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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
AGC GRK7 203
AGC AKT3 148
Other AURKC 43
CAMK CAMK2A 13
CAMK CAMK2D 14
CMGC CDC2 4
CMGC CDK2 4
CMGC CDK4 6
CMGC CDK6 13
CMGC CDK7 2.7.11.23
CMGC CDKL5 13
CAMK CHEK1 9
CAMK CHEK2 220
CMGC CSNK2A1 39
CMGC CSNK2A2 40
CAMK DAPK1 13
CAMK DAPK2 23
CAMK DAPK3 13
CMGC DYRK1A 150
CMGC DYRK1B 111
TK EGFR 712
Other GAK 40
AGC GRK1 190
AGC GRK4 187
CMGC GSK3A 119
CMGC GSK3B 56
CMGC HIPK1 190
CMGC HIPK2 199
CMGC HIPK3 197
CMGC ICK 4
TK JAK3 822
STE MAP3K2 356
STE MAP3K3 362
CMGC MAPK15 13
CAMK MARK2 53
CAMK MELK 11
CAMK NUAK1 55
CAMK NUAK2 97
CMGC PCTK1 165
AGC PDPK1 82
CAMK PHKG1 20
CAMK PIM1 38
CAMK PIM2 132
CAMK PIM3 40
AGC PKN2 657
Other PLK4 12
AGC PRKACA 44
AGC PRKACB 44
AGC PRKCB 342
AGC PRKCD 349
AGC PRKCH 355
AGC PRKCI 245
AGC PRKCQ 380
AGC PRKCZ 252
CAMK PRKD2 551
AGC PRKG1 375
AGC PRKG2 453
CMGC PRPF4B 687
AGC RPS6KA1 62
AGC RPS6KA2 59
AGC RPS6KA3 68
AGC RPS6KA6 73
AGC RPS6KB1 91
STE SLK 34
CAMK STK11 49
STE STK24 24
CAMK STK33 116
Other TLK1 477
STE YSK4 1162
---F-TEFRVLGKGGFGEV---CAVQV---K----N-TGK---MYACKKLDKKRLKK---KG--GE-KMAL------LEKEILEKV-S------SPF-----IVSLAYAFE--S--------KTHLC--LVMSL-MNGG--DLKFHIYN--VGTR--GL---DMSRVIFYSAQIACGMLHLHE--L--GIVYRDMKPENVLLD--DLGNC---------RLSDLGLAVE---------------MKGGKPITQ---RAGTNGYMAPEILM-----EKVSYSYPVDWFAMGCSIYEMVA-GRTP-------------FK-DY-----KEKVSKEDLKQRTLQDEVKFQHDNF---T-----------------------------------------------------------------EEAKDICRLFLAKKPEQRLG------SR-E-------KSDDPR--------
--FD--YLKLLGKGTFGKV---ILVRE---K----A-SGK---YYAMKILKKEVIIA---KD--EV-AHTL------TESRVLKNT-R------HPF-----LTSLKYSFQ--T--------KDRLC--FVMEY-VNGG--ELFFHLS----RER--VF---SEDRTRFYGAEIVSALDYLHS--G--KIVYRDLKLENLMLD--KDGHI---------KITDFGLCKEG--------------ITDAATMKT---FCGTPEYLAPEVLE------DNDYGRAVDWWGLGVVMYEMMC-GRLP-------------FY-NQ---------DHEKLFELILMEDIKFPRTLS---------------------------------------------------------------------SDAKSLLSGLLIKDPNKRLGGG-PDDAK-EIMRHSFF--------------
----FEIGRPLGKGKFGNV---YLARL---K----E-SHF---IVALKVLFKSQIEK---EG--LE-HQLR------REIEIQAHL-Q------HPN-----ILRLYNYFH--D--------ARRVY--LILEY-APRG--ELYKELQ----KSE--KL---DEQRTATIIEELADALTYCHD--K--KVIHRDIKPENLLLG--FRGEV---------KIADFGWSV----------------HTPSLRRKT---MCGTLDYLPPEMIE------GRTYDEKVDLWCIGVLCYELLV-GYPP-------------FE-SA---------SHSETYRRILKVDVRFPLSMP---------------------------------------------------------------------LGARDLISRLLRYQPLERLP------LA-QILKHPWV--------------
----YQLFEELGKGAFSVV---RRCVK---V----L-AGQ---EYAAKIINTKKLSA---RD--HQ-KLER-------EARICRLL-K------HPN-----IVRLHDSIS--E--------EGHHY--LIFDL-VTGG--ELFEDIV----ARE--YY---SEADASHCIQQILEAVLHCHQ--M--GVVHRDLKPENLLLA--SKLKGA------AVKLADFGLAIEV--------------EGEQQAWFG---FAGTPGYLSPEVLR------KDPYGKPVDLWACGVILYILLV-GYPP-------------FW-DE---------DQHRLYQQIKAGAYDFPSPEWDTVT-----------------------------------------------------------------PEAKDLINKMLTINPSKRIT------AA-EALKHPWI--------------
----YQLFEELGKGAFSVV---RRCMK---I----P-TGQ---EYAAKIINTKKLSA---RD--HQ-KLER-------EARICRLL-K------HPN-----IVRLHDSIS--E--------EGFHY--LVFDL-VTGG--ELFEDIV----ARE--YY---SEADASHCIQQILESVNHCHL--N--GIVHRDLKPENLLLA--SKSKGA------AVKLADFGLAIEV--------------QGDQQAWFG---FAGTPGYLSPEVLR------KDPYGKPVDMWACGVILYILLV-GYPP-------------FW-DE---------DQHRLYQQIKAGAYDFPSPEWDTVT-----------------------------------------------------------------PEAKDLINKMLTINPAKRIT------AS-EALKHPWI--------------
----YTKIEKIGEGTYGVV---YKGRH---K----T-TGQ---VVAMKKIRLESEEE---GV--PS-TAIR-------EISLLKEL-R------HPN-----IVSLQDVLM--Q--------DSRLY--LIFEF-LSM---DLKKYLDS-IPPGQ--YM---DSSLVKSYLYQILQGIVFCHS--R--RVLHRDLKPQNLLID--DKGTI---------KLADFGLARAF--------------GIPIRVYTH---EVVTLWYRSPEVLL-----GSARYSTPVDIWSIGTIFAELAT-KKPL-------------FH-GD------SEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKP-------------------------------------------GSLASHVKNLDENGLDLLSKMLIYDPAKRIS------GK-MALNHPYF--------------
----FQKVEKIGEGTYGVV---YKARN---K----L-TGE---VVALKKIRLDTETE---GV--PS-TAIR-------EISLLKEL-N------HPN-----IVKLLDVIH--T--------ENKLY--LVFEF-LHQ---DLKKFMDA--SALT--GI---PLPLIKSYLFQLLQGLAFCHS--H--RVLHRDLKPQNLLIN--TEGAI---------KLADFGLARAF--------------GVPVRTYTH---EVVTLWYRAPEILL-----GCKYYSTAVDIWSLGCIFAEMVT-RRAL-------------FP-GD------SEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR-------------------------------------------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS------AK-AALAHPFF--------------
