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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK FLT4 203
TK ALK 1116
Other AURKA 133
Other AURKB 77
Other AURKC 43
CMGC CDK2 4
TK CSF1R 582
TK EGFR 712
TK FGFR1 478
TKL IRAK4 186
TK JAK3 822
TK KDR 834
TK KIT 589
TK LTK 510
STE MAP4K4 25
STE MAP4K5 20
TK NTRK1 510
TK NTRK2 538
TK NTRK3 538
CAMK NUAK1 55
TK PDGFRB 600
TK PTK2 422
TK RET 724
TK SRC 270
TK ZAP70 338
----LHLGRVLGYGAFGKVVEASAFG--IHKGSSCDTVAVKMLK-EG-AT-ASEHR-ALM-S-ELKILIHIG-NHLNVVNLLGACT-KP------QGPLMVIVEFCKYGNLSNFLR----AKRDAFSPCAEKSPEQRGRFRAMVELARLDRRR-----------------------------------PGSSDRVLFARFSKTEGGARRASPDQEAEDLWLSPLTMEDLVCYSFQVARGMEFLASRKCIHRDLAARNILLSE---SDVVKICDFGLARDI--Y-K--DPDY--------------VRKGSARLPLKWMAPES--IF-----DKVYTTQSDVWSFGVLLWEIFSLGASP-------------YPGVQINEEFCQRLRDGTRMRAPELAT----------------------------PAIRRIMLNCWSGDPKARPAFSELVEIL-----
---I-TLIRGLGHGAFGEVYEGQVSG--MPNDPSPLQVAVKTLP-EV-CS-EQDEL-DFL-M-EALIISKF--NHQNIVRCIGVSL--Q------SLPRFILLELMAGGDLKSFLR----ETRP--------------------------------------------------------------------------------------------RPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDI--Y-R--ASYY--------------RKGGCAMLPVKWMPPEA--FM-----EGIFTSKTDTWSFGVLLWEIFSLGYMP-------------YPSK-SNQEVLEFVTSGGRMDPPKNCP----------------------------GPVYRIMTQCWQHQPEDRPNFAIILER--I---
----FEIGRPLGKGKFGNVYLAREK-------QSKFILALKVLFKAQLEKAGV--E-HQLRR-EVEIQSHL--RHPNILRLYGYFH--D------ATRVYLILEYAPLGTVYRELQ---KLS----------------------------------------------------------------------------------------------------KFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGS---AGELKIADFGWSV------HAPSSRR--------------TT---LCGTLDYLPPEM--IE-----GRMHDEKVDLWSLGVLCYEFLV-GKPP-------------FEAN----TYQETYKRISRVEFTFPDFVT--------------------------EGARDLISRLLKHNPSQRPMLREVLEHPWI---
----FEIGRPLGKGKFGNVYLAREK-------KSHFIVALKVLFKSQ-IEKEG--V-EHQLRREIEIQAHL--HHPNILRLYNYFY--D------RRRIYLILEYAPRGELYKELQ---KSC----------------------------------------------------------------------------------------------------TFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLGL---KGELKIADFGWSV------HAPSLRR--------------KT---MCGTLDYLPPEM--IE-----GRMHNEKVDLWCIGVLCYELLV-GNPP-------------FESA----SHNETYRRIVKVDLKFPASVP--------------------------MGAQDLISKLLRHNPSERLPLAQVSAHPWV---
----FEIGRPLGKGKFGNVYLARLK-------ESHFIVALKVLFKSQ-IEKEG--L-EHQLRREIEIQAHL--QHPNILRLYNYFH--D------ARRVYLILEYAPRGELYKELQ---KSE----------------------------------------------------------------------------------------------------KLDEQRTATIIEELADALTYCHDKKVIHRDIKPENLLLGF---RGEVKIADFGWSV------HTPSLRR--------------KT---MCGTLDYLPPEM--IE-----GRTYDEKVDLWCIGVLCYELLV-GYPP-------------FESA----SHSETYRRILKVDVRFPLSMP--------------------------LGARDLISRLLRYQPLERLPLAQILKHPWV---
----FQKVEKIGEGTYGVVYKARNK-------LTGEVVALKKIRLDT-ETEGV--P-STAIR-EISLLKEL--NHPNIVKLLDVIH--T------ENKLYLVFEFLHQ-DLKKFMDA-SALT----------------------------------------------------------------------------------------------------GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINT---EGAIKLADFGLARAF----GVPVRTY--------------TH---EVVTLWYRAPEI--LL----GCKYYSTAVDIWSLGCIFAEMVT-RRAL-------------FPGD-SEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF---
