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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK EPHB4 203
TKL ACVR1B 207
TK BLK 241
TK BMX 422
TK CSK 195
TK EPHA1 624
TK EPHA2 613
TK EPHA3 621
TK EPHA4 621
TK EPHA5 675
TK EPHA6 631
TK EPHB2 621
TK EPHB3 633
TK FGR 263
TK FYN 271
TK PTK6 191
TKL TGFBR1 205
TK TXK 271
TK YES1 277
------V-KIEEVIGAGEFGEVCRGRLK-APGKKESCVAIKTLK-GGYT-ERQRREFLSEASIMGQFEHPNIIRLEGVVT-N----SMPVMILTEFMENGALDSFLRLN-DGQFTVIQLVGMLRGIASGMRYLAEM--------SYVHRDLAARNILVNSNLVCKVSDFGLSRFLE-ENS--S--DPTY-TSSLGGKIPIRWTAPEAIA------FRKFTSASDAWSYGIVMWEVMSFGE----------RPYWDM-----SNQDVINAIEQDYRLPPPPDCP------TSLHQ-LMLDCWQKDRNARPRFPQVVSAL---
-----IV--LQEIIGKGRFGEVWRGRWR----GGD--VAVKIFSSREERSWF--REA--EIYQTVMLRHENILGFIAADN-KDNGTWTQLWLVSDYHEHGSLFDYLNRY---TVTIEGMIKLALSAASGLAHLHMEIVGTQGKPGIAHRDLKSKNILVKKNGMCAIADLGLAVRHDA---VTDTIDIAP-NQ---RVGTKRYMAPEVLDETINMKHFDSFKCADIYALGLVYWEIAR-RCNSGGVHEEYQLPYYDLVPSDPSIEEMRKVVCDQKLRPNIPNWWQSYEALRVMGK-MMRECWYANGAARLTALRIKK---TL
------L-RLVRKLGSGQFGEVWMGYYK-----NNMKVAIKTLK-EGTM-SP--EAFLGEANVMKALQHERLVRLYAVVT------KEPIYIVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQIAEGMAYIERM--------NSIHRDLRAANILVSEALCCKIADFGLARII----------DSEY-TAQEGAKFPIKWTAPEAIH------FGVFTIKADVWSFGVLLMEVVTYGR----------VPYPGM-----SNPEVIRNLERGYRMPRPDTCP------PELYRGVIAECWRSRPEERPTFEFLQSV-L--
-------ITLLKELGSGQFGVVQLGKWK-----GQYDVAVKMIK-EGSM-SE--DEFFQEAQTMMKLSHPKLVKFYGVCS-K----EYPIYIVTEYISNGCLLNYLRSH-GKGLEPSQLLEMCYDVCEGMAFLESH--------QFIHRDLAARNCLVDRDLCVKVSDFGMTRYV-------L--DDQY-VSSVGTKFPVKWSAPEVFH------YFKYSSKSDVWAFGILMWEVFSLGK----------QPYDLY-----DNSQVVLKVSQGHRLYRPHLAS------DTIYQ-IMYSCWHELPEKRPTFQQLLSS-I--
-------LKLLQTIGKGEFGDVMLGDYR------GNKVAVKCIK-NDAT-AQ---AFLAEASVMTQLRHSNLVQLLGVIVEE----KGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGN--------NFVHRDLAARNVLVSEDNVAKVSDFGLTKEA-------------S-STQDTGKLPVKWTAPEALR------EKKFSTKSDVWSFGILLWEIYSFGR----------VPYPRI-----PLKDVVPRVEKGYKMDAPDGCP------PAVYE-VMKNCWHLDAAMRPSFLQLREQL---
-----LM--VDTVIGEGEFGEVYRGTLR-LPSQDCKTVAIKTLK-DTSP-GGQWWNFLREATIMGQFSHPHILHLEGVVT-K----RKPIMIITEFMENGALDAFLRER-EDQLVPGQLVAMLQGIASGMNYLSNH--------NYVHRDLAARNILVNQNLCCKVSDFGLTRLL----D--D--FDGT-YETQGGKIPIRWTAPEAIA------HRIFTTASDVWSFGIVMWEVLSFGD----------KPYGEM-----SNQEVMKSIEDGYRLPPPVDCP------APLYE-LMKNCWAYDRARRPHFQKLQAHL---
