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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK FER 203
TK ABL1 261
TK ALK 1116
TKL BRAF 456
CAMK CHEK2 220
TK DDR1 572
TK EGFR 712
TK FGFR1 478
TK FGFR4 467
TK FGR 263
TK FYN 271
TK ITK 363
TK JAK1 875
TK JAK2 849
TK JAK3 822
TKL MAP3K7 36
TK PTK2 422
TK PTK2B 425
TK PTK6 191
TK RET 724
TKL RIPK2 18
TK SYK 371
TKL TNNI3K 463
TK ZAP70 338
--VI--LGELLGKGNFGEVYKGTLK-----------------DKTSVAVKTCK-E--DLP-QEL-KIKFL-Q------EAKILKQY-DHPNIVKLIGVCT--QRQP--VYIIMELVSGGDFLTFLR-RK-----------------------K-DEL---KLKQLVKFSLDAAAGMLYLES--K--N---CIHRDLAARNCLVGE---NN-VL---KISDFGMSRQE-------D--GGVY-SSSGLKQIPIKWTAPEALN---YGR---YSSESDVWSFGILLWETFSLGV-CP---------------YPGM---TNQQAREQV----ERGYR----MSAPQHCP------EDISKIMMKCWDYKPENRPKFSELQKEL-----
----ITMKHKLGGGQYGEVYEGVWK----------------KYSLTVAVKTLK-E--DTM-EV---EEFL-K------EAAVMKEI-KHPNLVQLLGVCT--REPP--FYIITEFMTYGNLLDYLR-EC----------------------NR-QEV---NAVVLLYMATQISSAMEYLEK--K--N---FIHRDLAARNCLVGE---NH-LV---KVADFGLSRLM-------T--GDTY-TAHAGAKFPIKWTAPESLA---YNK---FSIKSDVWAFGVLLWEIATYGM-SP---------------YPGI---DLSQVYELL----EKDYR----MERPEGCP------EKVYELMRACWQWNPSDRPSFAEIHQA--F---
---I-TLIRGLGHGAFGEVYEGQVSG-----------MPNDPSPLQVAVKTLP-E--VCS-EQD-ELDFL-M------EALIISKF-NHQNIVRCIGVSL--QSLP--RFILLELMAGGDLKSFLR-ETRP-----------------RPSQP-SSL---AMLDLLHVARDIACGCQYLEE--N--H---FIHRDIAARNCLLTCPGPGR-VA---KIGDFGMARDI---Y---R--ASYY-RKGGCAMLPVKWMPPEAFM---EGI---FTSKTDTWSFGVLLWEIFSLGY-MP---------------YPSK---SNQEVLEFV----TSGGR----MDPPKNCP------GPVYRIMTQCWQHQPEDRPNFAIILER--I---
----ITVGQRIGSGSFGTVYKGKWH-------------------GDVAVKMLN-V-TAPT-PQQ-LQAFK-N------EVGVLRKT-RHVNILLFMGYST---KPQ--LAIVTQWCEGSSLYHHLH-II-----------------------E-TKF---EMIKLIDIARQTAQGMDYLHA--K--S---IIHRDLKSNNIFLHE---DL-TV---KIGDFGLATVK---S---R--WSGS-HQFEQLSGSILWMAPEVIR---MQDKNPYSFQSDVYAFGIVLYELMT-GQ-LP---------------YSNI-N-NRDQIIFMV----GRGYLSPDLSKVRSNCP------KAMKRLMAECLKKKRDERPLFPQILA---SI--
--YI--MSKTLGSGACGEVKLAFER----------------KTCKKVAIKIISKR--KFAIGS---AREADPALNVETEIEILKKL-NHPCIIKIKNFF---DAED--YYIVLELMEGGELFDKVVGNK--------------------------RL---KEATCKLYFYQMLLAVQYLHE--N--G---IIHRDLKPENVLLSS---QE-EDCLIKITDFGHSKI--------LGETSLM-RT---LCGTPTYLAPEVLVSVGTAG---YNRAVDCWSLGVILFICLS-GY-PP---------------FSEH-----RTQVSLK----DQITS----GKYNFIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEALRHPWL---
----LRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILR-P--DAT-KNA-RNDFL-K------EVKIMSRL-KDPNIIRLLGVCV--QDDP--LCMITDYMENGDLNQFLS-AHQLEDKAAE-----GAPGDGQAAQG-PTI---SYPMLLHVAAQIASGMRYLAT--L--N---FVHRDLATRNCLVGE---NF-TI---KIADFGMSRNL---Y---A--GDYY-RVQGRAVLPIRWMAWECIL---MGK---FTTASDVWAFGVTLWEVLMLCRAQP---------------FGQL---TDEQVIENAGEFFRDQGRQ-VYLSRPPACP------QGLYELMLRCWSRESEQRPPFSQLHRFL-----
---F-KKIKVLGSGAFGTVYKGLWIP------------EGEKVKIPVAIKELR-E--ATS-PKA-NKEIL-D------EAYVMASV-DNPHVCRLLGICL---TST--VQLITQLMPFGCLLDYVR-EH-----------------------K-DNI---GSQYLLNWCVQIAKGMNYLED--R--R---LVHRDLAARNVLVKT---PQ-HV---KITDFGLAKLL---G---A--EEKE-YHAEGGKVPIKWMALESIL---HRI---YTHQSDVWSYGVTVWELMTFGS-KP---------------YDGI---PASEISSIL----EKGER----LPQPPICT------IDVYMIMVKCWMIDADSRPKFRELI----IEF-
---L-VLGKPLGEGCFGQVVLAEAIGL---------DKDKPNRVTKVAVKMLK-S--DAT-EKD-LSDLI-S------EMEMMKMIGKHKNIINLLGACT--QDGP--LYVIVEYASKGNLREYLQ-ARRPPGLEY--------CYNPSHNPE-EQL---SSKDLVSCAYQVARGMEYLAS--K--K---CIHRDLAARNVLVTE---DN-VM---KIADFGLARDI---H---H--IDYY-KKTTNGRLPVKWMAPEALF---DRI---YTHQSDVWSFGVLLWEIFTLGG-SP---------------YPGV---PVEELFKLL----KEGHR----MDKPSNCT------NELYMMMRDCWHAVPSQRPTFKQLVEDL-----
---L-VLGKPLGEGCFGQVVRAEAFGM---------DPARPDQASTVAVKMLK-D--NAS-DKD-LADLV-S------EMEVMKLIGRHKNIINLLGVCT--QEGP--LYVIVECAAKGNLREFLR-ARRPPGPDL--------SPDGPRSSE-GPL---SFPVLVSCAYQVARGMQYLES--R--K---CIHRDLAARNVLVTE---DN-VM---KIADFGLARGV---H---H--IDYY-KKTSNGRLPVKWMAPEALF---DRV---YTHQSDVWSFGILLWEIFTLGG-SP---------------YPGI---PVEELFSLL----REGHR----MDRPPHCP------PELYGLMRECWHAAPSQRPTFKQLVEAL-----
----ITLERRLGTGCFGDVWLGTWN-----------------GSTKVAVKTLK-P--GTM-SP---KAFL-E------EAQVMKLL-RHDKLVQLYAVVS---EEP--IYIVTEFMCHGSLLDFLK-NP----------------------EG-QDL---RLPQLVDMAAQVAEGMAYMER--M--N---YIHRDLRAANILVGE---RL-AC---KIADFGLARLI-------K--DDEY-NPCQGSKFPIKWTAPEAAL---FGR---FTIKSDVWSFGILLTELITKGR-IP---------------YPGM---NKREVLEQV----EQGYH----MPCPPGCP------ASLYEAMEQTWRLDPEERPTFEYLQSFL-----
----LQLIKRLGNGQFGEVWMGTWN-----------------GNTKVAIKTLK-P--GTM-SP---ESFL-E------EAQIMKKL-KHDKLVQLYAVVS---EEP--IYIVTEYMNKGSLLDFLK-DG----------------------EG-RAL---KLPNLVDMAAQVAAGMAYIER--M--N---YIHRDLRSANILVGN---GL-IC---KIADFGLARLI-------E--DNEY-TARQGAKFPIKWTAPEAAL---YGR---FTIKSDVWSFGILLTELVTKGR-VP---------------YPGM---NNREVLEQV----ERGYR----MPCPQDCP------ISLHELMIHCWKKDPEERPTFEYLQSFL-----
----LTFVQEIGSGQFGLVHLGYWL-----------------NKDKVAIKTIR-E--GAM-SE---EDFI-E------EAEVMMKL-SHPKLVQLYGVCL--EQAP--ICLVFEFMEHGCLSDYLR-TQ-----------------------R-GLF---AAETLLGMCLDVCEGMAYLEE--A--C---VIHRDLAARNCLVGE---NQ-VI---KVSDFGMTRFV-------L--DDQY-TSSTGTKFPVKWASPEVFS---FSR---YSSKSDVWSFGVLMWEVFSEGK-IP---------------YENR---SNSEVVEDI----STGFR----LYKPRLAS------THVYQIMNHCWKERPEDRPAFSRLLRQL-----
