|
|
Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK EPHA2 203
TK ALK 1116
TK EPHA3 621
TK FGFR2 481
TKL IRAK4 186
TK LCK 245
TK PTK2B 425
--V-TRQKVIGAGEFGEVYKGMLKT---SSGKKEVPVAIKTLK-AGYT-EKQRV-DFL-G-EAGIMGQF-SHHNIIRLEGVISKYKPMMIITEYMENGALDKFLR----EK---------------DGEFSVLQLVGMLRGIAAGMKYLANMNYVHRDLAARNILVNS---NLVCKVSDFGLSRVL-E-D--DPEATYTTSGGKIPIRWTAPEAISYRKFTSASDVWSFGIVMWEVMTYGERPYWELSNHEVMKAINDGFRLPTPMDCP--------------SAIYQLMMQCWQQERARRPKFADIVSIL----
--I-TLIRGLGHGAFGEVYEGQVSG--MPNDPSPLQVAVKTLP-EVCS-EQDEL-DFL-M-EALIISKF-NHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLR----ETRP---------RPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDI-Y-R--ASYY-RKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCP--------------GPVYRIMTQCWQHQPEDRPNFAIILER-I---
--I-SIDKVVGAGEFGEVCSGRLK----LPSKKEISVAIKTLK-VGYT-EKQRR-DFL-G-EASIMGQF-DHPNIIRLEGVVTKSKPVMIVTEYMENGSLDSFLR----KH---------------DAQFTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILINS---NLVCKVSDFGLSRVL-E-D--DPEAAYTTRGGKIPIRWTSPEAIAYRKFTSASDVWSYGIVLWEVMSYGERPYWEMSNQDVIKAVDEGYRLPPPMDCP--------------AALYQLMLDCWQKDRNNRPKFEQIVSIL----
---LTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLK-DDAT-EKDLS-DLV-S-EMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLR----ARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTE---NNVMKIADFGLARDI-N-N--IDYY-KKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCT--------------NELYMMMRDCWHAVPSQRPTFKQLVEDL----
VGG----NKMGEGGFGVVYKGYVN-------NTT--VAVKKLAAMVDITTE--ELKQQFDQEIKVMAKC-QHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTP-----------------PLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDE---AFTAKISDFGLARASE-KFAQTVMT-SR---IVGTTAYMAPEALR-GEITPKSDIYSFGVVLLEIIT-GLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQ---LLQ
---LKLVERLGAGQFGEVWMGYYN--------GHTKVAVKSLK-QGSM-SP--D-AFL-A-EANLMKQL-QHQRLVRLYAVVT-QEPIYIITEYMENGSLVDFLK----TP--------------SGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSD---TLSCKIADFGLARLI---E--DNEY-TAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCP--------------EELYQLMRLCWKERPEDRPTFDYLRSV-L---
--V-VLNRILGEGFFGEVYEGVYT----NHKGEKINVAVKTCK-KDCT-LDNKE-KFM-S-EAVIMKNL-DHPHIVKLIGIIE-EEPTWIIMELYPYGELGHYLE----RN---------------KNSLKVLTLVLYSLQICKAMAYLESINCVHRDIAVRNILVAS---PECVKLGDFGLSRYI---E--DEDY-YKASVTRLPIKWMSPESINFRRFTTASDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCP--------------PVLYTLMTRCWDYDPSDRPRFTELVCS-L---
|