---Y-EPVAEIGVGAYGTV---YKARD---P----H-SGH---FVALKSVRVPNGGGGGGGL--PI-STVR-------EVALLRRL-EA---FEHPN-----VVRLMDVCA--TSR---TDREIKVT--LVFEH-VDQ---DLRTYLDK--APPP--GL---PAETIKDLMRQFLRGLDFLHA--N--CIVHRDLKPENILVT--SGGTV---------KLADFGLARI---------------YSYQMALTP---VVVTLWYRAPEVLL------QSTYATPVDMWSVGCIFAEMFR-RKPL-------------FC-GN------SEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPR---------------------------------------------PVQSVVPEMEESGAQLLLEMLTFNPHKRIS------AF-RALQHSYL--------------
----YECVAEIGEGAYGKV---FKARD---L----K-NGG--RFVALKRVRVQTGEE---GM--PL-STIR-------EVAVLRHL-ET---FEHPN-----VVRLFDVCT--VSR---TDRETKLT--LVFEH-VDQ---DLTTYLDK--VPEP--GV---PTETIKDMMFQLLRGLDFLHS--H--RVVHRDLKPQNILVT--SSGQI---------KLADFGLARI---------------YSFQMALTS---VVVTLWYRAPEVLL------QSSYATPVDLWSVGCIFAEMFR-RKPL-------------FR-GS------SDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQ---------------------------------------------PIEKFVTDIDELGKDLLLKCLTFNPAKRIS------AY-SALSHPYF--------------
----YEKLDFLGEGQFATV---YKARD---K----N-TNQ---IVAIKKIKLGHRSE---AK--DG-INRTA----LREIKLLQEL-S------HPN-----IIGLLDAFG--H--------KSNIS--LVFDF-MET---DLEVIIK---DNSL--VL---TPSHIKAYMLMTLQGLEYLHQ--H--WILHRDLKPNNLLLD--ENGVL---------KLADFGLAKSF--------------GSPNRAYTH---QVVTRWYRAPELLF-----GARMYGVGVDMWAVGCILAELLL-RVPF-------------LP-GD------SDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPG--------------------------------------------IPLHHIFSAAGDDLLDLIQGLFLFNPCARIT------AT-QALKMKYF--------------
----FEILGVVGEGAYGVV---LKCRH---K----E-THE---IVAIKKFKDSEENE---EV--KE-TTLR-------ELKMLRTL-K------QEN-----IVELKEAFR--R--------RGKLY--LVFEY-VEK---NMLELLE---EMPN--GV---PPEKVKSYIYQLIKAIHWCHK--N--DIVHRDIKPENLLIS--HNDVL---------KLCDFGFARNL-------------SEGNNANYTE---YVATRWYRSPELLL------GAPYGKSVDMWSVGCILGELSD-GQPL-------------FP-GE------SEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHGLRFPAVNH----------------------------------------PQSLERRYLGILNSVLLDLMKNLLKLDPADRYL------TE-QCLNHPTF--------------
---W-DLVQTLGEGAYGEV---QLAVN---R----V-TEE---AVAVKIVDMKRAVD---CP--EN-I-KK-------EICINKML-N------HEN-----VVKFYGHRR--E--------GNIQY--LFLEY-CSGG--ELFDRIE----PDI--GM---PEPDAQRFFHQLMAGVVYLHG--I--GITHRDIKPENLLLD--ERDNL---------KISDFGLATVFR------------YNNRERLLNK---MCGTLPYVAPELLK-----RREFHAEPVDVWSCGIVLTAMLA-GELP-------------WD-QP--------SDSCQEYSDWKEKKTYLNPWKKI--D-----------------------------------------------------------------SAPLALLHKILVENPSARIT------IP-DIKKDRW-Y-------------
--YI--MSKTLGSGACGEV---KLAFE---R----K-TCK---KVAIKIISKRKFAI---GS--AR-EADPALN-VETEIEILKKL-N------HPC-----IIKIKNFF---D--------AEDYY--IVLEL-MEGG--ELFDKVV----GNK--RL---KEATCKLYFYQMLLAVQYLHE--N--GIIHRDLKPENVLLS--SQEEDC------LIKITDFGHSKI---------------LGETSLMRT---LCGTPTYLAPEVLVS---VGTAGYNRAVDCWSLGVILFICLS-GYPP-------------FS-EH--------RTQVSLKDQITSGKYNFIPEVWAEVS-----------------------------------------------------------------EKALDLVKKLLVVDPKARFT------TE-EALRHPWL--------------
----YQLVRKLGRGKYSEV---FEAIN---I----T-NNE---KVVVKILKPVKKKK---IK--R-------------EIKILENLRG------GPN-----IITLADIVK--DP------VSRTPA--LVFEH-VNNT--DFKQLY-------Q--TL---TDYDIRFYMYEILKALDYCHS--M--GIMHRDVKPHNVMID-HEHRKL---------RLIDWGLAEF---------------YHPGQEYNV---RVASRYFKGPELLV-----DYQMYDYSLDMWSLGCMLASMIF-RKEP-------------FFHGH------DNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRK-----------------------------------RWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLT------AR-EAMEHPYF--------------
----YQLVRKLGRGKYSEV---FEAIN---I----T-NNE---RVVVKILKPVKKKK---IK--R-------------EVKILENLRG------GTN-----IIKLIDTVK--DP------VSKTPA--LVFEY-INNT--DFKQLY-------Q--IL---TDFDIRFYMYELLKALDYCHS--K--GIMHRDVKPHNVMID-HQQKKL---------RLIDWGLAEF---------------YHPAQEYNV---RVASRYFKGPELLV-----DYQMYDYSLDMWSLGCMLASMIF-RREP-------------FFHGQ------DNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRK-----------------------------------RWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLT------AK-EAMEHPYF--------------
