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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK EGFR 203
TK BLK 241
TK BMX 422
TKL BRAF 456
TK BTK 402
TK EPHB3 633
TK ERBB4 718
TK FGFR1 478
TK FYN 271
TK JAK3 822
TK LCK 245
TK PTK2 422
TK SRC 270
STE STK10 36
TK TNK2 150
TK TXK 271
F-KKIKVLGSGAFGTVYKGLWIP---EGEKVKIPVAIKELR-E--ATS-PKANKEILDEAYVMASV-DNPHVCRLLGICL---TSTVQLITQLMPFGCLLDYVR--EH---------------KDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLL---GA--EEKEYHAEGGKVPIKWMALESIL-----HRI---YTHQSDVWSYGVTVWELMTFGSKP-------------YDGI-PASEISSIL-EKGER----LPQPPICT--IDVYM-IMVKCWMIDADSRPKFRELI----IEF
L-RLVRKLGSGQFGEVWMGYYK--------NNMKVAIKTLK-E--GTM-SP--EAFLGEANVMKAL-QHERLVRLYAVVT---KEPIYIVTEYMARGCLLDFLK--TD--------------EGSRLSLPRLIDMSAQIAEGMAYIERMNSIHRDLRAANILVSEALCCKIADFGLARII-------DSEYTAQEGAKFPIKWTAPEAIH-----FGV---FTIKADVWSFGVLLMEVVTYGRVP-------------YPGM-SNPEVIRNL-ERGYR----MPRPDTCP--PELYRGVIAECWRSRPEERPTFEFLQSV--L--
-ITLLKELGSGQFGVVQLGKWK--------GQYDVAVKMIK-E--GSM-SE--DEFFQEAQTMMKL-SHPKLVKFYGVCS--KEYPIYIVTEYISNGCLLNYLR--SH---------------GKGLEPSQLLEMCYDVCEGMAFLESHQFIHRDLAARNCLVDRDLCVKVSDFGMTRYV----L--DDQYVSSVGTKFPVKWSAPEVFH-----YFK---YSSKSDVWAFGILMWEVFSLGKQP-------------YDLY-DNSQVVLKV-SQGHR----LYRPHLAS--DTIYQ-IMYSCWHELPEKRPTFQQLLSS--I--
-ITVGQRIGSGSFGTVYKGKWH----------GDVAVKMLN-V-TAPT-PQQLQAFKNEVGVLRKT-RHVNILLFMGYST---KPQLAIVTQWCEGSSLYHHLH--II---------------ETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVK---SR--WSGSHQFEQLSGSILWMAPEVIR-----MQDKNPYSFQSDVYAFGIVLYELMT-GQLP-------------YSNINNRDQIIFMV-GRGYLSPDLSKVRSNCP--KAMKR-LMAECLKKKRDERPLFPQILA---SI-
-LTFLKELGTGQFGVVKYGKWR--------GQYDVAIKMIK-E--GSM-SE--DEFIEEAKVMMNL-SHEKLVQLYGVCT--KQRPIFIITEYMANGCLLNYLR--EM---------------RHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYV----L--DDEYTSSVGSKFPVRWSPPEVLM-----YSK---FSSKSDIWAFGVLMWEIYSLGKMP-------------YERF-TNSETAEHI-AQGLR----LYRPHLAS--EKVYT-IMYSCWHEKADERPTFKILLSN--I--
V-KIEEVIGAGEFGEVCRGRLK----QPGRREVFVAIKTLK-V--GYT-ERQRRDFLSEASIMGQF-DHPNIIRLEGVVT--KSRPVMILTEFMENCALDSFLR--LN---------------DGQFTVIQLVGMLRGIAAGMKYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDPS--DPTYTSSLGGKIPIRWTAPEAIA-----YRK---FTSASDVWSYGIVMWEVMSYGERP-------------YWDM-SNQDVINAV-EQDYR----LPPPMDCP--TALHQ-LMLDCWVRDRNLRPKFSQIVNTL----
L-KRVKVLGSGAFGTVYKGIWVP---EGETVKIPVAIKILN-E--TTG-PKANVEFMDEALIMASM-DHPHLVRLLGVCL---SPTIQLVTQLMPHGCLLEYVH--EH---------------KDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLL---EG--DEKEYNADGGKMPIKWMALECIH-----YRK---FTHQSDVWSYGVTIWELMTFGGKP-------------YDGI-PTREIPDLL-EKGER----LPQPPICT--IDVYM-VMVKCWMIDADSRPKFKELAAE--F--
L-VLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLK-S--DAT-EKDLSDLISEMEMMKMIGKHKNIINLLGACT--QDGPLYVIVEYASKGNLREYLQ--ARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDI---HH--IDYYKKTTNGRLPVKWMAPEALF-----DRI---YTHQSDVWSFGVLLWEIFTLGGSP-------------YPGV-PVEELFKLL-KEGHR----MDKPSNCT--NELYM-MMRDCWHAVPSQRPTFKQLVEDL----
