIFAEMFR-RKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQ--------------------------------PIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF-----------
-YTDIKVIGNGSFGVVYQARLAETRE-LVAIKKVLQDK-RFKNR--------ELQIMRKLD------HCNIVRLRYFFYSSG-EKKDELYLNLVLEYVPETVYRVARHFT---KAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVL--KLCDFGSAKQ---LVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLL-GQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH------------------------------PWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFF-----------
-YTDTKVIGNGSFGVVYQAKLCDSGE-LVAIKKVLQDK-RFKNR--------ELQIMRKLD------HCNIVRLRYFFYSSG-EKKDEVYLNLVLDYVPETVYRVA---RHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVL--KLCDFGSAKQ---LVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLL-GQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH------------------------------PWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFF-----------
-YELQETLGKGTYGKVKRATERFSGR-VVAIKSIRKDK-IKDEQDM-VHIRREIEIMSSLN------HPHIISIYEVFEN-----KDKIV--IIMEYASKG--ELYDYIS----ERRRLSERETRHFFRQIVSAVHYCHKNGVVHRDLKLENILLD-DNCNI--KIADFGLSNL---YQKDKFLQTFCGSPLYASPEIVNGRPYRGPEVDSWALGVLLYTLVY-GTMPFDGF---DHKNLIRQISSGEYREPTQP---------------------------------------------------------SDARGLIRWMLMVNPDRRATIEDIANHWW-V----------
F-KFGKILGEGSFSTVVLARELATSR-EYAIKILEKRH-IIKENKVPYVTR-ERDVMSRLD------HPFFVKLYFTFQD-----DEKLY--FGLSYAKNG--ELLKYIR----KIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLN-EDMHI--QITDFGTAKVLSPESKQARANSFVGTAQYVSPELLT-EKSACKSSDLWALGCIIYQLVA-GLPPFRAG---NEYLIFQKIIKLEYDFPEKFF--------------------------------------------------------PKARDLVEKLLVLDATKRLGCEEM------EGYGPLKAHPF
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