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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK FGR 203
TK ABL1 261
TK ABL2 288
TK ALK 1116
Other AURKA 133
Other AURKB 77
Other AURKC 43
TK AXL 527
TK BLK 241
TK BMX 422
TK BTK 402
Other CHUK 15
TK CSF1R 582
TK CSK 195
TK DDR1 572
TK DDR2 563
TK EGFR 712
TK EPHA2 613
TK EPHA8 635
TK EPHB1 619
TK EPHB2 621
TK EPHB4 615
TK EPHB6 670
TK ERBB4 718
TK FER 563
TK FES 561
TK FGFR1 478
TK FGFR2 481
TK FGFR3 472
TK FGFR4 467
TK FLT4 845
TK FYN 271
TK HCK 241
TK IGF1R 999
TK INSR 1023
TK INSRR 979
TK ITK 363
TK JAK1 875
TK JAK2 849
TK JAK3 822
TK KDR 834
TK LTK 510
STE MAP3K1 1242
STE MAP3K6 645
TKL MAP3K7 36
TK MATK 235
TK MERTK 587
TK MET 1078
TK MST1R 1082
TK MUSK 575
Other NEK5 4
TK NTRK1 510
TK NTRK2 538
TK NTRK3 538
TK PTK2 422
TK PTK6 191
TK RET 724
TK ROS1 1945
STE SLK 34
TK SRC 270
TK SRMS 230
STE STK24 24
TK SYK 371
TK TEC 370
TK TNK1 116
TK TNK2 150
TKL TNNI3K 463
TK TXK 271
TK TYK2 589
TK TYRO3 518
TK YES1 277
STE YSK4 1162
TK ZAP70 338
----ITLERRLGTGCFGDVWLGTWN-----------------GSTKVAVKTL---K-P--G-TM-SP---KAFL-E----EAQVMKLL-RHDKLVQLYAVVS--------EEP------IYIVTEFMCHGSLLDFLK----NP-------------------------------------------------------------------EG-QDL--RLPQLVDMAAQVAEGMAYMER--MN---YIHRDLRAANILVG-E-----RL-AC---KIADFGLARLI---------K--DDEY--------------NPCQGSKFPIKWTAPEAAL-----FGR-FTIKSDVWSFGILLTELITKGR-IP---------------YPGM-----------NKREVLEQV----EQ----GYH---MPCPPGCP------------ASLYE-AMEQTWRLDPEERPTFEYLQSFL-----------
----ITMKHKLGGGQYGEVYEGVWK----------------KYSLTVAVKTL---K-E--D-TM-EV---EEFL-K----EAAVMKEI-KHPNLVQLLGVCT--R-----EPP------FYIITEFMTYGNLLDYLR----EC-------------------------------------------------------------------NR-QEV--NAVVLLYMATQISSAMEYLEK--KN---FIHRDLAARNCLVG-E-----NH-LV---KVADFGLSRLM---------T--GDTY--------------TAHAGAKFPIKWTAPESLA-----YNK-FSIKSDVWAFGVLLWEIATYGM-SP---------------YPGI-----------DLSQVYELL----EK----DYR---MERPEGCP------------EKVYE-LMRACWQWNPSDRPSFAEIHQA--F---------
----ITMKHKLGGGQYGEVYVGVWK----------------KYSLTVAVKTL---K-E--D-TM-EV---EEFL-K----EAAVMKEI-KHPNLVQLLGVCT--L-----EPP------FYIVTEYMPYGNLLDYLR----EC-------------------------------------------------------------------NR-EEV--TAVVLLYMATQISSAMEYLEK--KN---FIHRDLAARNCLVG-E-----NH-VV---KVADFGLSRLM---------T--GDTY--------------TAHAGAKFPIKWTAPESLA-----YNT-FSIKSDVWAFGVLLWEIATYGM-SP---------------YPGI-----------DLSQVYDLL----EK----GYR---MEQPEGCP------------PKVYE-LMRACWKWSPADRPSFAETHQA--F---------
---I-TLIRGLGHGAFGEVYEGQVSG-----------MPNDPSPLQVAVKTL---P-E--V-CS-EQD-ELDFL-M----EALIISKF-NHQNIVRCIGVSL--Q-----SLP------RFILLELMAGGDLKSFLR----ETRP--------------------------------------------------------------RPSQP-SSL--AMLDLLHVARDIACGCQYLEE--NH---FIHRDIAARNCLLT-CP--GPGR-VA---KIGDFGMARDI-----Y---R--ASYY--------------RKGGCAMLPVKWMPPEAFM-----EGI-FTSKTDTWSFGVLLWEIFSLGY-MP---------------YPSK-----------SNQEVLEFV----TS----GGR---MDPPKNCP------------GPVYR-IMTQCWQHQPEDRPNFAIILER--I---------
----FEIGRPLGKGKFGNVYLAREK----------------QSKFILALKVL---FKA--QLEKAGV---EHQLRR----EVEIQSHL-RHPNILRLYGYFH--D-----ATR------VYLILEYAPLGTVYRELQ---KLS-----------------------------------------------------------------------KF--DEQRTATYITELANALSYCHS--KR---VIHRDIKPENLLLG-S-----AG-EL---KIADFGWSV-----------HAPSSRR--------------TT---LCGTLDYLPPEMIE-----GRM-HDEKVDLWSLGVLCYEFLV-GK-PP---------------FEAN--------------TYQETY----KR----ISR---VEFTFPDFVT----------EGARD-LISRLLKHNPSQRPMLREVLEHPWI---------
----FEIGRPLGKGKFGNVYLAREK----------------KSHFIVALKVL---FKS--Q-IEKEG---VEHQLR---REIEIQAHL-HHPNILRLYNYFY--D-----RRR------IYLILEYAPRGELYKELQ---KSC-----------------------------------------------------------------------TF--DEQRTATIMEELADALMYCHG--KK---VIHRDIKPENLLLG-L-----KG-EL---KIADFGWSV-----------HAPSLRR--------------KT---MCGTLDYLPPEMIE-----GRM-HNEKVDLWCIGVLCYELLV-GN-PP---------------FESA--------------SHNETY----RR----IVK---VDLKFPASVP----------MGAQD-LISKLLRHNPSERLPLAQVSAHPWV---------
----FEIGRPLGKGKFGNVYLARLK----------------ESHFIVALKVL---FKS--Q-IEKEG---LEHQLR---REIEIQAHL-QHPNILRLYNYFH--D-----ARR------VYLILEYAPRGELYKELQ---KSE-----------------------------------------------------------------------KL--DEQRTATIIEELADALTYCHD--KK---VIHRDIKPENLLLG-F-----RG-EV---KIADFGWSV-----------HTPSLRR--------------KT---MCGTLDYLPPEMIE-----GRT-YDEKVDLWCIGVLCYELLV-GY-PP---------------FESA--------------SHSETY----RR----ILK---VDVRFPLSMP----------LGARD-LISRLLRYQPLERLPLAQILKHPWV---------
