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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK FRK 203
TK ABL1 261
TK ABL2 288
TKL ACVR1 208
TKL ACVR1B 207
TKL ACVRL1 202
TKL BMPR2 203
TK EPHB1 619
TK EPHB4 615
TK FGR 263
TK FYN 271
TKL IRAK4 186
TK LCK 245
TKL MAP3K7 36
TKL RAF1 349
TK SRC 270
STE STK24 24
TKL TGFBR1 205
---IQLLKRLGSGQFGEVWEGLWN----NTTPVAVKTLK-P-GSM-DP--N-DFL-R-EAQIMKNLRHPKLIQLYAVCTL-----EDPIYIITELMRHGSLQEYLQ----NDTG-SKIHLTQQVDMAAQVASGMAYLESR---------N---YIHRDLAARNVLVGEHN-IYKVADFGLARVFK----VD----N--EDIYESRHEIKLPVKWTAPEAIR-------SNK---FSIKSDVWSFGILLYEIITYGK----------MPYSGM-----------------TGAQVIQMLAQNYR----LPQPSNCP--------------QQFYNIMLECWNAEPKERPTFETLRWK--L----
---ITMKHKLGGGQYGEVYEGVWK---KYSLTVAVKTLK-E-DTM-EV--E-EFL-K-EAAVMKEIKHPNLVQLLGVCTR-----EPPFYIITEFMTYGNLLDYLR----ECNR-QEVNAVVLLYMATQISSAMEYLEKK---------N---FIHRDLAARNCLVGENH-LVKVADFGLSRLM-----------T--GDTYTAHAGAKFPIKWTAPESLA-------YNK---FSIKSDVWAFGVLLWEIATYGM----------SPYPGI-----------------DLSQVYELLEKDYR----MERPEGCP--------------EKVYELMRACWQWNPSDRPSFAEIHQA--F----
---ITMKHKLGGGQYGEVYVGVWK---KYSLTVAVKTLK-E-DTM-EV--E-EFL-K-EAAVMKEIKHPNLVQLLGVCTL-----EPPFYIVTEYMPYGNLLDYLR----ECNR-EEVTAVVLLYMATQISSAMEYLEKK---------N---FIHRDLAARNCLVGENH-VVKVADFGLSRLM-----------T--GDTYTAHAGAKFPIKWTAPESLA-------YNT---FSIKSDVWAFGVLLWEIATYGM----------SPYPGI-----------------DLSQVYDLLEKGYR----MEQPEGCP--------------PKVYELMRACWKWSPADRPSFAETHQA--F----
--I-TLLECVGKGRYGEVWRGSWQ---GEN--VAVKIFSSR-DEKSWF--R-ET----ELYNTVMLRHENILGFIASDMTSR-HSSTQLWLITHYHEMGSLYDYLQ----LT----TLDTVSCLRIVLSIASGLAHLHIEIFGT-QGKPA---IAHRDLKSKNILVKKNG-QCCIADLGLAVMHSQ-------STNQLDVGNNP---RVGTKRYMAPEVLDET-IQVDCFD---SYKRVDIWAFGLVLWEVAR-RMVSNGIVEDYKPPFYDVVP------------NDPSFEDMRKVVCVDQQ----RPNIPNRWFSDPTL--------TSLAKLMKECWYQNPSARLTALRIKK----TL--
-IV--LQEIIGKGRFGEVWRGRWR---GGD--VAVKIFSSR-EERSWF--R-EA----EIYQTVMLRHENILGFIAADNKDN-GTWTQLWLVSDYHEHGSLFDYLN----RY----TVTIEGMIKLALSAASGLAHLHMEIVGT-QGKPG---IAHRDLKSKNILVKKNG-MCAIADLGLAVRHDA-------VTDTIDIAPNQ---RVGTKRYMAPEVLDET-INMKHFD---SFKCADIYALGLVYWEIAR-RCNSGGVHEEYQLPYYDLVP------------SDPSIEEMRKVVCDQKL----RPNIPNWWQSYEAL--------RVMGKMMRECWYANGAARLTALRIKK----TL--
