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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK FGFR1 203
TK ABL1 261
TK ABL2 288
TK ALK 1116
Other AURKB 77
Other AURKC 43
CMGC CDK2 4
CMGC CDKL2 4
Other CHUK 15
TK CSF1R 582
TK DDR1 572
TK DDR2 563
TK EPHA6 631
TK EPHB1 619
TK EPHB4 615
TK EPHB6 670
TK FGFR2 481
TK FGFR3 472
TK FGFR4 467
TK FGR 263
TK FLT4 845
TK FRK 234
TK FYN 271
CMGC ICK 4
TK IGF1R 999
TK INSR 1023
TK INSRR 979
TKL IRAK4 186
TK JAK2 849
TK JAK3 822
TK KDR 834
TK KIT 589
TK LCK 245
TK LTK 510
TK LYN 247
STE MAP4K3 16
STE MAP4K4 25
STE MAP4K5 20
CMGC MAPK14 24
CAMK MARK1 60
CAMK MARK2 53
CAMK MARK3 56
CAMK MARK4 59
CAMK MELK 11
TK MET 1078
STE MINK1 25
TK MUSK 575
TK NTRK1 510
TK NTRK2 538
TK NTRK3 538
CAMK NUAK1 55
CAMK NUAK2 97
STE PAK2 249
STE PAK3 268
TK PDGFRA 593
TK PDGFRB 600
AGC PKN1 615
CAMK PRKAA1 18
CAMK PRKAA2 16
TK PTK2 422
TK RET 724
TKL RIPK1 17
TK ROS1 1945
AGC RPS6KB1 91
CAMK SIK1 27
CAMK SIK2 20
STE SLK 34
TK SRC 270
STE STK10 36
STE STK24 24
TK TEK 824
TK TIE1 839
STE TNIK 25
TK TNK1 116
TK TNK2 150
TK YES1 277
TK ZAP70 338
------L-VLGKPLGEGCFGQVVLAEA---IGL---------DKDKPNRVTKVAVKML---K-S--DAT-EKDLS-DLI-S--EMEMMKMIG-K---HKNIINLLGACT--Q------DGPLYVIVEYASKGNLREYLQ------------------------ARRPPGLEY-----------------------------------------------------------------------------------CYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTE-----DNVM---KIADFGLARDI-------H-H--IDYY--------------KKTTNGRLPVKWMAPEA--LF-----DRI--YTHQSDVWSFGVLLWEIFTLGG-SP---------------YPGV-----------PVEELFKLL----KE----GHR---MD---KPSNCT------------------------------NELYMMMRDCWHAVPSQRPT-----FKQLVEDL-----------
-------ITMKHKLGGGQYGEVYEGVW---K----------------KYSLTVAVKTL---K-E--DTM-EV--E-EFL-K--EAAVMKEI--K---HPNLVQLLGVCT--R------EPPFYIITEFMTYGNLLDYLR------------------------EC-------------------------------------------------------------------------------------------------NRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGE-----NHLV---KVADFGLSRLM---------T--GDTY--------------TAHAGAKFPIKWTAPES--LA-----YNK--FSIKSDVWAFGVLLWEIATYGM-SP---------------YPGI-----------DLSQVYELL----EK----DYR---ME---RPEGCP------------------------------EKVYELMRACWQWNPSDRPS-----FAEIHQA--F---------
-------ITMKHKLGGGQYGEVYVGVW---K----------------KYSLTVAVKTL---K-E--DTM-EV--E-EFL-K--EAAVMKEI--K---HPNLVQLLGVCT--L------EPPFYIVTEYMPYGNLLDYLR------------------------EC-------------------------------------------------------------------------------------------------NREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGE-----NHVV---KVADFGLSRLM---------T--GDTY--------------TAHAGAKFPIKWTAPES--LA-----YNT--FSIKSDVWAFGVLLWEIATYGM-SP---------------YPGI-----------DLSQVYDLL----EK----GYR---ME---QPEGCP------------------------------PKVYELMRACWKWSPADRPS-----FAETHQA--F---------
------I-TLIRGLGHGAFGEVYEGQV---SG-----------MPNDPSPLQVAVKTL---P-E--VCS-EQDEL-DFL-M--EALIISKF--N---HQNIVRCIGVSL--Q------SLPRFILLELMAGGDLKSFLR------------------------ETRP--------------------------------------------------------------------------------------------RPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCP--GPGRVA---KIGDFGMARDI-------Y-R--ASYY--------------RKGGCAMLPVKWMPPEA--FM-----EGI--FTSKTDTWSFGVLLWEIFSLGY-MP---------------YPSK-----------SNQEVLEFV----TS----GGR---MD---PPKNCP------------------------------GPVYRIMTQCWQHQPEDRPN-----FAIILER--I---------
-------FEIGRPLGKGKFGNVYLARE---K----------------KSHFIVALKVL---FKS--QIEKEG--V-EHQLR-REIEIQAHL--H---HPNILRLYNYFY--D------RRRIYLILEYAPRGELYKELQ-----------------------KSC----------------------------------------------------------------------------------------------------TFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLGL-----KGEL---KIADFGWSV-----------HAPSLRR--------------KT---MCGTLDYLPPEM--IE-----GRM--HNEKVDLWCIGVLCYELLV-GN-PP---------------FESA--------------SHNETY----RR----IVK---VD---LKFPASVP----------------------------MGAQDLISKLLRHNPSERLP-----LAQVSAHPWV---------
-------FEIGRPLGKGKFGNVYLARL---K----------------ESHFIVALKVL---FKS--QIEKEG--L-EHQLR-REIEIQAHL--Q---HPNILRLYNYFH--D------ARRVYLILEYAPRGELYKELQ-----------------------KSE----------------------------------------------------------------------------------------------------KLDEQRTATIIEELADALTYCHDKKVIHRDIKPENLLLGF-----RGEV---KIADFGWSV-----------HTPSLRR--------------KT---MCGTLDYLPPEM--IE-----GRT--YDEKVDLWCIGVLCYELLV-GY-PP---------------FESA--------------SHSETY----RR----ILK---VD---VRFPLSMP----------------------------LGARDLISRLLRYQPLERLP-----LAQILKHPWV---------
-------FQKVEKIGEGTYGVVYKARN---K----------------LTGEVVALKKI---RLD--TETEGV--P-STAIR--EISLLKEL--N---HPNIVKLLDVIH--T------ENKLYLVFEFLHQ-DLKKFMDA---------------------SALT----------------------------------------------------------------------------------------------------GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINT-----EGAI---KLADFGLARAF---------GVPVRTY--------------TH---EVVTLWYRAPEI--LL----GCKY--YSTAVDIWSLGCIFAEMVT-RR-AL---------------FPGD-----------SEIDQLFRI----FR----TLG---TP---DEVVWPGVTSMPDYKPSFPKWAR--QDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS-----AKAALAHPFF---------
-------YENLGLVGEGSYGMVMKCRN---K----------------DTGRIVAIKKF---LES--DDDKMV--K-KIAMR--EIKLLKQL--R---HENLVNLLEVCK--K------KKRWYLVFEFVDHTILDDLEL-----------------------FPN----------------------------------------------------------------------------------------------------GLDYQVVQKYLFQIINGIGFCHSHNIIHRDIKPENILVSQ-----SGVV---KLCDFGFARTL---------AAPGEVY--------------TD---YVATRWYRAPEL--LV----GDVK--YGKAVDVWAIGCLVTEMFM-GE-PL---------------FPGD-----------SDIDQLYHI----MM----CLG---NL---IPRHQELFNKNPVFAGVRLPEIKEREPLERRYPKLSEVVIDLAKKCLHIDPDKRPF-----CAELLHHDFF---------