----YDTGEELGSGQFAVV---KKCRE---K----S-TGL---QYAAKFIKKRRTKS---SR--RG-VSREDI---EREVSILKEI-Q------HPN-----VITLHEVYE--N--------KTDVI--LILEL-VAGG--ELFDFLA----EKE--SL---TEEEATEFLKQILNGVYYLHS--L--QIAHFDLKPENIMLL--DRNVPKP-----RIKIIDFGLAHK---------------IDFGNEFKN---IFGTPEFVAPEIVN------YEPLGLEADMWSIGVITYILLS-GASP-------------FL-GD---------TKQETLANVSAVNYEFEDEYFSNTS-----------------------------------------------------------------ALAKDFIRRLLVKDPKKRMT------IQ-DSLQHPWI--------------
----YDIGEELGSGQFAIV---KKCRE---K----S-TGL---EYAAKFIKKRQSRA---SR--RG-VSREEI---EREVSILRQV-L------HHN-----VITLHDVYE--N--------RTDVV--LILEL-VSGG--ELFDFLA----QKE--SL---SEEEATSFIKQILDGVNYLHT--K--KIAHFDLKPENIMLL--DKNIPIP-----HIKLIDFGLAHE---------------IEDGVEFKN---IFGTPEFVAPEIVN------YEPLGLEADMWSIGVITYILLS-GASP-------------FL-GD---------TKQETLANITAVSYDFDEEFFSQTS-----------------------------------------------------------------ELAKDFIRKLLVKETRKRLT------IQ-EALRHPWI--------------
----YEMGEELGSGQFAIV---RKCRQ---K----G-TGK---EYAAKFIKKRRLSS---SR--RG-VSREEI---EREVNILREI-R------HPN-----IITLHDIFE--N--------KTDVV--LILEL-VSGG--ELFDFLA----EKE--SL---TEDEATQFLKQILDGVHYLHS--K--RIAHFDLKPENIMLL--DKNVPNP-----RIKLIDFGIAHK---------------IEAGNEFKN---IFGTPEFVAPEIVN------YEPLGLEADMWSIGVITYILLS-GASP-------------FL-GE---------TKQETLTNISAVNYDFDEEYFSNTS-----------------------------------------------------------------ELAKDFIRRLLVKDPKRRMT------IA-QSLEHSWI--------------
----YEIDSLIGKGSFGQV---VKAYD---R----V-EQE---WVAIKIIKNKKAFL---NQ--AQ-I----------EVRLLELMNK------HDTEMKYYIVHLKRHFM--F--------RNHLC--LVFEM-LSY---NLYDLLR-----NT--NFRGVSLNLTRKFAQQMCTALLFLATPEL--SIIHCDLKPENILLCNPKRSAI---------KIVDFGSSCQ-----------------LGQRIYQ---YIQSRFYRSPEVLL------GMPYDLAIDMWSLGCILVEMHT-GEPL-------------FS-GA------NEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGT--------RKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQ------PY-YALQHSFF--------------
----YEIDSLIGKGSFGQV---VKAYD---H----Q-TQE---LVAIKIIKNKKAFL---NQ--AQ-I----------ELRLLELMNQ------HDTEMKYYIVHLKRHFM--F--------RNHLC--LVFEL-LSY---NLYDLLR-----NT--HFRGVSLNLTRKLAQQLCTALLFLATPEL--SIIHCDLKPENILLCNPKRSAI---------KIVDFGSSCQ-----------------LGQRIYQ---YIQSRFYRSPEVLL------GTPYDLAIDMWSLGCILVEMHT-GEPL-------------FS-GS------NEVDQMNRIVEVLGIPPAAMLDQAPKARKYFERLPGGGWTLRRTKELRKDYQGPGT--------RRLQEVLGVQTGGPGGRRAGEPGHSPADYLRFQDLVLRMLEYEPAARIS------PL-GALQHGFF--------------
---F-KKIKVLGSGAFGTV---YKGLW---IPEGEK-VKI---PVAIKELR-EATS----PKANKE-IL-D-------EAYVMASV-D------NPH-----VCRLLGICL-----------TSTVQ--LITQL-MPFG--CLLDYVR-----EHKDNI---GSQYLLNWCVQIAKGMNYLED--R--RLVHRDLAARNVLVK--TPQHV---------KITDFGLAKLL-------G------A--EEKEYHAEGGKVPIKWMALESIL------HRIYTHQSDVWSYGVTVWELMTFGSKP-------------YD-GI------PASEISSILEKGERLPQPPICT-----------------------------------------------------------------------IDVYMIMVKCWMIDADSRPK------FR-ELI----IEF------------
--LR--VRRVLAEGGFAFV---YEAQD---V----G-SGR---EYALKRLLSNEEEK---NR--AI---IQ-------EVCFMKKLSG------HPN-----IVQFCSAAS--IGKEESDTGQAEFL--LLTEL-CKG---QLVEFLKK-MESRG--PL---SCDTVLKIFYQTCRAVQHMHR--QKPPIIHRDLKVENLLLS--NQGTI---------KLCDFGSATTISHYPDY--SWSAQRRALVEEEIT---RNTTPMYRTPEIIDL---YSNFPIGEKQDIWALGCILYLLCF-RQHP-------------FE-DG---------AKLRIVNGKYS-IPPHDTQY----------------------------------------------------------------------TVFHSLIRAMLQVNPEERLS------IA-EVVHQ---L-------------
FLDF----RVLGKGGFGEV---SACQM---K----A-TGK---LYACKKLNKKRLKK---RK--GY-QGAM------VEKKILMKV-H------SRF-----IVSLAYAFE--T--------KADLC--LVMTI-MNGG--DIRYHIYNVNEENP--GF---PEPRALFYTAQIICGLEHLHQ--R--RIVYRDLKPENVLLD--NDGNV---------RISDLGLAVEL--------------LDGQSKTKG---YAGTPGFMAPELLQ------GEEYDFSVDYFALGVTLYEMIA-ARGP-------------FR-AR-----GEKVENKELKHRIISEPVKYPDKFS---------------------------------------------------------------------QASKDFCEALLEKDPEKRLG------FR-D-------ETCDKLRAHPLF--
--FR--HYRVLGKGGFGEV---CACQV---R----A-TGK---MYACKKLQKKRIKK---RK--GE-AMAL------NEKRILEKV-Q------SRF-----VVSLAYAYE--T--------KDALC--LVLTI-MNGG--DLKFHIYN--LGNP--GF---DEQRAVFYAAELCCGLEDLQR--E--RIVYRDLKPENILLD--DRGHI---------RISDLGLATE---------------IPEGQRVRG---RVGTVGYMAPEVVN------NEKYTFSPDWWGLGCLIYEMIQ-GHSP-------------FK-KY------KEKVKWEEVDQRIKNDTEEYSE---KFS-----------------------------------------------------------------EDAKSICRMLLTKNPSKRLGCR-GEGAA-GVKQHPV-F-------------