---V-ALGKTLGEGEFGAVMEGQLN--------------QDDSILKVAVKTM---K-I-AI-CT-RSE-LEDFL-S----EAVCMKEF-DHPNVMRLIGVCF--Q-----GSERESFPAPVVILPFMKHGDLHSFLL----YSRL---------------------------------------------------------------GDQP-VYL--PTQMLVKFMADIASGMEYLST--KR---FIHRDLAARNCMLN-E-----NM-SV---CVADFGLSKKI-----Y---N--GDYY--------------RQGRIAKMPVKWIAIESLA-----DRV-YTSKSDVWSFGVTMWEIATRGQ-TP---------------YPGV-----------ENSEIYDYL----RQ----GNR---LKQPADCL------------DGLYA-LMSRCWELNPQDRPSFTELREDL-----------
---L-RLVRKLGSGQFGEVWMGYYK-----------------NNMKVAIKTL---K-E--G-TM-SP---EAFL-G----EANVMKAL-QHERLVRLYAVVT--------KEP------IYIVTEYMARGCLLDFLK----TD-------------------------------------------------------------------EG-SRL--SLPRLIDMSAQIAEGMAYIER--MN---SIHRDLRAANILVS-E-----AL-CC---KIADFGLARII------------DSEY--------------TAQEGAKFPIKWTAPEAIH-----FGV-FTIKADVWSFGVLLMEVVTYGR-VP---------------YPGM-----------SNPEVIRNL----ER----GYR---MPRPDTCP------------PELYRGVIAECWRSRPEERPTFEFLQSV--L---------
----ITLLKELGSGQFGVVQLGKWK-----------------GQYDVAVKMI---K-E--G-SM-SE---DEFF-Q----EAQTMMKL-SHPKLVKFYGVCS--K-----EYP------IYIVTEYISNGCLLNYLR----SH--------------------------------------------------------------------G-KGL--EPSQLLEMCYDVCEGMAFLES--HQ---FIHRDLAARNCLVD-R-----DL-CV---KVSDFGMTRYV---------L--DDQY--------------VSSVGTKFPVKWSAPEVFH-----YFK-YSSKSDVWAFGILMWEVFSLGK-QP---------------YDLY-----------DNSQVVLKV----SQ----GHR---LYRPHLAS------------DTIYQ-IMYSCWHELPEKRPTFQQLLSS--I---------
----LTFLKELGTGQFGVVKYGKWR-----------------GQYDVAIKMI---K-E--G-SM-SE---DEFI-E----EAKVMMNL-SHEKLVQLYGVCT--K-----QRP------IFIITEYMANGCLLNYLR----EM--------------------------------------------------------------------R-HRF--QTQQLLEMCKDVCEAMEYLES--KQ---FLHRDLAARNCLVN-D-----QG-VV---KVSDFGLSRYV---------L--DDEY--------------TSSVGSKFPVRWSPPEVLM-----YSK-FSSKSDIWAFGVLMWEIYSLGK-MP---------------YERF-----------TNSETAEHI----AQ----GLR---LYRPHLAS------------EKVYT-IMYSCWHEKADERPTFKILLSN--I---------
---W-EMRERLGTGGFGNVCLYQHR----------------ELDLKIAIKSC---RLE--L-STKNR---ER-WCH----EIQIMKKL-NHANVVKACDVPE--ELNILIHDV------PLLAMEYCSGGDLRKLLNKPENCC-----------------------------------------------------------------------GL--KESQILSLLSDIGSGIRYLHE--NK---IIHRDLKPENIVLQ-D-----VG-GKIIHKIIDLGYAKD----------VDQGSLC--------------TS---FVGTLQYLAPELFE-----NKP-YTATVDYWSFGTMVFECIA-GY-RP---------------FLHHLQPFTWHEKIKKKDPKCIFA----CE----EMS---GEVRFSSHLPQPNSLCSLVVEPMEN-WLQLMLNWDPQQRG-----------GPVDLTLKQ
----LQFGKTLGAGAFGKVVEATAFG-----------LGKEDAVLKVAVKML---K-S--T-AH-ADE-KEALM-S----ELKIMSHLGQHENIVNLLGACT--H-----GGP------VLVITEYCCYGDLLNFLR----RKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDG-RPL--ELRDLLHFSSQVAQGMAFLAS--KN---CIHRDVAARNVLLT-N-----GH-VA---KIGDFGLARDI-----M---N--DSNY--------------IVKGNARLPVKWMAPESIF-----DCV-YTVQSDVWSYGILLWEIFSLGL-NP---------------YPGI-L---------VNSKFYKLV----KD----GYQ---MAQPAFAP------------KNIYS-IMQACWALEPTHRPTFQQICSFL-----------
----LKLLQTIGKGEFGDVMLGDYR------------------GNKVAVKCI---K-N--D-AT-AQ----AFL-A----EASVMTQL-RHSNLVQLLGVIV-EE-----KGG------LYIVTEYMAKGSLVDYLR----SR-------------------------------------------------------------------GR-SVL--GGDCLLKFSLDVCEAMEYLEG--NN---FVHRDLAARNVLVS-E-----DN-VA---KVSDFGLTKEA---------------S--------------STQDTGKLPVKWTAPEALR-----EKK-FSTKSDVWSFGILLWEIYSFGR-VP---------------YPRI-----------PLKDVVPRV----EK----GYK---MDAPDGCP------------PAVYE-VMKNCWHLDAAMRPSFLQLREQL-----------
----LRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKIL---R-P--D-AT-KNA-RNDFL-K----EVKIMSRL-KDPNIIRLLGVCV--Q-----DDP------LCMITDYMENGDLNQFLS----AHQLEDKAAE--------------------------------------------------GAPGDGQAAQG-PTI--SYPMLLHVAAQIASGMRYLAT--LN---FVHRDLATRNCLVG-E-----NF-TI---KIADFGMSRNL-----Y---A--GDYY--------------RVQGRAVLPIRWMAWECIL-----MGK-FTTASDVWAFGVTLWEVLMLCRAQP---------------FGQL-----------TDEQVIENAGEFFRD----QGRQVYLSRPPACP------------QGLYE-LMLRCWSRESEQRPPFSQLHRFL-----------
----LTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKML---R-A--D-AN-KNA-RNDFL-K----EIKIMSRL-KDPNIIHLLAVCI--T-----DDP------LCMITEYMENGDLNQFLS----RHEPPN-----------------------------------------------------------SSSSDV-RTV--SYTNLKFMATQIASGMKYLSS--LN---FVHRDLATRNCLVG-K-----NY-TI---KIADFGMSRNL-----Y---S--GDYY--------------RIQGRAVLPIRWMSWESIL-----LGK-FTTASDVWAFGVTLWETFTFCQEQP---------------YSQL-----------SDEQVIENT----GEFFRDQGRQTYLPQPAICP------------DSVYK-LMLSCWRRDTKNRPSFQEIHL---LL--------
---F-KKIKVLGSGAFGTVYKGLWIP------------EGEKVKIPVAIKEL---R-E--A-TS-PKA-NKEIL-D----EAYVMASV-DNPHVCRLLGICL--------TST------VQLITQLMPFGCLLDYVR----EH--------------------------------------------------------------------K-DNI--GSQYLLNWCVQIAKGMNYLED--RR---LVHRDLAARNVLVK-T-----PQ-HV---KITDFGLAKLL-----G---A--EEKE--------------YHAEGGKVPIKWMALESIL-----HRI-YTHQSDVWSYGVTVWELMTFGS-KP---------------YDGI-----------PASEISSIL----EK----GER---LPQPPICT------------IDVYM-IMVKCWMIDADSRPKFRELI----IEF-------
