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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK EPHA1 203
TK ABL1 261
TK ABL2 288
TKL BRAF 456
TK DDR1 572
TK FGFR1 478
TK FLT1 827
TK FLT4 845
TK KDR 834
TK KIT 589
TK LCK 245
TK MET 1078
TK PDGFRA 593
TK PDGFRB 600
TKL RIPK1 17
TK TEK 824
TK TIE1 839
-LM--VDTVIGEGEFGEVYRGTLR-------------LPSQDCKTVAIKTL-KD-TSPGGQWWNFLREATIMGQF-SHPHILHLEGVVT-KRKPIMIITEFMENGALDAFLRER--------------------------------------------------------------------------------------------------EDQLVPGQLVAMLQGIASGMNYLSNHNYVHRDLAARNILVNQNLCCKVSDFGLTRLL-------DDFDGT------YETQGGKIPIRWTAPEAIAHRI---FTTASDVWSFGIVMWEVLSFGD-KPYGEM-SNQEVMKSI----EDGYR----LP---PPVDCPAPLYELMKNCWAYDRARRPHFQKLQAHL--
---ITMKHKLGGGQYGEVYEGVWK----------------KYSLTVAVKTL-KE-DTMEV--EEFLKEAAVMKEI-KHPNLVQLLGVCT-REPPFYIITEFMTYGNLLDYLREC-------------------------------------------------------------------------------------------------NRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLM--------TGDTY------TAHAGAKFPIKWTAPESLAYNK---FSIKSDVWAFGVLLWEIATYGM-SPYPGI-DLSQVYELL----EKDYR----ME---RPEGCPEKVYELMRACWQWNPSDRPSFAEIHQA-F-
---ITMKHKLGGGQYGEVYVGVWK----------------KYSLTVAVKTL-KE-DTMEV--EEFLKEAAVMKEI-KHPNLVQLLGVCT-LEPPFYIVTEYMPYGNLLDYLREC-------------------------------------------------------------------------------------------------NREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLM--------TGDTY------TAHAGAKFPIKWTAPESLAYNT---FSIKSDVWAFGVLLWEIATYGM-SPYPGI-DLSQVYDLL----EKGYR----ME---QPEGCPPKVYELMRACWKWSPADRPSFAETHQA-F-
---ITVGQRIGSGSFGTVYKGKWH-------------------GDVAVKML-NVTAPTPQQLQAFKNEVGVLRKT-RHVNILLFMGYST--KPQLAIVTQWCEGSSLYHHLHII--------------------------------------------------------------------------------------------------ETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVK-------SRWSGS------HQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMT-GQ-LPYSNINNRDQIIFMV----GRGYLSPDLSK---VRSNCPKAMKRLMAECLKKKRDERPLFPQILA--SI
---LRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKIL-RP-DATKNARNDFLKEVKIMSRL-KDPNIIRLLGVCV-QDDPLCMITDYMENGDLNQFLSAHQLEDKAAE--------------------------------------------------------------------------------GAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGMSRNL-------YAGDYY------RVQGRAVLPIRWMAWECILMGK---FTTASDVWAFGVTLWEVLMLCRAQPFGQL-TDEQVIENAGEFFRDQGRQ-VYLS---RPPACPQGLYELMLRCWSRESEQRPPFSQLHRFL--
--L-VLGKPLGEGCFGQVVLAEAIGL---------DKDKPNRVTKVAVKML-KS-DATEKDLSDLISEMEMMKMIGKHKNIINLLGACT-QDGPLYVIVEYASKGNLREYLQARRPPGLEY-----------------------------------------------------------------------------------CYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDI-------HHIDYY------KKTTNGRLPVKWMAPEALFDRI---YTHQSDVWSFGVLLWEIFTLGG-SPYPGV-PVEELFKLL----KEGHR----MD---KPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDL--
---LKLGKSLGRGAFGKVVQASAFG-----------IKKSPTCRTVAVKML-KE-GATASEYKALMTELKILTHIGHHLNVVNLLGACTKQGGPLMVIVEYCKYGNLSNYLKSKRDLFFLNKDAALHMEPKKEKMEPGLEQGKKPR--------------------------------LDSVTSSESFASSGFQEDKSLSDVEEEEDSDGFYKEPITMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENNVVKICDFGLARDI-------YKNPDY------VRKGDTRLPLKWMAPESIFDKI---YSTKSDVWSYGVLLWEIFSLGG-SPYPGVQMDEDFCSRL----REGMR----MR---APEYSTPEIYQIMLDCWHRDPKERPRFAELVEKL--
---LHLGRVLGYGAFGKVVEASAFG-----------IHKGSSCDTVAVKML-KE-GATASEHRALMSELKILIHIGNHLNVVNLLGACTKPQGPLMVIVEFCKYGNLSNFLRAKRDAFSPCAEKSPEQRGRFRAMVELARLDRRR-----------------------------------PGSSDRVLFARFSKTEGGARRASPDQEAEDLWLSPLTMEDLVCYSFQVARGMEFLASRKCIHRDLAARNILLSESDVVKICDFGLARDI-------YKDPDY------VRKGSARLPLKWMAPESIFDKV---YTTQSDVWSFGVLLWEIFSLGA-SPYPGVQINEEFCQRL----RDGTR----MR---APELATPAIRRIMLNCWSGDPKARPAFSELVEIL--