----YTDIKVIGNGSFGVV---YQARL---A----E-TRE---LVAIKKVLQDKRFK---NR----------------ELQIMRKL-D------HCN-----IVRLRYFFY--SSG----EKKDELYLNLVLEY-VPETVYRVARHFT---KAKL--TI---PILYVKVYMYQLFRSLAYIHS--Q--GVCHRDIKPQNLLVD-PDTAVL---------KLCDFGSAKQ---------------LVRGEPNVS---YICSRYYRAPELIF-----GATDYTSSIDVWSAGCVLAELLL-GQPI-------------FP-GD------SGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH-------------------------------------------PWTKVFKSRTPPEAIALCSSLLEYTPSSRLS------PL-EACAHSFF--------------
----YTDTKVIGNGSFGVV---YQAKL---C----D-SGE---LVAIKKVLQDKRFK---NR----------------ELQIMRKL-D------HCN-----IVRLRYFFY--SSG----EKKDEVYLNLVLDY-VPETVYRVA---RHYSRAKQ--TL---PVIYVKLYMYQLFRSLAYIHS--F--GICHRDIKPQNLLLD-PDTAVL---------KLCDFGSAKQ---------------LVRGEPNVS---YICSRYYRAPELIF-----GATDYTSSIDVWSAGCVLAELLL-GQPI-------------FP-GD------SGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH-------------------------------------------PWTKVFRPRTPPEAIALCSRLLEYTPTARLT------PL-EACAHSFF--------------
----YEVLEFLGRGTFGQV---AKCWK---R----S-TKE---IVAIKILKNHPSYA---RQ--GQ-I----------EVSILSRL-S------SENADEYNFVRSYECFQ--H--------KNHTC--LVFEM-LEQ---NLYDFLKQ--NKFS--PL---PLKYIRPILQQVATALMKLKS--L--GLIHADLKPENIMLV--DPVRQPY-----RVKVIDFGSAS----------------HVSKAVCST---YLQSRYYRAPEIIL------GLPFCEAIDMWSLGCVIAELFL-GWPL-------------YP-GA------SEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDPNLGYPLWRLKTPEEHELETGIKSKEARKYIFNCLDDMAQVNMSTDLEGTDMLAEKADRREYIDLLKKMLTIDADKRIT------PL-KTLNHQFV--------------
----YEVLEFLGRGTFGQV---VKCWK---R----G-TNE---IVAIKILKNHPSYA---RQ--GQ-I----------EVSILARL-STE-SADDYN-----FVRAYECFQ--H--------KNHTC--LVFEM-LEQ---NLYDFLKQ--NKFS--PL---PLKYIRPVLQQVATALMKLKS--L--GLIHADLKPENIMLV--DPSRQPY-----RVKVIDFGSAS----------------HVSKAVCST---YLQSRYYRAPEIIL------GLPFCEAIDMWSLGCVIAELFL-GWPL-------------YP-GA------SEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEAETGIKSKEARKYIFNCLDDMAQVNMTTDLEGSDMLVEKADRREFIDLLKKMLTIDADKRIT------PI-ETLNHPFV--------------
----YEVLDFLGRGTFGQV---VKCWK---R----G-TNE---IVAIKILKNHPSYA---RQ--GQ-I----------EVSILARL-S------TENADEYNFVRAYECFQ--H--------RNHTC--LVFEM-LEQ---NLYDFLKQ--NKFS--PL---PLKVIRPILQQVATALKKLKS--L--GLIHADLKPENIMLV--DPVRQPY-----RVKVIDFGSAS----------------HVSKTVCST---YLQSRYYRAPEIIL------GLPFCEAIDMWSLGCVIAELFL-GWPL-------------YP-GA------LEYDQIRYISQTQGLPGEQLLNVGTKSTRFFCKETDMSHSGWRLKTLEEHEAETGMKSKEARKYIFNSLDDVAHVNTVMDLEGSDLLAEKADRREFVSLLKKMLLIDADLRIT------PA-ETLNHPFV--------------
----YTTIRQLGDGTYGSV---LLGRS---I----E-SGE---LIAIKKMKRKFYSW---EE--C--MNLR-------EVKSLKKL-N------HAN-----VVKLKEVIR--E--------NDHLY--FIFEY-MKE---NLYQLIK---ERNK--LF---PESAIRNIMYQILQGLAFIHK--H--GFFHRDLKPENLLCM--GPELV---------KIADFGLARE---------------IRSKPPYTD---YVSTRWYRAPEVLL-----RSTNYSSPIDVWAVGCIMAEVYT-LRPL-------------FP-GA------SEIDTIFKICQVLGTPKKTDWPEGYQLSSAMNFRWPQCV------------------------------------------PNNLKTLIPNASSEAVQLLRDMLQWDPKKRPT------AS-QALRYPYF--------------
---L-KYISQLGKGNFGSV---ELCRY---DPLGDN-TGA---LVAVKQLQ-HSGP----DQ-QRD-FQ-R-------EIQILKAL-H------SDF-----IVKYRGVSYGPG--------RQSLR--LVMEY-LPSG--CLRDFLQ-----RHRARL---DASRLLLYSSQICKGMEYLGS--R--RCVHRDLAARNILVE--SEAHV---------KIADFGLAKLL------PL------D--KDYYVVREPGQSPIFWYAPESLS------DNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCER-DV-P----ALCRLLELLEEGQRLPAPPACP-----------------------------------------------------------------------AEVHELMKLCWAPSPQDRPS------FS-ALGP---QL-------------
----WRLGKLLGQGAFGRV---YLCYD---V----D-TGR---ELAVKQVQFDPDSP---ET--SK-EVNAL----ECEIQLLKNL-L------HER-----IVQYYGCLR--DP------QEKTLS--IFMEY-MPGG--SIKDQLK----AYG--AL---TENVTRKYTRQILEGVHYLHS--N--MIVHRDIKGANILRD--STGNV---------KLGDFGASKRLQ-----------TICLSGTGMKS---VTGTPYWMSPEVIS------GEGYGRKADIWSVACTVVEMLT-EKPP-------------WA-EF---------EAMAAIFKIATQPTNPKLPPHVS-------------------------------------------------------------------DYTRDFLKRIFV-EAKLRPS------AD-ELLRHMF-V-------------
---W-RRGKLLGQGAFGRV---YLCYD---V----D-TGR---ELASKQVQFDPDSP---ET--SK-EVSAL----ECEIQLLKNL-Q------HER-----IVQYYGCLR--DR------AEKTLT--IFMEY-MPGG--SVKDQLK----AYG--AL---TESVTRKYTRQILEGMSYLHS--N--MIVHRDIKGANILRD--SAGNV---------KLGDFGASKRLQ-----------TICMSGTGMRS---VTGTPYWMSPEVIS------GEGYGRKADVWSLGCTVVEMLT-EKPP-------------WA-EY---------EAMAAIFKIATQPTNPQLPSHIS-------------------------------------------------------------------EHGRDFLRRIFV-EARQRPS------AE-ELLTHHF-A-------------