---V-TRQKVIGAGEFGEVYKGMLKT------------SSGKKEVPVAIKTL---K-A--G-YT-EKQ-RVDFL-G----EAGIMGQF-SHHNIIRLEGVIS--K-----YKP------MMIITEYMENGALDKFLR----EK--------------------------------------------------------------------D-GEF--SVLQLVGMLRGIAAGMKYLAN--MN---YVHRDLAARNILVN-S-----NL-VC---KVSDFGLSRVL-----E---D--DPEA-------------TYTTSGGKIPIRWTAPEAIS-----YRK-FTSASDVWSFGIVMWEVMTYGE-RP---------------YWEL-----------SNHEVMKAI----ND----GFR---LPTPMDCP------------SAIYQ-LMMQCWQQERARRPKFADIVSIL-----------
----IHIEKIIGSGDSGEVCYGRLR-------------VPGQRDVPVAIKAL---K-A--G-YT-ERQ-RRDFL-S----EASIMGQF-DHPNIIRLEGVVT--R-----GRL------AMIVTEYMENGSLDTFLR----TH--------------------------------------------------------------------D-GQF--TIMQLVGMLRGVGAGMRYLSD--LG---YVHRDLAARNVLVD-S-----NL-VC---KVSDFGLSRVL-----E---D--DPDA-------------AYTTTGGKIPIRWTAPEAIA-----FRT-FSSASDVWSFGVVMWEVLAYGE-RP---------------YWNM-----------TNRDVISSV----EE----GYR---LPAPMGCP------------HALHQ-LMLDCWHKDRAQRPRFSQIVSVL-----------
---V-KIEEVIGAGEFGEVYKGRLK-------------LPGKREIYVAIKTL---K-A--G-YS-EKQ-RRDFL-S----EASIMGQF-DHPNIIRLEGVVT--K-----SRP------VMIITEFMENGALDSFLR----QN--------------------------------------------------------------------D-GQF--TVIQLVGMLRGIAAGMKYLAE--MN---YVHRDLAARNILVN-S-----NL-VC---KVSDFGLSRYLQ--DDT---S--DPTY--------------TSSLGGKIPVRWTAPEAIA-----YRK-FTSASDVWSYGIVMWEVMSFGE-RP---------------YWDM-----------SNQDVINAI----EQ----DYR---LPPPMDCP------------AALHQ-LMLDCWQKDRNSRPRFAEIVNTL-----------
---V-KIEQVIGAGEFGEVCSGHLK-------------LPGKREIFVAIKTL---K-S--G-YT-EKQ-RRDFL-S----EASIMGQF-DHPNVIHLEGVVT--K-----STP------VMIITEFMENGSLDSFLR----QN--------------------------------------------------------------------D-GQF--TVIQLVGMLRGIAAGMKYLAD--MN---YVHRDLAARNILVN-S-----NL-VC---KVSDFGLSRFLE--DDT---S--DPTY--------------TSALGGKIPIRWTAPEAIQ-----YRK-FTSASDVWSYGIVMWEVMSYGE-RP---------------YWDM-----------TNQDVINAI----EQ----DYR---LPPPMDCP------------SALHQ-LMLDCWQKDRNHRPKFGQIVNTL-----------
---V-KIEEVIGAGEFGEVCRGRLK-------------APGKKESCVAIKTL---K-G--G-YT-ERQ-RREFL-S----EASIMGQF-EHPNIIRLEGVVT--N-----SMP------VMILTEFMENGALDSFLR----LN--------------------------------------------------------------------D-GQF--TVIQLVGMLRGIASGMRYLAE--MS---YVHRDLAARNILVN-S-----NL-VC---KVSDFGLSRFLE--ENS---S--DPTY--------------TSSLGGKIPIRWTAPEAIA-----FRK-FTSASDAWSYGIVMWEVMSFGE-RP---------------YWDM-----------SNQDVINAI----EQ----DYR---LPPPPDCP------------TSLHQ-LMLDCWQKDRNARPRFPQVVSAL-----------
----IKIEEVIGTGSFGEVRQGRLQ-------------PRGRREQTVAIQAL---W-A--G-GA-ESL-QMTFL-G----RAAVLGQF-QHPNILRLEGVVT--K-----SRP------LMVLTEFMELGPLDSFLR----QR--------------------------------------------------------------------E-GQF--SSLQLVAMQRGVAAAMQYLSS--FA---FVHRSLSAHSVLVN-S-----HL-VC---KVARLGHSPQG-----------------------------------PSCLLRWAAPEVIA-----HGK-HTTSSDVWSFGILMWEVMSYGE-RP---------------YWDM-----------SEQEVLNAI----EQ----EFR---LPPPPGCP------------PGLHL-LMLDTWQKDRARRPHFDQLVA---AF--------
---L-KRVKVLGSGAFGTVYKGIWVP------------EGETVKIPVAIKIL---N-E--T-TG-PKA-NVEFM-D----EALIMASM-DHPHLVRLLGVCL--------SPT------IQLVTQLMPHGCLLEYVH----EH--------------------------------------------------------------------K-DNI--GSQLLLNWCVQIAKGMMYLEE--RR---LVHRDLAARNVLVK-S-----PN-HV---KITDFGLARLL-----E---G--DEKE--------------YNADGGKMPIKWMALECIH-----YRK-FTHQSDVWSYGVTIWELMTFGG-KP---------------YDGI-----------PTREIPDLL----EK----GER---LPQPPICT------------IDVYM-VMVKCWMIDADSRPKFKELAAE--F---------
--VI--LGELLGKGNFGEVYKGTLK-----------------DKTSVAVKTC---K-E--D-LP-QEL-KIKFL-Q----EAKILKQY-DHPNIVKLIGVCT--Q-----RQP------VYIIMELVSGGDFLTFLR----RK--------------------------------------------------------------------K-DEL--KLKQLVKFSLDAAAGMLYLES--KN---CIHRDLAARNCLVG-E-----NN-VL---KISDFGMSRQE---------D--GGVY--------------SSSGLKQIPIKWTAPEALN-----YGR-YSSESDVWSFGILLWETFSLGV-CP---------------YPGM-----------TNQQAREQV----ER----GYR---MSAPQHCP------------EDISK-IMMKCWDYKPENRPKFSELQKEL-----------
---L-VLGEQIGRGNFGEVFSGRLR----------------ADNTLVAVKSC---R-E--T-LP-PDL-KAKFL-Q----EARILKQY-SHPNIVRLIGVCT--Q-----KQP------IYIVMELVQGGDFLTFLR----TE--------------------------------------------------------------------G-ARL--RVKTLLQMVGDAAAGMEYLES--KC---CIHRDLAARNCLVT-E-----KN-VL---KISDFGMSREE-----A---D--GVYA--------------ASGGLRQVPVKWTAPEALN-----YGR-YSSESDVWSFGILLWETFSLGA-SP---------------YPNL-----------SNQQTREFV----EK----GGR---LPCPELCP------------DAVFR-LMEQCWAYEPGQRPSFSTIYQEL-----------