----LQFGKTLGAGAFGKVVEATAFG--LGKEDAVLKVAVKMLK-ST-AH-ADEKE-ALM-S-ELKIMSHLG-QHENIVNLLGACT--H------GGPVLVITEYCCYGDLLNFLR----RKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRR------------------------------DSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTN---GHVAKIGDFGLARDI--M-N--DSNY--------------IVKGNARLPVKWMAPES--IF-----DCVYTVQSDVWSYGILLWEIFSLGLNP-------------YPGILVNSKFYKLVKDGYQMAQPAFAP----------------------------KNIYSIMQACWALEPTHRPTFQQICSFL-----
---F-KKIKVLGSGAFGTVYKGLWIP---EGEKVKIPVAIKELR-EA-TS-PKANK-EIL-D-EAYVMASV--DNPHVCRLLGICL---------TSTVQLITQLMPFGCLLDYVR----EH--------------------------------------------------------------------------------------------------KDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKT---PQHVKITDFGLAKLL--G-A--EEKE--------------YHAEGGKVPIKWMALES--IL-----HRIYTHQSDVWSYGVTVWELMTFGSKP-------------YDGI-PASEISSILEKGERLPQPPICT----------------------------IDVYMIMVKCWMIDADSRPKFRELI----IEF-
---L-VLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLK-SD-AT-EKDLS-DLI-S-EMEMMKMIG-KHKNIINLLGACT--Q------DGPLYVIVEYASKGNLREYLQ----ARRPPGLEY-----------------------------------------------------------------------------------CYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTE---DNVMKIADFGLARDI--H-H--IDYY--------------KKTTNGRLPVKWMAPEA--LF-----DRIYTHQSDVWSFGVLLWEIFTLGGSP-------------YPGV-PVEELFKLLKEGHRMDKPSNCT----------------------------NELYMMMRDCWHAVPSQRPTFKQLVEDL-----
-VGG----NKMGEGGFGVVYKGYVN-------NTT--VAVKKLAAMV-DITTE--ELKQQFDQEIKVMAKC--QHENLVELLGFSS--D------GDDLCLVYVYMPNGSLLDRLSCLDGTP----------------------------------------------------------------------------------------------------PLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDE---AFTAKISDFGLARASE--KFAQTVMT--------------SR---IVGTTAYMAPEA--LR------GEITPKSDIYSFGVVLLEIIT-GLPA-------------VDEH-REPQLLLDIKEEIEDEEKTIEDYIDKKMNDAD--------------STSVEAMYSVASQCLHEKKNKRPDIKKVQQ----LLQ
---L-KYISQLGKGNFGSVELCRYDP---LGDNTGALVAVKQLQ-HS-GP-DQ-QR-DFQ-R-EIQILKAL--HSDFIVKYRGVSYGPG------RQSLRLVMEYLPSGCLRDFLQ----RH--------------------------------------------------------------------------------------------------RARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVES---EAHVKIADFGLAKLL-PL-D--KDYY--------------VVREPGQSPIFWYAPES--LS-----DNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACP----------------------------AEVHELMKLCWAPSPQDRPSFSALGP---QL--
----LKLGKPLGRGAFGQVIEADAFG--IDKTATCRTVAVKMLK-EG-AT-HSEHR-ALM-S-ELKILIHIG-HHLNVVNLLGACT-KP------GGPLMVIVEFCKFGNLSTYLR----SKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRL---------------------------------DSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSE---KNVVKICDFGLARDI--Y-K--DPDY--------------VRKGDARLPLKWMAPET--IF-----DRVYTIQSDVWSFGVLLWEIFSLGASP-------------YPGVKIDEEFCRRLKEGTRMRAPDYTT----------------------------PEMYQTMLDCWHGEPSQRPTFSELVEHL-----