--YL--LRRQLGQGAYGIV---WKAVD---R----R-TGE---VVAIKKIFDAFRDK---TD--AQ-RTFR-------EITLLQEFGD------HPN-----IISLLDVIR--AE------NDRDIY--LVFEF-MDT---DLNAVIR----KGG--LL---QDVHVRSIFYQLLRATRFLHS--G--HVVHRDQKPSNVLLD--ANCTV---------KLCDFGLARSLGD---------LPEGPEDQAVTE---YVATRWYRAPEVLL-----SSHRYTLGVDMWSLGCILGEMLR-GRPL-------------FP-GT------STLHQLELILETIPPPSEEDLLALGSGCRASVLHQLGSRP----------------------------------------RQTLDALLPPDTSPEALDLLRRLLVFAPDKRLS------AT-QALQHPYV--------------
----YRLLKTIGKGNFAKV---KLARH---I----L-TGK---EVAVKIIDKTQLNS---SS--LQ-KLFR-------EVRIMKVL-N------HPN-----IVKLFEVIE--T--------EKTLY--LVMEY-ASGG--EVFDYLV----AHG--RM---KEKEARAKFRQIVSAVQYCHQ--K--FIVHRDLKAENLLLD--ADMNI---------KIADFGFSNE---------------FTFGNKLDT---FCGSPPYAAPELFQ-----GKKYDGPEVDVWSLGVILYTLVS-GSLP-------------FD-GQ---------NLKELRERVLRGKYRIPFYMS---------------------------------------------------------------------TDCENLLKKFLILNPSKRGT------LE-QIMKDRWM--------------
----YELHETIGTGGFAKV---KLACH---I----L-TGE---MVAIKIMDKNTLGS---DL--PR-IKT--------EIEALKNL-R------HQH-----ICQLYHVLE--T--------ANKIF--MVLEY-CPGG--ELFDYII----SQD--RL---SEEETRVVFRQIVSAVAYVHS--Q--GYAHRDLKPENLLFD--EYHKL---------KLIDFGLCAKP-------------KGNKDYHLQT---CCGSLAYAAPELIQ-----GKSYLGSEADVWSMGILLYVLMC-GFLP-------------FD-DD---------NVMALYKKIMRGKYDVPKWLS---------------------------------------------------------------------PSSILLLQQMLQVDPKKRIS------MK-NLLNHPWI--------------
----YELQETLGKGTYGKV---KRATE---R----F-SGR---VVAIKSIRKDKIKD---EQ--DM-VHIR------REIEIMSSL-N------HPH-----IISIYEVFE--N--------KDKIV--IIMEY-ASKG--ELYDYIS----ERR--RL---SERETRHFFRQIVSAVHYCHK--N--GVVHRDLKLENILLD--DNCNI---------KIADFGLSNL---------------YQKDKFLQT---FCGSPLYASPEIVN-----GRPYRGPEVDSWALGVLLYTLVY-GTMP-------------FD-GF---------DHKNLIRQISSGEYREPTQP----------------------------------------------------------------------SDARGLIRWMLMVNPDRRAT------IE-DIANHWW-V-------------
----YEFLETLGKGTYGKV---KKARE---S----S-GR----LVAIKSIRKDKIKD---EQ--DL-MHIR------REIEIMSSL-N------HPH-----IIAIHEVFE--N--------SSKIV--IVMEY-ASRG--DLYDYIS----ERQ--QL---SEREARHFFRQIVSAVHYCHQ--N--RVVHRDLKLENILLD--ANGNI---------KIADFGLSNL---------------YHQGKFLQT---FCGSPLYASPEIVN-----GKPYTGPEVDSWSLGVLLYILVH-GTMP-------------FD-GH---------DHKILVKQISNGAYREPPK-----P-----------------------------------------------------------------SDACGLIRWLLMVNPTRRAT------LE-DVASHWW-V-------------
---Y-IKLDKLGEGTYATV---YKGKS---K----L-TDN---LVALKEIRLEHEEG---AP--C--TAIR-------EVSLLKDL-K------HAN-----IVTLHDIIH--T--------EKSLT--LVFEY-LDK---DLKQYLD---DCGN--II---NMHNVKLFLFQLLRGLAYCHR--Q--KVLHRDLKPQNLLIN--ERGEL---------KLADFGLARAK--------------SIPTKTYSN---EVVTLWYRPPDILL-----GSTDYSTQIDMWGVGCIFYEMAT-GRPL-------------FP-GS------TVEEQLHFIFRILGTPTEETWPGILSNEEFKTYNYPKYR------------------------------------------AEALLSHAPRLDSDGADLLTKLLQFEGRNRIS------AE-DAMKHPFF--------------
---F-KFGKILGEGSFSTV---VLARE---L----A-TSR---EYAIKILEKRHIIK---EN--KVPYVTR-------ERDVMSRL-D------HPF-----FVKLYFTFQ--D--------DEKLY--FGLSY-AKNG--ELLKYIR----KIG--SF---DETCTRFYTAEIVSALEYLHG--K--GIIHRDLKPENILLN--EDMHI---------QITDFGTAKVLS------------PESKQARANS---FVGTAQYVSPELLT------EKSACKSSDLWALGCIIYQLVA-GLPP-------------FR-AG---------NEYLIFQKIIKLEYDFPEKFF---------------------------------------------------------------------PKARDLVEKLLVLDATKRLG------CE-EM------EGYGPLKAHPF---
----YEPKEILGRGVSSVV---RRCIH---K----P-TSQ---EYAVKVIDVTGGGS---FS--PE-EVRELREATLKEVDILRKVSG------HPN-----IIQLKDTYE--T--------NTFFF--LVFDL-MKRG--ELFDYLT----EKV--TL---SEKETRKIMRALLEVICTLHK--L--NIVHRDLKPENILLD--DNMNI---------KLTDFGFSCQ---------------LEPGERLRE---VCGTPSYLAPEIIECSMNEDHPGYGKEVDMWSTGVIMYTLLA-GSPP-------------FW-HR---------KQMLMLRMIMSGNYQFGSPEWDDYS-----------------------------------------------------------------DTVKDLVSRFLVVQPQNRYT------AE-EALAHPFF--------------
----YQVGPLLGSGGFGSV---YSGIR---V----S-DNL---PVAIKHVEKDRISD---WG--EL-PNGTRV---PMEVVLLKKV-S------SGFS---GVIRLLDWFE--R--------PDSFV--LILER-PEPV-QDLFDFIT----ERG--AL---QEELARSFFWQVLEAVRHCHN--C--GVLHRDIKDENILID-LNRGEL---------KLIDFGSGA----------------LLKDTVYTD---FDGTRVYSPPEWIR-----YHRYHGRSAAVWSLGILLYDMVC-GDIP-------------FE-HD---------------EEIIRGQVFFRQRVS---------------------------------------------------------------------SECQHLIRWCLALRPSDRPT------FE-EIQNHPWM--------------
