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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK FLT4 203
CMGC CDK2 4
Other CHUK 15
TK EGFR 712
TK FGFR1 478
TK IGF1R 999
TK KDR 834
TK KIT 589
CMGC MAPK14 24
TK NTRK1 510
TK PDGFRA 593
TK PDGFRB 600
AGC PRKCA 339
TK TEK 824
--LHLGRVLGYGAFGKVVEASAFG--IHKGSSCDTVAVKMLK-EGAT-ASEHRALM-S-ELKILIHIG-NHLNVVNLLGACTKP------QGPLMVIVEFCKYGNLSNFLR----AKRDAFSPCAEKSPEQRGRFRAMVELARLDRRR-----------------------------------PGSSDRVLFARFSKTEGGARRASPDQEAEDLWLSPLTMEDLVCYSFQVARGMEFLASRKCIHRDLAARNILLSESDVV---KICDFGLARDIYK--DPDYVRKGSARLPLKWMAPESIF-DKVYTTQSDVWSFGVLLWEIFSLGASPYPGV-Q---------INEEFCQRLRDGTRMRAPELAT------------------------------PAIRRIMLNCWSGDPKARPAFSELVEIL----------------
--FQKVEKIGEGTYGVVYKARNK-------LTGEVVALKKIRLDTETEGV--PSTAIR-EISLLKEL--NHPNIVKLLDVIH-T------ENKLYLVFEFLHQ-DLKKFMDA-SALT----------------------------------------------------------------------------------------------------GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAI---KLADFGLARAF-GVPVRTYTH---EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGD-----------SEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR--QDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF--------------
-W-EMRERLGTGGFGNVCLYQHR-------ELDLKIAIKSCRLELSTKNR--ER-WCH-EIQIMKKL--NHANVVKACDVPE-ELN-ILIHDVPLLAMEYCSGGDLRKLLNKPENCC----------------------------------------------------------------------------------------------------GLKESQILSLLSDIGSGIRYLHENKIIHRDLKPENIVLQDVGGKIIHKIIDLGYAKD--VDQGSLCTS---FVGTLQYLAPELFE-NKPYTATVDYWSFGTMVFECIA-GYRPFLHHLQPFTWHEKIKKKDPKCIFACEEMSGEVRFSSHLPQPNSLCS------------------LVVEPMENWLQLMLNWDPQQRG-----------GPVDLTLKQ-----
-F-KKIKVLGSGAFGTVYKGLWIP---EGEKVKIPVAIKELR-EATS-PKANKEIL-D-EAYVMASV--DNPHVCRLLGICL--------TSTVQLITQLMPFGCLLDYVR----EH--------------------------------------------------------------------------------------------------KDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHV---KITDFGLAKLLGA--EEKEYHAEGGKVPIKWMALESIL-HRIYTHQSDVWSYGVTVWELMTFGSKPYDGI-----------PASEISSILEKGERLPQPPICT------------------------------IDVYMIMVKCWMIDADSRPKFRELI----IEF------------
-L-VLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLK-SDAT-EKDLSDLI-S-EMEMMKMIG-KHKNIINLLGACT-Q------DGPLYVIVEYASKGNLREYLQ----ARRPPGLEY-----------------------------------------------------------------------------------CYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVM---KIADFGLARDIHH--IDYYKKTTNGRLPVKWMAPEALF-DRIYTHQSDVWSFGVLLWEIFTLGGSPYPGV-----------PVEELFKLLKEGHRMDKPSNCT------------------------------NELYMMMRDCWHAVPSQRPTFKQLVEDL----------------
--ITMSRELGQGSFGMVYEGVAKG--VVKDEPETRVAIKTVN-EAAS-MRERIEFL-N-EASVMKEF--NCHHVVRLLGVVS-Q------GQPTLVIMELMTRGDLKSYLR----SLRPEM-----------------------------------------------------------------------------------------ENNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTV---KIGDFGMTRDIYE--TDYYRKGGKGLLPVRWMSPESLK-DGVFTTYSDVWSFGVVLWEIATLAEQPYQGL-----------SNEQVLRFVMEGGLLDKPDNCP------------------------------DMLFELMRMCWQYNPKMRPSFLEIISS--I--------------
--LKLGKPLGRGAFGQVIEADAFG--IDKTATCRTVAVKMLK-EGAT-HSEHRALM-S-ELKILIHIG-HHLNVVNLLGACTKP------GGPLMVIVEFCKFGNLSTYLR----SKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRL---------------------------------DSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVV---KICDFGLARDIYK--DPDYVRKGDARLPLKWMAPETIF-DRVYTIQSDVWSFGVLLWEIFSLGASPYPGV-K---------IDEEFCRRLKEGTRMRAPDYTT------------------------------PEMYQTMLDCWHGEPSQRPTFSELVEHL----------------
