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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK EGFR 203
TK ABL1 261
TK ERBB2 720
TK ERBB3 709
TK ERBB4 718
TK INSR 1023
STE MAP2K5 166
TK PDGFRB 600
STE SLK 34
--F-KKIKVLGSGAFGTVYKGLWIP-EGEKVKIPVAIKELR-EATS-PKANKEIL-DEAYVMASV-DNPHVCRLLGICL-TSTVQLITQLMPFGCLLDYVR--EH--------------------------------------------------------------------------------------------------KDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGA--EEKEYHAEGGKVPIKWMALESIL-----HRIYTHQSDVWSYGVTVWELMTFGSKPYDGI-PASEISSILEKGERLPQPPICT--------IDVYMIMVKCWMIDADSRPKFRELI----IEF
---ITMKHKLGGGQYGEVYEGVWK-----KYSLTVAVKTLK-EDTM-EV--EEFL-KEAAVMKEI-KHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLR--EC-------------------------------------------------------------------------------------------------NRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLM-T--GDTYTAHAGAKFPIKWTAPESLA-----YNKFSIKSDVWAFGVLLWEIATYGMSPYPGI-DLSQVYELLEKDYRMERPEGCP--------EKVYELMRACWQWNPSDRPSFAEIHQA--F--
--L-RKVKVLGSGAFGTVYKGIWIP-DGENVKIPVAIKVLR-ENTS-PKANKEIL-DEAYVMAGV-GSPYVSRLLGICL-TSTVQLVTQLMPYGCLLDHVR--EN--------------------------------------------------------------------------------------------------RGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDI--DETEYHADGGKVPIKWMALESIL-----RRRFTHQSDVWSYGVTVWELMTFGAKPYDGI-PAREIPDLLEKGERLPQPPICT--------IDVYMIMVKCWMIDSECRPRFRELVSE--F--
--L-RKLKVLGSGVFGTVHKGVWIP-EGESIKIPVCIKVIE-DKSG-RQSFQAVT-DHMLAIGSL-DHAHIVRLLGLCP-GSSLQLVTQYLPLGSLLDHVR--QH--------------------------------------------------------------------------------------------------RGALGPQLLLNWGVQIAKGMYYLEEHGMVHRNLAARNVLLKSPSQVQVADFGVADLLPP--DDKQLLYSEAKTPIKWMALESIH-----FGKYTHQSDVWSYGVTVWELMTFGAEPYAGL-RLAEVPDLLEKGERLAQPQICT--------IDVYMVMVKCWMIDENIRPTFKELANE--F--
--L-KRVKVLGSGAFGTVYKGIWVP-EGETVKIPVAIKILN-ETTG-PKANVEFM-DEALIMASM-DHPHLVRLLGVCL-SPTIQLVTQLMPHGCLLEYVH--EH--------------------------------------------------------------------------------------------------KDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEG--DEKEYNADGGKMPIKWMALECIH-----YRKFTHQSDVWSYGVTIWELMTFGGKPYDGI-PTREIPDLLEKGERLPQPPICT--------IDVYMVMVKCWMIDADSRPKFKELAAE--F--
---ITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVN-ESAS-LRERIEFL-NEASVMKGF-TCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLR--SLRPEA-----------------------------------------------------------------------------------------ENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYE--TDYYRKGGKGLLPVRWMAPESLK-----DGVFTTSSDMWSFGVVLWEITSLAEQPYQGL-SNEQVLKFVMDGGYLDQPDNCP--------ERVTDLMRMCWQFNPKMRPTFLEIVNLL----
IRY---RDTLGHGNGGTVYKAYHV-----PSGKILAVKVILLDITLELQ--KQI-MSELEILYKC-DSSYIIGFYGAFFVENRISICTEFMDGGSLD-----VYR----------------------------------------------------------------------------------------------------KMPEHVLGRIAVAVVKGLTYLWSLKILHRDVKPSNMLVNTRGQVKLCDFGVST---QLVNSIAKT---YVGTNAYMAPERIS-----GEQYGIHSDVWSLGISFMELAL-GRFPYPQI-QKNQGSLMPLQLLQCIVDEDSPVLPVGEFSEPFVHFITQCMRKQPKERPAPEELMGHPFI--
--L-VLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLK-STAR-SSEKQALM-SELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLH--RNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVLSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMR--DSNYISKGSTFLPLKWMAPESIF-----NSLYTTLSDVWSFGILLWEIFTLGGTPYPELPMNEQFYNAIKRGYRMAQPAHAS--------DEIYEIMQKCWEEKFEIRPPFSQLVL---LL-
---WEIIGELGDGAFGKVYKAQNK-----ETSVLAAAKVIDTKSEEELE--DYM--VEIDILASC-DHPNIVKLLDAFYYENNLWILIEFCAGGAVDAVMLELER----------------------------------------------------------------------------------------------------PLTESQIQVVCKQTLDALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKN-TRTIQRRDS---FIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIEMAE-IEPPHHEL-NPMRVLLKIAKSEPPTLAQPSRWS------SNFKDFLKKCLEKNVDARWTTSQLLQHPFV--
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