------W-EMRERLGTGGFGNVCLYQH---R----------------ELDLKIAIKSC---RLE--LSTKNR--E-R-WCH--EIQIMKKL--N---HANVVKACDVPE--ELN-ILIHDVPLLAMEYCSGGDLRKLLNK--------------------PENCC----------------------------------------------------------------------------------------------------GLKESQILSLLSDIGSGIRYLHENKIIHRDLKPENIVLQD-----VGGKIIHKIIDLGYAKD----------VDQGSLC--------------TS---FVGTLQYLAPEL--FE-----NKP--YTATVDYWSFGTMVFECIA-GY-RP---------------FLHHLQPFTWHEKIKKKDPKCIFA----CE----EMS---GE---VRFSSHLPQPNSLCS------------------LVVEPMENWLQLMLNWDPQQRG----------------GPVDLTLKQ
-------LQFGKTLGAGAFGKVVEATA---FG-----------LGKEDAVLKVAVKML---K-S--TAH-ADEKE-ALM-S--ELKIMSHLG-Q---HENIVNLLGACT--H------GGPVLVITEYCCYGDLLNFLR------------------------RKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRR------------------------------DSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTN-----GHVA---KIGDFGLARDI-------M-N--DSNY--------------IVKGNARLPVKWMAPES--IF-----DCV--YTVQSDVWSYGILLWEIFSLGL-NP---------------YPGI-L---------VNSKFYKLV----KD----GYQ---MA---QPAFAP------------------------------KNIYSIMQACWALEPTHRPT-----FQQICSFL-----------
-------LRFKEKLGEGQFGEVHLCEV---DSPQDLVSLDFPLNVRKGHPLLVAVKIL---R-P--DAT-KNARN-DFL-K--EVKIMSRL--K---DPNIIRLLGVCV--Q------DDPLCMITDYMENGDLNQFLS------------------------AHQLEDKAAE--------------------------------------------------------------------------------GAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGE-----NFTI---KIADFGMSRNL-------Y-A--GDYY--------------RVQGRAVLPIRWMAWEC--IL-----MGK--FTTASDVWAFGVTLWEVLMLCRAQP---------------FGQL-----------TDEQVIENAGEFFRD----QGRQVYLS---RPPACP------------------------------QGLYELMLRCWSRESEQRPP-----FSQLHRFL-----------
-------LTFKEKLGEGQFGEVHLCEV---EGMEKFKDKDFALDVSANQPVLVAVKML---R-A--DAN-KNARN-DFL-K--EIKIMSRL--K---DPNIIHLLAVCI--T------DDPLCMITEYMENGDLNQFLS------------------------RHEPPN-----------------------------------------------------------------------------------------SSSSDVRTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGK-----NYTI---KIADFGMSRNL-------Y-S--GDYY--------------RIQGRAVLPIRWMSWES--IL-----LGK--FTTASDVWAFGVTLWETFTFCQEQP---------------YSQL-----------SDEQVIENT----GEFFRDQGRQTYLP---QPAICP------------------------------DSVYKLMLSCWRRDTKNRPS-----FQEIHL---LL--------
LPPRIPA---------------------------------------------------------------------------------------------------------------GRPVMIVVEYMENGSLDSFLR------------------------KH--------------------------------------------------------------------------------------------------DGHFTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILVNS-----NLVC---KVSDFGLSRVL-------E-D--DPEA-------------AYTTTGGKIPIRWTAPEA--IA-----YRK--FSSASDAWSYGIVMWEVMSYGE-RP---------------YWEM-----------SNQDVILSI----EE----GYR---LP---APMGCP------------------------------ASLHQLMLHCWQKERNHRPK-----FTDIVSFL-----------
------V-KIEEVIGAGEFGEVYKGRL---K-------------LPGKREIYVAIKTL---K-A--GYS-EKQRR-DFL-S--EASIMGQF--D---HPNIIRLEGVVT--K------SRPVMIITEFMENGALDSFLR------------------------QN--------------------------------------------------------------------------------------------------DGQFTVIQLVGMLRGIAAGMKYLAEMNYVHRDLAARNILVNS-----NLVC---KVSDFGLSRYLQ----DDT-S--DPTY--------------TSSLGGKIPVRWTAPEA--IA-----YRK--FTSASDVWSYGIVMWEVMSFGE-RP---------------YWDM-----------SNQDVINAI----EQ----DYR---LP---PPMDCP------------------------------AALHQLMLDCWQKDRNSRPR-----FAEIVNTL-----------
------V-KIEEVIGAGEFGEVCRGRL---K-------------APGKKESCVAIKTL---K-G--GYT-ERQRR-EFL-S--EASIMGQF--E---HPNIIRLEGVVT--N------SMPVMILTEFMENGALDSFLR------------------------LN--------------------------------------------------------------------------------------------------DGQFTVIQLVGMLRGIASGMRYLAEMSYVHRDLAARNILVNS-----NLVC---KVSDFGLSRFLE----ENS-S--DPTY--------------TSSLGGKIPIRWTAPEA--IA-----FRK--FTSASDAWSYGIVMWEVMSFGE-RP---------------YWDM-----------SNQDVINAI----EQ----DYR---LP---PPPDCP------------------------------TSLHQLMLDCWQKDRNARPR-----FPQVVSAL-----------
-------IKIEEVIGTGSFGEVRQGRL---Q-------------PRGRREQTVAIQAL---W-A--GGA-ESLQM-TFL-G--RAAVLGQF--Q---HPNILRLEGVVT--K------SRPLMVLTEFMELGPLDSFLR------------------------QR--------------------------------------------------------------------------------------------------EGQFSSLQLVAMQRGVAAAMQYLSSFAFVHRSLSAHSVLVNS-----HLVC---KVARLGHSPQG-----------------------------------PSCLLRWAAPEV--IA-----HGK--HTTSSDVWSFGILMWEVMSYGE-RP---------------YWDM-----------SEQEVLNAI----EQ----EFR---LP---PPPGCP------------------------------PGLHLLMLDTWQKDRARRPH-----FDQLVA---AF--------
-------LTLGKPLGEGCFGQVVMAEA---VGI---------DKDKPKEAVTVAVKML---K-D--DAT-EKDLS-DLV-S--EMEMMKMIG-K---HKNIINLLGACT--Q------DGPLYVIVEYASKGNLREYLR------------------------ARRPPGMEY-----------------------------------------------------------------------------------SYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTE-----NNVM---KIADFGLARDI-------N-N--IDYY--------------KKTTNGRLPVKWMAPEA--LF-----DRV--YTHQSDVWSFGVLMWEIFTLGG-SP---------------YPGI-----------PVEELFKLL----KE----GHR---MD---KPANCT------------------------------NELYMMMRDCWHAVPSQRPT-----FKQLVEDL-----------
-------LTLGKPLGEGCFGQVVMAEA---IGI---------DKDRAAKPVTVAVKML---K-D--DAT-DKDLS-DLV-S--EMEMMKMIG-K---HKNIINLLGACT--Q------GGPLYVLVEYAAKGNLREFLR------------------------ARRPPGLDY-----------------------------------------------------------------------------------SFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTE-----DNVM---KIADFGLARDV-------H-N--LDYY--------------KKTTNGRLPVKWMAPEA--LF-----DRV--YTHQSDVWSFGVLLWEIFTLGG-SP---------------YPGI-----------PVEELFKLL----KE----GHR---MD---KPANCT------------------------------HDLYMIMRECWHAAPSQRPT-----FKQLVEDL-----------