-VA--LVECVGKGRYGEVWRGLWH---GES--VAVKIFSSR-DEQSWF--R-ET----EIYNTVLLRHDNILGFIASDMTSR-NSSTQLWLITHYHEHGSLYDFLQ----RQ----TLEPHLALRLAVSAACGLAHLHVEIFGT-QGKPA---IAHRDFKSRNVLVKSNL-QCCIADLGLAVMHSQ-------GSDYLDIGNNP---RVGTKRYMAPEVLDEQ-IRTDCFE---SYKWTDIWAFGLVLWEIAR-RTIVNGIVEDYRPPFYDVVP------------NDPSFEDMKKVVCVDQQ----TPTIPNRLAADPVL--------SGLAQMMRECWYPNPSARLTALRIKK----TLQ-
--L-KLLELIGRGRYGAVYKGSLD---ERP--VAVKVFSFA-NRQNFI--N-EK----NIYRVPLMEHDNIARFIVGDERVTADGRMEYLLVMEYYPNGSLCKYLS----LH----TSDWVSSCRLAHSVTRGLAYLHTELPRGDHYKPA---ISHRDLNSRNVLVKNDG-TCVISDFGLSMRLTGNR---LVRPGEEDNAAIS---EVGTIRYMAPEVLEGAVNLRDCES---ALKQVDMYALGLIYWEIFM-RC---------TDLFPGESVPEYQMAFQTEVGNHPTFEDMQVLVSREKQR---PKFPEAWKENSLAV--------RSLKETIEDCWDQDAEARLTAQCA------EERM
--V-KIEEVIGAGEFGEVYKGRLKLPGKREIYVAIKTLK-A-GYS-EKQRR-DFL-S-EASIMGQFDHPNIIRLEGVVTK-----SRPVMIITEFMENGALDSFLR----QN-D-GQFTVIQLVGMLRGIAAGMKYLAEM---------N---YVHRDLAARNILVNSNL-VCKVSDFGLSRYLQ---DDT----S--DPTYTSSLGGKIPVRWTAPEAIA-------YRK---FTSASDVWSYGIVMWEVMSFGE----------RPYWDM-----------------SNQDVINAIEQDYR----LPPPMDCP--------------AALHQLMLDCWQKDRNSRPRFAEIVNTL------
--V-KIEEVIGAGEFGEVCRGRLKAPGKKESCVAIKTLK-G-GYT-ERQRR-EFL-S-EASIMGQFEHPNIIRLEGVVTN-----SMPVMILTEFMENGALDSFLR----LN-D-GQFTVIQLVGMLRGIASGMRYLAEM---------S---YVHRDLAARNILVNSNL-VCKVSDFGLSRFLE---ENS----S--DPTYTSSLGGKIPIRWTAPEAIA-------FRK---FTSASDAWSYGIVMWEVMSFGE----------RPYWDM-----------------SNQDVINAIEQDYR----LPPPPDCP--------------TSLHQLMLDCWQKDRNARPRFPQVVSAL------
---ITLERRLGTGCFGDVWLGTWN----GSTKVAVKTLK-P-GTM-SP--K-AFL-E-EAQVMKLLRHDKLVQLYAVVS------EEPIYIVTEFMCHGSLLDFLK----NPEG-QDLRLPQLVDMAAQVAEGMAYMERM---------N---YIHRDLRAANILVGERL-ACKIADFGLARLI-----------K--DDEYNPCQGSKFPIKWTAPEAAL-------FGR---FTIKSDVWSFGILLTELITKGR----------IPYPGM-----------------NKREVLEQVEQGYH----MPCPPGCP--------------ASLYEAMEQTWRLDPEERPTFEYLQSFL------
---LQLIKRLGNGQFGEVWMGTWN----GNTKVAIKTLK-P-GTM-SP--E-SFL-E-EAQIMKKLKHDKLVQLYAVVS------EEPIYIVTEYMNKGSLLDFLK----DGEG-RALKLPNLVDMAAQVAAGMAYIERM---------N---YIHRDLRSANILVGNGL-ICKIADFGLARLI-----------E--DNEYTARQGAKFPIKWTAPEAAL-------YGR---FTIKSDVWSFGILLTELVTKGR----------VPYPGM-----------------NNREVLEQVERGYR----MPCPQDCP--------------ISLHELMIHCWKKDPEERPTFEYLQSFL------
VGG----NKMGEGGFGVVYKGYVN---NTT--VAVKKLAAM-VDITTE--ELKQQFDQEIKVMAKCQHENLVELLGFSSD-----GDDLCLVYVYMPNGSLLDRLSCLDGTP----PLSWHMRCKIAQGAANGINFLHEN---------H---HIHRDIKSANILLDEAF-TAKISDFGLARASE---------KFAQTVMTSR---IVGTTAYMAPEALR--------GE---ITPKSDIYSFGVVLLEIIT-GL----------PAVDEH-----------------REPQLLLDIKEEIE----DEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQ----LLQ-