----YRLGPLLGKGGFGTV---FAGHR---L----T-DRL---QVAIKVIPRNRVLG---WS--PL-SDSVTC---PLEVALLWKV-GAG--GGHPG-----VIRLLDWFE--T--------QEGFM--LVLERPLPAQ--DLFDYIT----EKG--PL---GEGPSRCFFGQVVAAIQHCHS--R--GVVHRDIKDENILID-LRRGCA---------KLIDFGSGA----------------LLHDEPYTD---FDGTRVYSPPEWIS-----RHQYHALPATVWSLGILLYDMVC-GDIP-------------FE-RD---------------QEILEAELHFPAHVS---------------------------------------------------------------------PDCCALIRRCLAPKPSSRPS------LE-EILLDPWM--------------
----YQVGAVLGSGGFGTV---YAGSR---I----A-DGL---PVAVKHVVKERVTE---WG--SL-GGATV----PLEVVLLRKV-GAA--GGARG-----VIRLLDWFE--R--------PDGFL--LVLER-PEPA-QDLFDFIT----ERG--AL---DEPLARRFFAQVLAAVRHCHS--C--GVVHRDIKDENLLVD-LRSGEL---------KLIDFGSGA----------------LLKDTVYTD---FDGTRVYSPPEWIR-----YHRYHGRSATVWSLGVLLYDMVC-GDIP-------------FE-QD---------------EEILRGRLLFRRRVS---------------------------------------------------------------------PECQQLIRWCLSLRPSERPS------LD-QIAAHPWM--------------
--FR--CCAVLGRGHFGKV---LLAEY---K----N-TNE---MFAIKALKKGDIVA---RD--EV-DSLM------CEKRIFETV-NS---VRHPF-----LVNLFACFQ--T--------KEHVC--FVMEY-AAGG--DLMMHIH-----TD--VF---SEPRAVFYAACVVLGLQYLHE--H--KIVYRDLKLDNLLLD--TEGFV---------KIADFGLCKEG--------------MGYGDRTST---FCGTPEFLAPEVLT------ETSYTRAVDWWGLGVLIYEMLV-GESP-------------FP-GD---------DEEEVFDSIVNDEVRYPRFLS---------------------------------------------------------------------TEAISIMRRLLRRNPERRLGAS-EKDAE-DVKKHPFF--------------
---F-KVGNLLGKGSFAGV---YRAES---I----H-TGL---EVAIKMIDKKAMYK---AG--MV-QRVQ------NEVKIHCQL-K------HPS-----ILELYNYFE--D--------SNYVY--LVLEM-CHNG--EMNRYLK---NRVK--PF---SENEARHFMHQIITGMLYLHS--H--GILHRDLTLSNLLLT--RNMNI---------KIADFGLATQL--------------KMPHEKHYT---LCGTPNYISPEIAT------RSAHGLESDVWSLGCMFYTLLI-GRPP-------------FD-TD---------TVKNTLNKVVLADYEMPSFLS---------------------------------------------------------------------IEAKDLIHQLLRRNPADRLS------LS-SVLDHPFM--------------
---F-ERIKTLGTGSFGRV---MLVKH---K----E-TGN---HYAMKILDKQKVVK---LK--QI-EHTL------NEKRILQAV-N------FPF-----LVKLEFSFK--D--------NSNLY--MVMEY-VPGG--EMFSHLR----RIG--RF---SEPHARFYAAQIVLTFEYLHS--L--DLIYRDLKPENLLID--QQGYI---------QVTDFGFAK-----------------RVKGRTWT---LCGTPEYLAPEIIL------SKGYNKAVDWWALGVLIYEMAA-GYPP-------------FF-AD---------QPIQIYEKIVSGKVRFPSHFS---------------------------------------------------------------------SDLKDLLRNLLQVDLTKRFGNL-KNGVN-DIKNHKWF--------------
---F-ERKKTLGTGSFGRV---MLVKH---K----A-TEQ---YYAMKILDKQKVVK---LK--QI-EHTL------NEKRILQAV-N------FPF-----LVRLEYAFK--D--------NSNLY--MVMEY-VPGG--EMFSHLR----RIG--RF---SEPHARFYAAQIVLTFEYLHS--L--DLIYRDLKPENLLID--HQGYI---------QVTDFGFAK-----------------RVKGRTWT---LCGTPEYLAPEIIL------SKGYNKAVDWWALGVLIYEMAA-GYPP-------------FF-AD---------QPIQIYEKIVSGKVRFPSHFS---------------------------------------------------------------------SDLKDLLRNLLQVDLTKRFGNL-KNGVS-DIKTHKWF--------------
---F-NFLMVLGKGSFGKV---MLSER---K----G-TDE---LYAVKILKKDVVIQ---DD--DV-ECTM------VEKRVLALPGK------PPF-----LTQLHSCFQ--T--------MDRLY--FVMEY-VNGG--DLMYHIQ----QVG--RF---KEPHAVFYAAEIAIGLFFLQS--K--GIIYRDLKLDNVMLD--SEGHI---------KIADFGMCKEN--------------IWDGVTTKT---FCGTPDYIAPEIIA------YQPYGKSVDWWAFGVLLYEMLA-GQAP-------------FE-GE---------DEDELFQSIMEHNVAYPKSMS---------------------------------------------------------------------KEAVAICKGLMTKHPGKRLG------C----------GPEGERDIKEHAFF
--FI--FHKVLGKGSFGKV---LLGEL---K----G-RGE---YFAIKALKKDVVLI---DD--DV-ECTM------VEKRVLTLAAE------NPF-----LTHLICTFQ--T--------KDHLF--FVMEF-LNGG--DLMYHIQ----DKG--RF---ELYRATFYAAEIMCGLQFLHS--K--GIIYRDLKLDNVLLD--RDGHI---------KIADFGMCKEN--------------IFGESRAST---FCGTPDYIAPEILQ------GLKYTFSVDWWSFGVLLYEMLI-GQSP-------------FH-GD---------DEDELFESIRVDTPHYPRWIT---------------------------------------------------------------------KESKDILEKLFEREPTKRLG-----VTG-NIKIHPFF--------------
----FEFIRVLGKGSFGKV---MLARV---K----E-TGD---LYAVKVLKKDVILQ---DD--DV-ECTM------TEKRILSLARN------HPF-----LTQLFCCFQ--T--------PDRLF--FVMEF-VNGG--DLMFHIQ----KSR--RF---DEARARFYAAEIISALMFLHD--K--GIIYRDLKLDNVLLD--HEGHC---------KLADFGMCKEG--------------ICNGVTTAT---FCGTPDYIAPEILQ------EMLYGPAVDWWAMGVLLYEMLC-GHAP-------------FE-AE---------NEDDLFEAILNDEVVYPTWLH---------------------------------------------------------------------EDATGILKSFMTKNPTMRLGSLTQGGEH-AILRHPF-F-------------