-LQLIKRLGNGQFGEVWMGTWN--------GNTKVAIKTLK-P--GTM-SP--ESFLEEAQIMKKL-KHDKLVQLYAVVS---EEPIYIVTEYMNKGSLLDFLK--DG--------------EGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLI----E--DNEYTARQGAKFPIKWTAPEAAL-----YGR---FTIKSDVWSFGILLTELVTKGRVP-------------YPGM-NNREVLEQV-ERGYR----MPCPQDCP--ISLHE-LMIHCWKKDPEERPTFEYLQSFL----
L-KYISQLGKGNFGSVELCRYDP---LGDNTGALVAVKQLQ-H--SGP-DQ-QRDFQREIQILKAL-HSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQ--RH---------------RARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLL--PLD--KDYYVVREPGQSPIFWYAPESLS-----DNI---FSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELL-EEGQR----LPAPPACP--AEVHE-LMKLCWAPSPQDRPSFSALGP---QL-
-LKLVERLGAGQFGEVWMGYYN--------GHTKVAVKSLK-Q--GSM-SP--DAFLAEANLMKQL-QHQRLVRLYAVVT---QEPIYIITEYMENGSLVDFLK--TP--------------SGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLI----E--DNEYTAREGAKFPIKWTAPEAIN-----YGT---FTIKSDVWSFGILLTEIVTHGRIP-------------YPGM-TNPEVIQNL-ERGYR----MVRPDNCP--EELYQ-LMRLCWKERPEDRPTFDYLRSV--L--
-IELGRCIGEGQFGDVHQGIYM----SPENPALAVAIKTCK-N--CTS-DSVREKFLQEALTMRQF-DHPHIVKLIGVIT---ENPVWIIMELCTLGELRSFLQ--VR---------------KYSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYM----E--DSTYYKASKGKLPIKWMAPESIN-----FRR---FTSASDVWMFGVCMWEILMHGVKP-------------FQGV-KNNDVIGRI-ENGER----LPMPPNCP--PTLYS-LMTKCWAYDPSRRPRFTELKAQL----
L-RLEVKLGQGCFGEVWMGTWN--------GTTRVAIKTLK-P--GTM-SP--EAFLQEAQVMKKL-RHEKLVQLYAVVS---EEPIYIVTEYMSKGSLLDFLK--GE--------------TGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLI----E--DNEYTARQGAKFPIKWTAPEAAL-----YGR---FTIKSDVWSFGILLTELTTKGRVP-------------YPGM-VNREVLDQV-ERGYR----MPCPPECP--ESLHD-LMCQCWRKEPEERPTFEYLQAF--L--
-WEIVGELGDGAFGKVYKAKNK-------ETGALAAAKVIETK--SEEELE--DYI-VEIEILATC-DHPYIVKLLGAYY--HDGKLWIMIEFCPGGAVDAIMLELDR-----------------GLTEPQIQVVCRQMLEALNFLHSKRIIHRDLKAGNVLMTLEGDIRLADFGVSAKN----LKTLQKRDS---FIGTPYWMAPEVVMCETMKDTP---YDYKADIWSLGITLIEMAQ-IEPP-------------HHEL-NPMRVLLKI-AKSDP----PTLLTPSKWSVEFRD-FLKIALDKNPETRPSAAQLLEHPFV--
L-RLLEKLGDGSFGVVRRGEWD----APSGKTVSVAVKCLK-PDVLSQ-PEAMDDFIREVNAMHSL-DHRNLIRLYGVVL---TPPMKMVTELAPLGSLLDRLR--KH---------------QGHFLLGTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRAL--PQN--DDHYVMQEHRKVPFAWCAPESLK-----TRT---FSHASDTWMFGVTLWEMFTYGQEP-------------WIGL-NGSQILHKIDKEGER----LPRPEDCP--QDIYN-VMVQCWAHKPEDRPTFVALRDF--L--
L-AFIKEIGSGQFGVVHLGEWR--------SHIQVAIKAIN-E--GSM-SE--EDFIEEAKVMMKL-SHSKLVQLYGVCI--QRKPLYIVTEFMENGCLLNYLR--EN---------------KGKLRKEMLLSVCQDICEGMEYLERNGYIHRDLAARNCLVSSTCIVKISDFGMTRYV----L--DDEYVSSFGAKFPIKWSPPEVFL-----FNK---YSSKSDVWSFGVLMWEVFTEGKMP-------------FENK-SNLQVVEAI-SEGFR----LYRPHLAP--MSIYE-VMYSCWHEKPEGRPTFAELLR---AV-
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