------V-TRQKVIGAGEFGEVYKGMLKTSSGKKEVPVAIKTLK-AGYT-EKQRVDFLGEAGIMGQFSHHNIIRLEGVIS-K----YKPMMIITEYMENGALDKFLREK-DGEFSVLQLVGMLRGIAAGMKYLANM--------NYVHRDLAARNILVNSNLVCKVSDFGLSRVL----E--D--DPEATYTTSGGKIPIRWTAPEAIS------YRKFTSASDVWSFGIVMWEVMTYGE----------RPYWEL-----SNHEVMKAINDGFRLPTPMDCP------SAIYQ-LMMQCWQQERARRPKFADIVSIL---
------I-SIDKVVGAGEFGEVCSGRLK-LPSKKEISVAIKTLK-VGYT-EKQRRDFLGEASIMGQFDHPNIIRLEGVVT-K----SKPVMIVTEYMENGSLDSFLRKH-DAQFTVIQLVGMLRGIASGMKYLSDM--------GYVHRDLAARNILINSNLVCKVSDFGLSRVL----E--D--DPEAAYTTRGGKIPIRWTSPEAIA------YRKFTSASDVWSYGIVLWEVMSYGE----------RPYWEM-----SNQDVIKAVDEGYRLPPPMDCP------AALYQ-LMLDCWQKDRNNRPKFEQIVSIL---
-------IKIEKVIGVGEFGEVCSGRLK-VPGKREICVAIKTLK-AGYT-DKQRRDFLSEASIMGQFDHPNIIHLEGVVT-K----CKPVMIITEYMENGSLDAFLRKN-DGRFTVIQLVGMLRGIGSGMKYLSDM--------SYVHRDLAARNILVNSNLVCKVSDFGMSRVL----E--D--DPEAAYTTRGGKIPIRWTAPEAIA------YRKFTSASDVWSYGIVMWEVMSYGE----------RPYWDM-----SNQDVIKAIEEGYRLPPPMDCP------IALHQ-LMLDCWQKERSDRPKFGQIVNML---
-------ITIERVIGAGEFGEVCSGRLK-LPGKRELPVAIKTLK-VGYT-EKQRRDFLGEASIMGQFDHPNIIHLEGVVT-K----SKPVMIVTEYMENGSLDTFLKKN-DGQFTVIQLVGMLRGISAGMKYLSDM--------GYVHRDLAARNILINSNLVCKVSDFGLSRVL----E--D--DPEAAYTTRGGKIPIRWTAPEAIA------FRKFTSASDVWSYGIVMWEVVSYGE----------RPYWEM-----TNQDVIKAVEEGYRLPSPMDCP------AALYQ-LMLDCWQKERNSRPKFDEIVNML---
LPPRIPA-------------------------------------------------------------------------------GRPVMIVVEYMENGSLDSFLRKH-DGHFTVIQLVGMLRGIASGMKYLSDM--------GYVHRDLAARNILVNSNLVCKVSDFGLSRVL----E--D--DPEAAYTTTGGKIPIRWTAPEAIA------YRKFSSASDAWSYGIVMWEVMSYGE----------RPYWEM-----SNQDVILSIEEGYRLPAPMGCP------ASLHQ-LMLHCWQKERNHRPKFTDIVSFL---
------V-KIEQVIGAGEFGEVCSGHLK-LPGKREIFVAIKTLK-SGYT-EKQRRDFLSEASIMGQFDHPNVIHLEGVVT-K----STPVMIITEFMENGSLDSFLRQN-DGQFTVIQLVGMLRGIAAGMKYLADM--------NYVHRDLAARNILVNSNLVCKVSDFGLSRFLE-DDT--S--DPTY-TSALGGKIPIRWTAPEAIQ------YRKFTSASDVWSYGIVMWEVMSYGE----------RPYWDM-----TNQDVINAIEQDYRLPPPMDCP------SALHQ-LMLDCWQKDRNHRPKFGQIVNTL---
------V-KIEEVIGAGEFGEVCRGRLK-QPGRREVFVAIKTLK-VGYT-ERQRRDFLSEASIMGQFDHPNIIRLEGVVT-K----SRPVMILTEFMENCALDSFLRLN-DGQFTVIQLVGMLRGIAAGMKYLSEM--------NYVHRDLAARNILVNSNLVCKVSDFGLSRFLE-DDP--S--DPTY-TSSLGGKIPIRWTAPEAIA------YRKFTSASDVWSYGIVMWEVMSYGE----------RPYWDM-----SNQDVINAVEQDYRLPPPMDCP------TALHQ-LMLDCWVRDRNLRPKFSQIVNTL---