---L-KRIRDLGEGHFGKVELCRYDP------------EGDNTGEQVAVKSLK-P--ESG-GNH-IADLK-K------EIEILRNL-YHENIVKYKGICT-ED-GGNGIKLIMEFLPSGSLKEYLP-KN-----------------------K-NKI---NLKQQLKYAVQICKGMDYLGS--R--Q---YVHRDLAARNVLVES---EH-QV---KIGDFGLTKAI--ET---D--KEYY-TVKDDRDSPVFWYAPECLM---QSK---FYIASDVWSFGVTLHELLTYCD-SDSSPMALF-LKMIGPTHGQM---TVTRLVNTL----KEGKR----LPCPPNCP------DEVYQLMRKCWEFQPSNRTSFQNLIE---GF--
----LKFLQQLGKGNFGSVEMCRYDP------------LQDNTGEVVAVKKLQ-H--STE--EH-LRDFE-R------EIEILKSL-QHDNIVKYKGVCYSAGRRN--LKLIMEYLPYGSLRDYLQ-KH-----------------------K-ERI---DHIKLLQYTSQICKGMEYLGT--K--R---YIHRDLATRNILVEN---EN-RV---KIGDFGLTKVL--PQ---D--KEYY-KVKEPGESPIFWYAPESLT---ESK---FSVASDVWSFGVVLYELFTYIE-KSKSPPAEFMRMIGNDKQGQM---IVFHLIELL----KNNGR----LPRPDGCP------DEIYMIMTECWNNNVNQRPSFRDLA----LRV-
---L-KYISQLGKGNFGSVELCRYDP------------LGDNTGALVAVKQLQ-H--SGP-DQ--QRDFQ-R------EIQILKAL-HSDFIVKYRGVSYGPGRQS--LRLVMEYLPSGCLRDFLQ-RH-----------------------R-ARL---DASRLLLYSSQICKGMEYLGS--R--R---CVHRDLAARNILVES---EA-HV---KIADFGLAKLL--PL---D--KDYY-VVREPGQSPIFWYAPESLS---DNI---FSRQSDVWSFGVVLYELFTYCD-KSCSPSAE--FLRMMGCERDV-P-ALCRLLELL----EEGQR----LPAPPACP------AEVHELMKLCWAPSPQDRPSFSALGP---QL--
----IEVEEVVGRGAFGVVCKAKWR------------------AKDVAIKQIE------S-ESE-RKAFI-V------ELRQLSRV-NHPNIVKLYGACL----NP--VCLVMEYAEGGSLYNVLH-GA----------------------EPLPYY---TAAHAMSWCLQCSQGVAYLHS--M--QPKALIHRDLKPPNLLLVA---GGTVL---KICDFGTACDI-------------Q-THMTNNKGSAAWMAPEVFE---GSN---YSEKCDVFSWGIILWEVITR-R-KP---------------FDEIGG-PAFRIMWAV----HNGTR----PPLIKNLP------KPIESLMTRCWSKDPSQRPSMEEIVKI--M---
----IELGRCIGEGQFGDVHQGIYM-------------SPENPALAVAIKTCK-N--CTS-DSV-REKFL-Q------EALTMRQF-DHPHIVKLIGVIT---ENP--VWIIMELCTLGELRSFLQ-VR-----------------------K-YSL---DLASLILYAYQLSTALAYLES--K--R---FVHRDIAARNVLVSS---ND-CV---KLGDFGLSRYM-------E--DSTY-YKASKGKLPIKWMAPESIN---FRR---FTSASDVWMFGVCMWEILMHGV-KP---------------FQGV---KNNDVIGRI----ENGER----LPMPPNCP------PTLYSLMTKCWAYDPSRRPRFTELKAQL-----
---V-VLNRILGEGFFGEVYEGVYT-------------NHKGEKINVAVKTCK-K--DCT-LDN-KEKFM-S------EAVIMKNL-DHPHIVKLIGIIE---EEP--TWIIMELYPYGELGHYLE-RN-----------------------K-NSL---KVLTLVLYSLQICKAMAYLES--I--N---CVHRDIAVRNILVAS---PE-CV---KLGDFGLSRYI-------E--DEDY-YKASVTRLPIKWMSPESIN---FRR---FTTASDVWMFAVCMWEILSFGK-QP---------------FFWL---ENKDVIGVL----EKGDR----LPKPDLCP------PVLYTLMTRCWDYDPSDRPRFTELVCS--L---