---L-VLGKPLGEGCFGQVVLAEAIGL---------DKDKPNRVTKVAVKML---K-S--D-AT-EKD-LSDLI-S----EMEMMKMIGKHKNIINLLGACT--Q-----DGP------LYVIVEYASKGNLREYLQ----ARRPPGLEY-----------------------------------------------------CYNPSHNPE-EQL--SSKDLVSCAYQVARGMEYLAS--KK---CIHRDLAARNVLVT-E-----DN-VM---KIADFGLARDI-----H---H--IDYY--------------KKTTNGRLPVKWMAPEALF-----DRI-YTHQSDVWSFGVLLWEIFTLGG-SP---------------YPGV-----------PVEELFKLL----KE----GHR---MDKPSNCT------------NELYM-MMRDCWHAVPSQRPTFKQLVEDL-----------
----LTLGKPLGEGCFGQVVMAEAVGI---------DKDKPKEAVTVAVKML---K-D--D-AT-EKD-LSDLV-S----EMEMMKMIGKHKNIINLLGACT--Q-----DGP------LYVIVEYASKGNLREYLR----ARRPPGMEY-----------------------------------------------------SYDINRVPE-EQM--TFKDLVSCTYQLARGMEYLAS--QK---CIHRDLAARNVLVT-E-----NN-VM---KIADFGLARDI-----N---N--IDYY--------------KKTTNGRLPVKWMAPEALF-----DRV-YTHQSDVWSFGVLMWEIFTLGG-SP---------------YPGI-----------PVEELFKLL----KE----GHR---MDKPANCT------------NELYM-MMRDCWHAVPSQRPTFKQLVEDL-----------
----LTLGKPLGEGCFGQVVMAEAIGI---------DKDRAAKPVTVAVKML---K-D--D-AT-DKD-LSDLV-S----EMEMMKMIGKHKNIINLLGACT--Q-----GGP------LYVLVEYAAKGNLREFLR----ARRPPGLDY-----------------------------------------------------SFDTCKPPE-EQL--TFKDLVSCAYQVARGMEYLAS--QK---CIHRDLAARNVLVT-E-----DN-VM---KIADFGLARDV-----H---N--LDYY--------------KKTTNGRLPVKWMAPEALF-----DRV-YTHQSDVWSFGVLLWEIFTLGG-SP---------------YPGI-----------PVEELFKLL----KE----GHR---MDKPANCT------------HDLYM-IMRECWHAAPSQRPTFKQLVEDL-----------
---L-VLGKPLGEGCFGQVVRAEAFGM---------DPARPDQASTVAVKML---K-D--N-AS-DKD-LADLV-S----EMEVMKLIGRHKNIINLLGVCT--Q-----EGP------LYVIVECAAKGNLREFLR----ARRPPGPDL-----------------------------------------------------SPDGPRSSE-GPL--SFPVLVSCAYQVARGMQYLES--RK---CIHRDLAARNVLVT-E-----DN-VM---KIADFGLARGV-----H---H--IDYY--------------KKTSNGRLPVKWMAPEALF-----DRV-YTHQSDVWSFGILLWEIFTLGG-SP---------------YPGI-----------PVEELFSLL----RE----GHR---MDRPPHCP------------PELYG-LMRECWHAAPSQRPTFKQLVEAL-----------
----LHLGRVLGYGAFGKVVEASAFG-----------IHKGSSCDTVAVKML---K-E--G-AT-ASE-HRALM-S----ELKILIHIGNHLNVVNLLGACT-KP-----QGP------LMVIVEFCKYGNLSNFLR----AKRDAFSPCAEKSPEQRGRFRAMVELARLDRRR-----PGSSDRVLFARFSKTEGGARRASPDQEAEDLWL-SPL--TMEDLVCYSFQVARGMEFLAS--RK---CIHRDLAARNILLS-E-----SD-VV---KICDFGLARDI-----Y---K--DPDY--------------VRKGSARLPLKWMAPESIF-----DKV-YTTQSDVWSFGVLLWEIFSLGA-SP---------------YPGV-Q---------INEEFCQRL----RD----GTR---MRAPELAT------------PAIRR-IMLNCWSGDPKARPAFSELVEIL-----------
----LQLIKRLGNGQFGEVWMGTWN-----------------GNTKVAIKTL---K-P--G-TM-SP---ESFL-E----EAQIMKKL-KHDKLVQLYAVVS--------EEP------IYIVTEYMNKGSLLDFLK----DG-------------------------------------------------------------------EG-RAL--KLPNLVDMAAQVAAGMAYIER--MN---YIHRDLRSANILVG-N-----GL-IC---KIADFGLARLI---------E--DNEY--------------TARQGAKFPIKWTAPEAAL-----YGR-FTIKSDVWSFGILLTELVTKGR-VP---------------YPGM-----------NNREVLEQV----ER----GYR---MPCPQDCP------------ISLHE-LMIHCWKKDPEERPTFEYLQSFL-----------
----LKLEKKLGAGQFGEVWMATYN-----------------KHTKVAVKTM---K-P--G-SM-SV---EAFL-A----EANVMKTL-QHDKLVKLHAVVT--------KEP------IYIITEFMAKGSLLDFLK----SD-------------------------------------------------------------------EG-SKQ--PLPKLIDFSAQIAEGMAFIEQ--RN---YIHRDLRAANILVS-A-----SL-VC---KIADFGLARVI---------E--DNEY--------------TAREGAKFPIKWTAPEAIN-----FGS-FTIKSDVWSFGILLMEIVTYGR-IP---------------YPGM-----------SNPEVIRAL----ER----GYR---MPRPENCP------------EELYN-IMMRCWKNRPEERPTFEYIQSV--L---------
----ITMSRELGQGSFGMVYEGVAKG-----------VVKDEPETRVAIKTV---N-E--A-AS-MRE-RIEFL-N----EASVMKEF-NCHHVVRLLGVVS--Q-----GQP------TLVIMELMTRGDLKSYLR----SLRPEM-----------------------------------------------------------ENNPVL-APP--SLSKMIQMAGEIADGMAYLNA--NK---FVHRDLAARNCMVA-E-----DF-TV---KIGDFGMTRDI-----Y---E--TDYY--------------RKGGKGLLPVRWMSPESLK-----DGV-FTTYSDVWSFGVVLWEIATLAE-QP---------------YQGL-----------SNEQVLRFV----ME----GGL---LDKPDNCP------------DMLFE-LMRMCWQYNPKMRPSFLEIISS--I---------
----ITLLRELGQGSFGMVYEGNARD-----------IIKGEAETRVAVKTV---N-E--S-AS-LRE-RIEFL-N----EASVMKGF-TCHHVVRLLGVVS--K-----GQP------TLVVMELMAHGDLKSYLR----SLRPEA-----------------------------------------------------------ENNPGR-PPP--TLQEMIQMAAEIADGMAYLNA--KK---FVHRDLAARNCMVA-H-----DF-TV---KIGDFGMTRDI-----Y---E--TDYY--------------RKGGKGLLPVRWMAPESLK-----DGV-FTTSSDMWSFGVVLWEITSLAE-QP---------------YQGL-----------SNEQVLKFV----MD----GGY---LDQPDNCP------------ERVTD-LMRMCWQFNPKMRPTFLEIVNLL-----------
---I-SIIRELGQGSFGMVYEGLARG-----------LEAGEESTPVALKTV---N-E--L-AS-PRE-CIEFL-K----EASVMKAF-KCHHVVRLLGVVS--Q-----GQP------TLVIMELMTRGDLKSHLR----SLRPEA-----------------------------------------------------------ENNPGL-PQP--ALGEMIQMAGEIADGMAYLAA--NK---FVHRDLAARNCMVS-Q-----DF-TV---KIGDFGMTRDV-----Y---E--TDYY--------------RKGGKGLLPVRWMAPESLK-----DGI-FTTHSDVWSFGVVLWEIVTLAE-QP---------------YQGL-----------SNEQVLKFV----MD----GGV---LEELEGCP------------LQLQE-LMSRCWQPNPRLRPSFTHILD---SI--------
