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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
AGC GRK7 203
TK ABL1 261
Other AURKA 133
Other AURKB 77
Other AURKC 43
CAMK BRSK1 50
CAMK BRSK2 19
TK BTK 402
CAMK CAMK2B 14
CAMK CAMK2D 14
CAMK CAMK2G 14
CMGC CDK5 4
CMGC CDK6 13
CMGC CDK9 2.7.11.23
CMGC CDKL2 4
CAMK CHEK1 9
CAMK CHEK2 220
CAMK DAPK1 13
CAMK DAPK2 23
CAMK DAPK3 13
CMGC DYRK1A 150
CMGC DYRK1B 111
TK EGFR 712
Other EIF2AK2 267
TK EPHB1 619
TK EPHB4 615
TK FGFR1 478
TK FGFR2 481
TK FGFR3 472
TK FGFR4 467
AGC GRK1 190
AGC GRK4 187
AGC GRK6 186
TK HCK 241
CMGC HIPK4 -1
CAMK HUNK 61
CMGC ICK 4
TK JAK2 849
TK JAK3 822
CMGC MAK 4
CAMK MARK2 53
CAMK MARK4 59
CAMK MGC42105 74
CAMK MKNK2 84
CAMK NUAK1 55
CAMK NUAK2 97
CAMK PHKG1 20
CAMK PHKG2 24
Other PLK2 82
CAMK PRKD1 583
CAMK PRKD2 551
CAMK PRKD3 576
TKL RIPK1 17
AGC RPS6KB1 91
Other SBK1 53
CAMK SIK1 27
CAMK SIK2 20
STE SLK 34
CAMK SNRK 16
STE STK10 36
CAMK STK17A 61
CAMK STK17B 33
STE STK24 24
TK SYK 371
Other TLK2 440
CAMK TSSK1B 12
----F-TEFRVLGKGGFGEVCAVQV---K-------NTGK-MYACKKL-DKKR-LKKKG---GEKMAL------LEKEILEKV--S-----SPF-----IVSLAYAFE--S-----------------------------KTHLCLVMSLMNGGDLKFHIYN--VGTR-----------------GL---DMSRVIFYSAQIACGMLHLHE--L--GIVYRDMKPENVLLD--DLGNC----RLSDLGLAVE-------------MKGGKPI------TQ---RAGTNGYMAPEILM-----EKVS--YSYPVDWFAMGCSIYEMVA-GR-TP---------------FKDY-----------KEKVSK-EDLKQRTLQDE---VKFQHDNF---T-----------------------------------------------------------------------EEAKDICRLFLAKKPEQRLG-----SRE-------KSDDPR------
-----ITMKHKLGGGQYGEVYEGVW---K-------KYSL-TVAVKTL-K-ED-TM-EV---EEFL-K-------EAAVMKEI--K-----HPN-----LVQLLGVCT--R-----------------------------EPPFYIITEFMTYGNLLDYLR-----EC--------------NRQEV---NAVVLLYMATQISSAMEYLEK--K--NFIHRDLAARNCLVG--ENHLV----KVADFGLSRLM------------T--GDTY------TAHAGAKFPIKWTAPESLA------YNK--FSIKSDVWAFGVLLWEIATYGM-SP---------------YPGI------------DLSQV-YELLEKDYRME---RPEGCP-----------------------------------------------------------------------------EKVYELMRACWQWNPSDRPS-----FAEIHQA--F------------
-----FEIGRPLGKGKFGNVYLARE---K-------QSKF-ILALKVL-FKAQLEKAGV---EHQLRR-------EVEIQSHL--R-----HPN-----ILRLYGYFH--D-----------------------------ATRVYLILEYAPLGTVYRELQ----KLS-----------------KF---DEQRTATYITELANALSYCHS--K--RVIHRDIKPENLLLG--SAGEL----KIADFGWSV--------------HAPSSRR------TT---LCGTLDYLPPEMIE------GRM--HDEKVDLWSLGVLCYEFLV-GK-PP---------------FEAN---------------TY-QETYKRISRVE---FTFPDFVT---------------------------------------------------------------------------EGARDLISRLLKHNPSQRPM-----LREVLEHPWI------------
-----FEIGRPLGKGKFGNVYLARE---K-------KSHF-IVALKVL-FKSQ-IEKEG---VEHQLR------REIEIQAHL--H-----HPN-----ILRLYNYFY--D-----------------------------RRRIYLILEYAPRGELYKELQ----KSC-----------------TF---DEQRTATIMEELADALMYCHG--K--KVIHRDIKPENLLLG--LKGEL----KIADFGWSV--------------HAPSLRR------KT---MCGTLDYLPPEMIE------GRM--HNEKVDLWCIGVLCYELLV-GN-PP---------------FESA---------------SH-NETYRRIVKVD---LKFPASVP---------------------------------------------------------------------------MGAQDLISKLLRHNPSERLP-----LAQVSAHPWV------------
-----FEIGRPLGKGKFGNVYLARL---K-------ESHF-IVALKVL-FKSQ-IEKEG---LEHQLR------REIEIQAHL--Q-----HPN-----ILRLYNYFH--D-----------------------------ARRVYLILEYAPRGELYKELQ----KSE-----------------KL---DEQRTATIIEELADALTYCHD--K--KVIHRDIKPENLLLG--FRGEV----KIADFGWSV--------------HTPSLRR------KT---MCGTLDYLPPEMIE------GRT--YDEKVDLWCIGVLCYELLV-GY-PP---------------FESA---------------SH-SETYRRILKVD---VRFPLSMP---------------------------------------------------------------------------LGARDLISRLLRYQPLERLP-----LAQILKHPWV------------
-----YRLEKTLGKGQTGLVKLGVH---C-------ITGQ-KVAIKIV-NREK-LSESV---LMKVER-------EIAILKLI--E-----HPH-----VLKLHDVYE--N-----------------------------KKYLYLVLEHVSGGELFDYLV----KKG-----------------RL---TPKEARKFFRQIVSALDFCHS--Y--SICHRDLKPENLLLD--EKNNI----RIADFGMASL-------------QVGDSLL------ET---SCGSPHYACPEVIK-----GEKY--DGRRADMWSCGVILFALLV-GA-LP---------------FDDD---------------NL-RQLLEKVKRGV---FHMPHFIP---------------------------------------------------------------------------PDCQSLLRGMIEVEPEKRLS-----LEQIQKHPW-Y-----------
-----YRLEKTLGKGQTGLVKLGVH---C-------VTCQ-KVAIKIV-NREK-LSESV---LMKVER-------EIAILKLI--E-----HPH-----VLKLHDVYE--N-----------------------------KKYLYLVLEHVSGGELFDYLV----KKG-----------------RL---TPKEARKFFRQIISALDFCHS--H--SICHRDLKPENLLLD--EKNNI----RIADFGMASL-------------QVGDSLL------ET---SCGSPHYACPEVIR-----GEKY--DGRKADVWSCGVILFALLV-GA-LP---------------FDDD---------------NL-RQLLEKVKRGV---FHMPHFIP---------------------------------------------------------------------------PDCQSLLRGMIEVDAARRLT-----LEHIQKHIW-Y-----------