------L-VLGKPLGEGCFGQVVRAEA---FGM---------DPARPDQASTVAVKML---K-D--NAS-DKDLA-DLV-S--EMEVMKLIG-R---HKNIINLLGVCT--Q------EGPLYVIVECAAKGNLREFLR------------------------ARRPPGPDL-----------------------------------------------------------------------------------SPDGPRSSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTE-----DNVM---KIADFGLARGV-------H-H--IDYY--------------KKTSNGRLPVKWMAPEA--LF-----DRV--YTHQSDVWSFGILLWEIFTLGG-SP---------------YPGI-----------PVEELFSLL----RE----GHR---MD---RPPHCP------------------------------PELYGLMRECWHAAPSQRPT-----FKQLVEAL-----------
-------ITLERRLGTGCFGDVWLGTW---N-----------------GSTKVAVKTL---K-P--GTM-SP--K-AFL-E--EAQVMKLL--R---HDKLVQLYAVVS---------EEPIYIVTEFMCHGSLLDFLK------------------------NP-------------------------------------------------------------------------------------------------EGQDLRLPQLVDMAAQVAEGMAYMERMNYIHRDLRAANILVGE-----RLAC---KIADFGLARLI---------K--DDEY--------------NPCQGSKFPIKWTAPEA--AL-----FGR--FTIKSDVWSFGILLTELITKGR-IP---------------YPGM-----------NKREVLEQV----EQ----GYH---MP---CPPGCP------------------------------ASLYEAMEQTWRLDPEERPT-----FEYLQSFL-----------
-------LHLGRVLGYGAFGKVVEASA---FG-----------IHKGSSCDTVAVKML---K-E--GAT-ASEHR-ALM-S--ELKILIHIG-N---HLNVVNLLGACT-KP------QGPLMVIVEFCKYGNLSNFLR------------------------AKRDAFSPCAEKSPEQRGRFRAMVELARLDRRR-----------------------------------PGSSDRVLFARFSKTEGGARRASPDQEAEDLWLSPLTMEDLVCYSFQVARGMEFLASRKCIHRDLAARNILLSE-----SDVV---KICDFGLARDI-------Y-K--DPDY--------------VRKGSARLPLKWMAPES--IF-----DKV--YTTQSDVWSFGVLLWEIFSLGA-SP---------------YPGV-Q---------INEEFCQRL----RD----GTR---MR---APELAT------------------------------PAIRRIMLNCWSGDPKARPA-----FSELVEIL-----------
-------IQLLKRLGSGQFGEVWEGLW---N-----------------NTTPVAVKTL---K-P--GSM-DP--N-DFL-R--EAQIMKNL--R---HPKLIQLYAVCT--L------EDPIYIITELMRHGSLQEYLQ------------------------ND-------------------------------------------------------------------------------------------------TGSKIHLTQQVDMAAQVASGMAYLESRNYIHRDLAARNVLVGE-----HNIY---KVADFGLARVFK-----VD-N--EDIY--------------ESRHEIKLPVKWTAPEA--IR-----SNK--FSIKSDVWSFGILLYEIITYGK-MP---------------YSGM-----------TGAQVIQML----AQ----NYR---LP---QPSNCP------------------------------QQFYNIMLECWNAEPKERPT-----FETLRWK--L---------
-------LQLIKRLGNGQFGEVWMGTW---N-----------------GNTKVAIKTL---K-P--GTM-SP--E-SFL-E--EAQIMKKL--K---HDKLVQLYAVVS---------EEPIYIVTEYMNKGSLLDFLK------------------------DG-------------------------------------------------------------------------------------------------EGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGN-----GLIC---KIADFGLARLI---------E--DNEY--------------TARQGAKFPIKWTAPEA--AL-----YGR--FTIKSDVWSFGILLTELVTKGR-VP---------------YPGM-----------NNREVLEQV----ER----GYR---MP---CPQDCP------------------------------ISLHELMIHCWKKDPEERPT-----FEYLQSFL-----------
-------YTTIRQLGDGTYGSVLLGRS---I----------------ESGELIAIKKM---KRK--FYSWEE--C--MNLR--EVKSLKKL--N---HANVVKLKEVIR--E------NDHLYFIFEYMKE-NLYQLIK----------------------ERNK----------------------------------------------------------------------------------------------------LFPESAIRNIMYQILQGLAFIHKHGFFHRDLKPENLLCMG-----PELV---KIADFGLARE----------IRSKPPY--------------TD---YVSTRWYRAPEV--LL----RSTN--YSSPIDVWAVGCIMAEVYT-LR-PL---------------FPGA-----------SEIDTIFKI----CQ----VLG---TP---KKTDWPEGYQLSSAMNFRWPQCV-PNNLKTLIPNASSEAVQLLRDMLQWDPKKRPT-----ASQALRYPYF---------
-------ITMSRELGQGSFGMVYEGVA---KG-----------VVKDEPETRVAIKTV---N-E--AAS-MRERI-EFL-N--EASVMKEF--N---CHHVVRLLGVVS--Q------GQPTLVIMELMTRGDLKSYLR------------------------SLRPEM-----------------------------------------------------------------------------------------ENNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAE-----DFTV---KIGDFGMTRDI-------Y-E--TDYY--------------RKGGKGLLPVRWMSPES--LK-----DGV--FTTYSDVWSFGVVLWEIATLAE-QP---------------YQGL-----------SNEQVLRFV----ME----GGL---LD---KPDNCP------------------------------DMLFELMRMCWQYNPKMRPS-----FLEIISS--I---------
-------ITLLRELGQGSFGMVYEGNA---RD-----------IIKGEAETRVAVKTV---N-E--SAS-LRERI-EFL-N--EASVMKGF--T---CHHVVRLLGVVS--K------GQPTLVVMELMAHGDLKSYLR------------------------SLRPEA-----------------------------------------------------------------------------------------ENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAH-----DFTV---KIGDFGMTRDI-------Y-E--TDYY--------------RKGGKGLLPVRWMAPES--LK-----DGV--FTTSSDMWSFGVVLWEITSLAE-QP---------------YQGL-----------SNEQVLKFV----MD----GGY---LD---QPDNCP------------------------------ERVTDLMRMCWQFNPKMRPT-----FLEIVNLL-----------
------I-SIIRELGQGSFGMVYEGLA---RG-----------LEAGEESTPVALKTV---N-E--LAS-PRECI-EFL-K--EASVMKAF--K---CHHVVRLLGVVS--Q------GQPTLVIMELMTRGDLKSHLR------------------------SLRPEA-----------------------------------------------------------------------------------------ENNPGLPQPALGEMIQMAGEIADGMAYLAANKFVHRDLAARNCMVSQ-----DFTV---KIGDFGMTRDV-------Y-E--TDYY--------------RKGGKGLLPVRWMAPES--LK-----DGI--FTTHSDVWSFGVVLWEIVTLAE-QP---------------YQGL-----------SNEQVLKFV----MD----GGV---LE---ELEGCP------------------------------LQLQELMSRCWQPNPRLRPS-----FTHILD---SI--------
----VGG----NKMGEGGFGVVYKGYV---N----------------NTT--VAVKKL---AAM--VDITTE--ELKQQFD-QEIKVMAKC--Q---HENLVELLGFSS--D------GDDLCLVYVYMPNGSLLDRLSC--------------------LDGTP----------------------------------------------------------------------------------------------------PLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDE-----AFTA---KISDFGLARASE-------KFAQTVMT--------------SR---IVGTTAYMAPEA--LR------GE--ITPKSDIYSFGVVLLEIIT-GL-PA---------------VDEH-----------REPQLLLDI----KE----EIE---DE---EKTIEDYIDKKMNDAD----------------STSVEAMYSVASQCLHEKKNKRPD-----IKKVQQ----LLQ------