----LTFVQEIGSGQFGLVHLGYWL-----------------NKDKVAIKTI---R-E--G-AM-SE---EDFI-E----EAEVMMKL-SHPKLVQLYGVCL--E-----QAP------ICLVFEFMEHGCLSDYLR----TQ--------------------------------------------------------------------R-GLF--AAETLLGMCLDVCEGMAYLEE--AC---VIHRDLAARNCLVG-E-----NQ-VI---KVSDFGMTRFV---------L--DDQY--------------TSSTGTKFPVKWASPEVFS-----FSR-YSSKSDVWSFGVLMWEVFSEGK-IP---------------YENR-----------SNSEVVEDI----ST----GFR---LYKPRLAS------------THVYQ-IMNHCWKERPEDRPAFSRLLRQL-----------
---L-KRIRDLGEGHFGKVELCRYDP------------EGDNTGEQVAVKSL---K-P--E-SG-GNH-IADLK-K----EIEILRNL-YHENIVKYKGICT-ED------GGN----GIKLIMEFLPSGSLKEYLP----KN--------------------------------------------------------------------K-NKI--NLKQQLKYAVQICKGMDYLGS--RQ---YVHRDLAARNVLVE-S-----EH-QV---KIGDFGLTKAI----ET---D--KEYY--------------TVKDDRDSPVFWYAPECLM-----QSK-FYIASDVWSFGVTLHELLTYCD-SDSSPMALF-LKMIGPTHGQM-----------TVTRLVNTL----KE----GKR---LPCPPNCP------------DEVYQ-LMRKCWEFQPSNRTSFQNLIE---GF--------
----LKFLQQLGKGNFGSVEMCRYDP------------LQDNTGEVVAVKKL---Q-H--S-TE--EH-LRDFE-R----EIEILKSL-QHDNIVKYKGVCYSAG-----RRN------LKLIMEYLPYGSLRDYLQ----KH--------------------------------------------------------------------K-ERI--DHIKLLQYTSQICKGMEYLGT--KR---YIHRDLATRNILVE-N-----EN-RV---KIGDFGLTKVL----PQ---D--KEYY--------------KVKEPGESPIFWYAPESLT-----ESK-FSVASDVWSFGVVLYELFTYIE-KSKSPPAEFMRMIGNDKQGQM-----------IVFHLIELL----KN----NGR---LPRPDGCP------------DEIYM-IMTECWNNNVNQRPSFRDLA----LRV-------
---L-KYISQLGKGNFGSVELCRYDP------------LGDNTGALVAVKQL---Q-H--S-GP-DQ--QRDFQ-R----EIQILKAL-HSDFIVKYRGVSYGPG-----RQS------LRLVMEYLPSGCLRDFLQ----RH--------------------------------------------------------------------R-ARL--DASRLLLYSSQICKGMEYLGS--RR---CVHRDLAARNILVE-S-----EA-HV---KIADFGLAKLL----PL---D--KDYY--------------VVREPGQSPIFWYAPESLS-----DNI-FSRQSDVWSFGVVLYELFTYCD-KSCSPSAE--FLRMMGCERDV-P---------ALCRLLELL----EE----GQR---LPAPPACP------------AEVHE-LMKLCWAPSPQDRPSFSALGP---QL--------
----LKLGKPLGRGAFGQVIEADAFG-----------IDKTATCRTVAVKML---K-E--G-AT-HSE-HRALM-S----ELKILIHIGHHLNVVNLLGACT-KP-----GGP------LMVIVEFCKFGNLSTYLR----SKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRL---DSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYK-DFL--TLEHLICYSFQVAKGMEFLAS--RK---CIHRDLAARNILLS-E-----KN-VV---KICDFGLARDI-----Y---K--DPDY--------------VRKGDARLPLKWMAPETIF-----DRV-YTIQSDVWSFGVLLWEIFSLGA-SP---------------YPGV-K---------IDEEFCRRL----KE----GTR---MRAPDYTT------------PEMYQ-TMLDCWHGEPSQRPTFSELVEHL-----------
---V-TLLRALGHGAFGEVYEGLVIG-----------LPGDSSPLQVAIKTL---P-E--L-CS-PQD-ELDFL-M----EALIISKF-RHQNIVRCVGLSL--R-----ATP------RLILLELMSGGDMKSFLR----HSRP--------------------------------------------------------------HLGQP-SPL--VMRDLLQLAQDIAQGCHYLEE--NH---FIHRDIAARNCLLS-CA--GPSR-VA---KIGDFGMARDI-----Y---R--ASYY--------------RRGDRALLPVKWMPPEAFL-----EGI-FTSKTDSWSFGVLLWEIFSLGY-MP---------------YPGR-----------TNQEVLDFV----VG----GGR---MDPPRGCP------------GPVYR-IMTQCWQHEPELRPSFASILERL-----------
--WL--KGQQIGLGAFSSCYQAQDV----------------GTGTLMAVKQV---TYV--R-NTSSE---QEEVVEALREEIRMMSHL-NHPNIIRMLGATC--E-----KSN------YNLFIEWMAGGSVAHLLS---KYG-----------------------------------------------------------------------AF--KESVVINYTEQLLRGLSYLHE--NQ---IIHRDVKGANLLID-S-----TG-QR--LRIADFGAAARLAS-----KGTGAGEFQ--------------GQ---LLGTIAFMAPEVLR-----GQQ-YGRSCDVWSVGCAIIEMAC-AK-PP---------------WNAE-----------KHSNHLALI----FK----IAS---ATTAPSIPSHLS--------PGLRD-VALRCLELQPQDRPPSRELLKHPVF---------
-ERL-----VLGKGTYGVVYAGRDR----------------HTRVRIAIKEI---PER--D-SRFSQ---PLH--E----EIALHRRL-RHKNIVRYLGSAS--Q-----GGY------LKIFMEEVPGGSLSSLLR--SVWG-----------------------------------------------------------------------PLKDNESTISFYTRQILQGLGYLHD--NH---IVHRDIKGDNVLINTF-----SG-LL---KISDFGTSKRL---------AGITPCT--------------ET---FTGTLQYMAPEIID---QGPRG-YGKAADIWSLGCTVIEMAT-GR-PP---------------FHEL-------------GSPQAAM----FQ----VGM---YKVHPPMPSSLS--------AEAQA-FLLRTFEPDPRLRASAQTLLGDPFL---------
----IEVEEVVGRGAFGVVCKAKWR------------------AKDVAIKQI---E-------S-ESE-RKAFI-V----ELRQLSRV-NHPNIVKLYGACL---------NP------VCLVMEYAEGGSLYNVLH----GA-------------------------------------------------------------------EPLPYY--TAAHAMSWCLQCSQGVAYLHS--MQPKALIHRDLKPPNLLLV-A-----GGTVL---KICDFGTACDI---------------Q--------------THMTNNKGSAAWMAPEVFE-----GSN-YSEKCDVFSWGIILWEVITR-R-KP---------------FDEIGG---------PAFRIMWAV----HN----GTR---PPLIKNLP------------KPIES-LMTRCWSKDPSQRPSMEEIVKI--M---------