-----LTFLKELGTGQFGVVKYGKW---R--------GQY-DVAIKMI-K-EG-SM-SE---DEFI-E-------EAKVMMNL--S-----HEK-----LVQLYGVCT--K-----------------------------QRPIFIITEYMANGCLLNYLR-----EM---------------RHRF---QTQQLLEMCKDVCEAMEYLES--K--QFLHRDLAARNCLVN--DQGVV----KVSDFGLSRYV------------L--DDEY------TSSVGSKFPVRWSPPEVLM------YSK--FSSKSDIWAFGVLMWEIYSLGK-MP---------------YERF------------TNSET-AEHIAQGLRLY---RPHLAS-----------------------------------------------------------------------------EKVYTIMYSCWHEKADERPT-----FKILLSN--I------------
-----YQLYEDIGKGAFSVVRRCVK---L-------CTGH-EYAAKII-NTKK-LSARD---HQKLER-------EARICRLL--K-----HSN-----IVRLHDSIS--E-----------------------------EGFHYLVFDLVTGGELFEDIV----ARE-----------------YY---SEADASHCIQQILEAVLHCHQ--M--GVVHRDLKPENLLLA--SKCKGA-AVKLADFGLAIEV------------QGDQQAW------FG---FAGTPGYLSPEVLR------KEA--YGKPVDIWACGVILYILLV-GY-PP---------------FWDE---------------DQ-HKLYQQIKAGA---YDFPSPEWDTVT-----------------------------------------------------------------------PEAKNLINQMLTINPAKRIT-----AHEALKHPWV------------
-----YQLFEELGKGAFSVVRRCMK---I-------PTGQ-EYAAKII-NTKK-LSARD---HQKLER-------EARICRLL--K-----HPN-----IVRLHDSIS--E-----------------------------EGFHYLVFDLVTGGELFEDIV----ARE-----------------YY---SEADASHCIQQILESVNHCHL--N--GIVHRDLKPENLLLA--SKSKGA-AVKLADFGLAIEV------------QGDQQAW------FG---FAGTPGYLSPEVLR------KDP--YGKPVDMWACGVILYILLV-GY-PP---------------FWDE---------------DQ-HRLYQQIKAGA---YDFPSPEWDTVT-----------------------------------------------------------------------PEAKDLINKMLTINPAKRIT-----ASEALKHPWI------------
-----YQLFEELGKGAFSVVRRCVK---K-------TSTQ-EYAAKII-NTKK-LSARD---HQKLER-------EARICRLL--K-----HPN-----IVRLHDSIS--E-----------------------------EGFHYLVFDLVTGGELFEDIV----ARE-----------------YY---SEADASHCIHQILESVNHIHQ--H--DIVHRDLKPENLLLA--SKCKGA-AVKLADFGLAIEV------------QGEQQAW------FG---FAGTPGYLSPEVLR------KDP--YGKPVDIWACGVILYILLV-GY-PP---------------FWDE---------------DQ-HKLYQQIKAGA---YDFPSPEWDTVT-----------------------------------------------------------------------PEAKNLINQMLTINPAKRIT-----ADQALKHPWV------------
-----YEKLEKIGEGTYGTVFKAKN---R-------ETHE-IVALKRV-RLDD-DDEGV---PSSALR-------EICLLKEL--K-----HKN-----IVRLHDVLH--S-----------------------------DKKLTLVFEFCDQ-DLKKYFD---SCNG-----------------DL---DPEIVKSFLFQLLKGLGFCHS--R--NVLHRDLKPQNLLIN--RNGEL----KLADFGLARAF------------GIPVRCY------SA---EVVTLWYRPPDVLF-----GAKL--YSTSIDMWSAGCIFAELANAGR-PL---------------FPGN------------DVDDQ-LKRIFRLLGTP---TEEQWPSMTKLPDYKPYPMYPAT-------------------------------------------------TSLVNVVPKLNATGRDLLQNLLKCNPVQRIS-----AEEALQHPYF------------
-----YECVAEIGEGAYGKVFKARD---L-------KNGGRFVALKRV-RVQT-GEEGM---PLSTIR-------EVAVLRHL--ET--FEHPN-----VVRLFDVCT--VSR------------------------TDRETKLTLVFEHVDQ-DLTTYLDK--VPEP-----------------GV---PTETIKDMMFQLLRGLDFLHS--H--RVVHRDLKPQNILVT--SSGQI----KLADFGLARI-------------YSFQMAL------TS---VVVTLWYRAPEVLL------QSS--YATPVDLWSVGCIFAEMFR-RK-PL---------------FRGS------------SDVDQ-LGKILDVIGLP---GEEDWPRDVALPRQAFHSKSAQ---------------------------------------------------PIEKFVTDIDELGKDLLLKCLTFNPAKRIS-----AYSALSHPYF------------
-----YEKLAKIGQGTFGEVFKARH---R-------KTGQ-KVALKKV-LMEN-EKEGF---PITALR-------EIKILQLL--K-----HEN-----VVNLIEICR--TKASP---------------------YNRCKGSIYLVFDFCEH-DLAGLLS---NVLV-----------------KF---TLSEIKRVMQMLLNGLYYIHR--N--KILHRDMKAANVLIT--RDGVL----KLADFGLARAFSL--------AKNSQPNRY------TN---RVVTLWYRPPELLL-----GERD--YGPPIDLWGAGCIMAEMWT-RS-PI---------------MQGN------------TEQHQ-LALISQLCGSI---TPEVWPNVDNYELYEKLELVKGQK----------------------------------------------RKVKDRLKAYVRDPYALDLIDKLLVLDPAQRID-----SDDALNHDFF------------
-----YENLGLVGEGSYGMVMKCRN---K-------DTGR-IVAIKKF-LESD-DDKMV---KKIAMR-------EIKLLKQL--R-----HEN-----LVNLLEVCK--K-----------------------------KKRWYLVFEFVDHTILDDLEL----FPN-----------------GL---DYQVVQKYLFQIINGIGFCHS--H--NIIHRDIKPENILVS--QSGVV----KLCDFGFARTL------------AAPGEVY------TD---YVATRWYRAPELLV-----GDVK--YGKAVDVWAIGCLVTEMFM-GE-PL---------------FPGD------------SDIDQ-LYHIMMCLGNL---IPRHQELFNKNPVFAGVRLPEIKE-----------------------------------------------REPLERRYPKLSEVVIDLAKKCLHIDPDKRPF-----CAELLHHDFF------------