---LKLVERLGAGQFGEVWMGYYN----GHTKVAVKSLK-Q-GSM-SP--D-AFL-A-EANLMKQLQHQRLVRLYAVVT------QEPIYIITEYMENGSLVDFLK----TPSG-IKLTINKLLDMAAQIAEGMAFIEER---------N---YIHRDLRAANILVSDTL-SCKIADFGLARLI-----------E--DNEYTAREGAKFPIKWTAPEAIN-------YGT---FTIKSDVWSFGILLTEIVTHGR----------IPYPGM-----------------TNPEVIQNLERGYR----MVRPDNCP--------------EELYQLMRLCWKERPEDRPTFDYLRSV--L----
---IEVEEVVGRGAFGVVCKAKWR-----AKDVAIKQIE-----S-ESERK-AFI-V-ELRQLSRVNHPNIVKLYGACL-------NPVCLVMEYAEGGSLYNVLH----GAEPLPYYTAAHAMSWCLQCSQGVAYLHSM---------QPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDI-----------------QTHMTNNKGSAAWMAPEVFE-------GSN---YSEKCDVFSWGIILWEVITR-R----------KPFDEIGG---------------PAFRIMWAVHNGTR----PPLIKNLP--------------KPIESLMTRCWSKDPSQRPSMEEIVKI--M----
-VM--LSTRIGSGSFGTVYKGKWH------GDVAVKILK-VVDPT-PEQFQ-AFR-N-EVAVLRKTRHVNILLFMGYMT------KDNLAIVTQWCEGSSLYKHLH----VQ-E-TKFQMFQLIDIARQTAQGMDYLHAK---------N---IIHRDMKSNNIFLHEGL-TVKIGDFGLATVK------S----R--WSGSQQVEQPTGSVLWMAPEVIR-------MQDNNPFSFQSDVYSYGIVLYELMT-GE----------LPYSHI-N---------------NRDQIIFMVGRGYASPDLSKLYKNCP--------------KAMKRLVADCVKKVKEERPLFPQILSS--I----
--L-RLEVKLGQGCFGEVWMGTWN----GTTRVAIKTLK-P-GTM-SP--E-AFL-Q-EAQVMKKLRHEKLVQLYAVVS------EEPIYIVTEYMSKGSLLDFLK----GETG-KYLRLPQLVDMAAQIASGMAYVERM---------N---YVHRDLRAANILVGENL-VCKVADFGLARLI-----------E--DNEYTARQGAKFPIKWTAPEAAL-------YGR---FTIKSDVWSFGILLTELTTKGR----------VPYPGM-----------------VNREVLDQVERGYR----MPCPPECP--------------ESLHDLMCQCWRKEPEERPTFEYLQAF--L----
---FTKLEKIGKGSFGEVFKGIDN---RTQKVVAIKIIDLE-EAEDEI--E-DIQ-Q-EITVLSQCDSPYVTKYYGSYLK-----DTKLWIIMEYLGGGSALDLLE----PG----PLDETQIATILREILKGLDYLHSE---------K---KIHRDIKAANVLLSEHG-EVKLADFGVAGQL-----------TDTQIKRNT---FVGTPFWMAPEVIK-------QSA---YDSKADIWSLGITAIELAR-GE----------PPHSEL-----------------HPMKVLFLIPKNNP----PTLEGNYS--------------KPLKEFVEACLNKEPSFRPTAKELLKHKFI----
-IV--LQESIGKGRFGEVWRGKWR---GEE--VAVKIFSSR-EERSWF--R-EA----EIYQTVMLRHENILGFIAADNKDN-GTWTQLWLVSDYHEHGSLFDYLN----RY----TVTVEGMIKLALSTASGLAHLHMEIVGT-QGKPA---IAHRDLKSKNILVKKNG-TCCIADLGLAVRHDS-------ATDTIDIAPNH---RVGTKRYMAPEVLDDS-INMKHFE---SFKRADIYAMGLVFWEIAR-RCSIGGIHEDYQLPYYDLVP------------SDPSVEEMRKVVCEQKL----RPNIPNRWQSCEAL--------RVMAKIMRECWYANGAARLTALRIKK----TL--
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