----LTLGAQIGEGEFGAVLQGEYL------------------GQKVAVKNI---K-C--D-VT-AQ----AFL-D----ETAVMTKM-QHENLVRLLGVIL--------HQG------LYIVMEHVSKGNLVNFLR----TR-------------------------------------------------------------------GR-ALV--NTAQLLQFSLHVAEGMEYLES--KK---LVHRDLAARNILVS-E-----DL-VA---KVSDFGLAKAE---------------R--------------KGLDSSRLPVKWTAPEALK-----HGK-FTSKSDVWSFGVLLWEVFSYGR-AP---------------YPKM-----------SLKEVSEAV----EK----GYR---MEPPEGCP------------GPVHV-LMSSCWEAEPARRPPFRKLAEKL-----------
---L-ILGKILGEGEFGSVMEGNLK-------------QEDGTSLKVAVKTM---KLD--N-SS-QRE-IEEFL-S----EAACMKDF-SHPNVIRLLGVCI--E-----MSSQG-IPKPMVILPFMKYGDLHTYLL----YSRL---------------------------------------------------------------ETGP-KHI--PLQTLLKFMVDIALGMEYLSN--RN---FLHRDLAARNCMLR-D-----DM-TV---CVADFGLSKKI-----Y---S--GDYY--------------RQGRIAKMPVKWIAIESLA-----DRV-YTSKSDVWAFGVTMWEIATRGM-TP---------------YPGV-----------QNHEMYDYL----LH----GHR---LKQPEDCL------------DELYE-IMYSCWRTDPLDRPTFSVLRLQ--L---------
----VHFNEVIGRGHFGCVYHGTLL-------------DNDGKKIHCAVKSL---N-R--I-TD-IGE-VSQFL-T----EGIIMKDF-SHPNVLSLLGICL-RS-----EGS------PLVVLPYMKHGDLRNFIR----NE--------------------------------------------------------------------T-HNP--TVKDLIGFGLQVAKGMKYLAS--KK---FVHRDLAARNCMLD-E-----KF-TV---KVADFGLARDM-----Y---D--KEYYS------------VHNKTGAKLPVKWMALESLQ-----TQK-FTTKSDVWSFGVLLWELMTRGA-PP---------------YPDV-----------NTFDITVYL----LQ----GRR---LLQPEYCP------------DPLYE-VMLKCWHPKAEMRPSFSELVSR--I---------
-THS---DRVIGKGHFGVVYHGEYI-------------DQAQNRIQCAIKSL---S-R--I-TE-MQQ-VEAFL-R----EGLLMRGL-NHPNVLALIGIML-PP-----EGL------PHVLLPYMCHGDLLQFIR----SP--------------------------------------------------------------------Q-RNP--TVKDLISFGLQVARSMEYLAE--QK---FVHRDLAARNCMLD-E-----SF-TV---KVADFGLARDI-----L---D--REYYS------------VQQHRHARLPVKWMALESLQ-----TYR-FTTKSDVWSFGVLLWELLTRGA-PP---------------YRHI-----------DPFDLTHFL----AQ----GRR---LPQPEYCP------------DSLYQ-VMQQCWEADPAVRPTFRVLV----GEV-------
---I-EYVRDIGEGAFGRVFQARAPG-----------LLPYEPFTMVAVKML---K-E--E-AS-ADM-QADFQ-R----EAALMAEF-DNPNIVKLLGVCA--V-----GKP------MCLLFEYMAYGDLNEFLR----SMSPHTVCSLSHS---------------------------------------------DLSMRAQVSSPGP-PPL--SCAEQLCIARQVAAGMAYLSE--RK---FVHRDLATRNCLVG-E-----NM-VV---KIADFGLSRNI-----Y---S--ADYY--------------KANENDAIPIRWMPPESIF-----YNR-YTTESDVWAYGVVLWEIFSYGL-QP---------------YYGM-----------AHEEVIYYV----RD----GNI---LSCPENCP------------VELYN-LMRLCWSKLPADRPSFTSIHRIL-----------
----YDVIKAIGQGAFGKAYLAKGK----------------SDSKHCVIKEI---NFE--K-MPIQE---KEASKK----EVILLEKM-KHPNIVAFFNSFQ--E-----NGR------LFIVMEYCDGGDLMKRINR-QRGV-----------------------------------------------------------------------LF--SEDQILGWFVQISLGLKHIHD--RK---ILHRDIKAQNIFLS-K-----NG-MV--AKLGDFGIARVL---------NNSMELA--------------RT---CIGTPYYLSPEICQ-----NKP-YNNKTDIWSLGCVLYELCT-LK-HP---------------FEGN--------------NLQQLV----LK----ICQ---AHFAPISPGF---S------RELHS-LISQLFQVSPRDRPSINSILKRPFL---------
--IV--LKWELGEGAFGKVFLAECHN-----------LLPEQDKMLVAVKAL---K-E--A-SE-SA--RQDFQ-R----EAELLTML-QHQHIVRFFGVCT--E-----GRP------LLMVFEYMRHGDLNRFLR----SHGPDAKL------------------------------------------------------LAGGEDVAP-GPL--GLGQLLAVASQVAAGMVYLAG--LH---FVHRDLATRNCLVG-Q-----GL-VV---KIGDFGMSRDI-----Y---S--TDYY--------------RVGGRTMLPIRWMPPESIL-----YRK-FTTESDVWSFGVVLWEIFTYGK-QP---------------WYQL-----------SNTEAIDCI----TQ----GRE---LERPRACP------------PEVYA-IMRGCWQREPQQRHSIKDVHARL-----------
---I-VLKRELGEGAFGKVFLAECYN-----------LCPEQDKILVAVKTL---K-D--A-SD-NA--RKDFH-R----EAELLTNL-QHEHIVKFYGVCV--E-----GDP------LIMVFEYMKHGDLNKFLR----AHGPDAV--------------------------------------------------------LMAEGNPP-TEL--TQSQMLHIAQQIAAGMVYLAS--QH---FVHRDLATRNCLVG-E-----NL-LV---KIGDFGMSRDV-----Y---S--TDYY--------------RVGGHTMLPIRWMPPESIM-----YRK-FTTESDVWSLGVVLWEIFTYGK-QP---------------WYQL-----------SNNEVIECI----TQ----GRV---LQRPRTCP------------QEVYE-LMLGCWQREPHMRKNIKGIHTL--L---------
---I-VLKRELGEGAFGKVFLAECYN-----------LSPTKDKMLVAVKAL---K-D--P-TL-AA--RKDFQ-R----EAELLTNL-QHEHIVKFYGVCG--D-----GDP------LIMVFEYMKHGDLNKFLR----AHGPDAMIL-----------------------------------------------------VDGQPRQAK-GEL--GLSQMLHIASQIASGMVYLAS--QH---FVHRDLATRNCLVG-A-----NL-LV---KIGDFGMSRDV-----Y---S--TDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIM-----YRK-FTTESDVWSFGVILWEIFTYGK-QP---------------WFQL-----------SNTEVIECI----TQ----GRV---LERPRVCP------------KEVYD-VMLGCWQREPQQRLNIKEIYKIL-----------