----W-DLVQTLGEGAYGEVQLAVN---R-------VTEE-AVAVKIV-DMKR-AVDCP---ENI-KK-------EICINKML--N-----HEN-----VVKFYGHRR--E-----------------------------GNIQYLFLEYCSGGELFDRIE----PDI-----------------GM---PEPDAQRFFHQLMAGVVYLHG--I--GITHRDIKPENLLLD--ERDNL----KISDFGLATVFR----------YNNRERLL------NK---MCGTLPYVAPELLK-----RREF--HAEPVDVWSCGIVLTAMLA-GE-LP---------------WDQP--------------SDS-CQEYSDWKEKK---TYLNPWKKI--D-----------------------------------------------------------------------SAPLALLHKILVENPSARIT-----IPDIKKDRW-Y-----------
---YI--MSKTLGSGACGEVKLAFE---R-------KTCK-KVAIKII-SKRK-FAIGS---AREADPALN-VETEIEILKKL--N-----HPC-----IIKIKNFF---D-----------------------------AEDYYIVLELMEGGELFDKVV----GNK-----------------RL---KEATCKLYFYQMLLAVQYLHE--N--GIIHRDLKPENVLLS--SQEEDC-LIKITDFGHSKI-------------LGETSLM------RT---LCGTPTYLAPEVLVS---VGTAG--YNRAVDCWSLGVILFICLS-GY-PP---------------FSEH--------------RTQ-VSLKDQITSGK---YNFIPEVWAEVS-----------------------------------------------------------------------EKALDLVKKLLVVDPKARFT-----TEEALRHPWL------------
-----YDTGEELGSGQFAVVKKCRE---K-------STGL-QYAAKFI-KKRR-TKSSR---RGVSREDI---EREVSILKEI--Q-----HPN-----VITLHEVYE--N-----------------------------KTDVILILELVAGGELFDFLA----EKE-----------------SL---TEEEATEFLKQILNGVYYLHS--L--QIAHFDLKPENIMLL--DRNVPKPRIKIIDFGLAHK-------------IDFGNEF------KN---IFGTPEFVAPEIVN------YEP--LGLEADMWSIGVITYILLS-GA-SP---------------FLGD---------------TK-QETLANVSAVN---YEFEDEYFSNTS-----------------------------------------------------------------------ALAKDFIRRLLVKDPKKRMT-----IQDSLQHPWI------------
-----YDIGEELGSGQFAIVKKCRE---K-------STGL-EYAAKFI-KKRQ-SRASR---RGVSREEI---EREVSILRQV--L-----HHN-----VITLHDVYE--N-----------------------------RTDVVLILELVSGGELFDFLA----QKE-----------------SL---SEEEATSFIKQILDGVNYLHT--K--KIAHFDLKPENIMLL--DKNIPIPHIKLIDFGLAHE-------------IEDGVEF------KN---IFGTPEFVAPEIVN------YEP--LGLEADMWSIGVITYILLS-GA-SP---------------FLGD---------------TK-QETLANITAVS---YDFDEEFFSQTS-----------------------------------------------------------------------ELAKDFIRKLLVKETRKRLT-----IQEALRHPWI------------
-----YEMGEELGSGQFAIVRKCRQ---K-------GTGK-EYAAKFI-KKRR-LSSSR---RGVSREEI---EREVNILREI--R-----HPN-----IITLHDIFE--N-----------------------------KTDVVLILELVSGGELFDFLA----EKE-----------------SL---TEDEATQFLKQILDGVHYLHS--K--RIAHFDLKPENIMLL--DKNVPNPRIKLIDFGIAHK-------------IEAGNEF------KN---IFGTPEFVAPEIVN------YEP--LGLEADMWSIGVITYILLS-GA-SP---------------FLGE---------------TK-QETLTNISAVN---YDFDEEYFSNTS-----------------------------------------------------------------------ELAKDFIRRLLVKDPKRRMT-----IAQSLEHSWI------------
-----YEIDSLIGKGSFGQVVKAYD---R-------VEQE-WVAIKII-KNKK-AFLNQ---AQI----------EVRLLELM-NK-----HDTEMKYYIVHLKRHFM--F-----------------------------RNHLCLVFEMLSY-NLYDLLR-----NT-----------------NFRGVSLNLTRKFAQQMCTALLFLATPEL--SIIHCDLKPENILLCNPKRSAI----KIVDFGSSCQ---------------LGQRI------YQ---YIQSRFYRSPEVLL------GMP--YDLAIDMWSLGCILVEMHT-GE-PL---------------FSGA------------NEVDQ-MNKIVEVLGIP---PAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGT--------------RKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQ-----PYYALQHSFF------------
-----YEIDSLIGKGSFGQVVKAYD---H-------QTQE-LVAIKII-KNKK-AFLNQ---AQI----------ELRLLELM-NQ-----HDTEMKYYIVHLKRHFM--F-----------------------------RNHLCLVFELLSY-NLYDLLR-----NT-----------------HFRGVSLNLTRKLAQQLCTALLFLATPEL--SIIHCDLKPENILLCNPKRSAI----KIVDFGSSCQ---------------LGQRI------YQ---YIQSRFYRSPEVLL------GTP--YDLAIDMWSLGCILVEMHT-GE-PL---------------FSGS------------NEVDQ-MNRIVEVLGIP---PAAMLDQAPKARKYFERLPGGGWTLRRTKELRKDYQGPGT--------------RRLQEVLGVQTGGPGGRRAGEPGHSPADYLRFQDLVLRMLEYEPAARIS-----PLGALQHGFF------------
----F-KKIKVLGSGAFGTVYKGLW---IP---EGEKVKI-PVAIKEL-R-EA-TS-PKA-NKEIL-D-------EAYVMASV--D-----NPH-----VCRLLGICL--------------------------------TSTVQLITQLMPFGCLLDYVR-----EH---------------KDNI---GSQYLLNWCVQIAKGMNYLED--R--RLVHRDLAARNVLVK--TPQHV----KITDFGLAKLL-------G----A--EEKE------YHAEGGKVPIKWMALESIL------HRI--YTHQSDVWSYGVTVWELMTFGS-KP---------------YDGI------------PASEI-SSILEKGERLP---QPPICT-----------------------------------------------------------------------------IDVYMIMVKCWMIDADSRPK-----FRELI----IEF----------
----F-KEIELIGSGGFGQVFKAKH---R-------IDGK-TYVIKRV-KYNN-EKAER----------------EVKALAKL--D-----HVN-----IVHYNGCWD--GFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEK--RRGE-----------------KL---DKVLALELFEQITKGVDYIHS--K--KLIHRDLKPSNIFLV--DTKQV----KIGDFGLVTS-------------LKNDGKR------TR---SKGTLRYMSPEQIS------SQD--YGKEVDLYALGLILAELLH-VCDTA---------------FET--------------------SKFFTDLRDG---IISDIFDK----------------------------------------------------------------------------KEKTLLQKLLSKKPEDRPN-----TSEILR----TLT---------