-------LKFLQQLGKGNFGSVEMCRY---DP------------LQDNTGEVVAVKKL---Q-H--STE--EHLR-DFE-R--EIEILKSL--Q---HDNIVKYKGVCYSAG------RRNLKLIMEYLPYGSLRDYLQ------------------------KH--------------------------------------------------------------------------------------------------KERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVEN-----ENRV---KIGDFGLTKVL------PQ-D--KEYY--------------KVKEPGESPIFWYAPES--LT-----ESK--FSVASDVWSFGVVLYELFTYIE-KSKSPPAEFMRMIGNDKQGQM-----------IVFHLIELL----KN----NGR---LP---RPDGCP------------------------------DEIYMIMTECWNNNVNQRPS-----FRDLA----LRV-------
------L-KYISQLGKGNFGSVELCRY---DP------------LGDNTGALVAVKQL---Q-H--SGP-DQ-QR-DFQ-R--EIQILKAL--H---SDFIVKYRGVSYGPG------RQSLRLVMEYLPSGCLRDFLQ------------------------RH--------------------------------------------------------------------------------------------------RARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVES-----EAHV---KIADFGLAKLL------PL-D--KDYY--------------VVREPGQSPIFWYAPES--LS-----DNI--FSRQSDVWSFGVVLYELFTYCD-KSCSPSAE--FLRMMGCERDV-P---------ALCRLLELL----EE----GQR---LP---APPACP------------------------------AEVHELMKLCWAPSPQDRPS-----FSALGP---QL--------
-------LKLGKPLGRGAFGQVIEADA---FG-----------IDKTATCRTVAVKML---K-E--GAT-HSEHR-ALM-S--ELKILIHIG-H---HLNVVNLLGACT-KP------GGPLMVIVEFCKFGNLSTYLR------------------------SKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRL---------------------------------DSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSE-----KNVV---KICDFGLARDI-------Y-K--DPDY--------------VRKGDARLPLKWMAPET--IF-----DRV--YTIQSDVWSFGVLLWEIFSLGA-SP---------------YPGV-K---------IDEEFCRRL----KE----GTR---MR---APDYTT------------------------------PEMYQTMLDCWHGEPSQRPT-----FSELVEHL-----------
-------LSFGKTLGAGAFGKVVEATA---YG-----------LIKSDAAMTVAVKML---K-P--SAH-LTERE-ALM-S--ELKVLSYLG-N---HMNIVNLLGACT--I------GGPTLVITEYCCYGDLLNFLR------------------------RKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYM-----------------------DMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTH-----GRIT---KICDFGLARDI-------K-N--DSNY--------------VVKGNARLPVKWMAPES--IF-----NCV--YTFESDVWSYGIFLWELFSLGS-SP---------------YPGM-P---------VDSKFYKMI----KE----GFR---ML---SPEHAP------------------------------AEMYDIMKTCWDADPLKRPT-----FKQIVQL--I---------
-------LKLVERLGAGQFGEVWMGYY---N-----------------GHTKVAVKSL---K-Q--GSM-SP--D-AFL-A--EANLMKQL--Q---HQRLVRLYAVVT---------QEPIYIITEYMENGSLVDFLK------------------------TP-------------------------------------------------------------------------------------------------SGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSD-----TLSC---KIADFGLARLI---------E--DNEY--------------TAREGAKFPIKWTAPEA--IN-----YGT--FTIKSDVWSFGILLTEIVTHGR-IP---------------YPGM-----------TNPEVIQNL----ER----GYR---MV---RPDNCP------------------------------EELYQLMRLCWKERPEDRPT-----FDYLRSV--L---------
------V-TLLRALGHGAFGEVYEGLV---IG-----------LPGDSSPLQVAIKTL---P-E--LCS-PQDEL-DFL-M--EALIISKF--R---HQNIVRCVGLSL--R------ATPRLILLELMSGGDMKSFLR------------------------HSRP--------------------------------------------------------------------------------------------HLGQPSPLVMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCA--GPSRVA---KIGDFGMARDI-------Y-R--ASYY--------------RRGDRALLPVKWMPPEA--FL-----EGI--FTSKTDSWSFGVLLWEIFSLGY-MP---------------YPGR-----------TNQEVLDFV----VG----GGR---MD---PPRGCP------------------------------GPVYRIMTQCWQHEPELRPS-----FASILERL-----------
-------IKLVKRLGAGQFGEVWMGYY---N-----------------NSTKVAVKTL---K-P--GTM-SV--Q-AFL-E--EANLMKTL--Q---HDKLVRLYAVVT--R------EEPIYIITEYMAKGSLLDFLK------------------------SD-------------------------------------------------------------------------------------------------EGGKVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSE-----SLMC---KIADFGLARVI---------E--DNEY--------------TAREGAKFPIKWTAPEA--IN-----FGC--FTIKSDVWSFGILLYEIVTYGK-IP---------------YPGR-----------TNADVMTAL----SQ----GYR---MP---RVENCP------------------------------DELYDIMKMCWKEKAEERPT-----FDYLQSV--L---------
-------FELIQRIGSGTYGDVYKARN---V----------------NTGELAAIKVI---KLE--PGEDFA--V-VQ--Q--EIIMMKDC--K---HPNIVAYFGSYL--R------RDKLWICMEFCGGGSLQDIYH-----------------------VTG----------------------------------------------------------------------------------------------------PLSELQIAYVSRETLQGLYYLHSKGKMHRDIKGANILLTD-----NGHV---KLADFGVSAQI---------TATIAKR--------------KS---FIGTPYWMAPEVAAVE----RKGG--YNQLCDLWAVGITAIELAE-LQ-PP---------------MFDL-----------HPMRALFLM----TK----SNF---QP---P--KLKDKMKWS------------------------NSFHHFVKMALTKNPKKRPT-----AEKLLQHPFV---------
-------FELVEVVGNGTYGQVYKGRH---V----------------KTGQLAAIKVM---DVT--EDEEEE--I-KL-----EINMLKKY-SH---HRNIATYYGAFI--KKSPPGHDDQLWLVMEFCGAGSITDLVKN---------------------TKGN----------------------------------------------------------------------------------------------------TLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTE-----NAEV---KLVDFGVSAQL---------DRTVGRR--------------NT---FIGTPYWMAPEV--IACDENPDAT--YDYRSDLWSCGITAIEMAE-GA-PP---------------LCDM-----------HPMRALFLI----PR----NPP---PR---LKSKKWS-----------------------------KKFFSFIEGCLVKNYMQRPS-----TEQLLKHPFI---------
-------YELVQRVGSGTYGDVYKARN---V----------------HTGELAAVKII---KLE--PGDDFS--L-IQ--Q--EIFMVKEC--K---HCNIVAYFGSYL--S------REKLWICMEYCGGGSLQDIYH-----------------------VTG----------------------------------------------------------------------------------------------------PLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTD-----HGDV---KLADFGVAAKI---------TATIAKR--------------KS---FIGTPYWMAPEVAAVE----KNGG--YNQLCDIWAVGITAIELGE-LQ-PP---------------MFDL-----------HPMRALFLM----SK----SNF---QP---PKLKDKTK--WS------------------------STFHNFVKIALTKNPKKRPT-----AERLLTHTFV---------