----IELGRCIGEGQFGDVHQGIYM-------------SPENPALAVAIKTC---K-N--C-TS-DSV-REKFL-Q----EALTMRQF-DHPHIVKLIGVIT--------ENP------VWIIMELCTLGELRSFLQ----VR--------------------------------------------------------------------K-YSL--DLASLILYAYQLSTALAYLES--KR---FVHRDIAARNVLVS-S-----ND-CV---KLGDFGLSRYM---------E--DSTY--------------YKASKGKLPIKWMAPESIN-----FRR-FTSASDVWMFGVCMWEILMHGV-KP---------------FQGV-----------KNNDVIGRI----EN----GER---LPMPPNCP------------PTLYS-LMTKCWAYDPSRRPRFTELKAQL-----------
---F-TLCRKLGSGYFGEVFEGLWK-----------------DRVQVAIKVI---S-R--D-NL-LH--QQMLQ-S----EIQAMKKL-RHKHILALYAVVS--V-----GDP------VYIITELMAKGSLLELLR----DS-------------------------------------------------------------------DE-KVL--PVSELLDIAWQVAEGMCYLES--QN---YIHRDLAARNILVG-E-----NT-LC---KVGDFGLARLI------------KEDV--------------YLSHDHNIPYKWTAPEALS-----RGH-YSTKSDVWSFGILLHEMFSRGQ-VP---------------YPGM-----------SNHEAFLRV----DA----GYR---MPCPLECP------------PSVHK-LMLTCWCRDPEQRPCFKALRERL-----------
---L-VLGKTLGEGEFGKVVKATAFH-----------LKGRAGYTTVAVKML---K-E--N-AS-PSE-LRDLL-S----EFNVLKQV-NHPHVIKLYGACS--Q-----DGP------LLLIVEYAKYGSLRGFLR----ESRKVGPGYLGSG---------------------------------------------GSRNSSSLDHPDE-RAL--TMGDLISFAWQISQGMQYLAE--MK---LVHRDLAARNILVA-E-----GR-KM---KISDFGLSRDV-----Y---E--EDSY--------------VKRSQGRIPVKWMAIESLF-----DHI-YTTQSDVWSFGVLLWEIVTLGG-NP---------------YPGI-----------PPERLFNLL----KT----GHR---MERPDNCS------------EEMYR-LMLQCWKQEPDKRPVFADISKDL-----------
--LT--LRLLLGSGAFGEVYEGTAVDI----------LGVGSGEIKVAVKTL---K-K--G-ST-DQE-KIEFL-K----EAHLMSKF-NHPNILKQLGVCL--L-----NEP------QYIILELMEGGDLLTYLR----KARM--------------------------------------------------------------ATFYG-PLL--TLVDLVDLCVDISKGCVYLER--MH---FIHRDLAARNCLVS-VKDYTSPR-IV---KIGDFGLARDI-----Y---K--NDYY--------------RKRGEGLLPVRWMAPESLM-----DGI-FTTQSDVWSFGILIWEILTLGH-QP---------------YPAH-----------SNLDVLNYV----QT----GGR---LEPPRNCP------------DDLWN-LMTQCWAQEPDQRPTFHRIQDQL-----------
----WEIIGELGDGAFGKVYKAQNK----------------ETSVLAAAKVI---DTK--S-EEELE---DYM--V----EIDILASC-DHPNIVKLLDAFY--Y-----ENN------LWILIEFCAGGAVDAVML--ELER-----------------------------------------------------------------------PL--TESQIQVVCKQTLDALNYLHD--NK---IIHRDLKAGNILFT-L-----DG-DI---KLADFGVSAKN---------TRTIQRR--------------DS---FIGTPYWMAPEVVMCETSKDRP-YDYKADVWSLGITLIEMAE-IE-PP---------------HHEL-----------NPMRVLLKI----AK----SEP---PTLAQPSRWS----------SNFKD-FLKKCLEKNVDARWTTSQLLQHPFV---------
---L-RLEVKLGQGCFGEVWMGTWN-----------------GTTRVAIKTL---K-P--G-TM-SP---EAFL-Q----EAQVMKKL-RHEKLVQLYAVVS--------EEP------IYIVTEYMSKGSLLDFLK----GE-------------------------------------------------------------------TG-KYL--RLPQLVDMAAQIASGMAYVER--MN---YVHRDLRAANILVG-E-----NL-VC---KVADFGLARLI---------E--DNEY--------------TARQGAKFPIKWTAPEAAL-----YGR-FTIKSDVWSFGILLTELTTKGR-VP---------------YPGM-----------VNREVLDQV----ER----GYR---MPCPPECP------------ESLHD-LMCQCWRKEPEERPTFEYLQAF--L---------
--FA--LGRKLGEGYFGEVWEGLWL-----------------GSLPVAIKVI---K-S--A-NM-K---LTDLA-K----EIQTLKGL-RHERLIRLHAVCS--G-----GEP------VYIVTELMRKGNLQAFLG----TP-------------------------------------------------------------------EG-RAL--RLPPLLGFACQVAEGMSYLEE--QR---VVHRDLAARNVLVD-D-----GL-AC---KVADFGLARLL---------K--DDIY--------------SPSSSSKIPVKWTAPEAAN-----YRV-FSQKSDVWSFGVLLHEVFTYGQ-CP---------------YEGM-----------TNHETLQQI----MR----GYR---LPRPAACP------------AEVYV-LMLECWRSSPEERPSFATLREKL-----------
----FTKLEKIGKGSFGEVFKGIDN----------------RTQKVVAIKII---DLE--E-AEDEI---EDIQ-Q----EITVLSQC-DSPYVTKYYGSYL--K-----DTK------LWIIMEYLGGGSALDLLE----PG-----------------------------------------------------------------------PL--DETQIATILREILKGLDYLHS--EK---KIHRDIKAANVLLS-E-----HG-EV---KLADFGVAGQL---------TDTQIKR--------------NT---FVGTPFWMAPEVIK-----QSA-YDSKADIWSLGITAIELAR-GE-PP---------------HSEL-----------HPMKVLFLI----PK----NNP---PTLEGNYS------------KPLKE-FVEACLNKEPSFRPTAKELLKHKFI---------
-TLE---DKELGSGNFGTVKKGYYQ--------------MKKVVKTVAVKIL---K-N--E-AN-DPALKDELL-A----EANVMQQL-DNPYIVRMIGICE--------AES------WMLVMEMAELGPLNKYLQ----QN----------------------------------------------------------------------RHV--KDKNIIELVHQVSMGMKYLEE--SN---FVHRDLAARNVLLV-T-----QH-YA---KISDFGLSKAL-----R---A--DENY-------------YKAQTHGKWPVKWYAPECIN-----YYK-FSSKSDVWSFGVLMWEAFSYGQ-KP---------------YRGM-----------KGSEVTAML----EK----GER---MGCPAGCP------------REMYD-LMNLCWTYDVENRPGFAAVE----LRL-------
----LTFMRELGSGLFGVVRLGKWR-----------------AQYKVAIKAI---R-E--G-AM-CE---EDFI-E----EAKVMMKL-THPKLVQLYGVCT--Q-----QKP------IYIVTEFMERGCLLNFLR----QR--------------------------------------------------------------------Q-GHF--SRDVLLSMCQDVCEGMEYLER--NS---FIHRDLAARNCLVS-E-----AG-VV---KVSDFGMARYV---------L--DDQY--------------TSSSGAKFPVKWCPPEVFN-----YSR-FSSKSDVWSFGVLMWEVFTEGR-MP---------------FEKY-----------TNYEVVTMV----TR----GHR---LYQPKLAS------------NYVYE-VMLRCWQEKPEGRPSFEDLLRT--I---------