----V-KIEEVIGAGEFGEVYKGRL---K----LPGKREI-YVAIKTL-K-AG-YS-EKQ-RRDFL-S-------EASIMGQF--D-----HPN-----IIRLEGVVT--K-----------------------------SRPVMIITEFMENGALDSFLR-----QN---------------DGQF---TVIQLVGMLRGIAAGMKYLAE--M--NYVHRDLAARNILVN--SNLVC----KVSDFGLSRYLQ----DDT----S--DPTY------TSSLGGKIPVRWTAPEAIA------YRK--FTSASDVWSYGIVMWEVMSFGE-RP---------------YWDM------------SNQDV-INAIEQDYRLP---PPMDCP-----------------------------------------------------------------------------AALHQLMLDCWQKDRNSRPR-----FAEIVNTL--------------
----V-KIEEVIGAGEFGEVCRGRL---K----APGKKES-CVAIKTL-K-GG-YT-ERQ-RREFL-S-------EASIMGQF--E-----HPN-----IIRLEGVVT--N-----------------------------SMPVMILTEFMENGALDSFLR-----LN---------------DGQF---TVIQLVGMLRGIASGMRYLAE--M--SYVHRDLAARNILVN--SNLVC----KVSDFGLSRFLE----ENS----S--DPTY------TSSLGGKIPIRWTAPEAIA------FRK--FTSASDAWSYGIVMWEVMSFGE-RP---------------YWDM------------SNQDV-INAIEQDYRLP---PPPDCP-----------------------------------------------------------------------------TSLHQLMLDCWQKDRNARPR-----FPQVVSAL--------------
----L-VLGKPLGEGCFGQVVLAEA---IGLDKDKPNRVT-KVAVKML-K-SD-AT-EKD-LSDLI-S-------EMEMMKMIG-K-----HKN-----IINLLGACT--Q-----------------------------DGPLYVIVEYASKGNLREYLQ-----ARRPPGLEYCYNPSHNPEEQL---SSKDLVSCAYQVARGMEYLAS--K--KCIHRDLAARNVLVT--EDNVM----KIADFGLARDI-------H----H--IDYY------KKTTNGRLPVKWMAPEALF------DRI--YTHQSDVWSFGVLLWEIFTLGG-SP---------------YPGV------------PVEEL-FKLLKEGHRMD---KPSNCT-----------------------------------------------------------------------------NELYMMMRDCWHAVPSQRPT-----FKQLVEDL--------------
-----LTLGKPLGEGCFGQVVMAEA---VGIDKDKPKEAV-TVAVKML-K-DD-AT-EKD-LSDLV-S-------EMEMMKMIG-K-----HKN-----IINLLGACT--Q-----------------------------DGPLYVIVEYASKGNLREYLR-----ARRPPGMEYSYDINRVPEEQM---TFKDLVSCTYQLARGMEYLAS--Q--KCIHRDLAARNVLVT--ENNVM----KIADFGLARDI-------N----N--IDYY------KKTTNGRLPVKWMAPEALF------DRV--YTHQSDVWSFGVLMWEIFTLGG-SP---------------YPGI------------PVEEL-FKLLKEGHRMD---KPANCT-----------------------------------------------------------------------------NELYMMMRDCWHAVPSQRPT-----FKQLVEDL--------------
-----LTLGKPLGEGCFGQVVMAEA---IGIDKDRAAKPV-TVAVKML-K-DD-AT-DKD-LSDLV-S-------EMEMMKMIG-K-----HKN-----IINLLGACT--Q-----------------------------GGPLYVLVEYAAKGNLREFLR-----ARRPPGLDYSFDTCKPPEEQL---TFKDLVSCAYQVARGMEYLAS--Q--KCIHRDLAARNVLVT--EDNVM----KIADFGLARDV-------H----N--LDYY------KKTTNGRLPVKWMAPEALF------DRV--YTHQSDVWSFGVLLWEIFTLGG-SP---------------YPGI------------PVEEL-FKLLKEGHRMD---KPANCT-----------------------------------------------------------------------------HDLYMIMRECWHAAPSQRPT-----FKQLVEDL--------------
----L-VLGKPLGEGCFGQVVRAEA---FGMDPARPDQAS-TVAVKML-K-DN-AS-DKD-LADLV-S-------EMEVMKLIG-R-----HKN-----IINLLGVCT--Q-----------------------------EGPLYVIVECAAKGNLREFLR-----ARRPPGPDLSPDGPRSSEGPL---SFPVLVSCAYQVARGMQYLES--R--KCIHRDLAARNVLVT--EDNVM----KIADFGLARGV-------H----H--IDYY------KKTSNGRLPVKWMAPEALF------DRV--YTHQSDVWSFGILLWEIFTLGG-SP---------------YPGI------------PVEEL-FSLLREGHRMD---RPPHCP-----------------------------------------------------------------------------PELYGLMRECWHAAPSQRPT-----FKQLVEAL--------------
-FLDF----RVLGKGGFGEVSACQM---K-------ATGK-LYACKKL-NKKR-LKKRK---GYQGAM------VEKKILMKV--H-----SRF-----IVSLAYAFE--T-----------------------------KADLCLVMTIMNGGDIRYHIYNVNEENP-----------------GF---PEPRALFYTAQIICGLEHLHQ--R--RIVYRDLKPENVLLD--NDGNV----RISDLGLAVEL------------LDGQSKT------KG---YAGTPGFMAPELLQ------GEE--YDFSVDYFALGVTLYEMIA-AR-GP---------------FRAR-----------GEKVEN-KELKHRIISEP---VKYPDKFS---------------------------------------------------------------------------QASKDFCEALLEKDPEKRLG-----FRD-------ETCDKLRAHPLF
---FR--HYRVLGKGGFGEVCACQV---R-------ATGK-MYACKKL-QKKR-IKKRK---GEAMAL------NEKRILEKV--Q-----SRF-----VVSLAYAYE--T-----------------------------KDALCLVLTIMNGGDLKFHIYN--LGNP-----------------GF---DEQRAVFYAAELCCGLEDLQR--E--RIVYRDLKPENILLD--DRGHI----RISDLGLATE-------------IPEGQRV------RG---RVGTVGYMAPEVVN------NEK--YTFSPDWWGLGCLIYEMIQ-GH-SP---------------FKKY------------KEKVK-WEEVDQRIKND---TEEYSE---KFS-----------------------------------------------------------------------EDAKSICRMLLTKNPSKRLGCRGEGAAGVKQHPV-F-----------