---F-TLCRKLGSGYFGEVFEGLWK-----------------DRVQVAIKVIS-R--DNL-LH--QQMLQ-S------EIQAMKKL-RHKHILALYAVVS--VGDP--VYIITELMAKGSLLELLR-DS----------------------DE-KVL---PVSELLDIAWQVAEGMCYLES--Q--N---YIHRDLAARNILVGE---NT-LC---KVGDFGLARLI----------KEDV-YLSHDHNIPYKWTAPEALS---RGH---YSTKSDVWSFGILLHEMFSRGQ-VP---------------YPGM---SNHEAFLRV----DAGYR----MPCPLECP------PSVHKLMLTCWCRDPEQRPCFKALRERL-----
---L-VLGKTLGEGEFGKVVKATAFH-----------LKGRAGYTTVAVKMLK-E--NAS-PSE-LRDLL-S------EFNVLKQV-NHPHVIKLYGACS--QDGP--LLLIVEYAKYGSLRGFLR-ESRKVGPGYLGSGGSRNSSSLDHPDE-RAL---TMGDLISFAWQISQGMQYLAE--M--K---LVHRDLAARNILVAE---GR-KM---KISDFGLSRDV---Y---E--EDSY-VKRSQGRIPVKWMAIESLF---DHI---YTTQSDVWSFGVLLWEIVTLGG-NP---------------YPGI---PPERLFNLL----KTGHR----MERPDNCS------EEMYRLMLQCWKQEPDKRPVFADISKDL-----
-LAD---LRYLSRGASGTVSSARHA----------------DWRVQVAVKHLHIH--TPLLDS---ERKDVL-----REAEILHKA-RFSYILPILGICN--EPEF--LGIVTEYMPNGSLNELLHRKT--------------------------EYPDVAWPLRFRILHEIALGVNYLHN--MTPP---LLHHDLKTQNILLDN---EF-HV---KIADFGLSKWRMM--SLSQSRSSKS-AP---EGGTIIYMPPENYEPGQKSR---ASIKHDIYSYAVITWEVLS-RK-QP---------------FEDVT-NPLQIMYSVS----QGHRP----VINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCL-----IEL
-TLE---DKELGSGNFGTVKKGYYQ--------------MKKVVKTVAVKILK-N--EAN-DPALKDELL-A------EANVMQQL-DNPYIVRMIGICE---AES--WMLVMEMAELGPLNKYLQ-QN-------------------------RHV---KDKNIIELVHQVSMGMKYLEE--S--N---FVHRDLAARNVLLVT---QH-YA---KISDFGLSKAL---R---A--DENYYKAQTHGKWPVKWYAPECIN---YYK---FSSKSDVWSFGVLMWEAFSYGQ-KP---------------YRGM---KGSEVTAML----EKGER----MGCPAGCP------REMYDLMNLCWTYDVENRPGFAAVE----LRL-
----IEFHEIIGSGSFGKVYKGRCR------------------NKIVAIKRYR-ANTYCS-KSD-VDMFC-R------EVSILCQL-NHPCVIQFVGACL-NDPSQ--FAIVTQYISGGSLFSLLH-EQ-----------------------K-RIL---DLQSKLIIAVDVAKGMEYLHNLTQ--P---IIHRDLNSHNILLYE---DG-HA---VVADFGESRFL---Q---S--LD-E-DNMTKQPGNLRWMAPEVFT---QCT--RYTIKADVFSYALCLWEILT-GE-IP---------------FAHL---KPAAAAADM---AYHHIR----PPIGYSIP------KPISSLLIRGWNACPEGRPEFSEVVMKL-----
LIAD----IELGCGNFGSVRQGVYR--------------MRKKQIDVAIKVLK-Q--GTE-KAD-TEEMM-R------EAQIMHQL-DNPYIVRLIGVCQ---AEA--LMLVMEMAGGGPLHKFLV-GK-----------------------R-EEI---PVSNVAELLHQVSMGMKYLEE--K--N---FVHRDLAARNVLLVN---RH-YA---KISDFGLSKAL--GA---D--DSYY-TARSAGKWPLKWYAPECIN---FRK---FSSRSDVWSYGVTMWEALSYGQ-KP---------------YKKM---KGPEVMAFI----EQGKR----MECPPECP------PELYALMSDCWIYKWEDRPDFLTVEQR--M---
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