-VCR---GELLGSGCFGVVHRGLWT-------------LPSGKSVPVAVKSLRVGP-E--G-PM-GTE-LGDFL-R----EVSVMMNL-EHPHVLRLHGLVL--------GQP------LQMVMELAPLGSLHARLT----AP------------------------------------------------------------------APT-PPL--LVALLCLFLRQLAGAMAYLGA--RG---LVHRDLATRNLLLA-S-----PR-TI---KVADFGLVRPL----GG---A--RGRY--------------VMGGPRPIPYAWCAPESLR-----HGA-FSSASDVWMFGVTLWEMFSGGE-EP---------------WAGV-----------PPYLILQRL----ED----RAR---LPRPPLCS------------RALYS-LALRCWAPHPADRPSFSHLE----GLL-------
---L-RLLEKLGDGSFGVVRRGEWD-------------APSGKTVSVAVKCL---K-PDVL-SQ-PEA-MDDFI-R----EVNAMHSL-DHRNLIRLYGVVL--------TPP------MKMVTELAPLGSLLDRLR----KH--------------------------------------------------------------------Q-GHF--LLGTLSRYAVQVAEGMGYLES--KR---FIHRDLAARNLLLA-T-----RD-LV---KIGDFGLMRAL----PQ---N--DDHY--------------VMQEHRKVPFAWCAPESLK-----TRT-FSHASDTWMFGVTLWEMFTYGQ-EP---------------WIGL-----------NGSQILHKI---DKE----GER---LPRPEDCP------------QDIYN-VMVQCWAHKPEDRPTFVALRDF--L---------
----IEFHEIIGSGSFGKVYKGRCR------------------NKIVAIKRY---R-ANTY-CS-KSD-VDMFC-R----EVSILCQL-NHPCVIQFVGACL-ND-----PSQ------FAIVTQYISGGSLFSLLH----EQ--------------------------------------------------------------------K-RIL--DLQSKLIIAVDVAKGMEYLHNLTQP---IIHRDLNSHNILLY-E-----DG-HA---VVADFGESRFL-----Q---S--LD-E--------------DNMTKQPGNLRWMAPEVFT-----QCTRYTIKADVFSYALCLWEILT-GE-IP---------------FAHL-----------KPAAAAADM---AYH----HIR---PPIGYSIP------------KPISS-LLIRGWNACPEGRPEFSEVVMKL-----------
---L-AFIKEIGSGQFGVVHLGEWR-----------------SHIQVAIKAI---N-E--G-SM-SE---EDFI-E----EAKVMMKL-SHSKLVQLYGVCI--Q-----RKP------LYIVTEFMENGCLLNYLR----EN--------------------------------------------------------------------K-GKL--RKEMLLSVCQDICEGMEYLER--NG---YIHRDLAARNCLVS-S-----TC-IV---KISDFGMTRYV---------L--DDEY--------------VSSFGAKFPIKWSPPEVFL-----FNK-YSSKSDVWSFGVLMWEVFTEGK-MP---------------FENK-----------SNLQVVEAI----SE----GFR---LYRPHLAP------------MSIYE-VMYSCWHEKPEGRPTFAELLR---AV--------
---L-KKIRDLGEGHFGKVSLYCYDP------------TNDGTGEMVAVKAL---K-A--D-CG-PQH-RSGWK-Q----EIDILRTL-YHEHIIKYKGCCEDQG-----EKS------LQLVMEYVPLGSLRDYLP----RH-----------------------------------------------------------------------SI--GLAQLLLFAQQICEGMAYLHA--QH---YIHRDLAARNVLLD-N-----DR-LV---KIGDFGLAKAV----PE---G--HEYY--------------RVREDGDSPVFWYAPECLK-----EYK-FYYASDVWSFGVTLYELLTHCD-SSQSPPTKF-LELIGIAQGQM-----------TVLRLTELL----ER----GER---LPRPDKCP------------CEVYH-LMKNCWETEASFRPTFENLIP---IL--------
---F-TLGRMLGKGEFGSVREAQLK-------------QEDGSFVKVAVKML---K-A-DI-IA-SSD-IEEFL-R----EAACMKEF-DHPHVAKLVGVSL--R-----SRAKGRLPIPMVILPFMKHGDLHAFLL----ASRI---------------------------------------------------------------GENP-FNL--PLQTLIRFMVDIACGMEYLSS--RN---FIHRDLAARNCMLA-E-----DM-TV---CVADFGLSRKI-----Y---S--GDYY--------------RQGCASKLPVKWLALESLA-----DNL-YTVQSDVWAFGVTMWEIMTRGQ-TP---------------YAGI-----------ENAEIYNYL----IG----GNR---LKQPPECM------------EDVYD-LMYQCWSADPKQRPSFTCLRME--L---------
---L-RLEVKLGQGCFGEVWMGTWN-----------------GTTKVAIKTL---K-P--G-TM-MP---EAFL-Q----EAQIMKKL-RHDKLVPLYAVVS--------EEP------IYIVTEFMSKGSLLDFLK----EG-------------------------------------------------------------------DG-KYL--KLPQLVDMAAQIADGMAYIER--MN---YIHRDLRAANILVG-E-----NL-VC---KIADFGLARLI---------E--DNEY--------------TARQGAKFPIKWTAPEAAL-----YGR-FTIKSDVWSFGILQTELVTKGR-VP---------------YPGM-----------VNREVLEQV----ER----GYR---MPCPQGCP------------ESLHE-LMNLCWKKDPDERPTFEYIQSFL-----------
----WTKGEILGKGAYGTVYCGLTS----------------QGQ-LIAVKQV---ALD--T-SNKLA---AEKEYRKLQEEVDLLKAL-KHVNIVAYLGTCL--Q-----ENT------VSIFMEFVPGGSISSIIN---RFG-----------------------------------------------------------------------PL--PEMVFCKYTKQILQGVAYLHE--NC---VVHRDIKGNNVMLM-P-----TG-II---KLIDFGCARRLAWA---GLNGTHSDML--------------KS---MHGTPYWMAPEVIN-----ESG-YGRKSDIWSIGCTVFEMAT-GK-PP---------------LASM-------------DRMAAMF----YI----GAH---RGLMPPLPDHFS--------ENAAD-FVRMCLTRDQHERPSALQLLKHSFL---------
LIAD----IELGCGNFGSVRQGVYR--------------MRKKQIDVAIKVL---K-Q--G-TE-KAD-TEEMM-R----EAQIMHQL-DNPYIVRLIGVCQ--------AEA------LMLVMEMAGGGPLHKFLV----GK--------------------------------------------------------------------R-EEI--PVSNVAELLHQVSMGMKYLEE--KN---FVHRDLAARNVLLV-N-----RH-YA---KISDFGLSKAL----GA---D--DSYY--------------TARSAGKWPLKWYAPECIN-----FRK-FSSRSDVWSYGVTMWEALSYGQ-KP---------------YKKM-----------KGPEVMAFI----EQ----GKR---MECPPECP------------PELYA-LMSDCWIYKWEDRPDFLTVEQR--M---------
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