----F-RQYRVLGKGGFGEVCACQV---R-------ATGK-MYACKKL-EKKR-IKKRK---GEAMAL------NEKQILEKV--N-----SRF-----VVSLAYAYE--T-----------------------------KDALCLVLTLMNGGDLKFHIYH--MGQA-----------------GF---PEARAVFYAAEICCGLEDLHR--E--RIVYRDLKPENILLD--DHGHI----RISDLGLAVH-------------VPEGQTI------KG---RVGTVGYMAPEVVK------NER--YTFSPDWWALGCLLYEMIA-GQ-SP---------------FQQR------------KKKIK-REEVERLVK-E---VPEEYSER--FS-----------------------------------------------------------------------PQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLF------------
-----LKLEKKLGAGQFGEVWMATY---N--------KHT-KVAVKTM-K-PG-SM-SV---EAFL-A-------EANVMKTL--Q-----HDK-----LVKLHAVVT--------------------------------KEPIYIITEFMAKGSLLDFLK-----SD--------------EGSKQ---PLPKLIDFSAQIAEGMAFIEQ--R--NYIHRDLRAANILVS--ASLVC----KIADFGLARVI------------E--DNEY------TAREGAKFPIKWTAPEAIN------FGS--FTIKSDVWSFGILLMEIVTYGR-IP---------------YPGM------------SNPEV-IRALERGYRMP---RPENCP-----------------------------------------------------------------------------EELYNIMMRCWKNRPEERPT-----FEYIQSV--L------------
-----YDIIEVLGKGTFGEVAKGWR---R-------STGE-MVAIKIL-KNDA-YRNRI---IKN----------ELKLLHCM--RGLDPEEAH-----VIRFLEFFH--D-----------------------------ALKFYLVFELLEQ-NLFEFQK-----EN-----------------NFAPLPARHIRTVTLQVLTALARLKE--L--AIIHADLKPENIMLV--DQTRCPFRVKVIDFGSASIF------------SEVRYVK------EP---YIQSRFYRAPEILL------GLP--FCEKVDVWSLGCVMAELHL-GW-PL---------------YPGN------------NEYDQ-VRYICETQGLP---KPHLLHAACKAHHFFKRNPHPDAANPWQLKSSADYLAETKVRPLERRKYMLKSLDQIETVNGGSVASRLTFPDREALAEHADLKSMVELIKRMLTWESHERIS-----PSAALRHPFV------------
--IGS----RKLGEGSFAKVREGLH---V-------LTGE-KVAIKVI-DKKR-AKKDT---YVTKNLR-----REGQIQQMI--R-----HPN-----ITQLLDILE--T-----------------------------ENSYYLVMELCPGGNLMHKIY----EKK-----------------RL---EESEARRYIRQLISAVEHLHR--A--GVVHRDLKIENLLLD--EDNNI----KLIDFGLSNCAG----------ILGYSDPF------ST---QCGSPAYAAPELLA------RKK--YGPKIDVWSIGVNMYAMLT-GT-LP---------------FTVE-------------PFSL-RALYQKMVD-K---EMNPLPTQ--LS-----------------------------------------------------------------------TGAISFLRSLLEPDPVKRPN-----IQQALANRWL------------
-----YTTIRQLGDGTYGSVLLGRS---I-------ESGE-LIAIKKM-KRKF-YSWEE---C-MNLR-------EVKSLKKL--N-----HAN-----VVKLKEVIR--E-----------------------------NDHLYFIFEYMKE-NLYQLIK---ERNK-----------------LF---PESAIRNIMYQILQGLAFIHK--H--GFFHRDLKPENLLCM--GPELV----KIADFGLARE-------------IRSKPPY------TD---YVSTRWYRAPEVLL-----RSTN--YSSPIDVWAVGCIMAEVYT-LR-PL---------------FPGA------------SEIDT-IFKICQVLGTP---KKTDWPEGYQLSSAMNFRWPQCV------------------------------------------------PNNLKTLIPNASSEAVQLLRDMLQWDPKKRPT-----ASQALRYPYF------------
-----LKFLQQLGKGNFGSVEMCRY---DP---LQDNTGE-VVAVKKL-Q-HS-TE--EH-LRDFE-R-------EIEILKSL--Q-----HDN-----IVKYKGVCYSAG-----------------------------RRNLKLIMEYLPYGSLRDYLQ-----KH---------------KERI---DHIKLLQYTSQICKGMEYLGT--K--RYIHRDLATRNILVE--NENRV----KIGDFGLTKVL------PQ----D--KEYY------KVKEPGESPIFWYAPESLT------ESK--FSVASDVWSFGVVLYELFTYIE-KSKSPPAEFMRMIGNDKQGQM------------IVFHL-IELLKNNGRLP---RPDGCP-----------------------------------------------------------------------------DEIYMIMTECWNNNVNQRPS-----FRDLA----LRV----------
----L-KYISQLGKGNFGSVELCRY---DP---LGDNTGA-LVAVKQL-Q-HS-GP-DQ--QRDFQ-R-------EIQILKAL--H-----SDF-----IVKYRGVSYGPG-----------------------------RQSLRLVMEYLPSGCLRDFLQ-----RH---------------RARL---DASRLLLYSSQICKGMEYLGS--R--RCVHRDLAARNILVE--SEAHV----KIADFGLAKLL------PL----D--KDYY------VVREPGQSPIFWYAPESLS------DNI--FSRQSDVWSFGVVLYELFTYCD-KSCSPSAE--FLRMMGCERDV-P----------ALCRL-LELLEEGQRLP---APPACP-----------------------------------------------------------------------------AEVHELMKLCWAPSPQDRPS-----FSALGP---QL-----------
-----YTTMRQLGDGTYGSVLMGKS---N-------ESGE-LVAIKRM-KRKF-YSWDE---CM-NLR-------EVKSLKKL--N-----HAN-----VIKLKEVIR--E-----------------------------NDHLYFIFEYMKE-NLYQLMK---DRNK-----------------LF---PESVIRNIMYQILQGLAFIHK--H--GFFHRDMKPENLLCM--GPELV----KIADFGLARE-------------LRSQPPY------TD---YVSTRWYRAPEVLL-----RSSV--YSSPIDVWAVGSIMAELYM-LR-PL---------------FPGT------------SEVDE-IFKICQVLGTP---KKSDWPEGYQLASSMNFRFPQCV------------------------------------------------PINLKTLIPNASNEAIQLMTEMLNWDPKKRPT-----ASQALKHPYF------------
-----YRLLKTIGKGNFAKVKLARH---I-------LTGK-EVAVKII-DKTQ-LNSSS---LQKLFR-------EVRIMKVL--N-----HPN-----IVKLFEVIE--T-----------------------------EKTLYLVMEYASGGEVFDYLV----AHG-----------------RM---KEKEARAKFRQIVSAVQYCHQ--K--FIVHRDLKAENLLLD--ADMNI----KIADFGFSNE-------------FTFGNKL------DT---FCGSPPYAAPELFQ-----GKKY--DGPEVDVWSLGVILYTLVS-GS-LP---------------FDGQ---------------NL-KELRERVLRGK---YRIPFYMS---------------------------------------------------------------------------TDCENLLKKFLILNPSKRGT-----LEQIMKDRWM------------