--LSFGKTLGAGAFGKVVEATAYG--LIKSDAAMTVAVKMLK-PSAH-LTEREALM-S-ELKVLSYLG-NHMNIVNLLGACT-I------GGPTLVITEYCCYGDLLNFLR----RKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYM-----------------------DMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRIT---KICDFGLARDIKN--DSNYVVKGNARLPVKWMAPESIF-NCVYTFESDVWSYGIFLWELFSLGSSPYPGM-P---------VDSKFYKMIKEGFRMLSPEHAP------------------------------AEMYDIMKTCWDADPLKRPTFKQIVQL--I--------------
--YQNLSPVGSGAYGSVCAAFDT-------KTGLRVAVKKLSRPFQSIIH--AKRTYR-ELRLLKHM--KHENVIGLLDVFT-PARSLEEFNDVYLVTHLMGA-DLNNIVK----CQ----------------------------------------------------------------------------------------------------KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCEL---KILDFGLAR----HTDDEMTG---YVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLFPGT-----------DHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYF--------------
IV--LKWELGEGAFGKVFLAECHN--LLPEQDKMLVAVKALK-EASE-SA-RQDFQ-R-EAELLTML--QHQHIVRFFGVCT-E------GRPLLMVFEYMRHGDLNRFLR----SHGPDAKL------------------------------------------------------------------------------------LAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVV---KIGDFGMSRDIYS--TDYYRVGGRTMLPIRWMPPESIL-YRKFTTESDVWSFGVVLWEIFTYGKQPWYQL-----------SNTEAIDCITQGRELERPRACP------------------------------PEVYAIMRGCWQREPQQRHSIKDVHARL----------------
-L-VLGRVLGSGAFGKVVEGTAYG--LSRSQPVMKVAVKMLK-PTAR-SSEKQALM-S-ELKIMTHLG-PHLNIVNLLGACT-K------SGPIYIITEYCFYGDLVNYLH----KNRDSFLSHHPEKPKKELDIFGLNPADESTRSYVILSFENNGDYMDMKQA-DTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIV---KICDFGLARDIMH--DSNYVSKGSTFLPVKWMAPESIF-DNLYTTLSDVWSYGILLWEIFSLGGTPYPGM-M---------VDSTFYNKIKSGYRMAKPDHAT------------------------------SEVYEIMVKCWNSEPEKRPSFYHLSE---IV-------------
-L-VLGRTLGSGAFGQVVEATAHG--LSHSQATMKVAVKMLK-STAR-SSEKQALM-S-ELKIMSHLG-PHLNVVNLLGACT-K------GGPIYIITEYCRYGDLVDYLH----RNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVLSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLV---KICDFGLARDIMR--DSNYISKGSTFLPLKWMAPESIF-NSLYTTLSDVWSFGILLWEIFTLGGTPYPEL-P---------MNEQFYNAIKRGYRMAQPAHAS------------------------------DEIYEIMQKCWEEKFEIRPPFSQLVL---LL-------------
-F-NFLMVLGKGSFGKVMLADRK-------GTEELYAIKILKKDVVIQDD--DVECTMVEKRVLALL-DKPPFLTQLHSCFQ-T------VDRLYFVMEYVNGGDLMYHIQ---QVG----------------------------------------------------------------------------------------------------KFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGHI---KIADFGMCKEH-MMDGVTTRT---FCGTPDYIAPEIIA-YQPYGKSVDWWAYGVLLYEMLA-GQPPFDGE--------------DEDELFQSIMEHNVSYPKSLS----------------------------KEAVSVCKGLMTKHPAKRLGC---------GPEGERDVREHAFF
--IKFQDVIGEGNFGQVLKARIK-----KDGLRMDAAIKRMK-EYAS-KDDHRDFA-G-ELEVLCKLG-HHPNIINLLGACE-H------RGYLYLAIEYAPHGNLLDFLR----KSRVLETDP-----------------------------------------------------------------------------------AFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVA---KIADFGLSRGQ-----EVYVKKTMGRLPVRWMAIESLN-YSVYTTNSDVWSYGVLLWEIVSLGGTPYCGM-----------TCAELYEKLPQGYRLEKPLNCD------------------------------DEVYDLMRQCWREKPYERPSFAQILV---SL-------------
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