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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK EPHB3 203
CMGC CDC2 4
CMGC CDK2 4
CMGC GSK3B 56
TK JAK2 849
V-KIEEVIGAGEFGEVCRGRLK-QPGRREVFVAIKTLK-VGYT-ERQRRDFL-SEASIMGQFDHPNIIRLEGVVT--K----SRPVM--ILTEFMENC--ALDSFLR-----LNDGQFTVIQLVGMLRGIAAGMKYLSEMNYVHRDLAARNILVN-SNLVCKVSDFGLSRFLEDDPS--DPTYTSSLGGKIPIRWTAPEAIA-YRKFTSASDVWSYGIVMWEVMSYGERP---------------YWDMSNQDVINAVEQDYRLPPPMDCP----------------------------TALHQLMLDCWVRDRNLRPKFSQIVNTL----
-YTKIEKIGEGTYGVVYKGRHK----TTGQVVAMKKIRLESEEEGV--PSTAIREISLLKELRHPNIVSLQDVLM--Q----DSRLY--LIFEFLSM---DLKKYLDS-IPPGQ--YMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLID-DKGTIKLADFGLARAF----GIPIRVYTH---EVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELAT-KKPL---------------FHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF--
-FQKVEKIGEGTYGVVYKARNK----LTGEVVALKKIRLDTETEGV--PSTAIREISLLKELNHPNIVKLLDVIH--T----ENKLY--LVFEFLHQ---DLKKFMDA--SALT--GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLIN-TEGAIKLADFGLARAF----GVPVRTYTH---EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRAL---------------FPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF--
-YTDTKVIGNGSFGVVYQAKLC----DSGELVAIKKVLQDKRFKNR--------ELQIMRKLDHCNIVRLRYFFY--SSGEKKDEVYLNLVLDYVPETVYRVA---RHYSRAKQ--TLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQ-----LVRGEPNVS---YICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLL-GQPI---------------FPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFF--
-LKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQ-HSTE--EHLRDFE-REIEILKSLQHDNIVKYKGVCYSAG----RRNLK--LIMEYLPYG--SLRDYLQ-----KHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVE-NENRVKIGDFGLTKVL--PQD--KEYYKVKEPGESPIFWYAPESLT-ESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCP----------------------------DEIYMIMTECWNNNVNQRPSFRDLA----LRV
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