-------YQNLSPVGSGAYGSVCAAFD---T----------------KTGLRVAVKKL---SRP--FQSIIH--A-KRTYR--ELRLLKHM--K---HENVIGLLDVFT--PARSLEEFNDVYLVTHLMGA-DLNNIVK------------------------CQ----------------------------------------------------------------------------------------------------KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNE-----DCEL---KILDFGLAR------------HTDDEM--------------TG---YVATRWYRAPEI--ML----NWMH--YNQTVDIWSVGCIMAELLT-GR-TL---------------FPGT-----------DHIDQLKLI----LR----LVG---TP---GAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRIT-----AAQALAHAYF---------
-------YRLQKTIGKGNFAKVKLARH---V----------------LTGREVAVKII---DKT--QLNPTS--L-QKLFR--EVRIMKIL--N---HPNIVKLFEVIE--T------EKTLYLVMEYASGGEVFDYLV-----------------------AHG----------------------------------------------------------------------------------------------------RMKEKEARAKFRQIVSAVQYCHQKYIVHRDLKAENLLLDG-----DMNI---KIADFGFSNE----------FTVGNKL--------------DT---FCGSPPYAAPEL--FQ----GKKY--DGPEVDVWSLGVILYTLVS-GS-LP---------------FDGQ--------------NLKELR----ER----VLR---GK---YRIPFYMS----------------------------TDCENLLKKLLVLNPIKRGS-----LEQIMKDRWM---------
-------YRLLKTIGKGNFAKVKLARH---I----------------LTGKEVAVKII---DKT--QLNSSS--L-QKLFR--EVRIMKVL--N---HPNIVKLFEVIE--T------EKTLYLVMEYASGGEVFDYLV-----------------------AHG----------------------------------------------------------------------------------------------------RMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLDA-----DMNI---KIADFGFSNE----------FTFGNKL--------------DT---FCGSPPYAAPEL--FQ----GKKY--DGPEVDVWSLGVILYTLVS-GS-LP---------------FDGQ--------------NLKELR----ER----VLR---GK---YRIPFYMS----------------------------TDCENLLKKFLILNPSKRGT-----LEQIMKDRWM---------
-------YRLLKTIGKGNFAKVKLARH---I----------------LTGREVAIKII---DKT--QLNPTS--L-QKLFR--EVRIMKIL--N---HPNIVKLFEVIE--T------EKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQGCQAGQTIKV----------------------------------------------------------------------------------------------------QVSFDLLSLMFTFIVSAVQYCHQKRIVHRDLKAENLLLDA-----DMNI---KIADFGFSNE----------FTVGGKL--------------DT---FCGSPPYAAPEL--FQ----GKKY--DGPEVDVWSLGVILYTLVS-GS-LP---------------FDGQ--------------NLKELR----ER----VLR---GK---YRIPFYMS----------------------------TDCENLLKRFLVLNPIKRGT-----LEQIMKDRWI---------
-------YRLLRTIGKGNFAKVKLARH---I----------------LTGREVAIKII---DKT--QLNPSS--L-QKLFR--EVRIMKGL--N---HPNIVKLFEVIE--T------EKTLYLVMEYASAGEVFDYLV-----------------------SHG----------------------------------------------------------------------------------------------------RMKEKEARAKFRQIVSAVHYCHQKNIVHRDLKAENLLLDA-----EANI---KIADFGFSNE----------FTLGSKL--------------DT---FCGSPPYAAPEL--FQ----GKKY--DGPEVDIWSLGVILYTLVS-GS-LP---------------FDGH--------------NLKELR----ER----VLR---GK---YRVPFYMS----------------------------TDCESILRRFLVLNPAKRCT-----LEQIMKDKWI---------
-------YELHETIGTGGFAKVKLACH---I----------------LTGEMVAIKIM---DKN--TLGSDL--P-RIKT---EIEALKNL--R---HQHICQLYHVLE--T------ANKIFMVLEYCPGGELFDYII-----------------------SQD----------------------------------------------------------------------------------------------------RLSEEETRVVFRQIVSAVAYVHSQGYAHRDLKPENLLFDE-----YHKL---KLIDFGLCAKP--------KGNKDYHL--------------QT---CCGSLAYAAPEL--IQ----GKSY--LGSEADVWSMGILLYVLMC-GF-LP---------------FDDD--------------NVMALY----KK----IMR---GK---YDVPKWLS----------------------------PSSILLLQQMLQVDPKKRIS-----MKNLLNHPWI---------
-------VHFNEVIGRGHFGCVYHGTL---L-------------DNDGKKIHCAVKSL---N-R--ITD-IGEVS-QFL-T--EGIIMKDF--S---HPNVLSLLGICL-RS------EGSPLVVLPYMKHGDLRNFIR------------------------NE--------------------------------------------------------------------------------------------------THNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDE-----KFTV---KVADFGLARDM-------Y-D--KEYYS------------VHNKTGAKLPVKWMALES--LQ-----TQK--FTTKSDVWSFGVLLWELMTRGA-PP---------------YPDV-----------NTFDITVYL----LQ----GRR---LL---QPEYCP------------------------------DPLYEVMLKCWHPKAEMRPS-----FSELVSR--I---------
-------FELVEVVGNGTYGQVYKGRH---V----------------KTGQLAAIKVM---DVT--EDEEEE--I-KQ-----EINMLKKY-SH---HRNIATYYGAFI--KKSPPGNDDQLWLVMEFCGAGSVTDLVKN---------------------TKGN----------------------------------------------------------------------------------------------------ALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTE-----NAEV---KLVDFGVSAQL---------DRTVGRR--------------NT---FIGTPYWMAPEV--IACDENPDAT--YDYRSDIWSLGITAIEMAE-GA-PP---------------LCDM-----------HPMRALFLI----PR----NPP---PR---LKSKKWS-----------------------------KKFIDFIDTCLIKTYLSRPP-----TEQLLKFPFI---------
------I-EYVRDIGEGAFGRVFQARA---PG-----------LLPYEPFTMVAVKML---K-E--EAS-ADMQA-DFQ-R--EAALMAEF--D---NPNIVKLLGVCA--V------GKPMCLLFEYMAYGDLNEFLR------------------------SMSPHTVCSLSHS---------------------------------------------------------------------------DLSMRAQVSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGE-----NMVV---KIADFGLSRNI-------Y-S--ADYY--------------KANENDAIPIRWMPPES--IF-----YNR--YTTESDVWAYGVVLWEIFSYGL-QP---------------YYGM-----------AHEEVIYYV----RD----GNI---LS---CPENCP------------------------------VELYNLMRLCWSKLPADRPS-----FTSIHRIL-----------