-----YRLLRTIGKGNFAKVKLARH---I-------LTGR-EVAIKII-DKTQ-LNPSS---LQKLFR-------EVRIMKGL--N-----HPN-----IVKLFEVIE--T-----------------------------EKTLYLVMEYASAGEVFDYLV----SHG-----------------RM---KEKEARAKFRQIVSAVHYCHQ--K--NIVHRDLKAENLLLD--AEANI----KIADFGFSNE-------------FTLGSKL------DT---FCGSPPYAAPELFQ-----GKKY--DGPEVDIWSLGVILYTLVS-GS-LP---------------FDGH---------------NL-KELRERVLRGK---YRVPFYMS---------------------------------------------------------------------------TDCESILRRFLVLNPAKRCT-----LEQIMKDKWI------------
-----YRIRGEIGSGNFSQVKLGIH---S-------LTKE-KVAIKIL-DKTK-LDQKT---QRLLSR-------EISSMEKL--H-----HPN-----IIRLYEVVE--T-----------------------------LSKLHLVMEYAGGGELFGKIS----TEG-----------------KL---SEPESKLIFSQIVSAVKHMHE--N--QIIHRDLKAENVFYT--SNTCV----KVGDFGFSTV-------------SKKGEML------NT---FCGSPPYAAPELFR-----DEHY--IGIYVDIWALGVLLYFMVT-GT-MP---------------FRAE---------------TV-AKLKKSILEGT---YSVPPHV----S-----------------------------------------------------------------------EPCHRLIRGVLQQIPTERYG-----IDCIMNDEWM------------
-QLQE----DVLGEGAHARVQTCIN---L-------ITSQ-EYAVKII-EKQP-GHIRS---R--VFR-------EVEMLYQC-QG-----HRN-----VLELIEFFE--E-----------------------------EDRFYLVFEKMRGGSILSHIH----KRR-----------------HF---NELEASVVVQDVASALDFLHN--K--GIAHRDLKPENILCE--HPNQVS-PVKICDFDLGSGIKLN-----GDCSPISTPEL------LT---PCGSAEYMAPEVVEAF-SEEASI--YDKRCDLWSLGVILYILLS-GY-PP---------------FVGRCGSDCGWDRGEACPACQ-NMLFESIQEGK---YEFPDKDWAHIS-----------------------------------------------------------------------CAAKDLISKLLVRDAKQRLS-----AAQVLQHPWV------------
-----YELQETLGKGTYGKVKRATE---R-------FSGR-VVAIKSI-RKDK-IKDEQ---DMVHIR------REIEIMSSL--N-----HPH-----IISIYEVFE--N-----------------------------KDKIVIIMEYASKGELYDYIS----ERR-----------------RL---SERETRHFFRQIVSAVHYCHK--N--GVVHRDLKLENILLD--DNCNI----KIADFGLSNL-------------YQKDKFL------QT---FCGSPLYASPEIVN-----GRPY--RGPEVDSWALGVLLYTLVY-GT-MP---------------FDGF---------------DH-KNLIRQISSGE---YREPTQP----------------------------------------------------------------------------SDARGLIRWMLMVNPDRRAT-----IEDIANHWW-V-----------
-----YEFLETLGKGTYGKVKKARE---S-------SGR--LVAIKSI-RKDK-IKDEQ---DLMHIR------REIEIMSSL--N-----HPH-----IIAIHEVFE--N-----------------------------SSKIVIVMEYASRGDLYDYIS----ERQ-----------------QL---SEREARHFFRQIVSAVHYCHQ--N--RVVHRDLKLENILLD--ANGNI----KIADFGLSNL-------------YHQGKFL------QT---FCGSPLYASPEIVN-----GKPY--TGPEVDSWSLGVLLYILVH-GT-MP---------------FDGH---------------DH-KILVKQISNGA---YREPPK-----P-----------------------------------------------------------------------SDACGLIRWLLMVNPTRRAT-----LEDVASHWW-V-----------
-----YEPKEILGRGVSSVVRRCIH---K-------PTSQ-EYAVKVI-DVTG-GGSFS---PEEVRELREATLKEVDILRKV-SG-----HPN-----IIQLKDTYE--T-----------------------------NTFFFLVFDLMKRGELFDYLT----EKV-----------------TL---SEKETRKIMRALLEVICTLHK--L--NIVHRDLKPENILLD--DNMNI----KLTDFGFSCQ-------------LEPGERL------RE---VCGTPSYLAPEIIECSMNEDHPG--YGKEVDMWSTGVIMYTLLA-GS-PP---------------FWHR---------------KQ-MLMLRMIMSGN---YQFGSPEWDDYS-----------------------------------------------------------------------DTVKDLVSRFLVVQPQNRYT-----AEEALAHPFF------------
--YDP---KDVIGRGVSSVVRRCVH---R-------ATGH-EFAVKIM-EVTA-ERLSP---EQLEEVREA-TRRETHILRQV-AG-----HPH-----IITLIDSYE--S-----------------------------SSFMFLVFDLMRKGELFDYLT----EKV-----------------AL---SEKETRSIMRSLLEAVSFLHA--N--NIVHRDLKPENILLD--DNMQI----RLSDFGFSCH-------------LEPGEKL------RE---LCGTPGYLAPEILKCSMDETHPG--YGKEVDLWACGVILFTLLA-GS-PP---------------FWHR---------------RQ-ILMLRMIMEGQ---YQFSSPEWDDRS-----------------------------------------------------------------------STVKDLISRLLQVDPEARLT-----AEQALQHPFF------------
----Y-CRGKVLGKGGFAKCYEMTD---L-------TNNK-VYAAKII-PHSR-VAKPH---QREKID------KEIELHRIL--H-----HKH-----VVQFYHYFE--D-----------------------------KENIYILLEYCSRRSMAHILK----ARK-----------------VL---TEPEVRYYLRQIVSGLKYLHE--Q--EILHRDLKLGNFFIN--EAMEL----KVGDFGLAARL------------EPLEHRR------RT---ICGTPNYLSPEVLN------KQG--HGCESDIWALGCVMYTMLL-GR-PP---------------FETT---------------NL-KETYRCIREAR---YTMPSSLL---------------------------------------------------------------------------APAKHLIASMLSKNPEDRPS-----LDDIIRHDFF------------