----LSFGKTLGAGAFGKVVEATAYG--LIKSDAAMTVAVKMLK-PS-AH-LTERE-ALM-S-ELKVLSYLG-NHMNIVNLLGACT--I------GGPTLVITEYCCYGDLLNFLR----RKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYM-----------------------DMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTH---GRITKICDFGLARDI--K-N--DSNY--------------VVKGNARLPVKWMAPES--IF-----NCVYTFESDVWSYGIFLWELFSLGSSP-------------YPGMPVDSKFYKMIKEGFRMLSPEHAP----------------------------AEMYDIMKTCWDADPLKRPTFKQIVQL--I---
---V-TLLRALGHGAFGEVYEGLVIG--LPGDSSPLQVAIKTLP-EL-CS-PQDEL-DFL-M-EALIISKF--RHQNIVRCVGLSL--R------ATPRLILLELMSGGDMKSFLR----HSRP--------------------------------------------------------------------------------------------HLGQPSPLVMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGPSRVAKIGDFGMARDI--Y-R--ASYY--------------RRGDRALLPVKWMPPEA--FL-----EGIFTSKTDSWSFGVLLWEIFSLGYMP-------------YPGR-TNQEVLDFVVGGGRMDPPRGCP----------------------------GPVYRIMTQCWQHEPELRPSFASILERL-----
----FELVEVVGNGTYGQVYKGRHV-------KTGQLAAIKVMDVTE-DEEEE--I-KL----EINMLKKY-SHHRNIATYYGAFI--KKSPPGHDDQLWLVMEFCGAGSITDLVKN-TKGN----------------------------------------------------------------------------------------------------TLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTE---NAEVKLVDFGVSAQL----DRTVGRR--------------NT---FIGTPYWMAPEV--IACDENPDATYDYRSDLWSCGITAIEMAE-GAPP-------------LCDM-HPMRALFLIPRNPPPRLKSKKWS---------------------------KKFFSFIEGCLVKNYMQRPSTEQLLKHPFI---
----YELVQRVGSGTYGDVYKARNV-------HTGELAAVKIIKLEP-GDDFS--L-IQ--Q-EIFMVKEC--KHCNIVAYFGSYL--S------REKLWICMEYCGGGSLQDIYH---VTG----------------------------------------------------------------------------------------------------PLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTD---HGDVKLADFGVAAKI----TATIAKR--------------KS---FIGTPYWMAPEVAAVE----KNGGYNQLCDIWAVGITAIELGE-LQPP-------------MFDL-HPMRALFLMSKSNFQPPKLKDKTK--WS----------------------STFHNFVKIALTKNPKKRPTAERLLTHTFV---
--IV--LKWELGEGAFGKVFLAECHN--LLPEQDKMLVAVKALK-EA-SE-SA-RQ-DFQ-R-EAELLTML--QHQHIVRFFGVCT--E------GRPLLMVFEYMRHGDLNRFLR----SHGPDAKL------------------------------------------------------------------------------------LAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQ---GLVVKIGDFGMSRDI--Y-S--TDYY--------------RVGGRTMLPIRWMPPES--IL-----YRKFTTESDVWSFGVVLWEIFTYGKQP-------------WYQL-SNTEAIDCITQGRELERPRACP----------------------------PEVYAIMRGCWQREPQQRHSIKDVHARL-----
---I-VLKRELGEGAFGKVFLAECYN--LCPEQDKILVAVKTLK-DA-SD-NA-RK-DFH-R-EAELLTNL--QHEHIVKFYGVCV--E------GDPLIMVFEYMKHGDLNKFLR----AHGPDAV--------------------------------------------------------------------------------------LMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGE---NLLVKIGDFGMSRDV--Y-S--TDYY--------------RVGGHTMLPIRWMPPES--IM-----YRKFTTESDVWSLGVVLWEIFTYGKQP-------------WYQL-SNNEVIECITQGRVLQRPRTCP----------------------------QEVYELMLGCWQREPHMRKNIKGIHTL--L---
---I-VLKRELGEGAFGKVFLAECYN--LSPTKDKMLVAVKALK-DP-TL-AA-RK-DFQ-R-EAELLTNL--QHEHIVKFYGVCG--D------GDPLIMVFEYMKHGDLNKFLR----AHGPDAMIL-----------------------------------------------------------------------------------VDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGA---NLLVKIGDFGMSRDV--Y-S--TDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPES--IM-----YRKFTTESDVWSFGVILWEIFTYGKQP-------------WFQL-SNTEVIECITQGRVLERPRVCP----------------------------KEVYDVMLGCWQREPQQRLNIKEIYKIL-----