---F-DLLRVIGRGSYAKV---LLVRL---K----K-TDR---IYAMKVVKKELVND---DE--DI-DWVQ------TEKHVFEQASN------HPF-----LVGLHSCFQ--T--------ESRLF--FVIEY-VNGG--DLMFHMQ----RQR--KL---PEEHARFYSAEISLALNYLHE--R--GIIYRDLKLDNVLLD--SEGHI---------KLTDYGMCKEG--------------LRPGDTTST---FCGTPNYIAPEILR------GEDYGFSVDWWALGVLMFEMMA-GRSP-------------FD-IVGSSDNPDQNTEDYLFQVILEKQIRIPRSLS---------------------------------------------------------------------VKAASVLKSFLNKDPKERLGCHPQTGFA-DIQGHPF-F-------------
--FI--LHKMLGKGSFGKV---FLAEF---K----K-TNQ---FFAIKALKKDVVLM---DD--DV-ECTM------VEKRVLSLAWE------HPF-----LTHMFCTFQ--T--------KENLF--FVMEY-LNGG--DLMYHIQ----SCH--KF---DLSRATFYAAEIILGLQFLHS--K--GIVYRDLKLDNILLD--KDGHI---------KIADFGMCKEN--------------MLGDAKTNT---FCGTPDYIAPEILL------GQKYNHSVDWWSFGVLLYEMLI-GQSP-------------FH-GQ---------DEEELFHSIRMDNPFYPRWLE---------------------------------------------------------------------KEAKDLLVKLFVREPEKRLG------VRGDIRQHPLF--------------
---F-DLIRVIGRGSYAKV---LLVRL---K----K-NDQ---IYAMKVVKKELVHD---DE--DI-DWVQ------TEKHVFEQASS------NPF-----LVGLHSCFQ--T--------TSRLF--LVIEY-VNGG--DLMFHMQ----RQR--KL---PEEHARFYAAEICIALNFLHE--R--GIIYRDLKLDNVLLD--ADGHI---------KLTDYGMCKEG--------------LGPGDTTST---FCGTPNYIAPEILR------GEEYGFSVDWWALGVLMFEMMA-GRSP-------------FD-IITD--NPDMNTEDYLFQVILEKPIRIPRFLS---------------------------------------------------------------------VKASHVLKGFLNKDPKERLGCRPQTGF----------SDIKSHAFF-----
--PD----EVLGSGQFGVV---YGGKH---R----K-TGR---DVAVKVIDKLRFPT---KQ--ES-QLRN-------EVAILQSL-R------HPG-----IVNLECMFE--T--------PEKVF--VVMEK-LHGD--MLEMILS---SEKG--RL---PERLTKFLITQILVALRHLHF--K--NIVHCDLKPENVLLA--SADPFP------QVKLCDFGFARI---------------IGEKSFRRS---VVGTPAYLAPEVLL------NQGYNRSLDMWSVGVIMYVSLS-GTFP-------------FN-ED-----------EDINDQIQNAAFMYPASPWSHIS-----------------------------------------------------------------AGAIDLINNLLQVKMRKRYS------VD-KSLSHPWL--------------
---F-NIIDTLGVGGFGRV---ELVQL---KS---E-ESK---TFAMKILKKRHIVD---TR--QQ-EHIR------SEKQIMQGA-H------SDF-----IVRLYRTFK--D--------SKYLY--MLMEA-CLGG--ELWTILR----DRG--SF---EDSTTRFYTACVVEAFAYLHS--K--GIIYRDLKPENLILD--HRGYA---------KLVDFGFAKK---------------IGFGKKTWT---FCGTPEYVAPEIIL------NKGHDISADYWSLGILMYELLT-GSPP-------------FS-GP---------DPMKTYNIILRGIDMIEFPKKIA-------------------------------------------------------------------KNAANLIKKLCRDNPSERLGNL-KNGVK-DIQKHKWF--------------
---L-EIIATLGVGGFGRV---ELVKV---K----N-ENV---AFAMKCIRKKHIVD---TK--QQ-EHVY------SEKRILEEL-C------SPF-----IVKLYRTFK--D--------NKYVY--MLLEA-CLGG--ELWSILR----DRG--SF---DEPTSKFCVACVTEAFDYLHR--L--GIIYRDLKPENLILD--AEGYL---------KLVDFGFAKK---------------IGSGQKTWT---FCGTPEYVAPEVIL------NKGHDFSVDFWSLGILVYELLT-GNPP-------------FS-GV---------DQMMTYNLILKGIEKMDFPRKIT-------------------------------------------------------------------RRPEDLIRRLCRQNPTERLGNL-KNGIN-DIKKHRWL--------------
YNVY----GYTGQGVFSNV---VRARD---N----ARANQ---EVAVKIIRNNELMQ---KT--G----LK-------ELEFLKKL-NDADPDDKFH-----CLRLFRHFY--H--------KQHLC--LVFEP-LSM---NLREVLKK-YGKDV--GL---HIKAVRSYSQQLFLALKLLKR--C--NILHADIKPDNILVN--ESKTI--------LKLCDFGSAS----------------HVADNDITP---YLVSRFYRAPEIII------GKSYDYGIDMWSVGCTLYELYT-GKIL-------------FP-GK------TNNHMLKLAMDLKGKMPNKMIRKGVFKDQHFDQNLNFMYIEVDKVTEREKVTVM------------STINPTKDLLADLIGCQRLPEDQRKKVHQLKDLLDQILMLDPAKRIS------IN-QALQHAFI--------------
----FELLKVLGQGSFGKVFLVRKVTR---P----D-SGH---LYAMKVLKKATLKV---RD--RV-RTKM-------ERDILADV-N------HPF-----VVKLHYAFQ--T--------EGKLY--LILDF-LRGG--DLFTRLS----KEV--MF---TEEDVKFYLAELALGLDHLHS--L--GIIYRDLKPENILLD--EEGHI---------KLTDFGLSKEA--------------IDHEKKAYS---FCGTVEYMAPEVVN------RQGHSHSADWWSYGVLMFEMLT-GSLP-------------FQ-GK---------DRKETMTLILKAKLGMPQFLS---------------------------------------------------------------------TEAQSLLRALFKRNPANRLGSG-PDGAE-EIKRHV--FY------------
----FELLKVLGQGSYGKV---FLVRK---V----K-GSDAGQLYAMKVLKKATLKV---RD--RV-RSKM-------ERDILAEV-N------HPF-----IVKLHYAFQ--T--------EGKLY--LILDF-LRGG--DLFTRLS----KEV--MF---TEEDVKFYLAELALALDHLHS--L--GIIYRDLKPENILLD--EEGHI---------KITDFGLSKEA--------------IDHDKRAYS---FCGTIEYMAPEVVN------RRGHTQSADWWSFGVLMFEMLT-GSLP-------------FQ-GK---------DRKETMALILKAKLGMPQFLS---------------------------------------------------------------------GEAQSLLRALFKRNPCNRLGAG-IDGVE-EIKRHPFF--------------