---PD----EVLGSGQFGIVYGGKH---R-------KTGR-DVAIKII-DKLR-FPTKQ---ESQLRN-------EVAILQNL--H-----HPG-----VVNLECMFE--T-----------------------------PERVFVVMEKLHGDMLEMILS---SEKG-----------------RL---PEHITKFLITQILVALRHLHF--K--NIVHCDLKPENVLLA--SADPFP-QVKLCDFGFARI-------------IGEKSFR------RS---VVGTPAYLAPEVLR------NKG--YNRSLDMWSVGVIIYVSLS-GT-FP---------------FNED------------------EDIHDQIQNAA---FMYPPNPWKEIS-----------------------------------------------------------------------HEAIDLINNLLQVKMRKRYS-----VDKTLSHPWL------------
---PD----EVLGSGQFGVVYGGKH---R-------KTGR-DVAVKVI-DKLR-FPTKQ---ESQLRN-------EVAILQSL--R-----HPG-----IVNLECMFE--T-----------------------------PEKVFVVMEKLHGDMLEMILS---SEKG-----------------RL---PERLTKFLITQILVALRHLHF--K--NIVHCDLKPENVLLA--SADPFP-QVKLCDFGFARI-------------IGEKSFR------RS---VVGTPAYLAPEVLL------NQG--YNRSLDMWSVGVIMYVSLS-GT-FP---------------FNED------------------EDINDQIQNAA---FMYPASPWSHIS-----------------------------------------------------------------------AGAIDLINNLLQVKMRKRYS-----VDKSLSHPWL------------
--FAD----EVLGSGQFGIVYGGKH---R-------KTGR-DVAIKVI-DKMR-FPTKQ---ESQLRN-------EVAILQNL--H-----HPG-----IVNLECMFE--T-----------------------------PERVFVVMEKLHGDMLEMILS---SEKS-----------------RL---PERITKFMVTQILVALRNLHF--K--NIVHCDLKPENVLLA--SAEPFP-QVKLCDFGFARI-------------IGEKSFR------RS---VVGTPAYLAPEVLR------SKG--YNRSLDMWSVGVIIYVSLS-GT-FP---------------FNED------------------EDINDQIQNAA---FMYPPNPWREIS-----------------------------------------------------------------------GEAIDLINNLLQVKMRKRYS-----VDKSLSHPWL------------
--LES----AELDSGGFGKVSLCFH---R--------TQG-LMIMKTVYK-GP-NC-IEH-NEALL-E-------EAKMMNRL--R-----HSR-----VVKLLGVII--E-----------------------------EGKYSLVMEYMEKGNLMHVLK-----AE----------------MST---PLSVKGRIILEIIEGMCYLHG--K--GVIHKDLKPENILVD--NDFHI----KIADLGLASFKMWSKLNNE--------EHNELREVDGTAKKNGGTLYYMAPEHLN------DVNAKPTEKSDVYSFAVVLWAIFA-NK-EP---------------YENA-I----------CEQQL-IMCIKSGNRPDVDDITEYCP-----------------------------------------------------------------------------REIISLMKLCWEANPEARPT-----FPGIEEK--F------------
-----FELLRVLGKGGYGKVFQVRKVTGA-------NTGK-IFAMKVL-KKAM-IVRNA---KDTAHTK-----AERNILEEV--K-----HPF-----IVDLIYAFQ--T-----------------------------GGKLYLILEYLSGGELFMQLE----REG-----------------IF---MEDTACFYLAEISMALGHLHQ--K--GIIYRDLKPENIMLN--HQGHV----KLTDFGLCKES------------IHDGTVT------HT---FCGTIEYMAPEILM------RSG--HNRAVDWWSLGALMYDMLT-GA-PP---------------FTGE---------------NR-KKTIDKILKCK---LNLPPYLT---------------------------------------------------------------------------QEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFF------------
-----YELVRELGKGTYGKVDLVVY---K-------GTGT-KMALKFV-NKSK-TKLKN---F---LR-------EVSITNSL-SS-----SPF-----IIKVFDVVF--E----------------------------TEDCYVFAQEYAPAGDLFDIIP----PQV-----------------GL---PEDTVKRCVQQLGLALDFMHG--R--QLVHRDIKPENVLLFDRECRRV----KLADFGMTR---------------RVGCRV------KR---VSGTIPYTAPEVCQAG-RADGLA--VDTGVDVWAFGVLIFCVLT-GN-FP---------------WEAA------------SGADAFFEEFVRWQRGR---LPGLPSQWRRFT-----------------------------------------------------------------------EPALRMFQRLLALEPERRGP-----AKEVF-----RFLKH-------
-----YDIERTLGKGNFAVVKLARH---R-------VTKT-QVAIKII-DKTR-LDSSN---LEKIYR-------EVQLMKLL--N-----HPH-----IIKLYQVME--T-----------------------------KDMLYIVTEFAKNGEMFDYLT----SNG-----------------HL---SENEARKKFWQILSAVEYCHD--H--HIVHRDLKTENLLLD--GNMDI----KLADFGFGNF-------------YKSGEPL------ST---WCGSPPYAAPEVFE-----GKEY--EGPQLDIWSLGVVLYVLVC-GS-LP---------------FDGP---------------NL-PTLRQRVLEGR---FRIPFFMS---------------------------------------------------------------------------QDCESLIRRMLVVDPARRIT-----IAQIRQHRWM------------
-----YDIEGTLGKGNFAVVKLGRH---R-------ITKT-EVAIKII-DKSQ-LDAVN---LEKIYR-------EVQIMKML--D-----HPH-----IIKLYQVME--T-----------------------------KSMLYLVTEYAKNGEIFDYLA----NHG-----------------RL---NESEARRKFWQILSAVDYCHG--R--KIVHRDLKAENLLLD--NNMNI----KIADFGFGNF-------------FKSGELL------AT---WCGSPPYAAPEVFE-----GQQY--EGPQLDIWSMGVVLYVLVC-GA-LP---------------FDGP---------------TL-PILRQRVLEGR---FRIPYFMS---------------------------------------------------------------------------EDCEHLIRRMLVLDPSKRLT-----IAQIKEHKWM------------
-----WEIIGELGDGAFGKVYKAQN---K-------ETSV-LAAAKVI-DTKS-EEELE---DYM--V-------EIDILASC--D-----HPN-----IVKLLDAFY--Y-----------------------------ENNLWILIEFCAGGAVDAVML---ELER-----------------PL---TESQIQVVCKQTLDALNYLHD--N--KIIHRDLKAGNILFT--LDGDI----KLADFGVSAKN------------TRTIQRR------DS---FIGTPYWMAPEVVMCE-TSKDRP--YDYKADVWSLGITLIEMAE-IE-PP---------------HHEL------------NPMRV-LLKIAKSEPPT---LAQPSRWS---------------------------------------------------------------------------SNFKDFLKKCLEKNVDARWT-----TSQLLQHPFV------------