----YELQETLGKGTYGKVKRATER-------FSGRVVAIKSIRKDK-IKDEQ--D-MVHIRREIEIMSSL--NHPHIISIYEVFE--N------KDKIVIIMEYASKGELYDYIS---ERR----------------------------------------------------------------------------------------------------RLSERETRHFFRQIVSAVHYCHKNGVVHRDLKLENILLDD---NCNIKIADFGLSNL-----YQKDKFL--------------QT---FCGSPLYASPEI--VN----GRPYRGPEVDSWALGVLLYTLVY-GTMP-------------FDGF----DHKNLIRQISSGEYREPTQP---------------------------SDARGLIRWMLMVNPDRRATIEDIANHWW-V--
---L-VLGRTLGSGAFGQVVEATAHG--LSHSQATMKVAVKMLK-ST-AR-SSEKQ-ALM-S-ELKIMSHLG-PHLNVVNLLGACT--K------GGPIYIITEYCRYGDLVDYLH----RNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVLSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICE---GKLVKICDFGLARDI--M-R--DSNY--------------ISKGSTFLPLKWMAPES--IF-----NSLYTTLSDVWSFGILLWEIFTLGGTP-------------YPELPMNEQFYNAIKRGYRMAQPAHAS----------------------------DEIYEIMQKCWEEKFEIRPPFSQLVL---LL--
----IELGRCIGEGQFGDVHQGIYM----SPENPALAVAIKTCK-NC-TS-DSVRE-KFL-Q-EALTMRQF--DHPHIVKLIGVIT---------ENPVWIIMELCTLGELRSFLQ----VR--------------------------------------------------------------------------------------------------KYSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSS---NDCVKLGDFGLSRYM----E--DSTY--------------YKASKGKLPIKWMAPES--IN-----FRRFTSASDVWMFGVCMWEILMHGVKP-------------FQGV-KNNDVIGRIENGERLPMPPNCP----------------------------PTLYSLMTKCWAYDPSRRPRFTELKAQL-----
---L-VLGKTLGEGEFGKVVKATAFH--LKGRAGYTTVAVKMLK-EN-AS-PSELR-DLL-S-EFNVLKQV--NHPHVIKLYGACS--Q------DGPLLLIVEYAKYGSLRGFLR----ESRKVGPGYLGSG---------------------------------------------------------------------------GSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAE---GRKMKISDFGLSRDV--Y-E--EDSY--------------VKRSQGRIPVKWMAIES--LF-----DHIYTTQSDVWSFGVLLWEIVTLGGNP-------------YPGI-PPERLFNLLKTGHRMERPDNCS----------------------------EEMYRLMLQCWKQEPDKRPVFADISKDL-----
---L-RLEVKLGQGCFGEVWMGTWN--------GTTRVAIKTLK-PG-TM-SP--E-AFL-Q-EAQVMKKL--RHEKLVQLYAVVS---------EEPIYIVTEYMSKGSLLDFLK----GE-------------------------------------------------------------------------------------------------TGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGE---NLVCKVADFGLARLI----E--DNEY--------------TARQGAKFPIKWTAPEA--AL-----YGRFTIKSDVWSFGILLTELTTKGRVP-------------YPGM-VNREVLDQVERGYRMPCPPECP----------------------------ESLHDLMCQCWRKEPEERPTFEYLQAF--L---
LIAD----IELGCGNFGSVRQGVYR-----MRKKQIDVAIKVLK-QG-TE-KADTE-EMM-R-EAQIMHQL--DNPYIVRLIGVCQ---------AEALMLVMEMAGGGPLHKFLV----GK--------------------------------------------------------------------------------------------------REEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVN---RHYAKISDFGLSKAL-GA-D--DSYY--------------TARSAGKWPLKWYAPEC--IN-----FRKFSSRSDVWSYGVTMWEALSYGQKP-------------YKKM-KGPEVMAFIEQGKRMECPPECP----------------------------PELYALMSDCWIYKWEDRPDFLTVEQR--M---
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