-----IV--LKWELGEGAFGKVFLAEC---HN-----------LLPEQDKMLVAVKAL---K-E--ASE-SA-RQ-DFQ-R--EAELLTML--Q---HQHIVRFFGVCT--E------GRPLLMVFEYMRHGDLNRFLR------------------------SHGPDAKL------------------------------------------------------------------------------------LAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQ-----GLVV---KIGDFGMSRDI-------Y-S--TDYY--------------RVGGRTMLPIRWMPPES--IL-----YRK--FTTESDVWSFGVVLWEIFTYGK-QP---------------WYQL-----------SNTEAIDCI----TQ----GRE---LE---RPRACP------------------------------PEVYAIMRGCWQREPQQRHS-----IKDVHARL-----------
------I-VLKRELGEGAFGKVFLAEC---YN-----------LCPEQDKILVAVKTL---K-D--ASD-NA-RK-DFH-R--EAELLTNL--Q---HEHIVKFYGVCV--E------GDPLIMVFEYMKHGDLNKFLR------------------------AHGPDAV--------------------------------------------------------------------------------------LMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGE-----NLLV---KIGDFGMSRDV-------Y-S--TDYY--------------RVGGHTMLPIRWMPPES--IM-----YRK--FTTESDVWSLGVVLWEIFTYGK-QP---------------WYQL-----------SNNEVIECI----TQ----GRV---LQ---RPRTCP------------------------------QEVYELMLGCWQREPHMRKN-----IKGIHTL--L---------
------I-VLKRELGEGAFGKVFLAEC---YN-----------LSPTKDKMLVAVKAL---K-D--PTL-AA-RK-DFQ-R--EAELLTNL--Q---HEHIVKFYGVCG--D------GDPLIMVFEYMKHGDLNKFLR------------------------AHGPDAMIL-----------------------------------------------------------------------------------VDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGA-----NLLV---KIGDFGMSRDV-------Y-S--TDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPES--IM-----YRK--FTTESDVWSFGVILWEIFTYGK-QP---------------WFQL-----------SNTEVIECI----TQ----GRV---LE---RPRVCP------------------------------KEVYDVMLGCWQREPQQRLN-----IKEIYKIL-----------
-------YELQETLGKGTYGKVKRATE---R----------------FSGRVVAIKSI---RKD--KIKDEQ--D-MVHIR-REIEIMSSL--N---HPHIISIYEVFE--N------KDKIVIIMEYASKGELYDYIS-----------------------ERR----------------------------------------------------------------------------------------------------RLSERETRHFFRQIVSAVHYCHKNGVVHRDLKLENILLDD-----NCNI---KIADFGLSNL----------YQKDKFL--------------QT---FCGSPLYASPEI--VN----GRPY--RGPEVDSWALGVLLYTLVY-GT-MP---------------FDGF--------------DHKNLI----RQ----ISS---GE---YREPTQP-----------------------------SDARGLIRWMLMVNPDRRAT-----IEDIANHWW-V--------
-------YEFLETLGKGTYGKVKKARE---S----------------SGR-LVAIKSI---RKD--KIKDEQ--D-LMHIR-REIEIMSSL--N---HPHIIAIHEVFE--N------SSKIVIVMEYASRGDLYDYIS-----------------------ERQ----------------------------------------------------------------------------------------------------QLSEREARHFFRQIVSAVHYCHQNRVVHRDLKLENILLDA-----NGNI---KIADFGLSNL----------YHQGKFL--------------QT---FCGSPLYASPEI--VN----GKPY--TGPEVDSWSLGVLLYILVH-GT-MP---------------FDGH--------------DHKILV----KQ----ISN---GA---YREPPK-----P------------------------SDACGLIRWLLMVNPTRRAT-----LEDVASHWW-V--------
-------YTRYEKIGQGASGTVFTATD---V----------------ALGQEVAIKQI---NLQ--KQPKKE--L-II--N--EILVMKEL--K---NPNIVNFLDSYL--V------GDELFVVMEYLAGGSLTDVVT------------------------ET----------------------------------------------------------------------------------------------------CMDEAQIAAVCRECLQALEFLHANQVIHRDIKSDNVLLGM-----EGSV---KLTDFGFCAQI---------TPEQSKR--------------ST---MVGTPYWMAPEV--VT-----RKA--YGPKVDIWSLGIMAIEMVE-GE-PP---------------YLNE-----------NPLRALYLI----AT----NGT---PE---LQNPEKLS----------------------------PIFRDFLNRCLEMDVEKRGS-----AKELLQHPFL---------
-------YTRFEKIGQGASGTVYTALD---I----------------ATGQEVAIKQM---NLQ--QQPKKE--L-II--N--EILVMREN--K---NPNIVNYLDSYL--V------GDELWVVMEYLAGGSLTDVVT------------------------ET----------------------------------------------------------------------------------------------------CMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGM-----DGSV---KLTDFGFCAQI---------TPEQSKR--------------ST---MVGTPYWMAPEV--VT-----RKA--YGPKVDIWSLGIMAIEMVE-GE-PP---------------YLNE-----------NPLRALYLI----AT----NGT---PE---LQNPERLS----------------------------AVFRDFLNRCLEMDVDRRGS-----AKELLQHPFL---------
------L-VLGRVLGSGAFGKVVEGTA---YG-----------LSRSQPVMKVAVKML---K-P--TAR-SSEKQ-ALM-S--ELKIMTHLG-P---HLNIVNLLGACT--K------SGPIYIITEYCFYGDLVNYLH------------------------KNRDSFLSHHPEKPKKELDIFGLNPADESTRSYVILSFENNGDYMDMKQA-DTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQ-----GKIV---KICDFGLARDI-------M-H--DSNY--------------VSKGSTFLPVKWMAPES--IF-----DNL--YTTLSDVWSYGILLWEIFSLGG-TP---------------YPGM-M---------VDSTFYNKI----KS----GYR---MA---KPDHAT------------------------------SEVYEIMVKCWNSEPEKRPS-----FYHLSE---IV--------
------L-VLGRTLGSGAFGQVVEATA---HG-----------LSHSQATMKVAVKML---K-S--TAR-SSEKQ-ALM-S--ELKIMSHLG-P---HLNVVNLLGACT--K------GGPIYIITEYCRYGDLVDYLH------------------------RNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVLSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICE-----GKLV---KICDFGLARDI-------M-R--DSNY--------------ISKGSTFLPLKWMAPES--IF-----NSL--YTTLSDVWSFGILLWEIFTLGG-TP---------------YPEL-P---------MNEQFYNAI----KR----GYR---MA---QPAHAS------------------------------DEIYEIMQKCWEEKFEIRPP-----FSQLVL---LL--------
------F-KFLAVLGRGHFGKVLLSEF---R----------------PSGELFAIKAL---KKG--DIVARD--E-VESLM-CEKRILAAV--TSAGHPFLVNLFGCFQ--T------PEHVCFVMEYSAGGDLMLHIH------------------------SD----------------------------------------------------------------------------------------------------VFSEPRAIFYSACVVLGLQFLHEHKIVYRDLKLDNLLLDT-----EGYV---KIADFGLCKEG---------MGYGDRT--------------ST---FCGTPEFLAPEV--LT-----DTS--YTRAVDWWGLGVLLYEMLV-GE-SP---------------FPGD--------------DEEEVF----DS----IVN---DE---VRYPRFLS----------------------------AEAIGIMRRLLRRNPERRLGSSERDAEDVKKQPFF---------