-----YDLDKTLGRGHFAVVKLARH---V-------FTGE-KVAVKVI-DKTK-LDTLA---TGHLFQ-------EVRCMKLV--Q-----HPN-----IVRLYEVID--T-----------------------------QTKLYLILELGDGGDMFDYIM---KHEE-----------------GL---NEDLAKKYFAQIVHAISYCHK--L--HVVHRDLKPENVVFF-EKQGLV----KLTDFGFSNK-------------FQPGKKL------TT---SCGSLAYSAPEILL-----GDEY--DAPAVDIWSLGVILFMLVC-GQ-PP---------------FQEA---------------ND-SETLTMIMDCK---YTVPSHVS---------------------------------------------------------------------------KECKDLITRMLQRDPKRRAS-----LEEIENHPWL------------
-----WEIVGELGDGAFGKVYKAKN---K-------ETGA-LAAAKVI-ETKS-EEELE---DYI--V-------EIEILATC--D-----HPY-----IVKLLGAYY--H-----------------------------DGKLWIMIEFCPGGAVDAIML---ELDR-----------------GL---TEPQIQVVCRQMLEALNFLHS--K--RIIHRDLKAGNVLMT--LEGDI----RLADFGVSAKN------------LKTLQKR------DS---FIGTPYWMAPEVVMCE-TMKDTP--YDYKADIWSLGITLIEMAQ-IE-PP---------------HHEL------------NPMRV-LLKIAKSDPPT---LLTPSKWS---------------------------------------------------------------------------VEFRDFLKIALDKNPETRPS-----AAQLLEHPFV------------
--LCP---GRELGRGKFAVVRKCIK---K-------DSGK-EFAAKFM-RKRR-KGQDC---RMEIIH-------EIAVLELA-QD-----NPW-----VINLHEVYE--T-----------------------------ASEMILVLEYAAGGEIFDQCVA--DREE-----------------AF---KEKDVQRLMRQILEGVHFLHT--R--DVVHLDLKPQNILLT--SESPLG-DIKIVDFGLSRI-------------LKNSEEL------RE---IMGTPEYVAPEILS------YDP--ISMATDMWSIGVLTYVMLT-GI-SP---------------FLGN---------------DK-QETFLNISQMN---LSYSEEEFDVLS-----------------------------------------------------------------------ESAVDFIRTLLVKKPEDRAT-----AEECLKHPWL------------
--ILT---SKELGRGKFAVVRQCIS---K-------STGQ-EYAAKFL-KKRR-RGQDC---RAEILH-------EIAVLELA-KS-----CPR-----VINLHEVYE--N-----------------------------TSEIILILEYAAGGEIFSLCLP--ELAE-----------------MV---SENDVIRLIKQILEGVYYLHQ--N--NIVHLDLKPQNILLS--SIYPLG-DIKIVDFGMSRK-------------IGHACEL------RE---IMGTPEYLAPEILN------YDP--ITTATDMWNIGIIAYMLLT-HT-SP---------------FVGE---------------DN-QETYLNISQVN---VDYSEETFSSVS-----------------------------------------------------------------------QLATDFIQSLLVKNPEKRPT-----AEICLSHSWL------------
-----FTKLEKIGKGSFGEVFKGID---N-------RTQK-VVAIKII-DLEE-AEDEI---EDIQ-Q-------EITVLSQC--D-----SPY-----VTKYYGSYL--K-----------------------------DTKLWIIMEYLGGGSALDLLE-----PG-----------------PL---DETQIATILREILKGLDYLHS--E--KKIHRDIKAANVLLS--EHGEV----KLADFGVAGQL------------TDTQIKR------NT---FVGTPFWMAPEVIK------QSA--YDSKADIWSLGITAIELAR-GE-PP---------------HSEL------------HPMKV-LFLIPKNNPPT---LEGNYS-----------------------------------------------------------------------------KPLKEFVEACLNKEPSFRPT-----AKELLKHKFI------------
--TLE---DKELGSGNFGTVKKGYY---Q-----MKKVVK-TVAVKIL-K-NE-AN-DPALKDELL-A-------EANVMQQL--D-----NPY-----IVRMIGICE--------------------------------AESWMLVMEMAELGPLNKYLQ-----QN----------------RHV---KDKNIIELVHQVSMGMKYLEE--S--NFVHRDLAARNVLLV--TQHYA----KISDFGLSKAL-------R----A--DENY-----YKAQTHGKWPVKWYAPECIN------YYK--FSSKSDVWSFGVLMWEAFSYGQ-KP---------------YRGM------------KGSEV-TAMLEKGERMG---CPAGCP-----------------------------------------------------------------------------REMYDLMNLCWTYDVENRPG-----FAAVE----LRL----------
---YL--LLHLLGRGGFSEVYKAFD---L-------TEQR-YVAVKIH-QLNK-NWRDE---KKENYHKH--ACREYRIHKEL--D-----HPR-----IVKLYDYFS--L----------------------------DTDSFCTVLEYCEGNDLDFYLK----QHK-----------------LM---SEKEARSIIMQIVNALKYLNE--IKPPIIHYDLKPGNILLV--NGTACG-EIKITDFGLSKIMDDD-----SYNSVDGMELT------SQ---GAGTYWYLPPECFVV--GKEPPK--ISNKVDVWSVGVIFYQCLY-GR-KP---------------FGHN-------------QSQQ-DILQENTILKA---TEVQFPPKPVVT-----------------------------------------------------------------------PEAKAFIRRCLAYRKEDRID-----VQQLACDPYL------------
YLLGI-----NLGEGSYAKVKSAYS---E-------RLKF-NVAIKII-DRKK-APADF---LEKFLP------REIEILAML--N-----HCS-----IIKTYEIFE--T----------------------------SHGKVYIVMELAVQGDLLELIK----TRG-----------------AL---HEDEARKKFHQLSLAIKYCHD--L--DVVHRDLKCDNLLLD--KDFNI----KLSDFSFSKRCLR--------DDSGRMALS------KT---FCGSPAYAAPEVLQ-----GIPY--QPKVYDIWSLGVILYIMVC-GS-MP---------------YDDS---------------NI-KKMLRIQKEHR---VNFPRSKHLT-------------------------------------------------------------------------GECKDLIYHMLQPDVNRRLH-----IDEILSHCWM------------
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