----FELLKVLGQGSFGKV---FLVKK---I----S-GSDARQLYAMKVLKKATLKV---RD--RV-RTKM-------ERDILVEV-N------HPF-----IVKLHYAFQ--T--------EGKLY--LILDF-LRGG--DLFTRLS----KEV--MF---TEEDVKFYLAELALALDHLHS--L--GIIYRDLKPENILLD--EEGHI---------KLTDFGLSKES--------------IDHEKKAYS---FCGTVEYMAPEVVN------RRGHTQSADWWSFGVLMFEMLT-GTLP-------------FQ-GK---------DRKETMTMILKAKLGMPQFLS---------------------------------------------------------------------PEAQSLLRMLFKRNPANRLGAG-PDGVE-EIKRHSFF--------------
----FELLKVLGQGSFGKV---FLVRK---K----T-GPDAGQLYAMKVLKKASLKV---RD--RV-RTKM-------ERDILVEV-N------HPF-----IVKLHYAFQ--T--------EGKLY--LILDF-LRGG--DVFTRLS----KEV--LF---TEEDVKFYLAELALALDHLHQ--L--GIVYRDLKPENILLD--EIGHI---------KLTDFGLSKES--------------VDQEKKAYS---FCGTVEYMAPEVVN------RRGHSQSADWWSYGVLMFEMLT-GTLP-------------FQ-GK---------DRNETMNMILKAKLGMPQFLS---------------------------------------------------------------------AEAQSLLRMLFKRNPANRLGS---EGVE-EIKRHLFF--------------
----FELLRVLGKGGYGKV---FQVRKVTGA----N-TGK---IFAMKVLKKAMIVR---NA--KD-TAHTK-----AERNILEEV-K------HPF-----IVDLIYAFQ--T--------GGKLY--LILEY-LSGG--ELFMQLE----REG--IF---MEDTACFYLAEISMALGHLHQ--K--GIIYRDLKPENIMLN--HQGHV---------KLTDFGLCKES--------------IHDGTVTHT---FCGTIEYMAPEILM------RSGHNRAVDWWSLGALMYDMLT-GAPP-------------FT-GE---------NRKKTIDKILKCKLNLPPYLT---------------------------------------------------------------------QEARDLLKKLLKRNAASRLGAG-PGDAG-EVQAHPFF--------------
----WEIIGELGDGAFGKV---YKAQN---K----E-TSV---LAAAKVIDTKSEEE---LE--DY-M--V-------EIDILASC-D------HPN-----IVKLLDAFY--Y--------ENNLW--ILIEF-CAGG--AVDAVML---ELER--PL---TESQIQVVCKQTLDALNYLHD--N--KIIHRDLKAGNILFT--LDGDI---------KLADFGVSAKN--------------TRTIQRRDS---FIGTPYWMAPEVVMCE-TSKDRPYDYKADVWSLGITLIEMAE-IEPP-------------HH-EL------NPMRVLLKIAKSEPPTLAQPSRWS---------------------------------------------------------------------SNFKDFLKKCLEKNVDARWT------TS-QLLQHPFV--------------
-YLM---GDLLGEGSYGKV---KEVLD---S----E-TLC---RRAVKILKKKKLRR---IP--NG-EANVK-----KEIQLLRRL-R------HKN-----VIQLVDVLY--NE------EKQKMY--MVMEY-CVCGMQEMLDSVP-----EK--RF---PVCQAHGYFCQLIDGLEYLHS--Q--GIVHKDIKPGNLLLT--TGGTL---------KISDLGVAEALH------------PFAADDTCRT---SQGSPAFQPPEIAN----GLDTFSGFKVDIWSAGVTLYNITT-GLYP-------------FE-GD---------NIYKLFENIGKGSYAIPGDCG---------------------------------------------------------------------PPLSDLLKGMLEYEPAKRFS------IR-QIRQHSWF--------------
----FTKLEKIGKGSFGEV---FKGID---N----R-TQK---VVAIKIIDLEEAED---EI--ED-IQ-Q-------EITVLSQC-D------SPY-----VTKYYGSYL--K--------DTKLW--IIMEY-LGGG--SALDLLE-----PG--PL---DETQIATILREILKGLDYLHS--E--KKIHRDIKAANVLLS--EHGEV---------KLADFGVAGQL--------------TDTQIKRNT---FVGTPFWMAPEVIK------QSAYDSKADIWSLGITAIELAR-GEPP-------------HS-EL------HPMKVLFLIPKNNPPTLEGNYS-----------------------------------------------------------------------KPLKEFVEACLNKEPSFRPT------AK-ELLKHKFI--------------
----YTFGRILGKGSFGIV---IEATD---K----E-TET---KWAIKKVNKEKAGS---SA--VK-LLER-------EVNILKSV-K------HEH-----IIHLEQVFE--T--------PKKMY--LVMEL-CEDG--ELKEILD----RKG--HF---SENETRWIIQSLASAIAYLHN--N--DIVHRDLKLENIMVK--SSLIDDNNEINLNIKVTDFGLAVKK-------------QSRSEAMLQA---TCGTPIYMAPEVIS------AHDYSQQCDIWSIGVVMYMLLR-GEPP-------------FL-AS---------SEEKLFELIRKGELHFENAVWNSIS-----------------------------------------------------------------DCAKSVLKQLMKVDPAHRIT------AK-ELLDNQWL--------------
--YL--LLHLLGRGGFSEV---YKAFD---L----Y-EQR---YAAVKIHQLNKSWR---DE--KK-ENYHKH--ACREYRIHKEL-D------HPR-----IVKLYDYFS--L-------DTDTFC--TVLEY-CEGN--DLDFYLK----QHK--LM---SEKEARSIVMQIVNALRYLNE--IKPPIIHYDLKPGNILLV--DGTACG------EIKITDFGLSKIMDDD--------SYGVDGMDLTSQ---GAGTYWYLPPECFVV--GKEPPKISNKVDVWSVGVIFFQCLY-GRKP-------------FG-HN-------QSQQDILQENTILKATEVQFPVKPVVS-----------------------------------------------------------------SEAKAFIRRCLAYRKEDRFD------VH-QLANDPYL--------------
----WTKGEILGKGAYGTV---YCGLT---S----Q-GQ----LIAVKQVALDTSNK---LA--AE-KEYRKL---QEEVDLLKAL-K------HVN-----IVAYLGTCL--Q--------ENTVS--IFMEF-VPGG--SISSIIN----RFG--PL---PEMVFCKYTKQILQGVAYLHE--N--CVVHRDIKGNNVMLM--PTGII---------KLIDFGCARRLAWA--------GLNGTHSDMLKS---MHGTPYWMAPEVIN------ESGYGRKSDIWSIGCTVFEMAT-GKPP-------------LA-SM--------DRMAAMFYIGAHRGLMPPLPDHFS-------------------------------------------------------------------ENAADFVRMCLTRDQHERPS------AL-QLLKHSFL--------------
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