------Y-ILGDTLGVGTFGKVKVGKH---E----------------LTGHKVAVKIL---NRQ--KIRSLD--V-VGKIR-REIQNLKLF--R---HPHIIKLYQVIS--T------PSDIFMVMEYVSGGELFDYIC-----------------------KNG----------------------------------------------------------------------------------------------------RLDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDA-----HMNA---KIADFGLSNM----------MSDGEFL--------------RT---SCGSPNYAAPEV--IS----GRLY--AGPEVDIWSSGVILYALLC-GT-LP---------------FDDD--------------HVPTLF----KK----ICD---GI---FYTPQYLN----------------------------PSVISLLKHMLQVDPMKRAT-----IKDIREHEWF---------
-------YVLGDTLGVGTFGKVKIGEH---Q----------------LTGHKVAVKIL---NRQ--KIRSLD--V-VGKIK-REIQNLKLF--R---HPHIIKLYQVIS--T------PTDFFMVMEYVSGGELFDYIC-----------------------KHG----------------------------------------------------------------------------------------------------RVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDA-----HMNA---KIADFGLSNM----------MSDGEFL--------------RT---SCGSPNYAAPEV--IS----GRLY--AGPEVDIWSCGVILYALLC-GT-LP---------------FDDE--------------HVPTLF----KK----IRG---GV---FYIPEYLN----------------------------RSVATLLMHMLQVDPLKRAT-----IKDIREHEWF---------
-------IELGRCIGEGQFGDVHQGIY---M-------------SPENPALAVAIKTC---K-N--CTS-DSVRE-KFL-Q--EALTMRQF--D---HPHIVKLIGVIT---------ENPVWIIMELCTLGELRSFLQ------------------------VR--------------------------------------------------------------------------------------------------KYSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSS-----NDCV---KLGDFGLSRYM---------E--DSTY--------------YKASKGKLPIKWMAPES--IN-----FRR--FTSASDVWMFGVCMWEILMHGV-KP---------------FQGV-----------KNNDVIGRI----EN----GER---LP---MPPNCP------------------------------PTLYSLMTKCWAYDPSRRPR-----FTELKAQL-----------
------L-VLGKTLGEGEFGKVVKATA---FH-----------LKGRAGYTTVAVKML---K-E--NAS-PSELR-DLL-S--EFNVLKQV--N---HPHVIKLYGACS--Q------DGPLLLIVEYAKYGSLRGFLR------------------------ESRKVGPGYLGSG---------------------------------------------------------------------------GSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAE-----GRKM---KISDFGLSRDV-------Y-E--EDSY--------------VKRSQGRIPVKWMAIES--LF-----DHI--YTTQSDVWSFGVLLWEIVTLGG-NP---------------YPGI-----------PPERLFNLL----KT----GHR---ME---RPDNCS------------------------------EEMYRLMLQCWKQEPDKRPV-----FADISKDL-----------
----LES----AELDSGGFGKVSLCFH---R-----------------TQGLMIMKTV--YK-G--PNC-IEHNE-ALL-E--EAKMMNRL--R---HSRVVKLLGVII--E------EGKYSLVMEYMEKGNLMHVLK------------------------AE---------------------------------------------------------------------------------------------------MSTPLSVKGRIILEIIEGMCYLHGKGVIHKDLKPENILVDN-----DFHI---KIADLGLASFKMWSKLNNE-----EHNELR--------EVDGTAKKNGGTLYYMAPEH--LN-----DVNAKPTEKSDVYSFAVVLWAIFA-NK-EP---------------YENA-I---------CEQQLIMCI----KS----GNR---PDVDDITEYCP------------------------------REIISLMKLCWEANPEARPT-----FPGIEEK--F---------
-----LT--LRLLLGSGAFGEVYEGTA---VDI----------LGVGSGEIKVAVKTL---K-K--GST-DQEKI-EFL-K--EAHLMSKF--N---HPNILKQLGVCL--L------NEPQYIILELMEGGDLLTYLR------------------------KARM--------------------------------------------------------------------------------------------ATFYGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIV---KIGDFGLARDI-------Y-K--NDYY--------------RKRGEGLLPVRWMAPES--LM-----DGI--FTTQSDVWSFGILIWEILTLGH-QP---------------YPAH-----------SNLDVLNYV----QT----GGR---LE---PPRNCP------------------------------DDLWNLMTQCWAQEPDQRPT-----FHRIQDQL-----------
-------FELLRVLGKGGYGKVFQVRKVTGA----------------NTGKIFAMKVL---KKA--MIVRNA--K-DTAHTKAERNILEEV--K---HPFIVDLIYAFQ--T------GGKLYLILEYLSGGELFMQLE-----------------------REG----------------------------------------------------------------------------------------------------IFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNH-----QGHV---KLTDFGLCKES---------IHDGTVT--------------HT---FCGTIEYMAPEI--LM-----RSG--HNRAVDWWSLGALMYDMLT-GA-PP---------------FTGE--------------NRKKTI----DK----ILK---CK---LNLPPYLT----------------------------QEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFF---------
-------YDIERTLGKGNFAVVKLARH---R----------------VTKTQVAIKII---DKT--RLDSSN--L-EKIYR--EVQLMKLL--N---HPHIIKLYQVME--T------KDMLYIVTEFAKNGEMFDYLT-----------------------SNG----------------------------------------------------------------------------------------------------HLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDG-----NMDI---KLADFGFGNF----------YKSGEPL--------------ST---WCGSPPYAAPEV--FE----GKEY--EGPQLDIWSLGVVLYVLVC-GS-LP---------------FDGP--------------NLPTLR----QR----VLE---GR---FRIPFFMS----------------------------QDCESLIRRMLVVDPARRIT-----IAQIRQHRWM---------
-------YDIEGTLGKGNFAVVKLGRH---R----------------ITKTEVAIKII---DKS--QLDAVN--L-EKIYR--EVQIMKML--D---HPHIIKLYQVME--T------KSMLYLVTEYAKNGEIFDYLA-----------------------NHG----------------------------------------------------------------------------------------------------RLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDN-----NMNI---KIADFGFGNF----------FKSGELL--------------AT---WCGSPPYAAPEV--FE----GQQY--EGPQLDIWSMGVVLYVLVC-GA-LP---------------FDGP--------------TLPILR----QR----VLE---GR---FRIPYFMS----------------------------EDCEHLIRRMLVLDPSKRLT-----IAQIKEHKWM---------
-------WEIIGELGDGAFGKVYKAQN---K----------------ETSVLAAAKVI---DTK--SEEELE--D-YM--V--EIDILASC--D---HPNIVKLLDAFY--Y------ENNLWILIEFCAGGAVDAVML----------------------ELER----------------------------------------------------------------------------------------------------PLTESQIQVVCKQTLDALNYLHDNKIIHRDLKAGNILFTL-----DGDI---KLADFGVSAKN---------TRTIQRR--------------DS---FIGTPYWMAPEV--VMCETSKDRP--YDYKADVWSLGITLIEMAE-IE-PP---------------HHEL-----------NPMRVLLKI----AK----SEP---PT---LAQPSRWS----------------------------SNFKDFLKKCLEKNVDARWT-----TSQLLQHPFV---------