-------ITLERRLGTGCFGDVWLGTWN-----GSTKVAVKTLK-PGTM-SP--KAFLEEAQVMKLLRHDKLVQLYAVVS------EEPIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEGMAYMERM--------NYIHRDLRAANILVGERLACKIADFGLARLI-------K--DDEY-NPCQGSKFPIKWTAPEAAL------FGRFTIKSDVWSFGILLTELITKGR----------IPYPGM-----NKREVLEQVEQGYHMPCPPGCP------ASLYE-AMEQTWRLDPEERPTFEYLQSFL---
-------LQLIKRLGNGQFGEVWMGTWN-----GNTKVAIKTLK-PGTM-SP--ESFLEEAQIMKKLKHDKLVQLYAVVS------EEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERM--------NYIHRDLRSANILVGNGLICKIADFGLARLI-------E--DNEY-TARQGAKFPIKWTAPEAAL------YGRFTIKSDVWSFGILLTELVTKGR----------VPYPGM-----NNREVLEQVERGYRMPCPQDCP------ISLHE-LMIHCWKKDPEERPTFEYLQSFL---
------F-TLCRKLGSGYFGEVFEGLWK-----DRVQVAIKVIS-RDNL-LH-QQMLQSEIQAMKKLRHKHILALYAVVS-V----GDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMCYLESQ--------NYIHRDLAARNILVGENTLCKVGDFGLARLI----------KEDV-YLSHDHNIPYKWTAPEALS------RGHYSTKSDVWSFGILLHEMFSRGQ----------VPYPGM-----SNHEAFLRVDAGYRMPCPLECP------PSVHK-LMLTCWCRDPEQRPCFKALRERL---
-----IV--LQESIGKGRFGEVWRGKWR----GEE--VAVKIFSSREERSWF--REA--EIYQTVMLRHENILGFIAADN-KDNGTWTQLWLVSDYHEHGSLFDYLNRY---TVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDS---ATDTIDIAP-NH---RVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIAR-RCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAK-IMRECWYANGAARLTALRIKK---TL
------L-AFIKEIGSGQFGVVHLGEWR-----SHIQVAIKAIN-EGSM-SE--EDFIEEAKVMMKLSHSKLVQLYGVCI-Q----RKPLYIVTEFMENGCLLNYLREN-KGKLRKEMLLSVCQDICEGMEYLERN--------GYIHRDLAARNCLVSSTCIVKISDFGMTRYV-------L--DDEY-VSSFGAKFPIKWSPPEVFL------FNKYSSKSDVWSFGVLMWEVFTEGK----------MPFENK-----SNLQVVEAISEGFRLYRPHLAP------MSIYE-VMYSCWHEKPEGRPTFAELLR--AV-
------L-RLEVKLGQGCFGEVWMGTWN-----GTTKVAIKTLK-PGTM-MP--EAFLQEAQIMKKLRHDKLVPLYAVVS------EEPIYIVTEFMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIERM--------NYIHRDLRAANILVGENLVCKIADFGLARLI-------E--DNEY-TARQGAKFPIKWTAPEAAL------YGRFTIKSDVWSFGILQTELVTKGR----------VPYPGM-----VNREVLEQVERGYRMPCPQGCP------ESLHE-LMNLCWKKDPDERPTFEYIQSFL---
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