---LKLGKPLGRGAFGQVIEADAFG-----------IDKTATCRTVAVKML-KE-GATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRL---------------------------------DSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDI-------YKDPDY------VRKGDARLPLKWMAPETIFDRV---YTIQSDVWSFGVLLWEIFSLGA-SPYPGVKIDEEFCRRL----KEGTR----MR---APDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHL--
---LSFGKTLGAGAFGKVVEATAYG-----------LIKSDAAMTVAVKML-KP-SAHLTEREALMSELKVLSYLGNHMNIVNLLGACT-IGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYM-----------------------DMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDI-------KNDSNY------VVKGNARLPVKWMAPESIFNCV---YTFESDVWSYGIFLWELFSLGS-SPYPGMPVDSKFYKMI----KEGFR----ML---SPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQL-I-
---LKLVERLGAGQFGEVWMGYYN-----------------GHTKVAVKSL-KQ-GSMSP--DAFLAEANLMKQL-QHQRLVRLYAVVT--QEPIYIITEYMENGSLVDFLKTP-------------------------------------------------------------------------------------------------SGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLI--------EDNEY------TAREGAKFPIKWTAPEAINYGT---FTIKSDVWSFGILLTEIVTHGR-IPYPGM-TNPEVIQNL----ERGYR----MV---RPDNCPEELYQLMRLCWKERPEDRPTFDYLRSV-L-
---VHFNEVIGRGHFGCVYHGTLL-------------DNDGKKIHCAVKSL-NR-ITDIGEVSQFLTEGIIMKDF-SHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNE--------------------------------------------------------------------------------------------------THNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDM-------YDKEYYS----VHNKTGAKLPVKWMALESLQTQK---FTTKSDVWSFGVLLWELMTRGA-PPYPDV-NTFDITVYL----LQGRR----LL---QPEYCPDPLYEVMLKCWHPKAEMRPSFSELVSR-I-
--L-VLGRVLGSGAFGKVVEGTAYG-----------LSRSQPVMKVAVKML-KP-TARSSEKQALMSELKIMTHLGPHLNIVNLLGACT-KSGPIYIITEYCFYGDLVNYLHKNRDSFLSHHPEKPKKELDIFGLNPADESTRSYVILSFENNGDYMDMKQA-DTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDI-------MHDSNY------VSKGSTFLPVKWMAPESIFDNL---YTTLSDVWSYGILLWEIFSLGG-TPYPGMMVDSTFYNKI----KSGYR----MA---KPDHATSEVYEIMVKCWNSEPEKRPSFYHLSE--IV
--L-VLGRTLGSGAFGQVVEATAHG-----------LSHSQATMKVAVKML-KS-TARSSEKQALMSELKIMSHLGPHLNVVNLLGACT-KGGPIYIITEYCRYGDLVDYLHRNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVLSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDI-------MRDSNY------ISKGSTFLPLKWMAPESIFNSL---YTTLSDVWSFGILLWEIFTLGG-TPYPELPMNEQFYNAI----KRGYR----MA---QPAHASDEIYEIMQKCWEEKFEIRPPFSQLVL--LL
LES----AELDSGGFGKVSLCFHR-----------------TQGLMIMKTVYKG-PNCIEHNEALLEEAKMMNRL-RHSRVVKLLGVII-EEGKYSLVMEYMEKGNLMHVLKAE---------------------------------------------------------------------------------------------------MSTPLSVKGRIILEIIEGMCYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNE--EHNELREVDGTAKKNGGTLYYMAPEHLNDVNA-KPTEKSDVYSFAVVLWAIFA-NK-EPYENAICEQQLIMCI----KSGNR----PDVDDITEYCPREIISLMKLCWEANPEARPTFPGIEEK-F-
---IKFQDVIGEGNFGQVLKARIK--------------KDGLRMDAAIKRM-KE-YASKDDHRDFAGELEVLCKLGHHPNIINLLGACE-HRGYLYLAIEYAPHGNLLDFLRKSRVLETDP-----------------------------------------------------------------------------------AFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQ----------EVY------VKKTMGRLPVRWMAIESLNYSV---YTTNSDVWSYGVLLWEIVSLGG-TPYCGM-TCAELYEKL----PQGYR----LE---KPLNCDDEVYDLMRQCWREKPYERPSFAQILV--SL
---ITFEDLIGEGNFGQVIRAMIK--------------KDGLKMNAAIKML-KE-YASENDHRDFAGELEVLCKLGHHPNIINLLGACK-NRGYLYIAIEYAPYGNLLDFLRKSRVLETDP-----------------------------------------------------------------------------------AFAREHGTASTLSSRQLLRFASDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSRGE----------EVY------VKKTMGRLPVRWMAIESLNYSV---YTTKSDVWSFGVLLWEIVSLGG-TPYCGM-TCAELYEKL----PQGYR----ME---QPRNCDDEVYELMRQCWRDRPYERPPFAQIALQ-L-
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