------L-RLEVKLGQGCFGEVWMGTW---N-----------------GTTRVAIKTL---K-P--GTM-SP--E-AFL-Q--EAQVMKKL--R---HEKLVQLYAVVS---------EEPIYIVTEYMSKGSLLDFLK------------------------GE-------------------------------------------------------------------------------------------------TGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGE-----NLVC---KVADFGLARLI---------E--DNEY--------------TARQGAKFPIKWTAPEA--AL-----YGR--FTIKSDVWSFGILLTELTTKGR-VP---------------YPGM-----------VNREVLDQV----ER----GYR---MP---CPPECP------------------------------ESLHDLMCQCWRKEPEERPT-----FEYLQAF--L---------
-------WEIVGELGDGAFGKVYKAKN---K----------------ETGALAAAKVI---ETK--SEEELE--D-YI--V--EIEILATC--D---HPYIVKLLGAYY--H------DGKLWIMIEFCPGGAVDAIML----------------------ELDR----------------------------------------------------------------------------------------------------GLTEPQIQVVCRQMLEALNFLHSKRIIHRDLKAGNVLMTL-----EGDI---RLADFGVSAKN---------LKTLQKR--------------DS---FIGTPYWMAPEV--VMCETMKDTP--YDYKADIWSLGITLIEMAQ-IE-PP---------------HHEL-----------NPMRVLLKI----AK----SDP---PT---LLTPSKWS----------------------------VEFRDFLKIALDKNPETRPS-----AAQLLEHPFV---------
-------FTKLEKIGKGSFGEVFKGID---N----------------RTQKVVAIKII---DLE--EAEDEI--E-DIQ-Q--EITVLSQC--D---SPYVTKYYGSYL--K------DTKLWIIMEYLGGGSALDLLE------------------------PG----------------------------------------------------------------------------------------------------PLDETQIATILREILKGLDYLHSEKKIHRDIKAANVLLSE-----HGEV---KLADFGVAGQL---------TDTQIKR--------------NT---FVGTPFWMAPEV--IK-----QSA--YDSKADIWSLGITAIELAR-GE-PP---------------HSEL-----------HPMKVLFLI----PK----NNP---PT---LEGNYS------------------------------KPLKEFVEACLNKEPSFRPT-----AKELLKHKFI---------
-------IKFQDVIGEGNFGQVLKARI---K--------------KDGLRMDAAIKRM---K-E--YAS-KDDHR-DFA-G--ELEVLCKLG-H---HPNIINLLGACE--H------RGYLYLAIEYAPHGNLLDFLR------------------------KSRVLETDP-----------------------------------------------------------------------------------AFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGE-----NYVA---KIADFGLSRGQ-------------EVY--------------VKKTMGRLPVRWMAIES--LN-----YSV--YTTNSDVWSYGVLLWEIVSLGG-TP---------------YCGM-----------TCAELYEKL----PQ----GYR---LE---KPLNCD------------------------------DEVYDLMRQCWREKPYERPS-----FAQILV---SL--------
-------ITFEDLIGEGNFGQVIRAMI---K--------------KDGLKMNAAIKML---K-E--YAS-ENDHR-DFA-G--ELEVLCKLG-H---HPNIINLLGACK--N------RGYLYIAIEYAPYGNLLDFLR------------------------KSRVLETDP-----------------------------------------------------------------------------------AFAREHGTASTLSSRQLLRFASDAANGMQYLSEKQFIHRDLAARNVLVGE-----NLAS---KIADFGLSRGE-------------EVY--------------VKKTMGRLPVRWMAIES--LN-----YSV--YTTKSDVWSFGVLLWEIVSLGG-TP---------------YCGM-----------TCAELYEKL----PQ----GYR---ME---QPRNCD------------------------------DEVYELMRQCWRDRPYERPP-----FAQIALQ--L---------
-------FELVELVGNGTYGQVYKGRH---V----------------KTGQLAAIKVM---DVT--GDEEEE--I-KQ-----EINMLKKY-SH---HRNIATYYGAFI--KKNPPGMDDQLWLVMEFCGAGSVTDLIKN---------------------TKGN----------------------------------------------------------------------------------------------------TLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTE-----NAEV---KLVDFGVSAQL---------DRTVGRR--------------NT---FIGTPYWMAPEV--IACDENPDAT--YDFKSDLWSLGITAIEMAE-GA-PP---------------LCDM-----------HPMRALFLI----PR----NPA---PR---LKSKKWS-----------------------------KKFQSFIESCLVKNHSQRPA-----TEQLMKHPFI---------
----VCR---GELLGSGCFGVVHRGLW---T-------------LPSGKSVPVAVKSLRVGP-E--GPM-GTELG-DFL-R--EVSVMMNL--E---HPHVLRLHGLVL---------GQPLQMVMELAPLGSLHARLT------------------------AP------------------------------------------------------------------------------------------------APTPPLLVALLCLFLRQLAGAMAYLGARGLVHRDLATRNLLLAS-----PRTI---KVADFGLVRPL------GG-A--RGRY--------------VMGGPRPIPYAWCAPES--LR-----HGA--FSSASDVWMFGVTLWEMFSGGE-EP---------------WAGV-----------PPYLILQRL----ED----RAR---LP---RPPLCS------------------------------RALYSLALRCWAPHPADRPS-----FSHLE----GLL-------
------L-RLLEKLGDGSFGVVRRGEW---D-------------APSGKTVSVAVKCL---K-PDVLSQ-PEAMD-DFI-R--EVNAMHSL--D---HRNLIRLYGVVL---------TPPMKMVTELAPLGSLLDRLR------------------------KH--------------------------------------------------------------------------------------------------QGHFLLGTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLAT-----RDLV---KIGDFGLMRAL------PQ-N--DDHY--------------VMQEHRKVPFAWCAPES--LK-----TRT--FSHASDTWMFGVTLWEMFTYGQ-EP---------------WIGL-----------NGSQILHKI---DKE----GER---LP---RPEDCP------------------------------QDIYNVMVQCWAHKPEDRPT-----FVALRDF--L---------
------L-RLEVKLGQGCFGEVWMGTW---N-----------------GTTKVAIKTL---K-P--GTM-MP--E-AFL-Q--EAQIMKKL--R---HDKLVPLYAVVS---------EEPIYIVTEFMSKGSLLDFLK------------------------EG-------------------------------------------------------------------------------------------------DGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGE-----NLVC---KIADFGLARLI---------E--DNEY--------------TARQGAKFPIKWTAPEA--AL-----YGR--FTIKSDVWSFGILQTELVTKGR-VP---------------YPGM-----------VNREVLEQV----ER----GYR---MP---CPQGCP------------------------------ESLHELMNLCWKKDPDERPT-----FEYIQSFL-----------
---LIAD----IELGCGNFGSVRQGVY---R--------------MRKKQIDVAIKVL---K-Q--GTE-KADTE-EMM-R--EAQIMHQL--D---NPYIVRLIGVCQ---------AEALMLVMEMAGGGPLHKFLV------------------------GK--------------------------------------------------------------------------------------------------REEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVN-----RHYA---KISDFGLSKAL------GA-D--DSYY--------------TARSAGKWPLKWYAPEC--IN-----FRK--FSSRSDVWSYGVTMWEALSYGQ-KP---------------YKKM-----------KGPEVMAFI----EQ----GKR---ME---CPPECP------------------------------PELYALMSDCWIYKWEDRPD-----FLTVEQR--M---------
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