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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK EPHA1 203
TK ABL1 261
TK ABL2 288
Other AURKA 133
TK FGFR1 478
CAMK MELK 11
TK NTRK2 538
TK NTRK3 538
CAMK PRKAA2 16
TK SRC 270
Other ULK1 16
TK YES1 277
LM--VDTVIGEGEFGEVYRGTLR----LPSQDCK-TVAIKTLK-DT-SP-GGQWWNFL-R-EATIMGQF-SHPHILHLEGVVTKRKPIMIITEFMENGALDAFLR-ER---------------EDQLVPGQLVAMLQGIASGMNYLSNHNYVHRDLAARNILVNQNLCC---------KVSDFGLTRLLD-D--FDGT--------------YETQGGKIPIRWTAPEAIA-HRIFTTASDVWSFGIVMWEVLSFGDKPYGEMSNQEVMKSIEDGYRLPPPVDCP--APLYELMKNCWAYDRARRPHFQKLQAHL--
--ITMKHKLGGGQYGEVYEGVWK-------KYSL-TVAVKTLK-ED-TM-EV--EEFL-K-EAAVMKEI-KHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLR-EC--------------NRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLV---------KVADFGLSRLM--T--GDTY--------------TAHAGAKFPIKWTAPESLA-YNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCP--EKVYELMRACWQWNPSDRPSFAEIHQA--F
--ITMKHKLGGGQYGEVYVGVWK-------KYSL-TVAVKTLK-ED-TM-EV--EEFL-K-EAAVMKEI-KHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLR-EC--------------NREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVV---------KVADFGLSRLM--T--GDTY--------------TAHAGAKFPIKWTAPESLA-YNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCP--PKVYELMRACWKWSPADRPSFAETHQA--F
--FEIGRPLGKGKFGNVYLAREK-------QSKF-ILALKVLFKAQLEKAGV--EHQLRR-EVEIQSHL-RHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLS-----------------KFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGEL---------KIADFGWSV----HAPSSRR--------------TT---LCGTLDYLPPEMIE-GRMHDEKVDLWSLGVLCYEFLV-GKPPFEAN---TYQETYKRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLREVLEHPWI
-L-VLGKPLGEGCFGQVVLAEAIGLDKDKPNRVT-KVAVKMLK-SD-AT-EKDLSDLI-S-EMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQ-ARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVM---------KIADFGLARDIH-H--IDYY--------------KKTTNGRLPVKWMAPEALF-DRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCT--NELYMMMRDCWHAVPSQRPTFKQLVEDL--
--YELHETIGTGGFAKVKLACHI-------LTGE-MVAIKIMDKNT-LGSDL--PRIKT--EIEALKNL-RHQHICQLYHVLETANKIFMVLEYCPGGELFDYIISQD-----------------RLSEEETRVVFRQIVSAVAYVHSQGYAHRDLKPENLLFDEYHKL---------KLIDFGLCAKP-KGNKDYHL--------------QT---CCGSLAYAAPELIQGKSYLGSEADVWSMGILLYVLMC-GFLPFDDD---NVMALYKKIMRGKYDVPKWLSPSSILLLQQMLQVDPKKRISMKNLLNHPWI
-I-VLKRELGEGAFGKVFLAECYN--LCPEQDKI-LVAVKTLK-DA-SD-NA-RKDFH-R-EAELLTNL-QHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLR-AHGPDAV---LMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLV---------KIGDFGMSRDVY-S--TDYY--------------RVGGHTMLPIRWMPPESIM-YRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCP--QEVYELMLGCWQREPHMRKNIKGIHTL--L
-I-VLKRELGEGAFGKVFLAECYN--LSPTKDKM-LVAVKALK-DP-TL-AA-RKDFQ-R-EAELLTNL-QHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLR-AHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLV---------KIGDFGMSRDVY-S--TDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIM-YRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCP--KEVYDVMLGCWQREPQQRLNIKEIYKIL--
--YVLGDTLGVGTFGKVKIGEHQ-------LTGH-KVAVKILNRQK-IRSLD--VVGKIKREIQNLKLF-RHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHG-----------------RVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNA---------KIADFGLSNM---MSDGEFL--------------RT---SCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLC-GTLPFDDE---HVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWF
-L-RLEVKLGQGCFGEVWMGTWN--------GTT-RVAIKTLK-PG-TM-SP--EAFL-Q-EAQVMKKL-RHEKLVQLYAVVS-EEPIYIVTEYMSKGSLLDFLK-GE--------------TGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVC---------KVADFGLARLI--E--DNEY--------------TARQGAKFPIKWTAPEAAL-YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECP--ESLHDLMCQCWRKEPEERPTFEYLQAF--L
FS--RKDLIGHGAFAVVFKGRHR-------EKHDLEVAVKCINKKN-LAKSQ--T-LLGK-EIKILKEL-KHENIVALYDFQEMANSVYLVMEYCNGGDLADYLHAMR-----------------TLSEDTIRLFLQQIAGAMRLLHSKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARY---LQSNMMA--------------AT---LCGSPMYMAPEVIM-SQHYDGKADLWSIGTIVYQCLT-GKAPFQASSPQDLRLFYEKNKTLVPTIPRETSAPLRQLLLALLQRNHKDRMDFDEFFHHPFL
-L-RLEVKLGQGCFGEVWMGTWN--------GTT-KVAIKTLK-PG-TM-MP--EAFL-Q-EAQIMKKL-RHDKLVPLYAVVS-EEPIYIVTEFMSKGSLLDFLK-EG--------------DGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLVC---------KIADFGLARLI--E--DNEY--------------TARQGAKFPIKWTAPEAAL-YGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCP--ESLHELMNLCWKKDPDERPTFEYIQSFL--
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