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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK FGFR2 203
TK ALK 1116
CMGC CDC2 4
TK EGFR 712
TK INSR 1023
TK JAK1 875
TK JAK2 849
TK JAK3 822
TK LCK 245
TK SRC 270
-LTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLK-DDAT-EKDLSDLV-SEMEMMKMIGKHKNIINLLGACT--QDGP--LYVIVEYASKGNLREYLR----ARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTE---NNVMKIADFGLARDI-NN--IDYYKKTTNGRLPVKWMAPEALF-DRVYTHQSDVWSFGVLMWEIFTLGGSP---------------YPGI-PVEELFKLLKEGHRMDKPANCT----------------------------NELYMMMRDCWHAVPSQRPTFKQLVEDL----
I-TLIRGLGHGAFGEVYEGQVSG--MPNDPSPLQVAVKTLP-EVCS-EQDELDFL-MEALIISKF-NHQNIVRCIGVSL--QSLP--RFILLELMAGGDLKSFLR----ETRP---------RPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDI-YR--ASYYRKGGCAMLPVKWMPPEAFM-EGIFTSKTDTWSFGVLLWEIFSLGYMP---------------YPSK-SNQEVLEFVTSGGRMDPPKNCP----------------------------GPVYRIMTQCWQHQPEDRPNFAIILER--I--
-YTKIEKIGEGTYGVVYKGRHK-------TTGQVVAMKKIRLESEEEGV--PSTAIREISLLKEL-RHPNIVSLQDVLM--QDSR--LYLIFEFLSM-DLKKYLDSIPPGQ-----------------YMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDD---KGTIKLADFGLARAF--GIPIRVYTH---EVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELAT-KKPL---------------FHGD-SEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF--
F-KKIKVLGSGAFGTVYKGLWIP---EGEKVKIPVAIKELR-EATS-PKANKEIL-DEAYVMASV-DNPHVCRLLGICL---TST--VQLITQLMPFGCLLDYVR----EH---------------KDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKT---PQHVKITDFGLAKLL-GA--EEKEYHAEGGKVPIKWMALESIL-HRIYTHQSDVWSYGVTVWELMTFGSKP---------------YDGI-PASEISSILEKGERLPQPPICT----------------------------IDVYMIMVKCWMIDADSRPKFRELI----IEF
-ITLLRELGQGSFGMVYEGNARD--IIKGEAETRVAVKTVN-ESAS-LRERIEFL-NEASVMKGF-TCHHVVRLLGVVS--KGQP--TLVVMELMAHGDLKSYLR----SLRPEA------ENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAH---DFTVKIGDFGMTRDI-YE--TDYYRKGGKGLLPVRWMAPESLK-DGVFTTSSDMWSFGVVLWEITSLAEQP---------------YQGL-SNEQVLKFVMDGGYLDQPDNCP----------------------------ERVTDLMRMCWQFNPKMRPTFLEIVNLL----
L-KRIRDLGEGHFGKVELCRYDP---EGDNTGEQVAVKSLK-PESG-GNHIADLK-KEIEILRNL-YHENIVKYKGICT-ED-GGNGIKLIMEFLPSGSLKEYLP----KN---------------KNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVES---EHQVKIGDFGLTKAIETD--KEYYTVKDDRDSPVFWYAPECLM-QSKFYIASDVWSFGVTLHELLTYCDSDSSPMALF-LKMIGPTHGQM-TVTRLVNTLKEGKRLPCPPNCP----------------------------DEVYQLMRKCWEFQPSNRTSFQNLIE---GF-
-LKFLQQLGKGNFGSVEMCRYDP---LQDNTGEVVAVKKLQ-HSTE--EHLRDFE-REIEILKSL-QHDNIVKYKGVCYSAGRRN--LKLIMEYLPYGSLRDYLQ----KH---------------KERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVEN---ENRVKIGDFGLTKVLPQD--KEYYKVKEPGESPIFWYAPESLT-ESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQM-IVFHLIELLKNNGRLPRPDGCP----------------------------DEIYMIMTECWNNNVNQRPSFRDLA----LRV
L-KYISQLGKGNFGSVELCRYDP---LGDNTGALVAVKQLQ-HSGP-DQ-QRDFQ-REIQILKAL-HSDFIVKYRGVSYGPGRQS--LRLVMEYLPSGCLRDFLQ----RH---------------RARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVES---EAHVKIADFGLAKLLPLD--KDYYVVREPGQSPIFWYAPESLS-DNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAE--FLRMMGCERDVPALCRLLELLEEGQRLPAPPACP----------------------------AEVHELMKLCWAPSPQDRPSFSALGP---QL-
-LKLVERLGAGQFGEVWMGYYN--------GHTKVAVKSLK-QGSM-SP--DAFL-AEANLMKQL-QHQRLVRLYAVVT---QEP--IYIITEYMENGSLVDFLK----TP--------------SGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSD---TLSCKIADFGLARLI--E--DNEYTAREGAKFPIKWTAPEAIN-YGTFTIKSDVWSFGILLTEIVTHGRIP---------------YPGM-TNPEVIQNLERGYRMVRPDNCP----------------------------EELYQLMRLCWKERPEDRPTFDYLRSV--L--
L-RLEVKLGQGCFGEVWMGTWN--------GTTRVAIKTLK-PGTM-SP--EAFL-QEAQVMKKL-RHEKLVQLYAVVS---EEP--IYIVTEYMSKGSLLDFLK----GE--------------TGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGE---NLVCKVADFGLARLI--E--DNEYTARQGAKFPIKWTAPEAAL-YGRFTIKSDVWSFGILLTELTTKGRVP---------------YPGM-VNREVLDQVERGYRMPCPPECP----------------------------ESLHDLMCQCWRKEPEERPTFEYLQAF--L--
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